Adam M Brickman

Summary

Affiliation: Columbia University
Country: USA

Publications

  1. pmc Brain morphology in older African Americans, Caribbean Hispanics, and whites from northern Manhattan
    Adam M Brickman
    Departmentof Neurology, Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Gertrude H Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY 10032
    Arch Neurol 65:1053-61. 2008
  2. pmc Contemplating Alzheimer's disease and the contribution of white matter hyperintensities
    Adam M Brickman
    Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Department of Neurology, College of Physicians and Surgeons, Columbia University, PS Box 16, 630 West 168th Street, New York, NY, 10032, USA
    Curr Neurol Neurosci Rep 13:415. 2013
  3. pmc Testing the white matter retrogenesis hypothesis of cognitive aging
    Adam M Brickman
    Taub Institute for Research on Alzheimer s Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Neurobiol Aging 33:1699-715. 2012
  4. pmc Category and letter verbal fluency across the adult lifespan: relationship to EEG theta power
    Adam M Brickman
    Brown Medical School, Department of Psychiatry, Centers for Behavioral and Preventive Medicine, USA
    Arch Clin Neuropsychol 20:561-73. 2005
  5. ncbi request reprint Regional white matter and neuropsychological functioning across the adult lifespan
    Adam M Brickman
    Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Columbia University Medical Center, New York, NY 10032, USA
    Biol Psychiatry 60:444-53. 2006
  6. pmc Quantitative approaches for assessment of white matter hyperintensities in elderly populations
    Adam M Brickman
    Taub Institute for Research on Alzheimer s Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Psychiatry Res 193:101-6. 2011
  7. pmc Reduction in cerebral blood flow in areas appearing as white matter hyperintensities on magnetic resonance imaging
    Adam M Brickman
    Taub Institute for Research on Alzheimer s Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, NY, United States
    Psychiatry Res 172:117-20. 2009
  8. pmc Memory after silent stroke: hippocampus and infarcts both matter
    S Blum
    Gertrude H Sergievsky Center, Department of Neurology, Columbia University, New York, NY, USA
    Neurology 78:38-46. 2012
  9. ncbi request reprint Structural MRI covariance patterns associated with normal aging and neuropsychological functioning
    Adam M Brickman
    Cognitive Neuroscience Division, Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Columbia University Medical Center, New York, NY 20032, USA
    Neurobiol Aging 28:284-95. 2007
  10. pmc Measuring cerebral atrophy and white matter hyperintensity burden to predict the rate of cognitive decline in Alzheimer disease
    Adam M Brickman
    Taub Institute for Research on Alzheimer s Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, 630 W 168th St, Campus Box 16, New York, NY 10032, USA
    Arch Neurol 65:1202-8. 2008

Research Grants

Detail Information

Publications89

  1. pmc Brain morphology in older African Americans, Caribbean Hispanics, and whites from northern Manhattan
    Adam M Brickman
    Departmentof Neurology, Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Gertrude H Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY 10032
    Arch Neurol 65:1053-61. 2008
    ..Aging is accompanied by a decrease in brain volume and by an increase in cerebrovascular disease...
  2. pmc Contemplating Alzheimer's disease and the contribution of white matter hyperintensities
    Adam M Brickman
    Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Department of Neurology, College of Physicians and Surgeons, Columbia University, PS Box 16, 630 West 168th Street, New York, NY, 10032, USA
    Curr Neurol Neurosci Rep 13:415. 2013
    ..Future work should focus on more inclusive models of that better define "normal" vs "pathological" aging. ..
  3. pmc Testing the white matter retrogenesis hypothesis of cognitive aging
    Adam M Brickman
    Taub Institute for Research on Alzheimer s Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Neurobiol Aging 33:1699-715. 2012
    ..Taken together, the findings highlight the importance of white matter coherence in cognitive aging and provide some, but not complete, support for the white matter retrogenesis hypothesis in normal cognitive aging...
  4. pmc Category and letter verbal fluency across the adult lifespan: relationship to EEG theta power
    Adam M Brickman
    Brown Medical School, Department of Psychiatry, Centers for Behavioral and Preventive Medicine, USA
    Arch Clin Neuropsychol 20:561-73. 2005
    ..The differential age-associated decline between category and letter fluency suggests separate neurobiological substrates underlying the two domains of performance, which is not related to theta activity...
  5. ncbi request reprint Regional white matter and neuropsychological functioning across the adult lifespan
    Adam M Brickman
    Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Columbia University Medical Center, New York, NY 10032, USA
    Biol Psychiatry 60:444-53. 2006
    ..The current study utilized magnetic resonance imaging (MRI) to more fully elucidate the relationship among age, regional white matter, and neuropsychological functioning...
  6. pmc Quantitative approaches for assessment of white matter hyperintensities in elderly populations
    Adam M Brickman
    Taub Institute for Research on Alzheimer s Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Psychiatry Res 193:101-6. 2011
    ..The operator-driven approach may be better suited for smaller studies with highly trained raters, whereas the fully automated quantitative approach may be more appropriate for larger, high-throughput studies...
  7. pmc Reduction in cerebral blood flow in areas appearing as white matter hyperintensities on magnetic resonance imaging
    Adam M Brickman
    Taub Institute for Research on Alzheimer s Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, NY, United States
    Psychiatry Res 172:117-20. 2009
    ..Regions with consistently lower CBF across individuals were more likely to appear as WMH. Results are consistent with an emerging literature linking diminished regional perfusion with the risk of developing WMH...
  8. pmc Memory after silent stroke: hippocampus and infarcts both matter
    S Blum
    Gertrude H Sergievsky Center, Department of Neurology, Columbia University, New York, NY, USA
    Neurology 78:38-46. 2012
    ..However, the contribution of vascular lesions, such as brain infarcts, to hippocampal integrity and age-associated memory decline remains unclear...
  9. ncbi request reprint Structural MRI covariance patterns associated with normal aging and neuropsychological functioning
    Adam M Brickman
    Cognitive Neuroscience Division, Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Columbia University Medical Center, New York, NY 20032, USA
    Neurobiol Aging 28:284-95. 2007
    ..The results suggest that identifiable networks of grey and white matter regions systematically decline with age and that pattern expression is linked to age-related cognitive decline...
  10. pmc Measuring cerebral atrophy and white matter hyperintensity burden to predict the rate of cognitive decline in Alzheimer disease
    Adam M Brickman
    Taub Institute for Research on Alzheimer s Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, 630 W 168th St, Campus Box 16, New York, NY 10032, USA
    Arch Neurol 65:1202-8. 2008
    ..To determine if baseline measurements of cerebral atrophy and severity of white matter hyperintensity (WMH) predict the rate of future cognitive decline in patients with Alzheimer disease (AD)...
  11. ncbi request reprint Internal capsule size in good-outcome and poor-outcome schizophrenia
    Adam M Brickman
    Taub Institute, P and S 16, Columbia University Medical Center, 630 West 168th St, New York, NY 10032, USA
    J Neuropsychiatry Clin Neurosci 18:364-76. 2006
    ..The findings suggest disruption of internal capsule fibers in poor-outcome patients with schizophrenia. These abnormalities may be independent of other structural changes in schizophrenia...
  12. pmc Long-term blood pressure fluctuation and cerebrovascular disease in an elderly cohort
    Adam M Brickman
    Taub Institute for Research on Alzheimer s Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    Arch Neurol 67:564-9. 2010
    ..Elevated blood pressure (BP) and fluctuation in BP may lead to cerebrovascular disease through ischemic changes and compromised cerebral autoregulation...
  13. pmc A forward application of age associated gray and white matter networks
    Adam M Brickman
    Cognitive Neuroscience Division, Taub Institute for Research on Alzheimer s Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    Hum Brain Mapp 29:1139-46. 2008
    ..405, P = 0.024). The findings suggest that the previously derived age-associated covariance pattern for gray matter is reliable and may provide information that is more functionally meaningful than chronological age...
  14. pmc White matter hyperintensities and cognition: testing the reserve hypothesis
    Adam M Brickman
    Taub Institute for Research on Alzheimer s Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Neurobiol Aging 32:1588-98. 2011
    ..We hypothesized that individuals with higher amounts of reserve would be able to tolerate greater amounts of pathology than those with lower reserve...
  15. pmc Structural neuroimaging in Altheimer's disease: do white matter hyperintensities matter?
    Adam M Brickman
    Taub Institute for Research on Alzheimer s Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Dialogues Clin Neurosci 11:181-90. 2009
    ....
  16. ncbi request reprint FDG-PET in never-previously medicated psychotic adolescents treated with olanzapine or haloperidol
    Monte S Buchsbaum
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
    Schizophr Res 94:293-305. 2007
    ..Haloperidol increased striatal metabolic rate more than olanzapine. Both drugs increased thalamic metabolic rates and this increase was significantly larger in younger (age 13-15) than older (16-21) patients...
  17. ncbi request reprint The relationship between frontal gray matter volume and cognition varies across the healthy adult lifespan
    Molly E Zimmerman
    Department of Psychiatry and Human Behavior, Brown Medical School, Providence, Rhode Island, USA
    Am J Geriatr Psychiatry 14:823-33. 2006
    ..The goal of the current study is to examine the relationship between age-related changes in regional gray matter volumes and cognitive function in a large, cross-sectional sample of healthy adults across the lifespan...
  18. pmc Validity of self-reported stroke in elderly African Americans, Caribbean Hispanics, and Whites
    Christiane Reitz
    Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Columbia University, New York, New York 10032, USA
    Arch Neurol 66:834-40. 2009
    ..The validity of a self-reported stroke remains inconclusive...
  19. pmc Poor outcome in chronic schizophrenia is associated with progressive loss of volume of the putamen
    Serge A Mitelman
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
    Schizophr Res 113:241-5. 2009
    ..Present longitudinal study was designed to investigate progressive differences in striatal volumes among chronic schizophrenia patients with different outcomes and healthy subjects...
  20. pmc Telephone-based identification of mild cognitive impairment and dementia in a multicultural cohort
    Jennifer J Manly
    Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Columbia University Medical Center, 630 W 168th Street, New York, NY 10032, USA
    Arch Neurol 68:607-14. 2011
    ..Telephone-based interviews can be used for screening and to obtain key study outcomes when participants in longitudinal studies die or cannot be seen in person, but must be validated among ethnically and educationally diverse people...
  21. pmc Physical activity and Alzheimer disease course
    Nikolaos Scarmeas
    Taub Institute for Research in Alzheimer s Disease and the Aging Brain, Columbia University Medical Center, NY 10032, USA
    Am J Geriatr Psychiatry 19:471-81. 2011
    ..To examine the association between physical activity (PA) and Alzheimer disease (AD) course...
  22. pmc Diffusion tensor anisotropy in adolescents and adults
    Jason S Schneiderman
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
    Neuropsychobiology 55:96-111. 2007
    ..Sex differences were found in the majority of areas but were most marked in the cingulum bundle and internal capsule. These results suggest continuing white matter development between adolescence and adulthood...
  23. pmc Age and diffusion tensor anisotropy in adolescent and adult patients with schizophrenia
    Jason S Schneiderman
    Department of Psychiatry, Mount Sinai School of Medicine, NY, USA
    Neuroimage 45:662-71. 2009
    ..This suggests that tracts involved in the connectivity of the temporal lobe white matter deficits were already well in place in adolescent patients, while frontal lobe pathology continues to develop from adolescence to adulthood...
  24. pmc A longitudinal study of the corpus callosum in chronic schizophrenia
    Serge A Mitelman
    Department of Psychiatry, Mount Sinai School of Medicine, New York, New York 10029, USA
    Schizophr Res 114:144-53. 2009
    ..Decreased callosal size and anisotropy have been described in schizophrenia patients but their longitudinal progression remains poorly understood...
  25. ncbi request reprint Abnormal glucose metabolism in the mediodorsal nucleus of the thalamus in schizophrenia
    Erin A Hazlett
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
    Am J Psychiatry 161:305-14. 2004
    ....
  26. ncbi request reprint MRI assessment of gray and white matter distribution in Brodmann's areas of the cortex in patients with schizophrenia with good and poor outcomes
    Serge A Mitelman
    Department of Psychiatry, Box 1505, Mount Sinai Medical Center, One Gustave L Levy Pl, New York, NY 10029, USA
    Am J Psychiatry 160:2154-68. 2003
    ..High-resolution magnetic resonance imaging (MRI) was used to compare cortical gray and white matter and CSF volumes in schizophrenia patients with poor outcomes, schizophrenia patients with good outcomes, and healthy comparison subjects...
  27. pmc Effects of sex and normal aging on regional brain activation during verbal memory performance
    Erin A Hazlett
    Department of Psychiatry, Mount Sinai School of Medicine, One Gustave Levy Place, New York, NY 10029, USA
    Neurobiol Aging 31:826-38. 2010
    ..These results suggest that both age-related metabolic decline and sex differences within frontal regions are more marked in medial frontal and cingulate areas, consistent with some age-related patterns of affective and cognitive change...
  28. pmc Course and etiology of dysexecutive MCI in a community sample
    Edward D Huey
    Taub Institute for Research on Alzheimer s Disease and the Aging Brain, The Gertrude H Sergievsky Center, Columbia University, New York, NY, USA Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, NY, USA Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA Division of Geriatric Psychiatry, New York State Psychiatric Institute, College of Physicians and Surgeons, Columbia University, New York, NY, USA Electronic address
    Alzheimers Dement 9:632-9. 2013
    ....
  29. pmc Separating function from structure in perfusion imaging of the aging brain
    Iris Asllani
    Program for Imaging and Cognitive Sciences in the Department of Radiology, Columbia University, New York, New York, USA
    Hum Brain Mapp 30:2927-35. 2009
    ....
  30. ncbi request reprint Cognitive status of young and older cigarette smokers: data from the international brain database
    Robert H Paul
    Centers for Behavioral and Preventive Medicine, Department of Psychiatry, Brown Medical School, Providence, RI 02903, USA
    J Clin Neurosci 13:457-65. 2006
    ..Cigarette smoking is associated with isolated and subtle cognitive difficulties among very healthy individuals...
  31. pmc Subcortical hyperintensities impact cognitive function among a select subset of healthy elderly
    Robert H Paul
    Brown Medical School, Centers for Behavioral and Preventive Medicine, Department of Psychiatry and Human Behavior, 1 Hoppin Street, Providence, RI 02903, USA
    Arch Clin Neuropsychol 20:697-704. 2005
    ..Further, the findings suggest that cognitive aging is largely determined by factors other than SH for most older adults...
  32. pmc Frequency of subclinical heart disease in elderly persons with dementia
    Christiane Reitz
    Gertrude H Sergievsky Center, Columbia University, New York, NY 10032, USA
    Am J Geriatr Cardiol 16:183-8. 2007
    ..With the increasing prevalence of Alzheimer's disease and vascular dementia, clinicians have to be more attentive to the presence of structural heart disease and its complications in persons with these conditions...
  33. pmc Linking hippocampal structure and function to memory performance in an aging population
    Christiane Reitz
    Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Gertrude H Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Arch Neurol 66:1385-92. 2009
    ..Magnetic resonance imaging is used to assess structure and function in the hippocampal formation...
  34. pmc Do neuropsychological tests have the same meaning in Spanish speakers as they do in English speakers?
    Karen L Siedlecki
    Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Columbia University Medical Center, New York, NY, USA
    Neuropsychology 24:402-11. 2010
    ..The purpose of this study was to examine whether neuropsychological tests translated into Spanish measure the same cognitive constructs as the original English versions...
  35. ncbi request reprint Age-dependent change in executive function and gamma 40 Hz phase synchrony
    Robert H Paul
    Centers for Behavioral and Preventive Medicine, Department of Psychiatry and Human Behavior, Brown Medical School, Providence, RI 02903, USA
    J Integr Neurosci 4:63-76. 2005
    ....
  36. pmc Quantifying cognitive reserve in older adults by decomposing episodic memory variance: replication and extension
    Laura B Zahodne
    Cognitive Neuroscience Division, Department of Neurology and Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Columbia University College of Physicians and Surgeons, New York, NY, USA
    J Int Neuropsychol Soc 19:854-62. 2013
    ..This method has the potential to facilitate research on the mechanisms of cognitive reserve and the efficacy of interventions designed to impart reserve...
  37. ncbi request reprint White matter fractional anisotropy and outcome in schizophrenia
    Serge A Mitelman
    Department of Psychiatry, Neuroscience PET Laboratory, Box 1505, Mount Sinai Medical Center, One Gustave L Levy Place, New York, NY 10029, USA
    Schizophr Res 87:138-59. 2006
    ..We examined whether there is a relationship between white matter FA and outcome in patients with schizophrenia...
  38. ncbi request reprint Neuropsychological functioning in first-break, never-medicated adolescents with psychosis
    Adam M Brickman
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Nerv Ment Dis 192:615-22. 2004
    ..The findings demonstrate neuropsychological deficits in adolescents with psychosis and suggest that cognitive deficits are core symptoms in psychotic disorders...
  39. pmc White matter predictors of cognitive functioning in older adults
    Irene B Meier
    Taub Institute for Research on Alzheimer s Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    J Int Neuropsychol Soc 18:414-27. 2012
    ..White matter microstructural changes, quantified with diffusion tensor imaging, appear to play a lesser role in our sample...
  40. pmc Contribution of vascular risk factors to the progression in Alzheimer disease
    Elizabeth P Helzner
    Gertrude H Sergievsky Center, Columbia University Medical Center, NY, New York, USA
    Arch Neurol 66:343-8. 2009
    ....
  41. pmc Physical activity, diet, and risk of Alzheimer disease
    Nikolaos Scarmeas
    Taub Institute for Research in Alzheimer s Disease and the Aging Brain and Department of Neurology, Columbia University Medical Center, 622 W 168th St, New York, NY 10032, USA
    JAMA 302:627-37. 2009
    ..Both higher adherence to a Mediterranean-type diet and more physical activity have been independently associated with lower Alzheimer disease (AD) risk but their combined association has not been investigated...
  42. pmc Quantitative brain measurements in community-dwelling elderly persons with mild parkinsonian signs
    Elan D Louis
    Unit 198, Department of Neurology, Columbia University, 710 W 168th St, New York, NY 10032, USA
    Arch Neurol 65:1649-54. 2008
    ..Also, if MPS are a marker for developing Alzheimer-type changes, hippocampal volume on MRI might be diminished in individuals with MPS...
  43. pmc Examining the multifactorial nature of cognitive aging with covariance analysis of positron emission tomography data
    Karen L Siedlecki
    Cognitive Neuroscience Division, Taub Institute for Research in Alzheimer s Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    J Int Neuropsychol Soc 15:973-81. 2009
    ..The findings from this study are consistent with the multifactorial nature of cognitive aging...
  44. pmc Hippocampal atrophy relates to fluid intelligence decline in the elderly
    Aaron Reuben
    Cognitive Neuroscience Division of the Taub Institute, Columbia University College of Physicians and Surgeons, New York, New York, USA
    J Int Neuropsychol Soc 17:56-61. 2011
    ..No relationship between the other cognitive domains and brain or hippocampal volume was found. The findings suggest a role of hippocampal atrophy in the decline in fluid intelligence in the elderly...
  45. ncbi request reprint Internal capsule, corpus callosum and long associative fibers in good and poor outcome schizophrenia: a diffusion tensor imaging survey
    Serge A Mitelman
    Department of Psychiatry, Mount Sinai School of Medicine, New York, New York, USA
    Schizophr Res 92:211-24. 2007
    ..We set out to confirm these exploratory findings and evaluate their relation to illness severity using a hypothesis-driven region-of-interest approach...
  46. ncbi request reprint Patterns of cognitive performance in middle-aged and older adults: A cluster analytic examination
    John Gunstad
    Department of Psychiatry, Brown Medical School, Centers for Behavioral and Preventive Medicine, Providence, RI 02903, USA
    J Geriatr Psychiatry Neurol 19:59-64. 2006
    ..Findings generally support the frontal aging hypothesis and may provide important information about healthy cognitive aging...
  47. ncbi request reprint Cortical intercorrelations of frontal area volumes in schizophrenia
    Serge A Mitelman
    Department of Psychiatry, Neuroscience PET Laboratory, Box 1505, Mount Sinai Medical Center, One Gustave L Levy Place, New York, NY 10029, USA
    Neuroimage 27:753-70. 2005
    ..Abnormal regional volume intercorrelations between selected cortical areas in schizophrenia patients were previously reported in several MRI studies...
  48. pmc Operationalizing diagnostic criteria for Alzheimer's disease and other age-related cognitive impairment-Part 1
    Richard Mayeux
    Gertrude H Sergievsky Center, Columbia University, New York, NY, USA
    Alzheimers Dement 7:15-34. 2011
    ..Biomarkers for AD could also facilitate studies of the interactions of various forms of neurodegenerative disorders with cerebrovascular disease, resulting in "mixed dementia"...
  49. pmc Cerebral blood flow and gray matter volume covariance patterns of cognition in aging
    Jason Steffener
    Cognitive Neuroscience Division of the Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Columbia University College of Physicians and Surgeons, New York, New York Department of Neurology, Columbia University of Physicians and Surgeons, New York, New York
    Hum Brain Mapp 34:3267-79. 2013
    ..The findings suggest that measures derived from multiple imaging modalities explain larger amounts of variance in cognition providing a more complete understanding of the aging brain...
  50. pmc Higher education is an age-independent predictor of white matter integrity and cognitive control in late adolescence
    Kimberly G Noble
    Department of Pediatrics, College of Physicians and Surgeons, Columbia University, USA Gertrude H Sergievsky Center, College of Physicians and Surgeons, Columbia University, USA
    Dev Sci 16:653-64. 2013
    ..The uncinate fasciculus, a late-myelinated control region not implicated in cognitive control, did not mediate this effect. ..
  51. pmc Dysexecutive versus amnestic Alzheimer disease subgroups: analysis of demographic, genetic, and vascular factors
    Jesse Mez
    Gertrude H Sergievsky Center, Taub Institute for Research on Alzheimer Disease and the Aging Brain, Department of Neurology, Columbia University, New York, NY, USA
    Alzheimer Dis Assoc Disord 27:218-25. 2013
    ..These distinct characteristics add to accumulating evidence that a dysexecutive subgroup of AD may have a unique underlying pathophysiology. ..
  52. pmc Lower cardiac output is associated with greater white matter hyperintensities in older adults with cardiovascular disease
    Angela L Jefferson
    Department of Neurology, Alzheimer s Disease Center, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Am Geriatr Soc 55:1044-8. 2007
    ..To preliminarily examine the association between cardiac output, a measure of systemic blood flow, and structural brain magnetic resonance imaging indices of white matter hyperintensities (WMHs)...
  53. ncbi request reprint White matter hyperintensities and cerebral amyloidosis: necessary and sufficient for clinical expression of Alzheimer disease?
    Frank A Provenzano
    Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    JAMA Neurol 70:455-61. 2013
    ..The impact of small-vessel cerebrovascular disease, visualized as white matter hyperintensities (WMHs) on magnetic resonance imaging scans, may be a key factor that contributes independently to AD presentation...
  54. pmc Hippocampal subregions differentially associate with standardized memory tests
    Adam M Brickman
    Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Hippocampus 21:923-8. 2011
    ....
  55. ncbi request reprint Thalamus size and outcome in schizophrenia
    Adam M Brickman
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, USA
    Schizophr Res 71:473-84. 2004
    ..These findings are consistent with post-mortem and MRI measurement suggesting reduction in volume of the pulvinar, which occupies a large proportion of the ventral thalamus and which has prominent connections to the temporal lobe...
  56. pmc Olfactory identification deficits and MCI in a multi-ethnic elderly community sample
    D P Devanand
    Division of Geriatric Psychiatry, Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Neurobiol Aging 31:1593-600. 2010
    ..These findings indicate that the predictive utility of olfactory identification deficits for decline from no MCI to MCI and AD needs to be assessed in longitudinal studies of elderly community samples...
  57. ncbi request reprint The progression of cognition, psychiatric symptoms, and functional abilities in dementia with Lewy bodies and Alzheimer disease
    Karina Stavitsky
    Gertrude H Sergievsky Center and Department of Neurology, Columbia University Medical Center, New York, NY, USA
    Arch Neurol 63:1450-6. 2006
    ..Although dementia with Lewy bodies (DLB) may be one of most common forms of dementia, relatively little is known about its cognitive and functional course...
  58. doi request reprint MRI signal hyperintensities and failure to remit following antidepressant treatment
    Joel R Sneed
    Queens College, City University of New York, Department of Psychology, New York, NY 11367, USA
    J Affect Disord 135:315-20. 2011
    ..Previous studies using volumetrics in outpatient samples have relied on total lesion volume. The purpose of this study was to test whether remission from geriatric depression depends on lesion volume by region of interest (ROI)...
  59. pmc Neuroimaging and cardiac correlates of cognitive function among patients with cardiac disease
    Robert H Paul
    Center for Behavioral Medicine, Department of Psychiatry and Human Behavior, Brown Medical School, Providence, R I 02903, USA
    Cerebrovasc Dis 20:129-33. 2005
    ....
  60. pmc Different demographic, genetic, and longitudinal traits in language versus memory Alzheimer's subgroups
    Jesse Mez
    Gertrude H Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    J Alzheimers Dis 37:137-46. 2013
    ..The study demonstrates that a language subgroup of AD has different demographics, genetic profile, and disease course in addition to cognitive phenotype. ..
  61. ncbi request reprint Progressive ventricular expansion in chronic poor-outcome schizophrenia
    Serge A Mitelman
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
    Cogn Behav Neurol 23:85-8. 2010
    ..To compare progressive changes in lateral ventricular size in chronic schizophrenia patients with good and poor outcomes...
  62. pmc A comprehensive assessment of gray and white matter volumes and their relationship to outcome and severity in schizophrenia
    Serge A Mitelman
    Department of Psychiatry, Neuroscience Positron Emission Tomography Laboratory, Box 1505, Mount Sinai Medical Center, One Gustave L Levy Place, New York, NY 10029, USA
    Neuroimage 37:449-62. 2007
    ..Poor outcome is associated with more posterior distribution (posteriorization) of both gray and white matter changes, and with preferential impairment in the unimodal visual and paralimbic cortical regions...
  63. ncbi request reprint The specificity of neuropsychological impairment in predicting antidepressant non-response in the very old depressed
    Joel R Sneed
    Department of Psychiatry, Columbia State University, New York State Psychiatric Institute, New York, NY 10032, USA
    Int J Geriatr Psychiatry 23:319-23. 2008
    ..2007). The purpose of this study was to ascertain whether this effect is specific to response inhibition or whether impairment in other cognitive domains also predicts non-response...
  64. pmc White matter hyperintensity volume and impaired mobility among older adults
    Joshua Z Willey
    Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    J Neurol 260:884-90. 2013
    ..WMH are associated with slowing of gait over time. Prevention of WMH presents a potential strategy for the prevention of gait speed decline...
  65. pmc Sleep onset/maintenance difficulties and cognitive function in nondemented older adults: the role of cognitive reserve
    Molly E Zimmerman
    Department of Neurology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Int Neuropsychol Soc 18:461-70. 2012
    ..5; p = .00)). Consistent with the cognitive reserve hypothesis, older adults with lower education appear selectively vulnerable to the negative effects of sleep onset/maintenance difficulties on tests of verbal fluency...
  66. ncbi request reprint Cortical intercorrelations of temporal area volumes in schizophrenia
    Serge A Mitelman
    Department of Psychiatry, Neuroscience PET Laboratory, Box 1505, Mount Sinai Hospital, One Gustave L Levy Place, New York, NY 10029, USA
    Schizophr Res 76:207-29. 2005
    ....
  67. pmc The brain in the age of old: the hippocampal formation is targeted differentially by diseases of late life
    William Wu
    Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Columbia University College of Physicians and Surgeons, New York, NY, USA
    Ann Neurol 64:698-706. 2008
    ..To rely on the anatomical organization of the hippocampal formation in understanding whether and how late-life diseases such as diabetes and stroke contribute to age-related cognitive decline...
  68. ncbi request reprint Caudate and putamen volumes in good and poor outcome patients with schizophrenia
    Monte S Buchsbaum
    Department of Psychiatry, Mount Sinai School of Medicine, Box 1505, 1 Gustave L Levy Place, New York, NY 10029 6574, USA
    Schizophr Res 64:53-62. 2003
    ..This suggests the possibility that the expansion of putamen size may be a physiological correlate of neuroleptic responsiveness or that small putamen size at disease onset may be a predictor of outcome...
  69. ncbi request reprint Volume of the cingulate and outcome in schizophrenia
    Serge A Mitelman
    Department of Psychiatry, Neuroscience PET Laboratory, Box 1505, Mount Sinai School of Medicine, Mount Sinai Medical Center, One Gustave L Levy Place, New York, NY 10029, USA
    Schizophr Res 72:91-108. 2005
    ..We examined whether this pattern is seen within the anteroposterior arch of the cingulate gyrus...
  70. ncbi request reprint Depression in autopsy-confirmed dementia with Lewy bodies and Alzheimer's disease
    Steven C Samuels
    Department of Psychiatry, Box 1230, Mount Sinai School of Medicine, One East 100th Street, New York, NY 10029, USA
    Mt Sinai J Med 71:55-62. 2004
    ..Furthermore, depressive symptomatology in DLB does not appear to be related to severity of cortical or subcortical LB pathology...
  71. ncbi request reprint Striatal size, glucose metabolic rate, and verbal learning in normal aging
    Adam M Brickman
    Department of Psychiatry, Neuroscience PET Laboratory, Box 1505, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Brain Res Cogn Brain Res 17:106-16. 2003
    ..Findings of significant involvement of striatal functioning in verbal learning are most likely accounted for by age and suggest an age-related shift from anterior to posterior circuitry in the human telencephalon...
  72. ncbi request reprint Longitudinal assessment of patient dependence in Alzheimer disease
    Adam M Brickman
    Department of Neurology, Gertrude H Sergievsky Center, Columbia University College of Physicians and Surgeons, 630 W 168th St, New York, NY 10032, USA
    Arch Neurol 59:1304-8. 2002
    ..Validity and reliability of this scale have been demonstrated, but the progression throughout long periods in patients with Alzheimer disease (AD) has not previously been examined...
  73. pmc An in vivo correlate of exercise-induced neurogenesis in the adult dentate gyrus
    Ana C Pereira
    The Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Department of Neurology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 104:5638-43. 2007
    ....
  74. ncbi request reprint Correlations between MRI-assessed volumes of the thalamus and cortical Brodmann's areas in schizophrenia
    Serge A Mitelman
    Department of Psychiatry, Neuroscience PET Laboratory, Mount Sinai School of Medicine, New York, NY 10029, USA
    Schizophr Res 75:265-81. 2005
    ..We compared the thalamic-cortical volumetric correlational patterns in patients with schizophrenia and normal comparison subjects, and evaluated their relations to outcome...
  75. pmc Pinpointing synaptic loss caused by Alzheimer's disease with fMRI
    Adam M Brickman
    Department of Neurology, Taub Institute for Research on Alzheimer s Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    Behav Neurol 21:93-100. 2009
    ..In this review, we will compare and contrast both approaches for pinpointing when and where synaptic loss in AD begins and for monitoring therapeutic efficacy...
  76. pmc MRI signal hyperintensities and treatment remission of geriatric depression
    Faith M Gunning-Dixon
    Weill Medical College of Cornell University, Weill Cornell Institute of Geriatric Psychiatry, White Plains, NY, United States
    J Affect Disord 126:395-401. 2010
    ..We hypothesized that patients who failed to remit during a 12-week controlled treatment trial of escitalopram would exhibit greater SH burden than patients who remitted...
  77. ncbi request reprint Progressive morphometric and cognitive changes in vascular dementia
    John Gunstad
    Department of Psychiatry and Human Behavior, Brown Medical School, Miriam Hospital, Coro West Third Floor, 1 Hoppin St, Providence RI 02903, USA
    Arch Clin Neuropsychol 20:229-41. 2005
    ..Further research is needed to determine whether this observed decline is attributable to differential lesion distribution or statistical artifact...
  78. ncbi request reprint Cognitive burden and excess Lewy-body pathology in the Lewy-body variant of Alzheimer disease
    Michael Serby
    Departments of Psychiatry and Psychology, Mount Sinai School of Medicine, New York, NY, USA
    Am J Geriatr Psychiatry 11:371-4. 2003
    ....
  79. pmc Mediterranean diet and magnetic resonance imaging-assessed cerebrovascular disease
    Nikolaos Scarmeas
    Taub Institute for Research in Alzheimer s Disease and the Aging Brain, University of California at Davis, Sacramento, USA
    Ann Neurol 69:257-68. 2011
    ..Cerebrovascular disease is 1 of the possible mechanisms of the previously reported relationship between Mediterranean-type diet (MeDi) and Alzheimer's disease (AD). We sought to investigate the association between MeDi and MRI infarcts...
  80. pmc Aging of cerebral white matter: a review of MRI findings
    Faith M Gunning-Dixon
    Institute of Geriatric Psychiatry, Department of Psychiatry, Weill Cornell Medical College, USA
    Int J Geriatr Psychiatry 24:109-17. 2009
    ..Structural magnetic resonance imaging (MRI) can be used to identify and quantify non-disease-related aging of the cerebral white matter...
  81. ncbi request reprint The prevalence, diagnosis and treatment of depression in dementia patients in chronic care facilities in the last six months of life
    Martin M Evers
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
    Int J Geriatr Psychiatry 17:464-72. 2002
    ..To assess the prevalence, diagnosis and treatment of depression among dementia patients and normal controls in chronic care facilities in the last six months of life...
  82. ncbi request reprint Magnetic resonance imaging of mediodorsal, pulvinar, and centromedian nuclei of the thalamus in patients with schizophrenia
    Eileen M Kemether
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
    Arch Gen Psychiatry 60:983-91. 2003
    ..The centromedian nucleus (CMN), important in attention and arousal, has not been previously studied with MRI...
  83. ncbi request reprint Ethical issues in cross-cultural neuropsychology
    Adam M Brickman
    Cognitive Neuroscience Division, Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Columbia University Medical Center, New York, New York 10032, USA
    Appl Neuropsychol 13:91-100. 2006
    ....
  84. ncbi request reprint Emotional processing deficits in individuals with unilateral brain damage
    Joan C Borod
    Department of Neurology, Mount Sinai School of Medicine, New York, New York, USA corrected
    Appl Neuropsychol 9:23-36. 2002
    ..The article is concluded by aligning these new data with findings from the general literature, providing added support for the right-hemisphere emotion hypothesis...
  85. ncbi request reprint Distinct serial position profiles and neuropsychological measures differentiate late life depression from normal aging and Alzheimer's disease
    Nancy S Foldi
    Department of Psychology, Queens College and the Graduate Center of the City University of New York, 65 30 Kissena Blvd, NSB E318, Flushing, NY 11367, USA
    Psychiatry Res 120:71-84. 2003
    ..Deficits in regional scores of the middle region are discussed in the context of lower resources in depression...
  86. pmc Apathy is associated with volume of the nucleus accumbens in patients infected with HIV
    Robert H Paul
    Brown Medical School Department of Psychiatry and Human Behavior, Providence, RI 02903, USA
    J Neuropsychiatry Clin Neurosci 17:167-71. 2005
    ..By contrast, ratings of depression were unrelated to either apathy or nucleus accumbens volume. These findings provide preliminary evidence that apathy reflects direct involvement of the central nervous system in patients with HIV...
  87. ncbi request reprint Changes in posed facial expression of emotion across the adult life span
    Joan C Borod
    Department of Psychology, Queens College, and the Graduate Center of the City University of New York, Flushing, New York 11367, USA
    Exp Aging Res 30:305-31. 2004
    ..The results are discussed in terms of theoretical models of aging...
  88. ncbi request reprint Facial expression during emotional monologues in unilateral stroke: an analysis of monologue segments
    Seta Kazandjian
    Department of Psychology, Queens College, Graduate Center of the City University of New York, NY 11367, USA
    Appl Neuropsychol 14:235-46. 2007
    ....
  89. ncbi request reprint Acoustical analysis of posed prosodic expressions: effects of emotion and sex
    Nancy Viscovich
    Department of Psychology, Queens College and the Graduate Center of the City University of New York, Flushing 11367, USA
    Percept Mot Skills 96:759-71. 2003
    ..Findings are discussed in terms of implications for the assessment and treatment of prosody in clinical populations...

Research Grants4

  1. Cognitive reserve and age-related brain changes
    Adam Brickman; Fiscal Year: 2005
    ..Results from the study will provide important insights into the normal aging process and will yield valuable information towards understanding the underpinnings of age-associated pathologies. ..
  2. The Effect of Age on Neuromorphology and its Cognitive Consequences
    Adam Brickman; Fiscal Year: 2007
    ....
  3. White matter hyperintensities in Aging and Dementia
    Adam M Brickman; Fiscal Year: 2010
    ..It will also identify important factors that may account for ethnic-group disparities in Alzheimer's disease. ..