Uttiya Basu

Summary

Affiliation: Columbia University
Country: USA

Publications

  1. ncbi request reprint The AID antibody diversification enzyme is regulated by protein kinase A phosphorylation
    Uttiya Basu
    The Howard Hughes Medical Institute, The Children s Hospital, The CBR Institute for Biomedical Research, and Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 438:508-11. 2005
  2. ncbi request reprint Regulation of activation induced deaminase via phosphorylation
    Uttiya Basu
    The Howard Hughes Medical Institute, The Children s Hospital, The CBR Institute for Biomedical Research, and Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    Adv Exp Med Biol 596:129-37. 2007
  3. pmc Regulation of activation-induced cytidine deaminase DNA deamination activity in B-cells by Ser38 phosphorylation
    Uttiya Basu
    Howard Hughes Medical Institute, Children s Hospital Boston, Boston, MA 02115, USA
    Biochem Soc Trans 37:561-8. 2009
  4. pmc The RNA exosome targets the AID cytidine deaminase to both strands of transcribed duplex DNA substrates
    Uttiya Basu
    Howard Hughes Medical Institute, Program in Cellular and Molecular Medicine, Immune Disease Institute, Children s Hospital Boston, Department of Genetics, Harvard Medical School, MA 02115, USA
    Cell 144:353-63. 2011
  5. pmc Evolution of phosphorylation-dependent regulation of activation-induced cytidine deaminase
    Uttiya Basu
    Howard Hughes Medical Institute, The Children s Hospital, Harvard Medical School, and the Immune Disease Institute, 300 Longwood Avenue, Boston, MA 02115, USA
    Mol Cell 32:285-91. 2008
  6. pmc Integrity of the AID serine-38 phosphorylation site is critical for class switch recombination and somatic hypermutation in mice
    Hwei Ling Cheng
    Howard Hughes Medical Institute, The Children s Hospital, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 106:2717-22. 2009
  7. pmc Post-translational regulation of activation-induced cytidine deaminase
    Uttiya Basu
    Howard Hughes Medical Institute, The Children s Hospital, Boston, MA 02115, USA
    Philos Trans R Soc Lond B Biol Sci 364:667-73. 2009

Collaborators

Detail Information

Publications8

  1. ncbi request reprint The AID antibody diversification enzyme is regulated by protein kinase A phosphorylation
    Uttiya Basu
    The Howard Hughes Medical Institute, The Children s Hospital, The CBR Institute for Biomedical Research, and Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 438:508-11. 2005
    ..We conclude that PKA has a critical role in post-translational regulation of AID activity in B cells...
  2. ncbi request reprint Regulation of activation induced deaminase via phosphorylation
    Uttiya Basu
    The Howard Hughes Medical Institute, The Children s Hospital, The CBR Institute for Biomedical Research, and Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    Adv Exp Med Biol 596:129-37. 2007
    ..Here, we will discuss the implications of recent studies that demonstrate the role of AID phosphorylation in augmenting AID activity with respect to these two processes...
  3. pmc Regulation of activation-induced cytidine deaminase DNA deamination activity in B-cells by Ser38 phosphorylation
    Uttiya Basu
    Howard Hughes Medical Institute, Children s Hospital Boston, Boston, MA 02115, USA
    Biochem Soc Trans 37:561-8. 2009
    ....
  4. pmc The RNA exosome targets the AID cytidine deaminase to both strands of transcribed duplex DNA substrates
    Uttiya Basu
    Howard Hughes Medical Institute, Program in Cellular and Molecular Medicine, Immune Disease Institute, Children s Hospital Boston, Department of Genetics, Harvard Medical School, MA 02115, USA
    Cell 144:353-63. 2011
    ..Our findings reveal a role for noncoding RNA surveillance machinery in generating antibody diversity...
  5. pmc Evolution of phosphorylation-dependent regulation of activation-induced cytidine deaminase
    Uttiya Basu
    Howard Hughes Medical Institute, The Children s Hospital, Harvard Medical School, and the Immune Disease Institute, 300 Longwood Avenue, Boston, MA 02115, USA
    Mol Cell 32:285-91. 2008
    ..Comparison of bony fish versus amphibian and mammalian AIDs suggests evolutionary divergence from constitutive to PKA-regulated RPA/AID interaction...
  6. pmc Integrity of the AID serine-38 phosphorylation site is critical for class switch recombination and somatic hypermutation in mice
    Hwei Ling Cheng
    Howard Hughes Medical Institute, The Children s Hospital, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 106:2717-22. 2009
    ....
  7. pmc Post-translational regulation of activation-induced cytidine deaminase
    Uttiya Basu
    Howard Hughes Medical Institute, The Children s Hospital, Boston, MA 02115, USA
    Philos Trans R Soc Lond B Biol Sci 364:667-73. 2009
    ..Here, we discuss our interpretation of the significance of AID regulation via phosphorylation and also discuss how this form of AID regulation may have evolved in higher organisms...