Harold Brem

Summary

Affiliation: Columbia University
Country: USA

Publications

  1. ncbi Protocol for the successful treatment of pressure ulcers
    Harold Brem
    Department of Surgery, Columbia University College of Physicians and Surgeons, 5141 Broadway, New York, New York 10034, USA
    Am J Surg 188:9-17. 2004
  2. ncbi Clinical efficacy and mechanism of bilayered living human skin equivalent (HSE) in treatment of diabetic foot ulcers
    Harold Brem
    Angiogenesis and Wound Healing Laboratory, Mount Sinai Medical Center, New York, NY, USA
    Surg Technol Int 11:23-31. 2003
  3. ncbi Healing of elderly patients with diabetic foot ulcers, venous stasis ulcers, and pressure ulcers
    Harold Brem
    Wound Healing Program, Angiogenesis and Wound Healing Laboratory, The Mount Sinai Medical Center, New York, New York
    Surg Technol Int 11:161-7. 2003
  4. ncbi Protocol for the successful treatment of venous ulcers
    Harold Brem
    Department of Surgery, Columbia University College of Physicians and Surgeons, 5141 Broadway, New York, New York 10034, USA
    Am J Surg 188:1-8. 2004
  5. ncbi Evidence-based protocol for diabetic foot ulcers
    Harold Brem
    Department of Surgery, Wound Healing Program, Columbia University College of Physicians and Surgeons, New York, NY, USA
    Plast Reconstr Surg 117:193S-209S; discussion 210S-211S. 2006
  6. pmc Cellular and molecular basis of wound healing in diabetes
    Harold Brem
    Wound Healing and Vascular Biology Laboratory, Division of Plastic Surgery, Columbia University College of Physicians and Surgeons, 5141 Broadway, New York, NY 10034, USA
    J Clin Invest 117:1219-22. 2007
  7. ncbi The synergism of age and db/db genotype impairs wound healing
    Harold Brem
    Department of Surgery, Columbia University College of Physicians and Surgeons, New York, NY, USA
    Exp Gerontol 42:523-31. 2007
  8. pmc Molecular markers in patients with chronic wounds to guide surgical debridement
    Harold Brem
    Columbia University College of Physicians and Surgeons, Department of Surgery, Wound Healing and Vascular Biology Laboratory, New York, NY, USA
    Mol Med 13:30-9. 2007
  9. doi Deregulation of keratinocyte differentiation and activation: a hallmark of venous ulcers
    Olivera Stojadinovic
    Hospital for Special Surgery of the Weill Cornell Medical College, Tissue Repair Lab, New York, NY 10021, USA
    J Cell Mol Med 12:2675-90. 2008
  10. ncbi Novel genomic effects of glucocorticoids in epidermal keratinocytes: inhibition of apoptosis, interferon-gamma pathway, and wound healing along with promotion of terminal differentiation
    Olivera Stojadinovic
    Hospital for Special Surgery, Tissue Repair Laboratory, Tissue Engineering, Regeneration and Repair Program, New York, New York 10021, USA
    J Biol Chem 282:4021-34. 2007

Research Grants

Collaborators

Detail Information

Publications38

  1. ncbi Protocol for the successful treatment of pressure ulcers
    Harold Brem
    Department of Surgery, Columbia University College of Physicians and Surgeons, 5141 Broadway, New York, New York 10034, USA
    Am J Surg 188:9-17. 2004
    ..Availability of the described treatment modalities, in combination with early recognition and regular monitoring, ensures rapid healing and minimizes morbidity, mortality, and costs...
  2. ncbi Clinical efficacy and mechanism of bilayered living human skin equivalent (HSE) in treatment of diabetic foot ulcers
    Harold Brem
    Angiogenesis and Wound Healing Laboratory, Mount Sinai Medical Center, New York, NY, USA
    Surg Technol Int 11:23-31. 2003
    ..We hypothesize that bilayered HSE generates its effect by way of the local synthesis and release of multiple growth factors in specific combination and concentration, which improves the impaired reparative process of chronic wounds...
  3. ncbi Healing of elderly patients with diabetic foot ulcers, venous stasis ulcers, and pressure ulcers
    Harold Brem
    Wound Healing Program, Angiogenesis and Wound Healing Laboratory, The Mount Sinai Medical Center, New York, New York
    Surg Technol Int 11:161-7. 2003
    ..We hypothesize that if all elderly patients with chronic wounds are provided early treatment, morbidities (e.g., amputation, sepsis, pain) and associated costs will decrease...
  4. ncbi Protocol for the successful treatment of venous ulcers
    Harold Brem
    Department of Surgery, Columbia University College of Physicians and Surgeons, 5141 Broadway, New York, New York 10034, USA
    Am J Surg 188:1-8. 2004
    ..These treatment modalities, in combination with early recognition and regular monitoring using digital photography and planimetry measurements, will ensure rapid healing and minimize complications and cost...
  5. ncbi Evidence-based protocol for diabetic foot ulcers
    Harold Brem
    Department of Surgery, Wound Healing Program, Columbia University College of Physicians and Surgeons, New York, NY, USA
    Plast Reconstr Surg 117:193S-209S; discussion 210S-211S. 2006
    ..Strict adherence to evidence-based protocols as described herein will prevent the majority of these amputations...
  6. pmc Cellular and molecular basis of wound healing in diabetes
    Harold Brem
    Wound Healing and Vascular Biology Laboratory, Division of Plastic Surgery, Columbia University College of Physicians and Surgeons, 5141 Broadway, New York, NY 10034, USA
    J Clin Invest 117:1219-22. 2007
    ..Thus, Gallagher et al. have identified novel potential targets for therapeutic intervention in diabetic wound healing...
  7. ncbi The synergism of age and db/db genotype impairs wound healing
    Harold Brem
    Department of Surgery, Columbia University College of Physicians and Surgeons, New York, NY, USA
    Exp Gerontol 42:523-31. 2007
    ....
  8. pmc Molecular markers in patients with chronic wounds to guide surgical debridement
    Harold Brem
    Columbia University College of Physicians and Surgeons, Department of Surgery, Wound Healing and Vascular Biology Laboratory, New York, NY, USA
    Mol Med 13:30-9. 2007
    ..In the future, molecular markers will be developed to identify the nonimpaired tissue, thereby making surgical debridement more accurate and more efficacious...
  9. doi Deregulation of keratinocyte differentiation and activation: a hallmark of venous ulcers
    Olivera Stojadinovic
    Hospital for Special Surgery of the Weill Cornell Medical College, Tissue Repair Lab, New York, NY 10021, USA
    J Cell Mol Med 12:2675-90. 2008
    ..We conclude that keratinocytes at the non-healing edges of venous ulcers do not execute either activation or differentiation pathway, resulting in thick callus-like formation at the edge of a venous ulcers...
  10. ncbi Novel genomic effects of glucocorticoids in epidermal keratinocytes: inhibition of apoptosis, interferon-gamma pathway, and wound healing along with promotion of terminal differentiation
    Olivera Stojadinovic
    Hospital for Special Surgery, Tissue Repair Laboratory, Tissue Engineering, Regeneration and Repair Program, New York, New York 10021, USA
    J Biol Chem 282:4021-34. 2007
    ..These results provide new insights into the beneficial and adverse effects of GCs in the epidermis, defining the participating genes and mechanisms that coordinate the cellular responses important for GC-based therapies...
  11. pmc Primary cultured fibroblasts derived from patients with chronic wounds: a methodology to produce human cell lines and test putative growth factor therapy such as GMCSF
    Harold Brem
    Department of Surgery, Division of Wound Healing and Regenerative Medicine, New York University School of Medicine, New York, NY, USA
    J Transl Med 6:75. 2008
    ..2) To describe a methodology to create fibroblast cell lines from patients with chronic wounds...
  12. doi Mechanism of sustained release of vascular endothelial growth factor in accelerating experimental diabetic healing
    Harold Brem
    Helen and Martin Kimmel Wound Center, Division of Wound Healing and Regenerative Medicine, Department of Surgery, New York University, New York, New York 10016, USA
    J Invest Dermatol 129:2275-87. 2009
    ..In the future, local administration and sustained, controlled release of VEGF(165) may decrease amputations in patients with diabetic foot ulcers and possibly accelerate closure of venous ulcers and pressure ulcers...
  13. pmc Molecular pathogenesis of chronic wounds: the role of beta-catenin and c-myc in the inhibition of epithelialization and wound healing
    Olivera Stojadinovic
    The Ronald O Perelman Department of Dermatology, New York University School of Medicine, 550 First Ave, TH100, New York, NY 10016, USA
    Am J Pathol 167:59-69. 2005
    ..The presence of activated beta-catenin and c-myc in the epidermis of chronic wounds may serve as a molecular marker of impaired healing and may provide future targets for therapeutic intervention...
  14. ncbi Wound-healing protocols for diabetic foot and pressure ulcers
    Harold Brem
    Wound Healing Program, Angiogenesis and Wound Healing Laboratory, The Mount Sinai Medical Center, New York, NY, USA
    Surg Technol Int 11:85-92. 2003
    ..If this paradigm is followed, most diabetic foot and pressure ulcers are expected to heal...
  15. pmc Using gene transcription patterns (bar coding scans) to guide wound debridement and healing
    Marjana Tomic-Canic
    Tissue Repair Laboratory, Tissue Engineering Regeneration and Repair Program, Weill Cornell Medical College, New York, NY, USA
    Adv Skin Wound Care 21:487-92; quiz 493-4. 2008
    ..Explain the role of keratinocytes in wound healing. 2. Discuss new research findings on the physiological differences between healing and nonhealing wounds.3. Identify implications of the new research for debridement of chronic wounds...
  16. ncbi Protocol for treatment of diabetic foot ulcers
    Harold Brem
    Department of Surgery, Columbia University College of Physicians and Surgeons, 5141 Broadway, New York, New York 10034, USA
    Am J Surg 187:1S-10S. 2004
    ....
  17. doi Surgical pathology to describe the clinical margin of debridement of chronic wounds using a wound electronic medical record
    Michael S Golinko
    Helen and Martin Kimmel Wound Center, Division of Wound Healing and Regenerative Medicine, Department of Surgery, New York University School of Medicine, New York, NY 10016, USA
    J Am Coll Surg 209:254-260.e1. 2009
    ..Unlike tumor resection, however, operative wound specimens are not routinely sent for pathology. The objective of this study was to describe the pathology present in chronic wounds...
  18. pmc Cortisol synthesis in epidermis is induced by IL-1 and tissue injury
    Sasa Vukelic
    Department of Medicine, Lenox Hill Hospital, New York, New York 10075, USA
    J Biol Chem 286:10265-75. 2011
    ..Inhibition of GC synthesis accelerated wound closure in vivo, providing the evidence that modulation of cortisol synthesis in epidermis may be an important regulatory mechanism during wound healing...
  19. pmc ADAM12: a potential target for the treatment of chronic wounds
    Asheesh Harsha
    Arthritis and Tissue Degeneration Program, Hospital for Special Surgery at Weill Medical College of Cornell University, New York, NY, USA
    J Mol Med (Berl) 86:961-9. 2008
    ....
  20. ncbi Prevention and reversal of diabetic nephropathy in db/db mice treated with alagebrium (ALT-711)
    Melpomeni Peppa
    Department of Geriatrics, Mount Sinai School of Medicine, New York, NY, USA
    Am J Nephrol 26:430-6. 2006
    ..Alagebrium (ALT-711) has been shown to improve renal dysfunction in animal models of diabetes...
  21. doi Growth factors and cytokines in wound healing
    Stephan Barrientos
    University of Rochester School of Medicine and Dentistry, Rochester, NY, USA
    Wound Repair Regen 16:585-601. 2008
    ..This review will focus on the specific roles of these growth factors and cytokines during the wound healing process...
  22. ncbi Pathogenesis and treatment of pain in patients with chronic wounds
    Gordon Freedman
    Division of Pain Medicine Department of Anesthesiology, Mount Sinai Medical Center, New York, NY, USA
    Surg Technol Int 11:168-79. 2003
    ..The expectation is that all pain should be resolved in all patients if both the wound-healing and pain-healthcare providers use current technologies and drugs...
  23. ncbi Wound emergencies: the importance of assessment, documentation, and early treatment using a wound electronic medical record
    Michael S Golinko
    Helen and Martin Kimmel Wound Center, Department of Surgery, New York University School of Medicine, 301 East 17th Street, New York, NY 10003, USA
    Ostomy Wound Manage 55:54-61. 2009
    ..Future research is needed utilizing the WEMR across multiple medical centers to further define criteria for a chronic wound emergency...
  24. pmc High cost of stage IV pressure ulcers
    Harold Brem
    Division of Wound Healing and Regenerative Medicine, Helen and Martin Kimmel Wound Center, Department of Surgery, New York University School of Medicine, New York, NY, USA
    Am J Surg 200:473-7. 2010
    ..The aim of this study was to calculate and analyze the cost of treatment for stage IV pressure ulcers...
  25. ncbi Practical treatment of pain in patients with chronic wounds: pathogenesis-guided management
    Gordon Freedman
    Department of Anesthesiology, Mount Sinai Pain Management Service, 5 East 98th Street, Box 1192, Mount Sinai School of Medicine, New York, New York 10029 6574, USA
    Am J Surg 188:31-5. 2004
    ..By following this protocol, the wound-healing clinician can expect decreased length of hospital stay and resolution of pain in nearly all patients with wounds...
  26. pmc Preliminary development of a diabetic foot ulcer database from a wound electronic medical record: a tool to decrease limb amputations
    Michael S Golinko
    Department of Surgery, Division of Wound Healing and Regenerative Medicine, Helen and Martin Kimmel Wound Center, New York University School of Medicine, 301 East 17th Street, New York, NY 10003, USA
    Wound Repair Regen 17:657-65. 2009
    ..This report describes a method of capturing data relevant to clinical care of a patient with a diabetic foot ulcer, and may enable clinicians to adapt such a system to their own patient population...
  27. ncbi Adverse effects of dietary glycotoxins on wound healing in genetically diabetic mice
    Melpomeni Peppa
    Division of Experimental Diabetes and Aging, Department of Geriatrics, Mount Sinai School of Medicine, New York, New York 10029, USA
    Diabetes 52:2805-13. 2003
    ..Thus, increased diet-derived AGE intake may be a significant retardant of wound closure in diabetic mice; dietary AGE restriction may improve impaired diabetic wound healing...
  28. pmc The role of vascular endothelial growth factor in wound healing
    Philip Bao
    University of Pittsburgh, Department of Surgery, Pittsburgh, Pennsylvania, USA
    J Surg Res 153:347-58. 2009
    ..The objective is to review is the multiple mechanisms of vascular endothelial growth factor (VEGF) in wound healing...
  29. ncbi Gene array technology and pathogenesis of chronic wounds
    Marjana Tomic-Canic
    Department of Dermatology, New York University School of Medicine, 550 First Avenue, MSB 234, New York, New York 10016, USA
    Am J Surg 188:67-72. 2004
    ....
  30. ncbi The book of opposites: the role of the nuclear receptor co-regulators in the suppression of epidermal genes by retinoic acid and thyroid hormone receptors
    Sang H Jho
    The Ronald O Perelman Department of Dermatology, New York University School of Medicine, New York, New York 10016, USA
    J Invest Dermatol 124:1034-43. 2005
    ..This novel molecular mechanism of transcriptional repression conveys how RA and T3 target specific groups of epidermal genes, thus exerting intrinsic tissue specificity...
  31. ncbi From an enhanceosome to a repressosome: molecular antagonism between glucocorticoids and EGF leads to inhibition of wound healing
    Brian Lee
    New York University School of Medicine, The Ronald O Perelman Department of Dermatology, 550 First Avenue, New York, NY 10016, USA
    J Mol Biol 345:1083-97. 2005
    ..Similar to clinical findings, pre-treatment of keratinocytes with RA blocks GC-mediated inhibition. In summary, our results identify complex molecular mechanisms through which RA alleviates GC-mediated inhibition of wound healing...
  32. doi Regional anaesthesia with sedation protocol to safely debride sacral pressure ulcers
    Daniel K O'Neill
    Department of Anesthesiology, New York University School of Medicine, New York, NY 10016, USA
    Int Wound J 9:525-43. 2012
    ..We are functioning under the hypothesis that regional anaesthesia has advantages over general anaesthesia. We describe our regional anaesthesia protocol for perioperative and postoperative management...
  33. ncbi Pyoderma gangrenosum versus chronic venous ulceration: comparison of diagnostic features
    Kathie Koo
    Department of Dermatology, Mount Sinai School of Medicine of New York University, New York, USA
    J Cutan Med Surg 10:26-30. 2006
    ..Diagnosis of pyoderma gangrenosum can be difficult, leading to overdiagnosis or underdiagnosis...
  34. ncbi Statistical analysis of wound-healing rates for pressure ulcers
    Sylvan Wallenstein
    Department of Biomathematical Sciences, 1 Gustave Levy Place, Box 1023, Mount Sinai School of Medicine, New York, New York 10029, USA
    Am J Surg 188:73-8. 2004
    ..This approach yields a model useful for identifying prognostic factors, evaluating treatments, and improving our understanding of the variables that affect the wound-healing process...
  35. doi Cultured bilayered skin allograft for vaginal construction
    Albert Altchek
    Department of Obstetrics, Gynecology and Reproductive Science, Mount Sinai School of Medicine and Hospital, New York, NY, USA
    J Pediatr Adolesc Gynecol 23:e5-8. 2010
    ..This is the first report of live human cultured bilayered skin allograft (taken from another person) (LHCBSA) to line a dissected space to create a vagina...
  36. ncbi Pressure ulcers in the chronically critically ill patient
    Harold Brem
    Department of Surgery and Medicine, Mount Sinai School of Medicine, One Gustav L Levy Place, New York, NY 10029, USA
    Crit Care Clin 18:683-94. 2002
    ..Treatment decisions should be made within the context of the patient's overall care goals...
  37. doi Guidelines for the prevention of diabetic ulcers
    David L Steed
    University of Pittsburgh UPMC, Pittsburgh, Pennsylvania, USA
    Wound Repair Regen 16:169-74. 2008
  38. ncbi Development of a severity scale for evaluating the need for Graftskin in nonhealing venous ulcers
    Morris D Kerstein
    Veterans Administration Hospital, Wilmington, DE, USA
    Adv Skin Wound Care 15:66-71. 2002
    ..To construct an easy-to-use severity scale based on data from a multicenter venous leg ulcer trial to predict which wounds will progress toward closure and which will remain unhealed...

Research Grants2

  1. Local Angiogenic Gene Therapy/VEGF/Treat Diabetic Ulcers
    Harold Brem; Fiscal Year: 2003
    ..In addition, we will analyze the wound fluid in order to determine the temporal expression of VEGF in a diabetic ulcer. ..
  2. Local Angiogenic Therapy for Diabetic Ulcers
    Harold Brem; Fiscal Year: 2006
    ..Support from this proposal will allow the applicant to use knowledge from the fields of gene therapy, angiogenesis and wound healing to develop a safe angiogenic gene therapy for diabetic foot ulcers. ..