Research Topics
| DAVID JONATHAN BRENNERSummaryAffiliation: Columbia University Country: USA Publications
Research Grants
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Detail Information
Publications
It is time to retire the computed tomography dose index (CTDI) for CT quality assurance and dose optimization. For the propositionDavid J Brenner
Center for Radiological Research, Columbia University Medical Center, New York, New York 10032, USA
Med Phys 33:1189-90. 2006
We can do better than effective dose for estimating or comparing low-dose radiation risksD J Brenner
Center for Radiological Research, Columbia University Medical Center, New York, NY 10032, USA Electronic address
Ann ICRP 41:124-8. 2012..An added major advantage is that it gives the users some feel for the actual numerical values of the radiation risks they are trying to control...- Minimising medically unwarranted computed tomography scansD J Brenner
Center for Radiological Research, Columbia University Medical Center, New York, NY 10032, USA Electronic address
Ann ICRP 41:161-9. 2012.... 
A comparison of mantle versus involved-field radiotherapy for Hodgkin's lymphoma: reduction in normal tissue dose and second cancer riskEng Siew Koh
University of Toronto, Department of Radiation Oncology, Princess Margaret Hospital, Toronto, Ontario, Canada
Radiat Oncol 2:13. 2007....
A new view of radiation-induced cancer: integrating short- and long-term processes. Part I: approachIgor Shuryak
Center for Radiological Research, Columbia University Medical Center, New York, NY 10032, USA
Radiat Environ Biophys 48:263-74. 2009....- A new view of radiation-induced cancer: integrating short- and long-term processes. Part II: second cancer risk estimationIgor Shuryak
Center for Radiological Research, Columbia University Medical Center, New York, NY 10032, USA
Radiat Environ Biophys 48:275-86. 2009..Potentially, the model can be incorporated into radiotherapy treatment planning algorithms, adding second cancer risk as an optimization criterion... - Biological effects in unirradiated human tissue induced by radiation damage up to 1 mm awayOleg V Belyakov
Center for Radiological Research, Columbia University, New York, NY 10032, USA
Proc Natl Acad Sci U S A 102:14203-8. 2005.... - Estimating radiation-induced cancer risks at very low doses: rationale for using a linear no-threshold approachDavid J Brenner
Center for Radiological Research, Columbia University Medical Center, 630 W 168th St, New York, NY 10032, USA
Radiat Environ Biophys 44:253-6. 2006..Consequently, we do not know the magnitude, nor even the direction of any such deviations from linearity-the risks could indeed be lower than those predicted by a linear extrapolation, but they could well be higher... - Mass screening with CT colonography: should the radiation exposure be of concern?David J Brenner
Center for Radiological Research, Columbia University Medical Center, New York, New York 10032, USA
Gastroenterology 129:328-37. 2005..Therefore, it is pertinent to consider the radiation exposure and any potential radiation risk to the population from such a mass CTC screening program... - Do low dose-rate bystander effects influence domestic radon risks?D J Brenner
Center for Radiological Research, Columbia University, 630 West 168th Street, New York, NY 10032, USA
Int J Radiat Biol 78:593-604. 2002..Therefore, we extend an earlier quantitative mechanistic model of bystander effects to include protracted exposure, with the aim of quantifying the significance of the bystander effect for very prolonged exposures... - Computed tomography--an increasing source of radiation exposureDavid J Brenner
Center for Radiological Research, Columbia University Medical Center, New York, NY 10032, USA
N Engl J Med 357:2277-84. 2007 - Secondary neutrons in clinical proton radiotherapy: a charged issueDavid J Brenner
Center for Radiological Research, Columbia University Medical Center, NY 10032, USA
Radiother Oncol 86:165-70. 2008..We discuss here the neutron doses involved, and the associated potential second cancer risks, with an emphasis on the uncertainties involved... - The linear-quadratic model is an appropriate methodology for determining isoeffective doses at large doses per fractionDavid J Brenner
Center for Radiological Research, Columbia University Medical Center, 630 West 168th Street, New York, NY 10032, USA
Semin Radiat Oncol 18:234-9. 2008..To date, there is no evidence of problems when the LQ model has been applied in the clinic... - Reduction of the secondary neutron dose in passively scattered proton radiotherapy, using an optimized pre-collimator/collimatorDavid J Brenner
Center for Radiological Research, Columbia University Medical Center, 630 West 168th Street, New York, NY 10032, USA
Phys Med Biol 54:6065-78. 2009.... - Extrapolating radiation-induced cancer risks from low doses to very low dosesDavid J Brenner
Center for Radiological Research, Columbia University Medical Center, 630 West 168th Street, New York, NY 10032, USA
Health Phys 97:505-9. 2009.... - Slowing the increase in the population dose resulting from CT scansD J Brenner
Center for Radiological Research, Columbia University Medical Center, New York, New York 10032, USA
Radiat Res 174:809-15. 2010.... - Impact of reduced patient life expectancy on potential cancer risks from radiologic imagingDavid J Brenner
Center for Radiological Research and Department of Medicine and Radiology, College of Physicians and Surgeons, Columbia University Medical Center, New York, NY 10032, USA
Radiology 261:193-8. 2011.... - Effective dose: a flawed concept that could and should be replacedD J Brenner
Center for Radiological Research, Columbia University Medical Center, New York, NY 10032, USA
Br J Radiol 81:521-3. 2008.... - Estimated radiation risks potentially associated with full-body CT screeningDavid J Brenner
Center for Radiological Research, Columbia University, 630 W 168th St, New York, NY 10032, USA
Radiology 232:735-8. 2004..To estimate the radiation-related cancer mortality risks associated with single or repeated full-body computed tomographic (CT) examinations by using standard radiation risk estimation methods... - Estimating cancer risks from pediatric CT: going from the qualitative to the quantitativeDavid J Brenner
Center for Radiological Research, Columbia University, 630 West 168th Street, New York, NY 10032, USA
Pediatr Radiol 32:228-3; discussion 242-4. 2002 - Direct evidence that prostate tumors show high sensitivity to fractionation (low alpha/beta ratio), similar to late-responding normal tissueDavid J Brenner
Center for Radiological Research, Department of Radiation Oncology, Columbia University, New York, NY 10032, USA
Int J Radiat Oncol Biol Phys 52:6-13. 2002..A direct approach to the question of whether prostate tumors have an atypically high sensitivity to fractionation (low alpha/beta ratio), more typical of the surrounding late-responding normal tissue... - Biomarkers specific to densely-ionising (high LET) radiationsD J Brenner
Center for Radiological Research, Columbia University 630 West 168th Street, New York, NY 10032, USA
Radiat Prot Dosimetry 97:69-73. 2001..The approach is currently being tested in a population of Russian radiation workers exposed several decades ago to high- or low LET radiation... - Microbeams: a potent mix of physics and biology. Summary of the 5th International Workshop on Microbeam Probes of Cellular Radiation ResponseD J Brenner
Center for Radiological Research, Columbia University, 630 West 168th Street, New York, NY 10032, USA
Radiat Prot Dosimetry 99:283-6. 2002.... - Clinical relative biological effectiveness of low-energy x-rays emitted by miniature x-ray devicesD J Brenner
Center for Radiological Research, Columbia University, New York, NY 10032, USA
Phys Med Biol 44:323-33. 1999..The estimated clinically relevant RBEs are sufficiently large that they should be taken into account during the treatment design stage... - Radiation biology in brachytherapyD J Brenner
Center for Radiological Research, College of Physicians and Surgeons, Columbia University, New York, New York, USA
J Surg Oncol 65:66-70. 1997..Some of the newer alternatives that have recently been developed, such as pulsed dose rate (PDR) brachytherapy, are discussed... - The potential impact of bystander effects on radiation risks in a Mars missionD J Brenner
Center for Radiological Research, Columbia University, New York, New York 10032, USA
Radiat Res 156:612-7. 2001.... - Routine screening mammography: how important is the radiation-risk side of the benefit-risk equation?D J Brenner
Center for Radiological Research, Columbia University, 630 West 168th Street, New York, NY 10032, USA
Int J Radiat Biol 78:1065-7. 2002.... - Long-term efficacy of intracoronary irradiation in inhibiting in-stent restenosisD J Brenner
Center for Radiological Research, Columbia University, New York, NY 10032, USA
Circulation 103:1330-2. 2001.... - Domestic radon risks may be dominated by bystander effects--but the risks are unlikely to be greater than we thoughtD J Brenner
Center for Radiological Research, Columbia University, 630 West 168th Street, New York, NY 10032, USA
Health Phys 85:103-8. 2003..Thus current domestic radon risk estimates are unlikely to be underestimates as a result of bystander effects... - Cancer risks attributable to low doses of ionizing radiation: assessing what we really knowDavid J Brenner
Center for Radiological Research, Columbia University, 630 West 168th Street, New York, NY 10032, USA
Proc Natl Acad Sci U S A 100:13761-6. 2003..This linearity assumption is not necessarily the most conservative approach, and it is likely that it will result in an underestimate of some radiation-induced cancer risks and an overestimate of others... - Radiation risks potentially associated with low-dose CT screening of adult smokers for lung cancerDavid J Brenner
Center for Radiological Research, Columbia University, 630 W 168th St, New York, NY 10032, USA
Radiology 231:440-5. 2004.... - Past exposure to densely ionizing radiation leaves a unique permanent signature in the genomeM Prakash Hande
Center for Radiological Research, Columbia University, New York, NY 10032, USA
Am J Hum Genet 72:1162-70. 2003..Quantification of this large-scale chromosomal damage in human populations exposed many years earlier will lead to new insights into the mechanisms and risks of cytogenetic damage... - Mrad9 and atm haploinsufficiency enhance spontaneous and X-ray-induced cataractogenesis in miceNorman J Kleiman
Center for Radiological Research, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
Radiat Res 168:567-73. 2007..These findings demonstrate that Mrad9 and Atm are important determinants of lens opacification and, given the roles of Atm and Rad9 in maintaining genomic stability, are consistent with a genotoxic basis for radiation cataractogenesis... - Atm heterozygous mice are more sensitive to radiation-induced cataracts than are their wild-type counterpartsBasil V Worgul
Eye Radiation and Environmental Research Laboratory and Center for Radiological Research, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA
Proc Natl Acad Sci U S A 99:9836-9. 2002.... - Complex chromosome aberrations persist in individuals many years after occupational exposure to densely ionizing radiation: an mFISH studyM Prakash Hande
Center for Radiological Research, Columbia University Medical Center, New York, USA
Genes Chromosomes Cancer 44:1-9. 2005..The results suggest that stable complex chromosomal translocations represent a long-lived, quantitative, low-background biomarker of densely ionizing radiation for human populations exposed many years ago... - Cancer risks after radiation exposure in middle ageIgor Shuryak
Center for Radiological Research, Department of Radiation Oncology, Columbia University Medical Center, New York, NY, USA
J Natl Cancer Inst 102:1628-36. 2010..These observations are inconsistent with most standard models of radiation-induced cancer, which predict that relative risks decrease monotonically with increasing age at exposure, at all ages... - A model of interactions between radiation-induced oxidative stress, protein and DNA damage in Deinococcus radioduransIgor Shuryak
Center for Radiological Research, Columbia University Medical Center, 630 West 168th St, New York, NY 10032, USA
J Theor Biol 261:305-17. 2009..Our model of radiogenic oxidative stress is consistent with these data and can potentially be generalized to other organisms and lower radiation doses... - Radiation dose from single-heartbeat coronary CT angiography performed with a 320-detector row volume scannerAndrew J Einstein
Department of Medicine, Cardiology Division, Department of Radiology, and Center for Radiological Research, Columbia University Medical Center and New York Presbyterian Hospital, 622 W 168th St, PH 10 203A, New York, NY 10032, USA
Radiology 254:698-706. 2010..When conversion coefficients are used to estimate effective dose from DLP, they should be appropriate for the scanner and scan mode used and reflect current tissue-weighting factors. (c) RSNA, 2010... - Should we be concerned about the rapid increase in CT usage?David J Brenner
Center for Radiological Research, Columbia University Medical Center, 630 West 168th Street, VC 11 230, New York, NY 10032, USA
Rev Environ Health 25:63-8. 2010..Communication between physician and patient about the benefits and also about the potential small risks of CT is a positive development, unlikely to reduce patient compliance... - Stable intrachromosomal biomarkers of past exposure to densely ionizing radiation in several chromosomes of exposed individualsCatherine R Mitchell
Center for Radiological Research, Columbia University, New York, New York 10032, USA
Radiat Res 162:257-63. 2004.... - Advances in radiobiological studies using a microbeamTom K Hei
Center for Radiological Research, Mailman School of Public Health, Columbia University, New York, NY 10032, USA
J Radiat Res 50:A7-A12. 2009..The identification of specific signaling pathways provides mechanistic insight on the nature of the bystander process... - Microbeam irradiation of the C. elegans nematodeAntonella Bertucci
Center for Radiological Research, Columbia University Medical Center, New York, NY 10032, USA
J Radiat Res 50:A49-54. 2009..We used the RARAF microbeam to site specifically deliver 3 MeV protons to a site in the tail of young worms. GFP expression was enhanced after 24 hours in a number dependent manner at distances > 100 microm from the site of irradiation... - Biological responses in known bystander cells relative to known microbeam-irradiated cellsBrian Ponnaiya
Center for Radiological Research, Columbia University, New York, New York 10032, USA
Radiat Res 162:426-32. 2004..They indicate that the phenomenon has a quantitative basis and imply that the target for radiation effects cannot be considered to be the individual cell... - Interaction between radiation-induced adaptive response and bystander mutagenesis in mammalian cellsHongning Zhou
Center for Radiological Research, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
Radiat Res 160:512-6. 2003..Results from the present study address some of the pressing issues regarding both the actual target size and the radiation dose response and can improve on our current understanding of radiation risk assessment... - The weight of evidence does not support the suggestion that exposure to low doses of X rays increases longevityEric J Hall
Center for Radiological Research, Columbia University, 630 W 168th Street, New York, NY 10024, USA
Radiology 229:18-9. 2003 - The relative biological effectiveness of densely ionizing heavy-ion radiation for inducing ocular cataracts in wild type versus mice heterozygous for the ATM geneEric J Hall
Center for Radiological Research, Columbia University Medical Center, 630 West 168th Street, New York, NY 10032, USA
Radiat Environ Biophys 45:99-104. 2006..Haploinsufficiency for ATM results in an enhanced sensitivity to X-rays compared with the wild type, and this enhancement appears even larger after exposure to high-LET heavy ions... - Mechanism of radiation-induced bystander effects: a unifying modelTom K Hei
Center for Radiological Research, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
J Pharm Pharmacol 60:943-50. 2008.... - Modification of shirt buttons for retrospective radiation dosimetry after a radiological eventStephen A Marino
Center for Radiological Research, Columbia University, New York, NY, USA
Health Phys 100:542-7. 2011..In both comparisons for LiF:Mg,Cu,P rods, the response of laundered rods was 1-3% lower than for the same rods before cleaning. Both these materials are potential candidates for button dosimeters... - Adapting the γ-H2AX assay for automated processing in human lymphocytes. 1. Technological aspectsHelen C Turner
Center for Radiological Research, Columbia University Medical Center, New York, New York 10032, USA
Radiat Res 175:282-90. 2011..This study demonstrates for the first time the optimization and use of our robotically based biodosimetry workstation to successfully quantify γ-H2AX total fluorescence in irradiated peripheral lymphocytes... - The RABIT: a rapid automated biodosimetry tool for radiological triageGuy Garty
Center for Radiological Research, Columbia University Medical Center, New York, NY 10032, USA
Health Phys 98:209-17. 2010..Here the authors describe the development of each of the individual modules of the RABIT system and show preliminary data from key modules. System integration is ongoing, followed by calibration and validation... - Radiation-induced leukemia at doses relevant to radiation therapy: modeling mechanisms and estimating risksIgor Shuryak
Center for Radiological Research, Columbia University Medical Center, 630 West 168th St, New York, NY 10032, USA
J Natl Cancer Inst 98:1794-806. 2006.... - Reducing second breast cancers: a potential role for prophylactic mammary irradiationDavid J Brenner
Center for Radiological Research, Department of Radiation Oncology, Columbia University Medical Center, New York, NY, USA
J Clin Oncol 25:4868-72. 2007 - Mechanism of radiation-induced bystander effect: role of the cyclooxygenase-2 signaling pathwayHongning Zhou
Center for Radiological Research, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
Proc Natl Acad Sci U S A 102:14641-6. 2005..These results provide evidence that the COX-2-related pathway, which is essential in mediating cellular inflammatory response, is the critical signaling link for the bystander phenomenon... - The balance between initiation and promotion in radiation-induced murine carcinogenesisIgor Shuryak
Center for Radiological Research, Columbia University Medical Center, New York, New York 10032, USA
Radiat Res 174:357-66. 2010..Also similar to findings in humans, initiation dominates the ERR at young ages in mice, when there are few background pre-malignant cells, and promotion becomes important at older ages... - Biophysical models of radiation bystander effects: 1. Spatial effects in three-dimensional tissuesIgor Shuryak
Center for Radiological Research, Columbia University Medical Center, New York, New York 10032, USA
Radiat Res 168:741-9. 2007..These assumptions are implemented by a mathematical formalism and computational algorithms. The model adequately describes data on bystander responses in the 3D system using a small number of adjustable parameters... - Chromosomes are predominantly located randomly with respect to each other in interphase human cellsMichael N Cornforth
Department of Radiation Oncology, University of Texas Medical Branch, Galveston, TX 77555, USA
J Cell Biol 159:237-44. 2002..Thus, whereas some chromosome-chromosome associations are clearly present, at the whole-chromosomal level, the predominant overall pattern appears to be spatially random... - Microbeam-integrated multiphoton imaging systemAlan W Bigelow
Center for Radiological Research, Columbia University, New York, New York 10032, USA
Rev Sci Instrum 79:123707. 2008..Design details and biology applications using this enhanced 3D-imaging technique at RARAF are reviewed...
Research Grants
- Cancer Risks Attributable To Radiation from Pediatric CTDavid Brenner; Fiscal Year: 2006..The target audiences will be radiologists, pediatricians, family physicians, and the CT industry. We will use telephone interviews supplemented with survey questions, to aid in web content decisions. ..
- RADIOLOGICAL RESEARCH ACCELERATOR FACILITY (RARAF)David Brenner; Fiscal Year: 2007....
- High Stability Accelerator for Sub-Cellular MicrobeamDavid Brenner; Fiscal Year: 2003..We have considerably more demand for microbeam time than we can cope with, primarily because of limited physicist manpower. ..
- RADIOLOGICAL RESEARCH ACCELERATOR FACILITY (RARAF)David Brenner; Fiscal Year: 2002..abstract_text> ..