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Genomes and Genes | Antoni BarrientosSummaryAffiliation: Columbia University Country: USA Publications
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Publications
In vivo and in organello assessment of OXPHOS activitiesAntoni Barrientos
Department of Biological Sciences, Columbia University, New York, NY 10027, USA
Methods 26:307-16. 2002....- Yeast models of human mitochondrial diseasesAntoni Barrientos
Department of Biological Sciences, Columbia University, New York, NY 10027, USA
IUBMB Life 55:83-95. 2003..The usefulness of yeast as a model system for human mitochondrial disorders is evaluated... 
Mss51p and Cox14p jointly regulate mitochondrial Cox1p expression in Saccharomyces cerevisiaeAntoni Barrientos
Department of Biological Sciences, Columbia University, New York, NY, USA
EMBO J 23:3472-82. 2004..The release of Mss51p from the complex occurs at a downstream step in the assembly pathway, probably catalyzed by Shy1p...- SIT4 regulation of Mig1p-mediated catabolite repression in Saccharomyces cerevisiaeCan Jin
Department of Biological Sciences, Columbia University, New York, NY 10027, USA
FEBS Lett 581:5658-63. 2007..Our evidence suggests that this pathway involves turnover of Mig1p... - MTG1 codes for a conserved protein required for mitochondrial translationAntoni Barrientos
Department of Biological Sciences, Columbia University, New York, New York 10027, USA
Mol Biol Cell 14:2292-302. 2003..This is consistent with the peripheral localization of Mtg1p on the matrix side of the inner membrane and the results of in vivo mitochondrial translation assays in a temperature-sensitive mtg1 mutant... - Atp10p assists assembly of Atp6p into the F0 unit of the yeast mitochondrial ATPaseAlexander Tzagoloff
Department of Biological Sciences, Columbia University, New York, NY 10027, USA
J Biol Chem 279:19775-80. 2004..Based on these observations, we propose Atp10p to be an Atp6p-specific chaperone that facilitates the incorporation of Atp6p into an intermediate subcomplex of ATPase subunits... - Cytochrome oxidase assembly does not require catalytically active cytochrome CAntoni Barrientos
Department of Biological Sciences, Columbia University, New York, New York, 10027, USA
J Biol Chem 278:8881-7. 2003..Mutants containing wild type apocytochrome c in mitochondria lack COX, suggesting that only the folded and mature protein is able to promote COX assembly... - Cytochrome oxidase in health and diseaseAntoni Barrientos
Department of Biological Sciences, Columbia University, New York, NY 10027, USA
Gene 286:53-63. 2002..The latter impinge on all aspects of the biogenesis process. Here we review the current state of information about the functions of the COX-specific gene products and of their relationship to human COX deficiencies... - Yeast dihydroxybutanone phosphate synthase, an enzyme of the riboflavin biosynthetic pathway, has a second unrelated function in expression of mitochondrial respirationCan Jin
Department of Biological Sciences, Columbia University, New York, New York 10027, USA
J Biol Chem 278:14698-703. 2003..Most of the protein was localized in the cytosolic fraction, but a small fraction was detected in the mitochondrial intermembrane space... - Shy1p is necessary for full expression of mitochondrial COX1 in the yeast model of Leigh's syndromeAntoni Barrientos
Department of Biological Sciences, Columbia University, New York, NY 10027, USA
EMBO J 21:43-52. 2002..We propose that Shy1p promotes the formation of an assembly intermediate in which Cox1 is one of the partners... - COX16 encodes a novel protein required for the assembly of cytochrome oxidase in Saccharomyces cerevisiaeChristopher G Carlson
Department of Medical Genetics, University of Alberta, Edmonton, Canada
J Biol Chem 278:3770-5. 2003..Like other recently described nuclear gene products involved in expression of cytochrome oxidase, COX16 is a candidate for screening in inherited human COX deficiencies... - Cmc1p is a conserved mitochondrial twin CX9C protein involved in cytochrome c oxidase biogenesisDarryl Horn
Department of Biochemistry and Molecular Biology, The John T Macdonald Foundation Center for Medical Genetics, University of Miami Miller School of Medicine, Miami, Florida, USA
Mol Cell Biol 28:4354-64. 2008..Our results suggest that Cmc1p could play a direct or indirect role in copper trafficking and distribution to COX and Sod1p... - Cytotoxicity of a mutant huntingtin fragment in yeast involves early alterations in mitochondrial OXPHOS complexes II and IIIAsun Solans
Department of Neurology, Dr John T Macdonald Foundation Center for Medical Genetics, University of Miami, Miller School of Medicine, 1600 NW 10th Avenue, Miami, FL 33136, USA
Hum Mol Genet 15:3063-81. 2006..Our yeast model represents a very useful paradigm to study mitochondrial physiology alterations in the pathogenic mechanism of HD... - Role of cytochrome C in apoptosis: increased sensitivity to tumor necrosis factor alpha is associated with respiratory defects but not with lack of cytochrome C releaseUma D Vempati
University of Miami Miller School of Medicine, 1095 NW 14th Terrace, Miami, FL 33136, USA
Mol Cell Biol 27:1771-83. 2007..These studies underscore the importance of oxidative phosphorylation and apoptosome function to both the intrinsic and extrinsic apoptotic pathways... - Cytochrome c release and mitochondria involvement in programmed cell death induced by acetic acid in Saccharomyces cerevisiaePaula Ludovico
, Departamento de Biologia, Universidade do Minho, 4710-057 Braga, Portugal
Mol Biol Cell 13:2598-606. 2002..The understanding of the involvement of a mitochondria-dependent apoptotic pathway in S. cerevisiae PCD process will be most useful in the further elucidation of an ancestral pathway common to PCD in metazoans... - Mitochondrial copper metabolism and delivery to cytochrome c oxidaseDarryl Horn
Department of Biochemistry and Molecular Biology, The John T Macdonald Foundation Center for Medical Genetics, University of Miami Miller School of Medicine, Miami, FL 33136, USA
IUBMB Life 60:421-9. 2008..The different pathways are reviewed and discussed in the context of both mitochondrial COX assembly and copper homeostasis... - Ischemic preconditioning targets the respiration of synaptic mitochondria via protein kinase C epsilonKunjan R Dave
The Cerebral Vascular Disease Research Center, and The John T MacDonald Center for Medical Genetics, Leonard M Miller School of Medicine, University of Miami, Miami, Florida 33136, USA
J Neurosci 28:4172-82. 2008..We propose that, at 48 h of reperfusion after ischemic preconditioning, epsilonPKC is poised at synaptic mitochondria to respond to ischemia either by direct phosphorylation or activation of the epsilonPKC signaling pathway... - Bot1p is required for mitochondrial translation, respiratory function, and normal cell morphology in the fission yeast Schizosaccharomyces pombeDavid J Wiley
Department of Molecular and Cellular Pharmacology, University of Miami School of Medicine, P O Box 016129, Miami, FL 33101 6129, USA
Eukaryot Cell 7:619-29. 2008..Our observations also indicate that in fission yeast, alterations of mitochondrial function are linked to changes in cell cycle and cell morphology control mechanisms... - Transcriptional activators HAP/NF-Y rescue a cytochrome c oxidase defect in yeast and human cellsFlavia Fontanesi
Department of Neurology, The John T Macdonald Foundation Center for Medical Genetics, University of Miami Miller School of Medicine, Miami, FL, USA
Hum Mol Genet 17:775-88. 2008..Analogously, overexpression of the Hap complex human homologue NF-YA/B/C transcription complex in SURF1-deficient fibroblasts from an LS patient efficiently rescues their COX deficiency... - Aberrant translation of cytochrome c oxidase subunit 1 mRNA species in the absence of Mss51p in the yeast Saccharomyces cerevisiaeAndrea Zambrano
Department of Neurology and Biochemistry and Molecular Biology, The John T Macdonald Foundation Center for Medical Genetics, University of Miami School of Medicine, Miami, FL 33136, USA
Mol Biol Cell 18:523-35. 2007..These results support a key role for Mss51p in translationally regulating Cox1p synthesis by the status of cytochrome oxidase assembly... - Assembly of mitochondrial cytochrome c-oxidase, a complicated and highly regulated cellular processFlavia Fontanesi
Departments of Neurology, The John T. MacDonald Foundation Center for Medical Genetics, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
Am J Physiol Cell Physiol 291:C1129-47. 2006.... - Defects in the biosynthesis of mitochondrial heme c and heme a in yeast and mammalsCarlos T Moraes
Department of Neurology, University of Miami School of Medicine, USA
Biochim Biophys Acta 1659:153-9. 2004..The production of mouse models recapitulating these diseases is providing novel information on the pathogenesis of clinical syndromes... - Cytochrome c oxidase biogenesis: new levels of regulationFlavia Fontanesi
Department of Neurology, The John T Macdonald Foundation Center for Medical Genetics, University of Miami Miller School of Medicine, Miami, FL 33136, USA
IUBMB Life 60:557-68. 2008..The different mechanisms of regulation of COX assembly are reviewed and discussed...