J Bhattacharya

Summary

Affiliation: Columbia University
Country: USA

Publications

  1. ncbi request reprint Pressure-induced endothelial Ca(2+) oscillations in lung capillaries
    Wolfgang M Kuebler
    Department of Medicine, College of Physicians and Surgeons, Columbia University, St Luke s Roosevelt Hospital Center, New York, New York 10019, USA
    Am J Physiol Lung Cell Mol Physiol 282:L917-23. 2002
  2. doi request reprint F-actin scaffold stabilizes lamellar bodies during surfactant secretion
    Mohammad N Islam
    630 West 168th St, BB 8 812, New York, NY 10032
    Am J Physiol Lung Cell Mol Physiol 306:L50-7. 2014
  3. doi request reprint Regulation and repair of the alveolar-capillary barrier in acute lung injury
    Jahar Bhattacharya
    Division of Pulmonary Allergy and Critical Care, Department of Medicine, Columbia University Medical Center, New York, NY 10032, USA
    Annu Rev Physiol 75:593-615. 2013
  4. pmc Lung capillaries raise the hypoxia alarm
    Jahar Bhattacharya
    Division of Pulmonary, Allergy and Critical Care, Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    J Clin Invest 122:3845-7. 2012
  5. pmc Erythrocytes induce proinflammatory endothelial activation in hypoxia
    Alice Huertas
    Lung Biology Laboratory, Pulmonary Division, Department of Medicine, Columbia University Medical Center, New York, NY 10032, USA
    Am J Respir Cell Mol Biol 48:78-86. 2013
  6. pmc Acid contact in the rodent pulmonary alveolus causes proinflammatory signaling by membrane pore formation
    Kristin Westphalen
    Lung Biology Laboratory, Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York, USA
    Am J Physiol Lung Cell Mol Physiol 303:L107-16. 2012
  7. ncbi request reprint Alveolocapillary cross-talk: Giles F. Filley lecture
    Jahar Bhattacharya
    Lung Biology Laboratory, St Luke s Roosevelt Hospital Center, New York, NY 10019, USA
    Chest 128:553S-555S. 2005
  8. ncbi request reprint Interpreting the lung microvascular filtration coefficient
    Jahar Bhattacharya
    Columbia University, New York, New York, USA
    Am J Physiol Lung Cell Mol Physiol 293:L9-L10. 2007
  9. ncbi request reprint Soluble ligands of the alpha v beta 3 integrin mediate enhanced tyrosine phosphorylation of multiple proteins in adherent bovine pulmonary artery endothelial cells
    S Bhattacharya
    St Luke s Roosevelt Hospital Center, New York, New York 10019, USA
    J Biol Chem 270:16781-7. 1995
  10. ncbi request reprint Rapid alveolar liquid removal by a novel convective mechanism
    P M Wang
    Department of Medicine, College of Physicians and Surgeons and St. Luke's-Roosevelt Hospital Center, Columbia University, New York, New York 10019, USA
    Am J Physiol Lung Cell Mol Physiol 281:L1327-34. 2001

Research Grants

  1. CALCIUM REGULATION IN LUNG MICROVASCULAR ENDOTHELIUM
    Jahar Bhattacharya; Fiscal Year: 2000
  2. ALVEOLO-CAPILLARY SIGNALING IN LUNG IMMUNOBIOLOGY
    Jahar Bhattacharya; Fiscal Year: 2004
  3. CALCIUM REGULATION IN LUNG MICROVASCULAR ENDOTHELIUM
    Jahar Bhattacharya; Fiscal Year: 2007
  4. MICROPUNCTURE STUDIES OF LUNG WATER AND SOLUTE EXCHANGE
    Jahar Bhattacharya; Fiscal Year: 2007
  5. ALVEOLO-CAPILLARY SIGNALING IN LUNG IMMUNOLOGY
    Jahar Bhattacharya; Fiscal Year: 2009
  6. MICROPUNCTURE STUDIES OF LUNG WATER AND SOLUTE EXCHANGE
    Jahar Bhattacharya; Fiscal Year: 2010
  7. Proinflammatory Signaling in the Pulmonary Circulation
    Jahar Bhattacharya; Fiscal Year: 2002
  8. CALCIUM REGULATION IN LUNG MICROVASCULAR ENDOTHELIUM
    Jahar Bhattacharya; Fiscal Year: 2004
  9. CALCIUM REGULATION IN LUNG MICROVASCULAR ENDOTHELIUM
    Jahar Bhattacharya; Fiscal Year: 2009
  10. MICROSCOPIC IMAGING OF ALVEOLAR FUNCTION
    Jahar Bhattacharya; Fiscal Year: 2010

Collaborators

Detail Information

Publications41

  1. ncbi request reprint Pressure-induced endothelial Ca(2+) oscillations in lung capillaries
    Wolfgang M Kuebler
    Department of Medicine, College of Physicians and Surgeons, Columbia University, St Luke s Roosevelt Hospital Center, New York, New York 10019, USA
    Am J Physiol Lung Cell Mol Physiol 282:L917-23. 2002
    ..Our findings indicate the presence of a sensitive, active endothelial response to pressure challenge in lung venular capillaries that may be relevant in the pathogenesis of pressure-induced lung microvascular injury...
  2. doi request reprint F-actin scaffold stabilizes lamellar bodies during surfactant secretion
    Mohammad N Islam
    630 West 168th St, BB 8 812, New York, NY 10032
    Am J Physiol Lung Cell Mol Physiol 306:L50-7. 2014
    ..This is the first instance of a secretory process in which the secretory vesicles are immobile, but form a conduit for the secretory material. ..
  3. doi request reprint Regulation and repair of the alveolar-capillary barrier in acute lung injury
    Jahar Bhattacharya
    Division of Pulmonary Allergy and Critical Care, Department of Medicine, Columbia University Medical Center, New York, NY 10032, USA
    Annu Rev Physiol 75:593-615. 2013
    ..Novel treatment strategies include the possibility of cell-based therapy that may reduce the severity of lung injury and enhance lung repair...
  4. pmc Lung capillaries raise the hypoxia alarm
    Jahar Bhattacharya
    Division of Pulmonary, Allergy and Critical Care, Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    J Clin Invest 122:3845-7. 2012
    ..In this issue of the JCI, Wang et al. reveal that the endothelial lining of the hypoxic alveoli plays a key role in sensing hypoxia and transmitting the signal to initiate HPV...
  5. pmc Erythrocytes induce proinflammatory endothelial activation in hypoxia
    Alice Huertas
    Lung Biology Laboratory, Pulmonary Division, Department of Medicine, Columbia University Medical Center, New York, NY 10032, USA
    Am J Respir Cell Mol Biol 48:78-86. 2013
    ..These data indicate for the first time, to our knowledge, that erythrocytes are responsible for endothelial transcriptional responses in hypoxia...
  6. pmc Acid contact in the rodent pulmonary alveolus causes proinflammatory signaling by membrane pore formation
    Kristin Westphalen
    Lung Biology Laboratory, Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York, USA
    Am J Physiol Lung Cell Mol Physiol 303:L107-16. 2012
    ..These responses identify alveolar H(2)O(2) release as the signaling mechanism responsible for lung inflammation induced by acid and suggest that intra-alveolar PEG-catalase might be therapeutic in acid-induced lung injury...
  7. ncbi request reprint Alveolocapillary cross-talk: Giles F. Filley lecture
    Jahar Bhattacharya
    Lung Biology Laboratory, St Luke s Roosevelt Hospital Center, New York, NY 10019, USA
    Chest 128:553S-555S. 2005
  8. ncbi request reprint Interpreting the lung microvascular filtration coefficient
    Jahar Bhattacharya
    Columbia University, New York, New York, USA
    Am J Physiol Lung Cell Mol Physiol 293:L9-L10. 2007
  9. ncbi request reprint Soluble ligands of the alpha v beta 3 integrin mediate enhanced tyrosine phosphorylation of multiple proteins in adherent bovine pulmonary artery endothelial cells
    S Bhattacharya
    St Luke s Roosevelt Hospital Center, New York, New York 10019, USA
    J Biol Chem 270:16781-7. 1995
    ....
  10. ncbi request reprint Rapid alveolar liquid removal by a novel convective mechanism
    P M Wang
    Department of Medicine, College of Physicians and Surgeons and St. Luke's-Roosevelt Hospital Center, Columbia University, New York, New York 10019, USA
    Am J Physiol Lung Cell Mol Physiol 281:L1327-34. 2001
    ..We speculate that removal of liquid from the alveolar surface is determined by the curvature and surface-active properties of the air-liquid interface...
  11. pmc Mechano-oxidative coupling by mitochondria induces proinflammatory responses in lung venular capillaries
    Hideo Ichimura
    Lung Biology Laboratory, Department of Physiology and Cellular Biophysics, College of Physicians and Surgeons, St Luke s Roosevelt Hospital Center, Columbia University, New York, New York 10019, USA
    J Clin Invest 111:691-9. 2003
    ..These findings implicate mitochondrial mechanisms in the lung's proinflammatory response to pressure elevation and identify mitochondrial ROS as critical to P-selectin exocytosis in lung capillary ECs...
  12. ncbi request reprint Mitochondrial reactive oxygen species regulate spatial profile of proinflammatory responses in lung venular capillaries
    Kaushik Parthasarathi
    St Luke s Roosevelt Hospital Center, Department of Physiology and Cellular Biophysics, College of Physicians and Surgeons, Columbia University, New York, NY 10019, USA
    J Immunol 169:7078-86. 2002
    ..Responses to TNF-alpha revealed that EC mitochondria regulate the proinflammatory process by generating ROS that activate P-selectin expression...
  13. pmc Circulating KL-6, a biomarker of lung injury, in obstructive sleep apnoea
    D J Lederer
    Dept of Medicine, Columbia University, New York, NY 10032, USA
    Eur Respir J 33:793-6. 2009
    ..Circulating KL-6 levels are elevated in some patients with obstructive sleep apnoea, possibly reflecting increased alveolar wall permeability...
  14. ncbi request reprint High tidal volume ventilation induces proinflammatory signaling in rat lung endothelium
    Sunita Bhattacharya
    Department of Pediatrics, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    Am J Respir Cell Mol Biol 28:218-24. 2003
    ..These results indicate that in HV, EC signaling in situ causes FA formation and induces TyrP-dependent P-selectin expression. These signaling mechanisms may promote leukocyte-mediated responses in HV...
  15. pmc Connexin 43 mediates spread of Ca2+-dependent proinflammatory responses in lung capillaries
    Kaushik Parthasarathi
    Lung Biology Laboratory, St Luke s Roosevelt Hospital Center, Department of Physiology and Cellular Biophysics, College of Physicians and Surgeons, Columbia University, New York, New York 10019, USA
    J Clin Invest 116:2193-200. 2006
    ..Gap junctional mechanisms require further consideration in the understanding of ALI...
  16. ncbi request reprint Ongoing angiogenesis in blood vessels of the abdominal aortic aneurysm
    David C Paik
    Department of Ophthalmology and Medicine, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Exp Mol Med 36:524-33. 2004
    ..The upregulation of av mRNA and the avb3 integrin in blood vessels surrounded by a matrix expressing tenascin, indicates that angiogenesis is an ongoing process in the mature aortic aneurysm...
  17. ncbi request reprint Resealing of endothelial junctions by focal adhesion kinase
    Sadiqa K Quadri
    Lung Biology Laboratory, College of Physicians and Surgeons, Columbia University, St Luke s Roosevelt Hospital Center, 432 West 58th Street, New York, NY 10019, USA
    Am J Physiol Lung Cell Mol Physiol 292:L334-42. 2007
    ..These findings indicate that in oxidant-induced EC junction opening, FAK plays a critical role in remodeling the adherens junction to reseal the barrier...
  18. ncbi request reprint Lung surfactant secretion by interalveolar Ca2+ signaling
    Hideo Ichimura
    Lung Biology Laboratory, Department of Physiology and Cellular Biophysics, College of Physicians and Surgeons, Columbia University, St Luke s Roosevelt Hospital Center, New York, NY 10019, USA
    Am J Physiol Lung Cell Mol Physiol 291:L596-601. 2006
    ..We conclude that Cx43-dependent, interalveolar Ca2+ signals regulate type 2 cell secretion in adjacent alveoli. Such interalveolar communication might facilitate acinar coordination of alveolar function...
  19. ncbi request reprint Dual signaling by the alpha(v)beta(3)-integrin activates cytosolic PLA(2) in bovine pulmonary artery endothelial cells
    S Bhattacharya
    Department of Pediatrics, College of Physicians and Surgeons and St Luke s Roosevelt Hospital Center, Columbia University, New York, New York 10019, USA
    Am J Physiol Lung Cell Mol Physiol 280:L1049-56. 2001
    ..This is the first instance of a tyrosine phosphorylation-initiated "two-hit" signaling pathway that regulates an integrin-induced proinflammatory response...
  20. pmc Concentration-dependent inhibition of angiogenesis by mesenchymal stem cells
    Keishi Otsu
    Lung Biology Laboratory, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Blood 113:4197-205. 2009
    ..Thus, our findings show for the first time that at high numbers, MSCs are potentially cytotoxic and that when injected locally in tumor tissue they might be effective antiangiogenesis agents suitable for cancer therapy...
  21. pmc Red blood cells induce hypoxic lung inflammation
    Rainer Kiefmann
    Lung Biology Laboratory, College of Physicians and Surgeons, Columbia University, St Luke s Roosevelt Hospital Center, New York, NY, USA
    Blood 111:5205-14. 2008
    ..These findings are the first evidence that RBCs contribute to hypoxia-induced inflammation...
  22. ncbi request reprint Endothelial barrier strengthening by activation of focal adhesion kinase
    Sadiqa K Quadri
    Lung Biology Laboratory, College of Physicians and Surgeons, Columbia University, St Luke s Roosevelt Hospital Center, New York, New York 10019, USA
    J Biol Chem 278:13342-9. 2003
    ..These findings indicate that in EC exposed to hyperosmolar challenge, the involvement of focal adhesion kinase was critical in establishing barrier strengthening...
  23. pmc Hyperosmolarity enhances the lung capillary barrier
    Zeenat Safdar
    Division of Pulmonary Critical Care Medicine, St Luke s Roosevelt Hospital Center, New York, New York 10019, USA
    J Clin Invest 112:1541-9. 2003
    ..Hyperosmolar therapy may be beneficial in lung inflammatory disease...
  24. ncbi request reprint Vascular regulation of type II cell exocytosis
    P M Wang
    Department of Medicine, College of Physicians and Surgeons and St Luke s Roosevelt Hospital Center, Columbia University, New York, New York 10019, USA
    Am J Physiol Lung Cell Mol Physiol 282:L912-6. 2002
    ..We conclude that capillary pressure and surfactant secretion are mechanically coupled. The secretion initiates in a Ca(2+)-dependent manner but is sustained by Ca(2+)-independent mechanisms...
  25. ncbi request reprint Vascular expression of the alpha(v)beta(3)-integrin in lung and other organs
    B Singh
    Department of Physiology and Cellular Biophysics, Department of Medicine, and St Luke s Roosevelt Institute of Health Sciences, College of Physicians and Surgeons, Columbia University, New York, New York 10019, USA
    Am J Physiol Lung Cell Mol Physiol 278:L217-26. 2000
    ..Because it binds vitronectin, the lung vascular alpha(v)beta(3)-integrin may play a role in ligation of bloodborne, vitronectin-containing macromolecular complexes formed in inflammation...
  26. pmc Paracrine purinergic signaling determines lung endothelial nitric oxide production
    Rainer Kiefmann
    Lung Biology Laboratory, Department of Medicine, College of Physicians and Surgeons, Columbia University, St Luke s Roosevelt Hospital Center, New York, New York, USA
    Am J Physiol Lung Cell Mol Physiol 296:L901-10. 2009
    ..These findings reveal a novel mechanism in which mechanically induced purinergic signaling couples cross-compartmental Ca(2+)cyt oscillations to microvascular NO production...
  27. ncbi request reprint Pressure-induced leukocyte margination in lung postcapillary venules
    Hideo Ichimura
    Lung Biology Laboratory, Department of Physiology and Cellular Biophysics, Columbia University, New York, New York, USA
    Am J Physiol Lung Cell Mol Physiol 289:L407-12. 2005
    ..Our findings show that in lung postcapillary venules, the decrease in plasma velocity critically determines pressure-induced leukocyte margination...
  28. pmc Atomic force microscope elastography reveals phenotypic differences in alveolar cell stiffness
    Evren U Azeloglu
    Department of Biomedical Engineering, Columbia University, and Department of Medicine and Physiology, St Luke s Roosevelt Hospital Center, 1210 Amsterdam Ave, 351 H Engineering Terrace, MC8904, New York, NY 10027, USA
    J Appl Physiol (1985) 105:652-61. 2008
    ..These findings partially explain reported heterogeneity of alveolar cell deformation during in situ lung inflation and provide needed data for better understanding of how mechanical stretch influences surfactant release...
  29. pmc Micromechanics of alveolar edema
    Carrie E Perlman
    Department of Medicine, College of Physicians and Surgeons, Columbia University, 630 West 168th Street, New York, NY 10032, USA
    Am J Respir Cell Mol Biol 44:34-9. 2011
    ..Because of increased mechanical stress, air-filled alveoli may be susceptible to overdistension injury during mechanical ventilation of the edematous lung...
  30. ncbi request reprint Cell signaling underlying the pathophysiology of pneumonia
    Alice S Prince
    Department of Pediatrics and Pharmacology, Columbia University, New York, New York, USA
    Am J Physiol Lung Cell Mol Physiol 291:L297-300. 2006
    ..Also considered were mechanisms of bacterial virulence in the clinical setting (Wiener-Kronish) and the role of alveolar-capillary signaling mechanisms in the initiation of lung inflammation...
  31. ncbi request reprint Alveolar expansion imaged by optical sectioning microscopy
    Carrie E Perlman
    Department of Medicine and Physiology, College of Physicians and Surgeons and St Luke s Roosevelt Hospital Center, Columbia University, New York, New York 10019, USA
    J Appl Physiol 103:1037-44. 2007
    ..These findings indicate that alveoli expand nonuniformly, suggesting that segments that distend the most might be preferred alveolar locations for injury in conditions associated with lung overdistension...
  32. pmc Chloride-dependent secretion of alveolar wall liquid determined by optical-sectioning microscopy
    Jens Lindert
    Lung Biology Laboratory, Department of Physiology and Cellular Biophysics, Columbia University, College of Physicians and Surgeons, SLRHC, New York, New York, USA
    Am J Respir Cell Mol Biol 36:688-96. 2007
    ..We conclude that CFTR-dependent liquid secretion is present in alveoli of the adult mouse. Defective alveolar secretion might impair alveolar immune defense and promote alveolar disease...
  33. ncbi request reprint Integrated control of lung fluid balance
    Dolly Mehta
    Department of Pharmacology, University of Illinois Chicago Medical Center, Chicago, IL 60612, USA
    Am J Physiol Lung Cell Mol Physiol 287:L1081-90. 2004
    ..Development of mouse models in which the function of regulatory proteins (identified in cell culture studies) can be systematically analyzed will provide a better and more integrated picture of lung fluid balance. In vivo veritas!..
  34. ncbi request reprint Endothelial and epithelial signaling in the lung
    Shampa Chatterjee
    Institute for Environmental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Am J Physiol Lung Cell Mol Physiol 293:L517-9. 2007
    ..Several perspectives on endothelial and epithelial signaling, as well as their contributions to pulmonary inflammation and damage, as presented and discussed in the session are summarized here...
  35. ncbi request reprint Lung injury: sphingosine-1-phosphate to the rescue
    Jahar Bhattacharya
    Am J Respir Crit Care Med 170:928-9. 2004
  36. ncbi request reprint Real-time lung microscopy
    Wolfgang M Kuebler
    Charite Universitatsmedizin, Berlin, Germany
    J Appl Physiol 102:1255-64. 2007
    ..Here we summarize new developments in classical intravital microscopy and discuss real-time fluorescence imaging as a novel technique for studying second-messenger mechanisms in the alveolo-capillary region...
  37. ncbi request reprint Pressure-induced capillary stress failure: is it regulated?
    Jahar Bhattacharya
    Am J Physiol Lung Cell Mol Physiol 284:L701-2. 2003
  38. doi request reprint Lung neovascularization: a tale of two circulations
    Jahar Bhattacharya
    Am J Physiol Lung Cell Mol Physiol 294:L417-8. 2008
  39. ncbi request reprint The alveolar water gate
    Jahar Bhattacharya
    Am J Physiol Lung Cell Mol Physiol 286:L257-8. 2004
  40. pmc ITF1697, a stable Lys-Pro-containing peptide, inhibits weibel-palade body exocytosis induced by ischemia/reperfusion and pressure elevation
    Silvia Bertuglia
    CNR Institute of Clinical Physiology, Medical School, University of Pisa, Pisa, Italy
    Mol Med 13:615-24. 2007
    ....
  41. ncbi request reprint Cell-cell interactions in regulating lung function
    Scott Boitano
    Department of Physiology, University of Arizona Health Sciences Center, Tucson, Arizona 85724, USA
    Am J Physiol Lung Cell Mol Physiol 287:L455-9. 2004
    ....

Research Grants45

  1. CALCIUM REGULATION IN LUNG MICROVASCULAR ENDOTHELIUM
    Jahar Bhattacharya; Fiscal Year: 2000
    ..No previous understanding of such mechanisms exist in lung. These proposed studies are therefore, outstandingly novel and important. ..
  2. ALVEOLO-CAPILLARY SIGNALING IN LUNG IMMUNOBIOLOGY
    Jahar Bhattacharya; Fiscal Year: 2004
    ..No previous research addresses these issues. A novel understanding of lung immune processes will be achieved...
  3. CALCIUM REGULATION IN LUNG MICROVASCULAR ENDOTHELIUM
    Jahar Bhattacharya; Fiscal Year: 2007
    ..We will understand the role of these interactions in regulating proinflammatory receptor expression. These considerations will advance the understanding of the inception of lung inflammation. ..
  4. MICROPUNCTURE STUDIES OF LUNG WATER AND SOLUTE EXCHANGE
    Jahar Bhattacharya; Fiscal Year: 2007
    ..The FAKP studies are outstandingly novel. They will directly test the critical role of FAK in causing barrier enhancement, and reveal FAK therapy as a novel therapeutic possibility for ALI. ..
  5. ALVEOLO-CAPILLARY SIGNALING IN LUNG IMMUNOLOGY
    Jahar Bhattacharya; Fiscal Year: 2009
    ..This research is novel and it will advance our understanding of fundamental mechanisms regulating lung inflammation. ..
  6. MICROPUNCTURE STUDIES OF LUNG WATER AND SOLUTE EXCHANGE
    Jahar Bhattacharya; Fiscal Year: 2010
    ..The findings of this research are likely to impact understanding of mechanisms of acute lung injury and the development of relevant therapy. ..
  7. Proinflammatory Signaling in the Pulmonary Circulation
    Jahar Bhattacharya; Fiscal Year: 2002
    ..Both the site and the format of the conference have proved successful in earlier meetings. ..
  8. CALCIUM REGULATION IN LUNG MICROVASCULAR ENDOTHELIUM
    Jahar Bhattacharya; Fiscal Year: 2004
    ..The proposed studies are therefore novel and important, and will reveal a fundamental, new understanding of pressure-induced responses in the lung capillary. ..
  9. CALCIUM REGULATION IN LUNG MICROVASCULAR ENDOTHELIUM
    Jahar Bhattacharya; Fiscal Year: 2009
    ..We will understand the role of these interactions in regulating proinflammatory receptor expression. These considerations will advance the understanding of the inception of lung inflammation. ..
  10. MICROSCOPIC IMAGING OF ALVEOLAR FUNCTION
    Jahar Bhattacharya; Fiscal Year: 2010
    ..The findings of this research are likely to impact understanding of mechanisms of acute lung injury and the development of relevant therapy. ..
  11. MICROPUNCTURE STUDIES OF LUNG WATER AND SOLUTE EXCHANGE
    Jahar Bhattacharya; Fiscal Year: 2009
    ..The findings of this research are likely to impact understanding of mechanisms of acute lung injury and the development of relevant therapy. ..
  12. OPTICAL IMAGING OF LUNG CAPILLARIES IN VIVO
    Jahar Bhattacharya; Fiscal Year: 2007
    ..If the preliminary data hold, then this research will prove for the first time that mitochondrial mechanisms regulate specific pro-inflammatory responses. ..
  13. OPTICAL IMAGING OF MESENCHYMAL STEM CELL INTERACTIONS WITH LUNG MICROVESSELS
    Jahar Bhattacharya; Fiscal Year: 2010
    ..The findings of this research are likely to impact understanding of mechanisms of acute lung injury and the development of relevant therapy. ..
  14. MICROSCOPIC IMAGING OF ALVEOLAR FUNCTION
    Jahar Bhattacharya; Fiscal Year: 2007
    ..No previous understanding of these mechanisms exists. These proposed studies are therefore, outstandingly novel and important. ..
  15. MICROSCOPIC IMAGING OF ALVEOLAR FUNCTION
    Jahar Bhattacharya; Fiscal Year: 2003
    ..No previous understanding of such mechanisms exist in lung alveoli. These proposed studies are therefore, outstandingly novel and important. ..