Amer A Beg

Summary

Affiliation: Columbia University
Country: USA

Publications

  1. pmc Combined deficiency of p50 and cRel in CD4+ T cells reveals an essential requirement for nuclear factor kappaB in regulating mature T cell survival and in vivo function
    Ye Zheng
    Department of Biological Sciences, Columbia University, New York, NY 10027, USA
    J Exp Med 197:861-74. 2003
  2. ncbi Endogenous ligands of Toll-like receptors: implications for regulating inflammatory and immune responses
    Amer A Beg
    Dept of Biological Sciences, 1110 Fairchild Center, 1212 Amsterdam Ave, Columbia University, New York, NY 10027, USA
    Trends Immunol 23:509-12. 2002
  3. ncbi Regulation of developing B cell survival by RelA-containing NF-kappa B complexes
    Maria Prendes
    Department of Biological Sciences, Columbia University, New York, NY 10027, USA
    J Immunol 171:3963-9. 2003
  4. ncbi Dendritic cell development and survival require distinct NF-kappaB subunits
    Fateh Ouaaz
    Columbia University, Department of Biological Sciences, 1110 Fairchild Center, 1212 Amsterdam Avenue, New York, NY 10027, USA
    Immunity 16:257-70. 2002
  5. ncbi An extensively associated dimer in the structure of the C713S mutant of the TIR domain of human TLR2
    Xiao Tao
    Department of Biological Sciences, Columbia University, 10027, New York, NY, USA
    Biochem Biophys Res Commun 299:216-21. 2002
  6. pmc PAK4 kinase is essential for embryonic viability and for proper neuronal development
    Jian Qu
    Department of Biological Sciences, Columbia University, New York, New York 10025, USA
    Mol Cell Biol 23:7122-33. 2003
  7. pmc Interferons direct an effective innate response to Legionella pneumophila infection
    Courtney R Plumlee
    Department of Biological Sciences, Columbia University, New York, New York 10032, USA
    J Biol Chem 284:30058-66. 2009
  8. ncbi Distinct roles of different NF-kappa B subunits in regulating inflammatory and T cell stimulatory gene expression in dendritic cells
    Junmei Wang
    Department of Interdisciplinary Oncology, H Lee Moffitt Cancer Center and Research Institute, University of South Florida, Tampa, FL 33612, USA
    J Immunol 178:6777-88. 2007

Collaborators

  • Yongwon Choi
  • Howard A Shuman
  • Liang Tong
  • Thomas Decker
  • Ye Zheng
  • Courtney R Plumlee
  • Junmei Wang
  • Maria Prendes
  • Jian Qu
  • Fateh Ouaaz
  • Xiao Tao
  • Christian Schindler
  • Carolyn Lee
  • Fatah Ouaaz
  • Xingyu Wang
  • Shomyseh Sanjabi
  • Sofia Hussain
  • Matthew Kohn
  • Audrey Minden
  • Spencer Kozinn
  • Jian Ming Xie
  • Roderick Bronson
  • Luk Van Parijs
  • Monika Vig
  • Xiaofan Li
  • Jesse Lyons
  • Bennet G Novitch
  • Yingwu Xu
  • Joseph Arron

Detail Information

Publications8

  1. pmc Combined deficiency of p50 and cRel in CD4+ T cells reveals an essential requirement for nuclear factor kappaB in regulating mature T cell survival and in vivo function
    Ye Zheng
    Department of Biological Sciences, Columbia University, New York, NY 10027, USA
    J Exp Med 197:861-74. 2003
    ..These findings provide the first demonstration of a role for NF-kappaB proteins in regulating T cell function in vivo and establish a critically important function of NF-kappaB in TCR-induced regulation of survival...
  2. ncbi Endogenous ligands of Toll-like receptors: implications for regulating inflammatory and immune responses
    Amer A Beg
    Dept of Biological Sciences, 1110 Fairchild Center, 1212 Amsterdam Ave, Columbia University, New York, NY 10027, USA
    Trends Immunol 23:509-12. 2002
    ..However, potential complications associated with microbial contamination of endogenous agents and the specific nature of in vivo responses induced by these agents remain to be determined...
  3. ncbi Regulation of developing B cell survival by RelA-containing NF-kappa B complexes
    Maria Prendes
    Department of Biological Sciences, Columbia University, New York, NY 10027, USA
    J Immunol 171:3963-9. 2003
    ..Together, these results indicate that RelA plays a crucial role in regulating developing B cell survival by inhibiting TNF-alpha cytotoxicity...
  4. ncbi Dendritic cell development and survival require distinct NF-kappaB subunits
    Fateh Ouaaz
    Columbia University, Department of Biological Sciences, 1110 Fairchild Center, 1212 Amsterdam Avenue, New York, NY 10027, USA
    Immunity 16:257-70. 2002
    ..These results therefore indicate essential, subunit-specific functions for NF-kappaB proteins in regulating DC development, survival, and cytokine production...
  5. ncbi An extensively associated dimer in the structure of the C713S mutant of the TIR domain of human TLR2
    Xiao Tao
    Department of Biological Sciences, Columbia University, 10027, New York, NY, USA
    Biochem Biophys Res Commun 299:216-21. 2002
    ..Moreover, the structure shows that the BB loop can adopt different conformations, which are required for the formation of this dimer. This asymmetric dimer might represent the TLR2:TLRx heterodimer in the function of this receptor...
  6. pmc PAK4 kinase is essential for embryonic viability and for proper neuronal development
    Jian Qu
    Department of Biological Sciences, Columbia University, New York, New York 10025, USA
    Mol Cell Biol 23:7122-33. 2003
    ..PAK4-null embryos also had defects in proper folding of the caudal portion of the neural tube, suggesting an important role for PAK4 in neural tube development...
  7. pmc Interferons direct an effective innate response to Legionella pneumophila infection
    Courtney R Plumlee
    Department of Biological Sciences, Columbia University, New York, New York 10032, USA
    J Biol Chem 284:30058-66. 2009
    ..pneumophila. Surprisingly, this suppression is mediated by a pathway that is independent of Stat1, Stat2, Stat3, but correlates with the polarization of macrophages toward the M1 or classically activated phenotype...
  8. ncbi Distinct roles of different NF-kappa B subunits in regulating inflammatory and T cell stimulatory gene expression in dendritic cells
    Junmei Wang
    Department of Interdisciplinary Oncology, H Lee Moffitt Cancer Center and Research Institute, University of South Florida, Tampa, FL 33612, USA
    J Immunol 178:6777-88. 2007
    ..Together, our findings indicate novel and critically important overall roles of NF-kappaB in TLR-induced gene expression that are mediated by unique functions of distinct subunits...