Alain C Borczuk

Summary

Affiliation: Columbia University
Country: USA

Publications

  1. ncbi request reprint Sebaceous carcinoma of the lung: histologic and immunohistochemical characterization of an unusual pulmonary neoplasm: report of a case and review of the literature
    Alain C Borczuk
    Department of Pathology, Columbia Presbyterian Medical Center, New York, NY 10032, USA
    Am J Surg Pathol 26:795-8. 2002
  2. ncbi request reprint The heparan sulfate proteoglycan GPC3 is a potential lung tumor suppressor
    Han Kim
    Division of Pulmonary, Allergy and Critical Care Medicine, Columbia University, 630 West 168th Street, Box 91, New York, New York 10032, USA
    Am J Respir Cell Mol Biol 29:694-701. 2003
  3. ncbi request reprint Histologic assessment of non-small cell lung carcinoma after neoadjuvant therapy
    Xiaolin Liu-Jarin
    Department of Pathology, Columbia Presbyterian Medical Center, New York, New York, USA
    Mod Pathol 16:1102-8. 2003
  4. pmc Lung adenocarcinoma global profiling identifies type II transforming growth factor-beta receptor as a repressor of invasiveness
    Alain C Borczuk
    Department of Pathology, Herbert Irving Comprehensive Cancer Center, Columbia University College of Physicians and Surgeons, New York, New York, USA
    Am J Respir Crit Care Med 172:729-37. 2005
  5. ncbi request reprint Platelet-derived growth factor is increased in pulmonary capillary hemangiomatosis
    Adel M Assaad
    Department of Pathology, Division of Surgical Pathology, 630 West 168th St, VC14 215, New York, NY 10032, USA
    Chest 131:850-5. 2007
  6. ncbi request reprint Neoplastic and nonneoplastic benign mass lesions of the lung
    Alain C Borczuk
    Department of Pathology and Cell Biology, Columbia University Medical Center, 630 W 168th St, VC14 215, New York, NY 10032, USA
    Arch Pathol Lab Med 136:1227-33. 2012
  7. doi request reprint Assessment of invasion in lung adenocarcinoma classification, including adenocarcinoma in situ and minimally invasive adenocarcinoma
    Alain C Borczuk
    Department of Pathology and Cell Biology, Columbia University Medical Center, New York, NY 10032, USA
    Mod Pathol 25:S1-10. 2012
  8. doi request reprint Benign tumors and tumorlike conditions of the lung
    Alain C Borczuk
    Department of Surgical Pathology, Columbia University Medical Center, New York, NY 10032, USA
    Arch Pathol Lab Med 132:1133-48. 2008
  9. pmc Invasive size is an independent predictor of survival in pulmonary adenocarcinoma
    Alain C Borczuk
    Department of Surgical Pathology, Columbia University Medical Center, New York, NY 10032, USA
    Am J Surg Pathol 33:462-9. 2009
  10. ncbi request reprint P16 loss and mitotic activity predict poor survival in patients with peritoneal malignant mesothelioma
    Alain C Borczuk
    Department of Pathology, Columbia University Medical Center, and the Columbia University Mesothelioma Center, New York, New York 10032, USA
    Clin Cancer Res 11:3303-8. 2005

Collaborators

Detail Information

Publications38

  1. ncbi request reprint Sebaceous carcinoma of the lung: histologic and immunohistochemical characterization of an unusual pulmonary neoplasm: report of a case and review of the literature
    Alain C Borczuk
    Department of Pathology, Columbia Presbyterian Medical Center, New York, NY 10032, USA
    Am J Surg Pathol 26:795-8. 2002
    ..This unique tumor extends the spectrum of extraocular, extracutaneous neoplasms with sebaceous differentiation from existing single reports in the hypopharyx and larynx to now include bronchus...
  2. ncbi request reprint The heparan sulfate proteoglycan GPC3 is a potential lung tumor suppressor
    Han Kim
    Division of Pulmonary, Allergy and Critical Care Medicine, Columbia University, 630 West 168th Street, Box 91, New York, New York 10032, USA
    Am J Respir Cell Mol Biol 29:694-701. 2003
    ..These findings suggest that GPC3 is a candidate lung tumor suppressor gene whose expression may be regulated by exposure to cigarette smoke and functions to modulate cellular response to exogenous damage...
  3. ncbi request reprint Histologic assessment of non-small cell lung carcinoma after neoadjuvant therapy
    Xiaolin Liu-Jarin
    Department of Pathology, Columbia Presbyterian Medical Center, New York, New York, USA
    Mod Pathol 16:1102-8. 2003
    ..However, a positive correlation was found between extent of fibrosis and radiologic estimate of size reduction...
  4. pmc Lung adenocarcinoma global profiling identifies type II transforming growth factor-beta receptor as a repressor of invasiveness
    Alain C Borczuk
    Department of Pathology, Herbert Irving Comprehensive Cancer Center, Columbia University College of Physicians and Surgeons, New York, New York, USA
    Am J Respir Crit Care Med 172:729-37. 2005
    ..Lung adenocarcinoma histology and clinical outcome are heterogeneous and associated with tumor invasiveness...
  5. ncbi request reprint Platelet-derived growth factor is increased in pulmonary capillary hemangiomatosis
    Adel M Assaad
    Department of Pathology, Division of Surgical Pathology, 630 West 168th St, VC14 215, New York, NY 10032, USA
    Chest 131:850-5. 2007
    ..Pulmonary capillary hemangiomatosis (PCH) is a rare cause of pulmonary arterial hypertension with no effective medical therapy and a high risk of mortality. The pathogenesis of PCH is unknown...
  6. ncbi request reprint Neoplastic and nonneoplastic benign mass lesions of the lung
    Alain C Borczuk
    Department of Pathology and Cell Biology, Columbia University Medical Center, 630 W 168th St, VC14 215, New York, NY 10032, USA
    Arch Pathol Lab Med 136:1227-33. 2012
    ..There is also a group of relatively rare, mainly inflammatory and fibrous tumor-like lesions that are encountered on core biopsy and excisions of lung tissue...
  7. doi request reprint Assessment of invasion in lung adenocarcinoma classification, including adenocarcinoma in situ and minimally invasive adenocarcinoma
    Alain C Borczuk
    Department of Pathology and Cell Biology, Columbia University Medical Center, New York, NY 10032, USA
    Mod Pathol 25:S1-10. 2012
    ..Focusing on invasion and using an illustrative case, we will explore the current recommendations that incorporate assessment of invasion to clarify the confusion caused by the different uses of the historical term 'BAC'...
  8. doi request reprint Benign tumors and tumorlike conditions of the lung
    Alain C Borczuk
    Department of Surgical Pathology, Columbia University Medical Center, New York, NY 10032, USA
    Arch Pathol Lab Med 132:1133-48. 2008
    ..Benign tumors and tumorlike conditions of the lung are encountered in the pathologic evaluation of asymptomatic and symptomatic lung nodules. Since many of these lesions are uncommon, they can be diagnostically challenging...
  9. pmc Invasive size is an independent predictor of survival in pulmonary adenocarcinoma
    Alain C Borczuk
    Department of Surgical Pathology, Columbia University Medical Center, New York, NY 10032, USA
    Am J Surg Pathol 33:462-9. 2009
    ..In conclusion, among lung adenocarcinomas, histologic assessment of invasive growth may provide valuable prognostic information, and tumors with invasion under 0.6 cm have a more indolent clinical course after resection...
  10. ncbi request reprint P16 loss and mitotic activity predict poor survival in patients with peritoneal malignant mesothelioma
    Alain C Borczuk
    Department of Pathology, Columbia University Medical Center, and the Columbia University Mesothelioma Center, New York, New York 10032, USA
    Clin Cancer Res 11:3303-8. 2005
    ..We hypothesized that pathologic variables would stratify patients into favorable and unfavorable survival subgroups...
  11. doi request reprint Progression of human bronchioloalveolar carcinoma to invasive adenocarcinoma is modeled in a transgenic mouse model of K-ras-induced lung cancer by loss of the TGF-╬▓ type II receptor
    Alain C Borczuk
    Department of Pathology, Columbia University College of Physicians and Surgeons, New York, New York, USA
    Cancer Res 71:6665-75. 2011
    ....
  12. pmc Tgf-beta signaling pathway in lung adenocarcinoma invasion
    Rebecca L Toonkel
    Division of Pulmonary and Critical Care Medicine, Columbia University Medical Center, New York, NY, USA
    J Thorac Oncol 5:153-7. 2010
    ..Taken together, these studies illustrate how information gained from global expression profiling of tumors can be used to identify key pathways and genes mediating tumor growth, invasion, and metastasis...
  13. ncbi request reprint Expression of syndecan-1 and expression of epidermal growth factor receptor are associated with survival in patients with nonsmall cell lung carcinoma
    Lori Shah
    Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Cancer 101:1632-8. 2004
    ..They hypothesized that genetic classifiers of histology would provide insight into lung tumorigenesis and would be associated with clinical outcome when evaluated in a broader set of specimens...
  14. doi request reprint Pulmonary arteriole gene expression signature in idiopathic pulmonary fibrosis
    Nina M Patel
    Division of Pulmonary, Allergy and Critical Care Medicine, Columbia University, New York, NY 10032, USA
    Eur Respir J 41:1324-30. 2013
    ..Pathways involved in vascular proliferation and aberrant apoptosis, which may contribute to pulmonary vascular remodelling, are activated in IPF patients...
  15. ncbi request reprint Molecular signatures in biopsy specimens of lung cancer
    Alain C Borczuk
    Department of Pathology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Am J Respir Crit Care Med 170:167-74. 2004
    ..The procedures are safe and feasible; the efficacy and utility of this strategy will ultimately be determined by prospective clinical trials...
  16. doi request reprint Lysyl oxidase: a lung adenocarcinoma biomarker of invasion and survival
    May Lin Wilgus
    Division of Pulmonary, Allergy and Critical Care, Columbia University Medical Center, New York, New York, USA
    Cancer 117:2186-91. 2011
    ..The authors hypothesized that LOX expression is associated with extent of invasion and survival in patients with lung adenocarcinoma...
  17. ncbi request reprint Non-small cell lung cancer molecular profiles are associated with lung development
    Alain C Borczuk
    Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Chest 125:115S-6S. 2004
  18. ncbi request reprint Expression profiling and lung cancer development
    Alain C Borczuk
    Department of Pathology and Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Proc Am Thorac Soc 4:127-32. 2007
    ....
  19. ncbi request reprint Pulmonary capillary hemangiomatosis: results of gene expression analysis
    Steven M Kawut
    Department of Medicine, College of Physicians and Surgeons, New York, NY, USA
    Chest 128:575S-5766S. 2005
  20. ncbi request reprint Utility of CD138 (syndecan-1) in distinguishing carcinomas from mesotheliomas
    Anjali Saqi
    Department of Pathology, New York Presbyterian Hospital, Columbia University Medical Center, NY 10032, USA
    Diagn Cytopathol 33:65-70. 2005
    ..It should be an integral component of the epithelial-mesothelial antibody panel...
  21. ncbi request reprint Epigenetic inactivation of Betaig-h3 gene in human cancer cells
    Genze Shao
    Center for Radiological Research and Department of Pathology, Columbia University, New York, New York 10032, USA
    Cancer Res 66:4566-73. 2006
    ..These results suggest that promoter methylation plays a critical role in promoter silencing of the Betaig-h3 gene in human tumor cells...
  22. ncbi request reprint Class prediction of lung nodule gene expression profiles
    Kristin L Walter
    Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Chest 125:104S. 2004
  23. pmc Non-small-cell lung cancer molecular signatures recapitulate lung developmental pathways
    Alain C Borczuk
    Department of Pathology, Columbia University College of Physicians and Surgeons, 630 West 168th Street, New York, NY 10032, USA
    Am J Pathol 163:1949-60. 2003
    ..The identification of developmentally regulated pathways active in tumorigenesis provides insights into lung carcinogenesis and suggests early steps may differ according to the eventual tumor morphology...
  24. pmc Dual specificity phosphatase 6 (DUSP6) is an ETS-regulated negative feedback mediator of oncogenic ERK signaling in lung cancer cells
    Zhenfeng Zhang
    Department of Pathology, Case Western Reserve University School of Medicine, University Hospitals Case Medical Center and Ireland Cancer Center, Case Comprehensive Cancer Center, Cleveland, OH 44106, USA
    Carcinogenesis 31:577-86. 2010
    ..Further studies assessing the tumor suppressive role of DUSP6 and strategies aimed at modulation of its activity are warranted...
  25. doi request reprint Thymidylate synthase expression and molecular alterations in adenosquamous carcinoma of the lung
    Catherine Shu
    Department of Internal Medicine, New York Presbyterian Hospital Columbia University Medical Center, New York, NY, USA
    Mod Pathol 26:239-46. 2013
    ....
  26. doi request reprint Utility of glucose transporter 1 in the distinction of benign and malignant thoracic and abdominal mesothelial lesions
    Stephen M Lagana
    Department of Pathology and Cell Biology, Columbia University Medical Center, New York, New York 10032, USA
    Arch Pathol Lab Med 136:804-9. 2012
    ..It has recently been reported as specific and sensitive in discriminating malignant pleural mesothelioma from reactive hyperplasia. The application of GLUT-1 staining in peritoneal mesothelioma has not been fully explored...
  27. ncbi request reprint CDX2 immunostaining as a gastrointestinal marker: expression in lung carcinomas is a potential pitfall
    Robert M Mazziotta
    Department of Pathology, Vanderbilt Clinic, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Appl Immunohistochem Mol Morphol 13:55-60. 2005
    ....
  28. pmc Genomics of lung cancer
    Alain C Borczuk
    Department of Pathology, Columbia University College of Physicaians and Surgeons, New York, New York, USA
    Proc Am Thorac Soc 6:152-8. 2009
    ..This review focuses on recent research using genomics to examine lung carcinogenesis, histologic differentiation, and progression...
  29. doi request reprint Guidelines for pathologic diagnosis of malignant mesothelioma: 2012 update of the consensus statement from the International Mesothelioma Interest Group
    Aliya N Husain
    Department of Pathology, University of Chicago, Chicago, IL 60637, USA
    Arch Pathol Lab Med 137:647-67. 2013
    ..Malignant mesothelioma (MM) is an uncommon tumor that can be difficult to diagnose...
  30. pmc A molecular profile of focal segmental glomerulosclerosis from formalin-fixed, paraffin-embedded tissue
    Jeffrey B Hodgin
    Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, New York, USA
    Am J Pathol 177:1674-86. 2010
    ..Our findings reveal novel insights into the molecular pathogenesis of glomerular injury and structural degeneration in FSGS...
  31. pmc Gene expression profiling of pulmonary fibrosis identifies Twist1 as an antiapoptotic molecular "rectifier" of growth factor signaling
    Robert S Bridges
    Department of Pharmacology, Columbia University College of Physicians and Surgeons, New York, New York, USA
    Am J Pathol 175:2351-61. 2009
    ..We propose that Twist1 represents one of the factors that promotes pathogenic accumulation of fibroblasts in fibrotic lung disease...
  32. doi request reprint Sarcoidosis-associated fibrosing mediastinitis with resultant pulmonary hypertension: a case report and review of the literature
    Rebecca L Toonkel
    Division of Pulmonary, Allergy, and Critical Care Medicine, Columbia University Medical Center, New York, NY, USA
    Respiration 79:341-5. 2010
    ..While pulmonary hypertension is a common complication of sarcoidosis, fibrosing mediastinitis is an unusual etiology that should be considered by clinicians...
  33. ncbi request reprint Expression of PAX2 in papillary serous carcinoma of the ovary: immunohistochemical evidence of fallopian tube or secondary M├╝llerian system origin?
    Guo Xia Tong
    Department of Pathology, Columbia University Medical Center, New York, NY 10032, USA
    Mod Pathol 20:856-63. 2007
    ....
  34. doi request reprint Cytological, histological, and immunohistochemical findings of pulmonary carcinomas with basaloid features
    John P Crapanzano
    Department of Pathology and Cell Biology, Columbia University Medical Center, 630 West 168th St, New York, NY 10032, USA
    Diagn Cytopathol 39:92-100. 2011
    ..However, immunostains were the very helpful and probably necessary to accurately diagnosing BC/BSQCC, which show the immunostaining pattern of p63 (+), HMWCK (+), and TTF-1 (-)...
  35. ncbi request reprint Patterns of allelic loss differ in lung adenocarcinomas of smokers and nonsmokers
    Charles A Powell
    Department of Medicine, Columbia College of Physicians and Surgeons, New York, NY, USA
    Lung Cancer 39:23-9. 2003
    ..Our results suggest that the early steps of lung carcinogenesis differ in nonsmokers compared with smokers. In addition, the chromosomal sites of LOH may identify genes important for lung carcinogenesis in nonsmokers...
  36. ncbi request reprint Pulmonary hypertension in idiopathic pulmonary fibrosis
    Nina M Patel
    Department of Medicine, Division of Pulmonary, Allergy and Critical Care, Columbia University, 622 W 168th St, PH 8 East, Room 101, New York, NY 10032, USA
    Chest 132:998-1006. 2007
    ..However, possible treatments such as long-term supplemental oxygen and targeted vascular therapy are either unstudied or remain unproven...
  37. pmc A postinfluenza model of Staphylococcus aureus pneumonia
    Mei Ho Lee
    Division of Infectious Diseases, Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York, USA
    J Infect Dis 201:508-15. 2010
    ..Postinfluenza Staphylococcus aureus pneumonias are increasingly recognized as a major form of life-threatening infections...
  38. ncbi request reprint Significant pulmonary toxicity associated with interferon and ribavirin therapy for hepatitis C
    K Shiva Kumar
    Center for Liver Disease and Transplantation, New York Presbyterian Hospital, New York, USA
    Am J Gastroenterol 97:2432-40. 2002
    ..The aim of this study was to analyze the clinical presentation and outcomes of significant pulmonary toxicity associated with interferon and ribavirin...