Antoni Barrientos

Summary

Affiliation: Columbia University
Country: USA

Publications

  1. ncbi In vivo and in organello assessment of OXPHOS activities
    Antoni Barrientos
    Department of Biological Sciences, Columbia University, New York, NY 10027, USA
    Methods 26:307-16. 2002
  2. ncbi Yeast models of human mitochondrial diseases
    Antoni Barrientos
    Department of Biological Sciences, Columbia University, New York, NY 10027, USA
    IUBMB Life 55:83-95. 2003
  3. pmc Mss51p and Cox14p jointly regulate mitochondrial Cox1p expression in Saccharomyces cerevisiae
    Antoni Barrientos
    Department of Biological Sciences, Columbia University, New York, NY, USA
    EMBO J 23:3472-82. 2004
  4. pmc SIT4 regulation of Mig1p-mediated catabolite repression in Saccharomyces cerevisiae
    Can Jin
    Department of Biological Sciences, Columbia University, New York, NY 10027, USA
    FEBS Lett 581:5658-63. 2007
  5. pmc MTG1 codes for a conserved protein required for mitochondrial translation
    Antoni Barrientos
    Department of Biological Sciences, Columbia University, New York, New York 10027, USA
    Mol Biol Cell 14:2292-302. 2003
  6. ncbi Atp10p assists assembly of Atp6p into the F0 unit of the yeast mitochondrial ATPase
    Alexander Tzagoloff
    Department of Biological Sciences, Columbia University, New York, NY 10027, USA
    J Biol Chem 279:19775-80. 2004
  7. ncbi Cytochrome oxidase assembly does not require catalytically active cytochrome C
    Antoni Barrientos
    Department of Biological Sciences, Columbia University, New York, New York, 10027, USA
    J Biol Chem 278:8881-7. 2003
  8. ncbi Cytochrome oxidase in health and disease
    Antoni Barrientos
    Department of Biological Sciences, Columbia University, New York, NY 10027, USA
    Gene 286:53-63. 2002
  9. ncbi Yeast dihydroxybutanone phosphate synthase, an enzyme of the riboflavin biosynthetic pathway, has a second unrelated function in expression of mitochondrial respiration
    Can Jin
    Department of Biological Sciences, Columbia University, New York, New York 10027, USA
    J Biol Chem 278:14698-703. 2003
  10. pmc Shy1p is necessary for full expression of mitochondrial COX1 in the yeast model of Leigh's syndrome
    Antoni Barrientos
    Department of Biological Sciences, Columbia University, New York, NY 10027, USA
    EMBO J 21:43-52. 2002

Collaborators

  • Walter Neupert
  • Johannes M Herrmann
  • Pierre Rustin
  • Sharon Ackerman
  • CARLOS MORAES
  • RONALD BUTOW
  • Flavia Fontanesi
  • Alexander Tzagoloff
  • Darryl Horn
  • Can Jin
  • Andrea Zambrano
  • Asun Solans
  • Kunjan R Dave
  • David J Wiley
  • Uma D Vempati
  • Ileana C Soto
  • Christopher G Carlson
  • Paula Ludovico
  • Miguel A Perez-Pinzon
  • Paola Catanuto
  • Natalie Sanchez
  • Isabel Saul
  • Ami P Raval
  • Alessandra Torraco
  • Hassan Al-Ali
  • Carmen Rios
  • Fulvia Verde
  • R Anthony DeFazio
  • Rodrigo Leite de Oliveira
  • Sonoko Narisawa
  • Charles B Epstein
  • Francisca Diaz
  • Thomas D Fox
  • Abdul M Mian
  • Lawrence H Boise
  • Jose Luis Millan
  • Mayra Rodriguez
  • D Moira Glerum
  • Fernando Rodrigues
  • Manuela Corte-Real
  • Agostinho Almeida
  • Manuel T Silva

Detail Information

Publications23

  1. ncbi In vivo and in organello assessment of OXPHOS activities
    Antoni Barrientos
    Department of Biological Sciences, Columbia University, New York, NY 10027, USA
    Methods 26:307-16. 2002
    ....
  2. ncbi Yeast models of human mitochondrial diseases
    Antoni Barrientos
    Department of Biological Sciences, Columbia University, New York, NY 10027, USA
    IUBMB Life 55:83-95. 2003
    ..The usefulness of yeast as a model system for human mitochondrial disorders is evaluated...
  3. pmc Mss51p and Cox14p jointly regulate mitochondrial Cox1p expression in Saccharomyces cerevisiae
    Antoni Barrientos
    Department of Biological Sciences, Columbia University, New York, NY, USA
    EMBO J 23:3472-82. 2004
    ..The release of Mss51p from the complex occurs at a downstream step in the assembly pathway, probably catalyzed by Shy1p...
  4. pmc SIT4 regulation of Mig1p-mediated catabolite repression in Saccharomyces cerevisiae
    Can Jin
    Department of Biological Sciences, Columbia University, New York, NY 10027, USA
    FEBS Lett 581:5658-63. 2007
    ..Our evidence suggests that this pathway involves turnover of Mig1p...
  5. pmc MTG1 codes for a conserved protein required for mitochondrial translation
    Antoni Barrientos
    Department of Biological Sciences, Columbia University, New York, New York 10027, USA
    Mol Biol Cell 14:2292-302. 2003
    ..This is consistent with the peripheral localization of Mtg1p on the matrix side of the inner membrane and the results of in vivo mitochondrial translation assays in a temperature-sensitive mtg1 mutant...
  6. ncbi Atp10p assists assembly of Atp6p into the F0 unit of the yeast mitochondrial ATPase
    Alexander Tzagoloff
    Department of Biological Sciences, Columbia University, New York, NY 10027, USA
    J Biol Chem 279:19775-80. 2004
    ..Based on these observations, we propose Atp10p to be an Atp6p-specific chaperone that facilitates the incorporation of Atp6p into an intermediate subcomplex of ATPase subunits...
  7. ncbi Cytochrome oxidase assembly does not require catalytically active cytochrome C
    Antoni Barrientos
    Department of Biological Sciences, Columbia University, New York, New York, 10027, USA
    J Biol Chem 278:8881-7. 2003
    ..Mutants containing wild type apocytochrome c in mitochondria lack COX, suggesting that only the folded and mature protein is able to promote COX assembly...
  8. ncbi Cytochrome oxidase in health and disease
    Antoni Barrientos
    Department of Biological Sciences, Columbia University, New York, NY 10027, USA
    Gene 286:53-63. 2002
    ..The latter impinge on all aspects of the biogenesis process. Here we review the current state of information about the functions of the COX-specific gene products and of their relationship to human COX deficiencies...
  9. ncbi Yeast dihydroxybutanone phosphate synthase, an enzyme of the riboflavin biosynthetic pathway, has a second unrelated function in expression of mitochondrial respiration
    Can Jin
    Department of Biological Sciences, Columbia University, New York, New York 10027, USA
    J Biol Chem 278:14698-703. 2003
    ..Most of the protein was localized in the cytosolic fraction, but a small fraction was detected in the mitochondrial intermembrane space...
  10. pmc Shy1p is necessary for full expression of mitochondrial COX1 in the yeast model of Leigh's syndrome
    Antoni Barrientos
    Department of Biological Sciences, Columbia University, New York, NY 10027, USA
    EMBO J 21:43-52. 2002
    ..We propose that Shy1p promotes the formation of an assembly intermediate in which Cox1 is one of the partners...
  11. ncbi COX16 encodes a novel protein required for the assembly of cytochrome oxidase in Saccharomyces cerevisiae
    Christopher G Carlson
    Department of Medical Genetics, University of Alberta, Edmonton, Canada
    J Biol Chem 278:3770-5. 2003
    ..Like other recently described nuclear gene products involved in expression of cytochrome oxidase, COX16 is a candidate for screening in inherited human COX deficiencies...
  12. pmc Cmc1p is a conserved mitochondrial twin CX9C protein involved in cytochrome c oxidase biogenesis
    Darryl Horn
    Department of Biochemistry and Molecular Biology, The John T Macdonald Foundation Center for Medical Genetics, University of Miami Miller School of Medicine, Miami, Florida, USA
    Mol Cell Biol 28:4354-64. 2008
    ..Our results suggest that Cmc1p could play a direct or indirect role in copper trafficking and distribution to COX and Sod1p...
  13. ncbi Cytotoxicity of a mutant huntingtin fragment in yeast involves early alterations in mitochondrial OXPHOS complexes II and III
    Asun Solans
    Department of Neurology, Dr John T Macdonald Foundation Center for Medical Genetics, University of Miami, Miller School of Medicine, 1600 NW 10th Avenue, Miami, FL 33136, USA
    Hum Mol Genet 15:3063-81. 2006
    ..Our yeast model represents a very useful paradigm to study mitochondrial physiology alterations in the pathogenic mechanism of HD...
  14. pmc Role of cytochrome C in apoptosis: increased sensitivity to tumor necrosis factor alpha is associated with respiratory defects but not with lack of cytochrome C release
    Uma D Vempati
    University of Miami Miller School of Medicine, 1095 NW 14th Terrace, Miami, FL 33136, USA
    Mol Cell Biol 27:1771-83. 2007
    ..These studies underscore the importance of oxidative phosphorylation and apoptosome function to both the intrinsic and extrinsic apoptotic pathways...
  15. pmc Cytochrome c release and mitochondria involvement in programmed cell death induced by acetic acid in Saccharomyces cerevisiae
    Paula Ludovico
    Centro de Ciências do Ambiente, Departamento de Biologia, Universidade do Minho, 4710 057 Braga, Portugal
    Mol Biol Cell 13:2598-606. 2002
    ..The understanding of the involvement of a mitochondria-dependent apoptotic pathway in S. cerevisiae PCD process will be most useful in the further elucidation of an ancestral pathway common to PCD in metazoans...
  16. pmc Mitochondrial copper metabolism and delivery to cytochrome c oxidase
    Darryl Horn
    Department of Biochemistry and Molecular Biology, The John T Macdonald Foundation Center for Medical Genetics, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    IUBMB Life 60:421-9. 2008
    ..The different pathways are reviewed and discussed in the context of both mitochondrial COX assembly and copper homeostasis...
  17. pmc Ischemic preconditioning targets the respiration of synaptic mitochondria via protein kinase C epsilon
    Kunjan R Dave
    The Cerebral Vascular Disease Research Center, and The John T MacDonald Center for Medical Genetics, Leonard M Miller School of Medicine, University of Miami, Miami, Florida 33136, USA
    J Neurosci 28:4172-82. 2008
    ..We propose that, at 48 h of reperfusion after ischemic preconditioning, epsilonPKC is poised at synaptic mitochondria to respond to ischemia either by direct phosphorylation or activation of the epsilonPKC signaling pathway...
  18. pmc Bot1p is required for mitochondrial translation, respiratory function, and normal cell morphology in the fission yeast Schizosaccharomyces pombe
    David J Wiley
    Department of Molecular and Cellular Pharmacology, University of Miami School of Medicine, P O Box 016129, Miami, FL 33101 6129, USA
    Eukaryot Cell 7:619-29. 2008
    ..Our observations also indicate that in fission yeast, alterations of mitochondrial function are linked to changes in cell cycle and cell morphology control mechanisms...
  19. ncbi Transcriptional activators HAP/NF-Y rescue a cytochrome c oxidase defect in yeast and human cells
    Flavia Fontanesi
    Department of Neurology, The John T Macdonald Foundation Center for Medical Genetics, University of Miami Miller School of Medicine, Miami, FL, USA
    Hum Mol Genet 17:775-88. 2008
    ..Analogously, overexpression of the Hap complex human homologue NF-YA/B/C transcription complex in SURF1-deficient fibroblasts from an LS patient efficiently rescues their COX deficiency...
  20. pmc Aberrant translation of cytochrome c oxidase subunit 1 mRNA species in the absence of Mss51p in the yeast Saccharomyces cerevisiae
    Andrea Zambrano
    Department of Neurology and Biochemistry and Molecular Biology, The John T Macdonald Foundation Center for Medical Genetics, University of Miami School of Medicine, Miami, FL 33136, USA
    Mol Biol Cell 18:523-35. 2007
    ..These results support a key role for Mss51p in translationally regulating Cox1p synthesis by the status of cytochrome oxidase assembly...
  21. ncbi Assembly of mitochondrial cytochrome c-oxidase, a complicated and highly regulated cellular process
    Flavia Fontanesi
    Departments of Neurology, The John T Macdonald Foundation Center for Medical Genetics, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
    Am J Physiol Cell Physiol 291:C1129-47. 2006
    ....
  22. ncbi Defects in the biosynthesis of mitochondrial heme c and heme a in yeast and mammals
    Carlos T Moraes
    Department of Neurology, University of Miami School of Medicine, USA
    Biochim Biophys Acta 1659:153-9. 2004
    ..The production of mouse models recapitulating these diseases is providing novel information on the pathogenesis of clinical syndromes...
  23. pmc Cytochrome c oxidase biogenesis: new levels of regulation
    Flavia Fontanesi
    Department of Neurology, The John T Macdonald Foundation Center for Medical Genetics, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    IUBMB Life 60:557-68. 2008
    ..The different mechanisms of regulation of COX assembly are reviewed and discussed...