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Genomes and Genes | Alain C BorczukSummaryAffiliation: Columbia University Country: USA Publications
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Publications
Sebaceous carcinoma of the lung: histologic and immunohistochemical characterization of an unusual pulmonary neoplasm: report of a case and review of the literatureAlain C Borczuk
Department of Pathology, Columbia Presbyterian Medical Center, New York, NY 10032, USA
Am J Surg Pathol 26:795-8. 2002..This unique tumor extends the spectrum of extraocular, extracutaneous neoplasms with sebaceous differentiation from existing single reports in the hypopharyx and larynx to now include bronchus...- The heparan sulfate proteoglycan GPC3 is a potential lung tumor suppressorHan Kim
Division of Pulmonary, Allergy and Critical Care Medicine, Columbia University, 630 West 168th Street, Box 91, New York, New York 10032, USA
Am J Respir Cell Mol Biol 29:694-701. 2003..These findings suggest that GPC3 is a candidate lung tumor suppressor gene whose expression may be regulated by exposure to cigarette smoke and functions to modulate cellular response to exogenous damage... - Histologic assessment of non-small cell lung carcinoma after neoadjuvant therapyXiaolin Liu-Jarin
Department of Pathology, Columbia Presbyterian Medical Center, New York, New York, USA
Mod Pathol 16:1102-8. 2003..However, a positive correlation was found between extent of fibrosis and radiologic estimate of size reduction... 
Lung adenocarcinoma global profiling identifies type II transforming growth factor-beta receptor as a repressor of invasivenessAlain C Borczuk
Department of Pathology, Herbert Irving Comprehensive Cancer Center, Columbia University College of Physicians and Surgeons, New York, New York, USA
Am J Respir Crit Care Med 172:729-37. 2005..Lung adenocarcinoma histology and clinical outcome are heterogeneous and associated with tumor invasiveness...- Platelet-derived growth factor is increased in pulmonary capillary hemangiomatosisAdel M Assaad
Department of Pathology, Division of Surgical Pathology, 630 West 168th St, VC14 215, New York, NY 10032, USA
Chest 131:850-5. 2007..Pulmonary capillary hemangiomatosis (PCH) is a rare cause of pulmonary arterial hypertension with no effective medical therapy and a high risk of mortality. The pathogenesis of PCH is unknown... - Neoplastic and nonneoplastic benign mass lesions of the lungAlain C Borczuk
Department of Pathology and Cell Biology, Columbia University Medical Center, 630 W 168th St, VC14 215, New York, NY 10032, USA
Arch Pathol Lab Med 136:1227-33. 2012..There is also a group of relatively rare, mainly inflammatory and fibrous tumor-like lesions that are encountered on core biopsy and excisions of lung tissue... 
Assessment of invasion in lung adenocarcinoma classification, including adenocarcinoma in situ and minimally invasive adenocarcinomaAlain C Borczuk
Department of Pathology and Cell Biology, Columbia University Medical Center, New York, NY 10032, USA
Mod Pathol 25:S1-10. 2012..Focusing on invasion and using an illustrative case, we will explore the current recommendations that incorporate assessment of invasion to clarify the confusion caused by the different uses of the historical term 'BAC'...- Invasive size is an independent predictor of survival in pulmonary adenocarcinomaAlain C Borczuk
Department of Surgical Pathology, Columbia University Medical Center, New York, NY 10032, USA
Am J Surg Pathol 33:462-9. 2009..In conclusion, among lung adenocarcinomas, histologic assessment of invasive growth may provide valuable prognostic information, and tumors with invasion under 0.6 cm have a more indolent clinical course after resection... - Benign tumors and tumorlike conditions of the lungAlain C Borczuk
Department of Surgical Pathology, Columbia University Medical Center, New York, NY 10032, USA
Arch Pathol Lab Med 132:1133-48. 2008..Benign tumors and tumorlike conditions of the lung are encountered in the pathologic evaluation of asymptomatic and symptomatic lung nodules. Since many of these lesions are uncommon, they can be diagnostically challenging... - P16 loss and mitotic activity predict poor survival in patients with peritoneal malignant mesotheliomaAlain C Borczuk
Department of Pathology, Columbia University Medical Center, and the Columbia University Mesothelioma Center, New York, New York 10032, USA
Clin Cancer Res 11:3303-8. 2005..We hypothesized that pathologic variables would stratify patients into favorable and unfavorable survival subgroups... - Progression of human bronchioloalveolar carcinoma to invasive adenocarcinoma is modeled in a transgenic mouse model of K-ras-induced lung cancer by loss of the TGF-β type II receptorAlain C Borczuk
Department of Pathology, Columbia University College of Physicians and Surgeons, New York, New York, USA
Cancer Res 71:6665-75. 2011.... - Expression of syndecan-1 and expression of epidermal growth factor receptor are associated with survival in patients with nonsmall cell lung carcinomaLori Shah
Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
Cancer 101:1632-8. 2004..If their significance can be validated prospectively, these biomarkers may be used to guide therapeutic planning for patients with nonsmall cell lung carcinoma... - Tgf-beta signaling pathway in lung adenocarcinoma invasionRebecca L Toonkel
Division of Pulmonary and Critical Care Medicine, Columbia University Medical Center, New York, NY, USA
J Thorac Oncol 5:153-7. 2010..Taken together, these studies illustrate how information gained from global expression profiling of tumors can be used to identify key pathways and genes mediating tumor growth, invasion, and metastasis... - Molecular signatures in biopsy specimens of lung cancerAlain C Borczuk
Department of Pathology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
Am J Respir Crit Care Med 170:167-74. 2004..The procedures are safe and feasible; the efficacy and utility of this strategy will ultimately be determined by prospective clinical trials... - Expression profiling and lung cancer developmentAlain C Borczuk
Department of Pathology and Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
Proc Am Thorac Soc 4:127-32. 2007.... - Lysyl oxidase: a lung adenocarcinoma biomarker of invasion and survivalMay Lin Wilgus
Division of Pulmonary, Allergy and Critical Care, Columbia University Medical Center, New York, New York, USA
Cancer 117:2186-91. 2011..The authors hypothesized that LOX expression is associated with extent of invasion and survival in patients with lung adenocarcinoma... - Pulmonary capillary hemangiomatosis: results of gene expression analysisSteven M Kawut
Department of Medicine, College of Physicians and Surgeons, New York, NY, USA
Chest 128:575S-5766S. 2005 - Utility of CD138 (syndecan-1) in distinguishing carcinomas from mesotheliomasAnjali Saqi
Department of Pathology, New York Presbyterian Hospital, Columbia University Medical Center, NY 10032, USA
Diagn Cytopathol 33:65-70. 2005..It should be an integral component of the epithelial-mesothelial antibody panel... - Non-small cell lung cancer molecular profiles are associated with lung developmentAlain C Borczuk
Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
Chest 125:115S-6S. 2004 - Non-small-cell lung cancer molecular signatures recapitulate lung developmental pathwaysAlain C Borczuk
Department of Pathology, Columbia University College of Physicians and Surgeons, 630 West 168th Street, New York, NY 10032, USA
Am J Pathol 163:1949-60. 2003..The identification of developmentally regulated pathways active in tumorigenesis provides insights into lung carcinogenesis and suggests early steps may differ according to the eventual tumor morphology... - Class prediction of lung nodule gene expression profilesKristin L Walter
Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
Chest 125:104S. 2004 - Epigenetic inactivation of Betaig-h3 gene in human cancer cellsGenze Shao
Center for Radiological Research and Department of Pathology, Columbia University, New York, New York 10032, USA
Cancer Res 66:4566-73. 2006..These results suggest that promoter methylation plays a critical role in promoter silencing of the Betaig-h3 gene in human tumor cells... - Dual specificity phosphatase 6 (DUSP6) is an ETS-regulated negative feedback mediator of oncogenic ERK signaling in lung cancer cellsZhenfeng Zhang
Department of Pathology, Case Western Reserve University School of Medicine, University Hospitals Case Medical Center and Ireland Cancer Center, Case Comprehensive Cancer Center, Cleveland, OH 44106, USA
Carcinogenesis 31:577-86. 2010..Further studies assessing the tumor suppressive role of DUSP6 and strategies aimed at modulation of its activity are warranted... - Utility of glucose transporter 1 in the distinction of benign and malignant thoracic and abdominal mesothelial lesionsStephen M Lagana
Department of Pathology and Cell Biology, Columbia University Medical Center, New York, New York 10032, USA
Arch Pathol Lab Med 136:804-9. 2012..It has recently been reported as specific and sensitive in discriminating malignant pleural mesothelioma from reactive hyperplasia. The application of GLUT-1 staining in peritoneal mesothelioma has not been fully explored... - Genomics of lung cancerAlain C Borczuk
Department of Pathology, Columbia University College of Physicaians and Surgeons, New York, New York, USA
Proc Am Thorac Soc 6:152-8. 2009..This review focuses on recent research using genomics to examine lung carcinogenesis, histologic differentiation, and progression... - CDX2 immunostaining as a gastrointestinal marker: expression in lung carcinomas is a potential pitfallRobert M Mazziotta
Department of Pathology, Vanderbilt Clinic, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
Appl Immunohistochem Mol Morphol 13:55-60. 2005.... - A molecular profile of focal segmental glomerulosclerosis from formalin-fixed, paraffin-embedded tissueJeffrey B Hodgin
Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, New York, USA
Am J Pathol 177:1674-86. 2010..Our findings reveal novel insights into the molecular pathogenesis of glomerular injury and structural degeneration in FSGS... - Gene expression profiling of pulmonary fibrosis identifies Twist1 as an antiapoptotic molecular "rectifier" of growth factor signalingRobert S Bridges
Department of Pharmacology, Columbia University College of Physicians and Surgeons, New York, New York, USA
Am J Pathol 175:2351-61. 2009..We propose that Twist1 represents one of the factors that promotes pathogenic accumulation of fibroblasts in fibrotic lung disease... - Sarcoidosis-associated fibrosing mediastinitis with resultant pulmonary hypertension: a case report and review of the literatureRebecca L Toonkel
Division of Pulmonary, Allergy, and Critical Care Medicine, Columbia University Medical Center, New York, NY, USA
Respiration 79:341-5. 2010..While pulmonary hypertension is a common complication of sarcoidosis, fibrosing mediastinitis is an unusual etiology that should be considered by clinicians... - Expression of PAX2 in papillary serous carcinoma of the ovary: immunohistochemical evidence of fallopian tube or secondary Müllerian system origin?Guo Xia Tong
Department of Pathology, Columbia University Medical Center, New York, NY 10032, USA
Mod Pathol 20:856-63. 2007.... - Thymidylate synthase expression and molecular alterations in adenosquamous carcinoma of the lungCatherine Shu
Department of Internal Medicine, New York Presbyterian Hospital Columbia University Medical Center, New York, NY, USA
Mod Pathol 26:239-46. 2013.... - Cytological, histological, and immunohistochemical findings of pulmonary carcinomas with basaloid featuresJohn P Crapanzano
Department of Pathology and Cell Biology, Columbia University Medical Center, 630 West 168th St, New York, NY 10032, USA
Diagn Cytopathol 39:92-100. 2011..However, immunostains were the very helpful and probably necessary to accurately diagnosing BC/BSQCC, which show the immunostaining pattern of p63 (+), HMWCK (+), and TTF-1 (-)... - Pulmonary hypertension in idiopathic pulmonary fibrosisNina M Patel
Department of Medicine, Division of Pulmonary, Allergy and Critical Care, Columbia University, 622 W 168th St, PH 8 East, Room 101, New York, NY 10032, USA
Chest 132:998-1006. 2007..However, possible treatments such as long-term supplemental oxygen and targeted vascular therapy are either unstudied or remain unproven... - Patterns of allelic loss differ in lung adenocarcinomas of smokers and nonsmokersCharles A Powell
Department of Medicine, Columbia College of Physicians and Surgeons, New York, NY, USA
Lung Cancer 39:23-9. 2003..Our results suggest that the early steps of lung carcinogenesis differ in nonsmokers compared with smokers. In addition, the chromosomal sites of LOH may identify genes important for lung carcinogenesis in nonsmokers... - A postinfluenza model of Staphylococcus aureus pneumoniaMei Ho Lee
Division of Infectious Diseases, Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York, USA
J Infect Dis 201:508-15. 2010..Postinfluenza Staphylococcus aureus pneumonias are increasingly recognized as a major form of life-threatening infections... - Significant pulmonary toxicity associated with interferon and ribavirin therapy for hepatitis CK Shiva Kumar
Center for Liver Disease and Transplantation, New York-Presbyterian Hospital, New York, USA
Am J Gastroenterol 97:2432-40. 2002..Though usually reversible, at least one case has required long-term steroids with inadequate resolution. Though pulmonary toxicity is rare, symptoms which are more than mild or progressive in nature should likely be investigated...