Mohammad Athar

Summary

Affiliation: Columbia University
Country: USA

Publications

  1. ncbi request reprint Oxidative stress and experimental carcinogenesis
    Mohammad Athar
    Department of Medical Elementology and Toxicology, Jamia Hamdard Hamdard University, Hamdard Nagar, New Delhi 110 062, India
    Indian J Exp Biol 40:656-67. 2002
  2. pmc A critical role for the proapoptotic protein bid in ultraviolet-induced immune suppression and cutaneous apoptosis
    Sanjay Pradhan
    Department of Dermatology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Immunol 181:3077-88. 2008
  3. ncbi request reprint Photoprotective effects of sulindac against ultraviolet B-induced phototoxicity in the skin of SKH-1 hairless mice
    Mohammad Athar
    Department of Dermatology and Skin Disease Center, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Toxicol Appl Pharmacol 195:370-8. 2004
  4. ncbi request reprint Hedgehog signalling in skin development and cancer
    Mohammad Athar
    Department of Dermatology, Columbia University, New York, NY 10032, USA
    Exp Dermatol 15:667-77. 2006
  5. pmc Mechanism of in vitro pancreatic cancer cell growth inhibition by melanoma differentiation-associated gene-7/interleukin-24 and perillyl alcohol
    Irina V Lebedeva
    Department of Urology, Herbert Irving Comprehensive Cancer Center, Columbia University, College of Physicians and Surgeons, New York, New York, USA
    Cancer Res 68:7439-47. 2008
  6. ncbi request reprint Protective effect of Rumex patientia (English Spinach) roots on ferric nitrilotriacetate (Fe-NTA) induced hepatic oxidative stress and tumor promotion response
    Irshad A Lone
    Department of Chemistry, Faculty of Science, Jamia Hamdard, Hamdard Nagar, New Delhi 110062, India
    Food Chem Toxicol 45:1821-9. 2007
  7. pmc CP-31398 restores mutant p53 tumor suppressor function and inhibits UVB-induced skin carcinogenesis in mice
    Xiuwei Tang
    Department of Dermatology, Columbia University College of Physicians and Surgeons, New York, New York, USA
    J Clin Invest 117:3753-64. 2007
  8. ncbi request reprint Eruca sativa seeds possess antioxidant activity and exert a protective effect on mercuric chloride induced renal toxicity
    M Sarwar Alam
    Department of Chemistry, Faculty of Science, Jamia Hamdard, Hamdard Nagar, New Delhi 110 062, India
    Food Chem Toxicol 45:910-20. 2007
  9. ncbi request reprint Free radical generating agents lead to the rapid progression of benign skin tumors to carcinoma in iron-overloaded mice
    Gayatri Bhasin
    Department of Medical Elementology and Toxicology, Faculty of Science, Hamdard University, 110062 New Delhi, India
    Arch Toxicol 78:139-46. 2004
  10. ncbi request reprint Quercus infectoria galls possess antioxidant activity and abrogates oxidative stress-induced functional alterations in murine macrophages
    Gurpreet Kaur
    Department of Medical Elementology and Toxicology, Faculty of Science, Jamia Hamdard, Hamdard Nagar, New Delhi, India
    Chem Biol Interact 171:272-82. 2008

Collaborators

Detail Information

Publications74

  1. ncbi request reprint Oxidative stress and experimental carcinogenesis
    Mohammad Athar
    Department of Medical Elementology and Toxicology, Jamia Hamdard Hamdard University, Hamdard Nagar, New Delhi 110 062, India
    Indian J Exp Biol 40:656-67. 2002
    ....
  2. pmc A critical role for the proapoptotic protein bid in ultraviolet-induced immune suppression and cutaneous apoptosis
    Sanjay Pradhan
    Department of Dermatology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Immunol 181:3077-88. 2008
    ..These studies provide evidence that Bid activation is a critical upstream mediator in UV-induced keratinocyte and LC apoptosis and that its absence abrogates UV-induced immune tolerance...
  3. ncbi request reprint Photoprotective effects of sulindac against ultraviolet B-induced phototoxicity in the skin of SKH-1 hairless mice
    Mohammad Athar
    Department of Dermatology and Skin Disease Center, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Toxicol Appl Pharmacol 195:370-8. 2004
    ....
  4. ncbi request reprint Hedgehog signalling in skin development and cancer
    Mohammad Athar
    Department of Dermatology, Columbia University, New York, NY 10032, USA
    Exp Dermatol 15:667-77. 2006
    ..This review therefore provides a current understanding of the role of the Shh pathway in skin development and neoplasia. It also provides a basis for the molecular target-based chemoprevention and therapeutic management of skin cancer...
  5. pmc Mechanism of in vitro pancreatic cancer cell growth inhibition by melanoma differentiation-associated gene-7/interleukin-24 and perillyl alcohol
    Irina V Lebedeva
    Department of Urology, Herbert Irving Comprehensive Cancer Center, Columbia University, College of Physicians and Surgeons, New York, New York, USA
    Cancer Res 68:7439-47. 2008
    ..Because both POH and Ad.mda-7 are being evaluated in clinical trials, combining a dietary agent and a virally delivered therapeutic cytokine provides an innovative approach for potentially treating human pancreatic cancer...
  6. ncbi request reprint Protective effect of Rumex patientia (English Spinach) roots on ferric nitrilotriacetate (Fe-NTA) induced hepatic oxidative stress and tumor promotion response
    Irshad A Lone
    Department of Chemistry, Faculty of Science, Jamia Hamdard, Hamdard Nagar, New Delhi 110062, India
    Food Chem Toxicol 45:1821-9. 2007
    ..The data obtained in the present study illustrates R. patientia roots to possess potent antioxidant and free radical scavenging activities and thwart oxidative damage and hyperproliferation in hepatic tissues...
  7. pmc CP-31398 restores mutant p53 tumor suppressor function and inhibits UVB-induced skin carcinogenesis in mice
    Xiuwei Tang
    Department of Dermatology, Columbia University College of Physicians and Surgeons, New York, New York, USA
    J Clin Invest 117:3753-64. 2007
    ..Blocking MPT diminished p53 translocation and apoptosis. These studies indicate that reconstituting p53 tumor suppressor functions in vivo by small molecular weight compounds may block the pathogenesis and progression of skin cancer...
  8. ncbi request reprint Eruca sativa seeds possess antioxidant activity and exert a protective effect on mercuric chloride induced renal toxicity
    M Sarwar Alam
    Department of Chemistry, Faculty of Science, Jamia Hamdard, Hamdard Nagar, New Delhi 110 062, India
    Food Chem Toxicol 45:910-20. 2007
    ..The data obtained in the present study suggests E. sativa seeds to possess a potent antioxidant and renal protective activity and preclude oxidative damage inflicted to the kidney...
  9. ncbi request reprint Free radical generating agents lead to the rapid progression of benign skin tumors to carcinoma in iron-overloaded mice
    Gayatri Bhasin
    Department of Medical Elementology and Toxicology, Faculty of Science, Hamdard University, 110062 New Delhi, India
    Arch Toxicol 78:139-46. 2004
    ..Thus, we observe that in iron-overloaded animals, free radical generating agents bring about the rapid progression of benign mouse skin papillomas to carcinomas...
  10. ncbi request reprint Quercus infectoria galls possess antioxidant activity and abrogates oxidative stress-induced functional alterations in murine macrophages
    Gurpreet Kaur
    Department of Medical Elementology and Toxicology, Faculty of Science, Jamia Hamdard, Hamdard Nagar, New Delhi, India
    Chem Biol Interact 171:272-82. 2008
    ..MTT assay revealed gall extract to enhance percent survival of tBOOH exposed macrophages. These results indicate that Q. infectoria galls possess potent antioxidant activity, when tested both in chemical as well as biological models...
  11. doi request reprint Dietary supplementation of silymarin protects against chemically induced nephrotoxicity, inflammation and renal tumor promotion response
    Gurpreet Kaur
    Department of Chemistry, Faculty of Science, Jamia Hamdard, Hamdard Nagar, New Delhi 110062, India
    Invest New Drugs 28:703-13. 2010
    ..From these results, it could be concluded that silymarin markedly protects against chemically induced renal cancer and acts plausibly by virtue of its antioxidant, anti-inflammatory and antiproliferative activities...
  12. doi request reprint Chemoprevention by perillyl alcohol coupled with viral gene therapy reduces pancreatic cancer pathogenesis
    Irina V Lebedeva
    Department of Urology, Herbert Irving Comprehensive Cancer Center, Columbia University, College of Physicians and Surgeons, New York, New York, USA
    Mol Cancer Ther 7:2042-50. 2008
    ..This novel and innovative approach combining a dietary agent and a virally delivered therapeutic cytokine provides a means of both preventing and treating human pancreatic cancer with significant clinical translational potential...
  13. ncbi request reprint Evaluation of antioxidant activity of Cassia siamea flowers
    Gurpreet Kaur
    Department of Medical Elementology and Toxicology, Jamia Hamdard, Hamdard Nagar, New Delhi 110062, India
    J Ethnopharmacol 108:340-8. 2006
    ..siamea flowers have potent antioxidant activity against free radicals, prevent oxidative damage to major biomolecules and afford significant protection against oxidative damage in the liver...
  14. ncbi request reprint Reduced cyclin D1 ubiquitination in UVB-induced murine squamous cell carcinomas
    Arianna L Kim
    Department of Dermatology, Columbia University College of Physicians and Surgeons, 630 West 168th Street, New York, NY 10032, USA
    Biochem Biophys Res Commun 298:377-82. 2002
    ....
  15. ncbi request reprint Punica granatum (pomegranate) flower extract possesses potent antioxidant activity and abrogates Fe-NTA induced hepatotoxicity in mice
    Gurpreet Kaur
    Department of Medical Elementology and Toxicology, Faculty of Science, Jamia Hamdard, Hamdard Nagar, New Delhi 110062, India
    Food Chem Toxicol 44:984-93. 2006
    ..These results indicate pomegranate flowers to possess potent antioxidant and hepatoprotective property, the former being probably responsible for the latter...
  16. ncbi request reprint Guilandina bonduc L. possesses antioxidant activity and precludes Ferric Nitrilotriacetate (Fe-NTA) induced renal toxicity and tumor promotion response
    Gurpreet Kaur
    Division of Radiopharmaceuticals and Radiation Biology, Institute of Nuclear Medicine and Allied Sciences, Delhi Department of Medical Elementology and Toxicology, Jamia Hamdard, Hamdard Nagar, New Delhi 110062, India
    J Environ Pathol Toxicol Oncol 28:163-75. 2009
    ..The data obtained in the present study indicate G. bonduc fruit pods to possess a potent antioxidant activity and avert chemically inflicted renal oxidative damage and tumor promotion response...
  17. pmc Nitric oxide-releasing sulindac is a novel skin cancer chemopreventive agent for UVB-induced photocarcinogenesis
    Sandeep C Chaudhary
    Department of Dermatology, University of Alabama at Birmingham, 1530 3rd Avenue South, VH509, Birmingham, AL 35294 0019, USA
    Toxicol Appl Pharmacol 268:249-55. 2013
    ..Our data suggest that NO-sulindac is a potent inhibitor of UVB-induced skin carcinogenesis and acts by targeting proliferation-regulatory pathways...
  18. pmc Nitric oxide donor exisulind is an effective inhibitor of murine photocarcinogenesis
    Tripti Singh
    Department of Dermatology, University of Alabama at Birmingham, Birmingham, AL, USA
    Photochem Photobiol 88:1141-8. 2012
    ..These data suggest that NO-exisulind reduces tumor growth and inhibits tumor progression by blocking proliferation, inducing apoptosis and reducing EMT...
  19. doi request reprint Cumene hydroperoxide debilitates macrophage physiology by inducing oxidative stress: possible protection by alpha-tocopherol
    Gurpreet Kaur
    Department of Medical Elementology and Toxicology, Faculty of Science, Jamia Hamdard, Hamdard Nagar, New Delhi 110062, India
    Chem Biol Interact 179:94-102. 2009
    ..These data suggest that exposure to Cum-OOH may impair the physiology of immune cells such as macrophages and that supplementation with alpha-tocopherol can safeguard these cells against Cum-OOH toxicity...
  20. ncbi request reprint Progressive iron overload enhances chemically mediated tumor promotion in murine skin
    Gayatri Bhasin
    Department of Medical Elementology and Toxicology, Faculty of Science, Hamdard University, 110062, New Delhi, India
    Arch Biochem Biophys 409:262-73. 2003
    ..These data suggest that progressive iron overload can enhance the tumor promotion ability of TPA/BPO in DMBA-initiated murine skin...
  21. ncbi request reprint Inhibition of smoothened signaling prevents ultraviolet B-induced basal cell carcinomas through regulation of Fas expression and apoptosis
    Mohammad Athar
    Department of Dermatology, College of Physicians and Surgeons, Columbia University, New York, New York, USA
    Cancer Res 64:7545-52. 2004
    ....
  22. pmc Resveratrol targets transforming growth factor-β2 signaling to block UV-induced tumor progression
    Kwang Ho Kim
    Department of Dermatology, Columbia University Medical Center, Irving Cancer Research Center, New York, New York, USA
    J Invest Dermatol 131:195-202. 2011
    ....
  23. ncbi request reprint Protective effect of Didymocarpus pedicellata on ferric nitrilotriacetate (Fe-NTA) induced renal oxidative stress and hyperproliferative response
    Gurpreet Kaur
    Department of Medical Elementology and Toxicology, Faculty of Science, Jamia Hamdard, Hamdard Nagar, New Delhi 110062, India
    Chem Biol Interact 165:33-44. 2007
    ..BUN and SCr. The results of the present study indicate D. pedicellata to possess potent antioxidant and free radical scavenging activities and preclude oxidative damage and hyperproliferation in renal tissues...
  24. ncbi request reprint Garlic oil ameliorates ferric nitrilotriacetate (Fe-NTA)-induced damage and tumor promotion: implications for cancer prevention
    Mukesh Kumar Agarwal
    Department of Medical Elementology and Toxicology, Faculty of Science, Jamia Hamdard Hamdard University, Hamdard Nagar, New Delhi 110062, India
    Food Chem Toxicol 45:1634-40. 2007
    ....
  25. pmc Ornithine decarboxylase is a target for chemoprevention of basal and squamous cell carcinomas in Ptch1+/- mice
    Xiuwei Tang
    Department of Dermatology, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    J Clin Invest 113:867-75. 2004
    ..These results demonstrate the crucial importance of ODC for the induction of BCCs and indicate that chemopreventive strategies directed at inhibiting this enzyme may be useful in reducing BCCs in human populations...
  26. pmc Targeting wild-type and mutant p53 with small molecule CP-31398 blocks the growth of rhabdomyosarcoma by inducing reactive oxygen species-dependent apoptosis
    Jianmin Xu
    Department of Dermatology, University of Alabama at Birmingham, Birmingham, Alabama 35294 0019, USA
    Cancer Res 70:6566-76. 2010
    ..Our findings indicate that the ability of CP-31398 to modulate wild-type and mutant p53 results in the inhibition of RMS growth and invasiveness...
  27. ncbi request reprint Resveratrol inhibits proliferation of human epidermoid carcinoma A431 cells by modulating MEK1 and AP-1 signalling pathways
    Arianna L Kim
    Department of Dermatology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Exp Dermatol 15:538-46. 2006
    ..Our results demonstrate that resveratrol affects multiple cellular targets in A431 cells, and that the downregulation of both AP-1 and pRb contributes to its antiproliferative activity in these cells...
  28. ncbi request reprint Low iron diet retards 12-O-tetradecanoyl phorbol-13-acetate-mediated tumor promotion in murine skin
    Gayatri Bhasin
    Department of Medical Elementology and Toxicology, Faculty of Science, Hamdard University, 110062, New Delhi, India
    Arch Toxicol 78:283-9. 2004
    ..Thus, in this study we observe that the tumor promoting potential of TPA is reduced in mice fed on low iron diet, which is also accompanied by lesser inflammatory changes in the skin of tumor-bearing mice fed on low iron diet...
  29. pmc Multiple molecular targets of resveratrol: Anti-carcinogenic mechanisms
    Mohammad Athar
    Departments of Dermatology, Columbia University Medical Center, Irving Cancer Research Center, New York, NY 10032, USA
    Arch Biochem Biophys 486:95-102. 2009
    ..This review summarizes in vitro mechanistic data available for resveratrol and discusses new potential anti-cancer targets and the antiproliferative mechanisms of resveratrol...
  30. ncbi request reprint Differential expression of E prostanoid receptors in murine and human non-melanoma skin cancer
    Juliette Lois Lee
    Department of Dermatology, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    J Invest Dermatol 125:818-25. 2005
    ..These data suggest that altered EP receptor expression may play a differential role in the development of UVB-induced SCC and BCC in murine and human skin...
  31. doi request reprint Chemopreventive effect of farnesol on DMBA/TPA-induced skin tumorigenesis: involvement of inflammation, Ras-ERK pathway and apoptosis
    Sandeep Chand Chaudhary
    Department of Medical Elementology and Toxicology, Faculty of Science, Jamia Hamdard, Hamdard Nagar, New Delhi 110062, India
    Life Sci 85:196-205. 2009
    ..The present study demonstrates the chemopreventive potential of farnesol on 9,10-dimethylbenz(a)anthracene (DMBA)-initiated and 12-O-tetradecanoylphorbol-13-acetate (TPA)-promoted skin tumorigenesis in Swiss albino mice...
  32. doi request reprint Cyclooxygenase-2 inhibitor nimesulide blocks ultraviolet B-induced photocarcinogenesis in SKH-1 hairless mice
    Xiuwei Tang
    Department of Dermatology, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    Photochem Photobiol 84:522-7. 2008
    ..These results show that alternative classes of COX-2 inhibitors may likely be efficacious as cancer chemopreventive agents and may have an improved therapeutic index...
  33. pmc Cancer cell survival following DNA damage-mediated premature senescence is regulated by mammalian target of rapamycin (mTOR)-dependent Inhibition of sirtuin 1
    Jung Ho Back
    Department of Dermatology, Columbia University Medical Center, New York, New York 10032, USA
    J Biol Chem 286:19100-8. 2011
    ..These results demonstrate that the inhibition of SIRT1 by mTOR fosters survival of DNA damage-induced prematurely senescent SCC cells via Bfl-1/A1 in the absence of functional p53...
  34. pmc New agents for prevention of ultraviolet-induced nonmelanoma skin cancer
    William L Camp
    Department of Dermatology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Semin Cutan Med Surg 30:6-13. 2011
    ....
  35. doi request reprint Topically applied vitamin E prevents massive cutaneous inflammatory and oxidative stress responses induced by double application of 12-O-tetradecanoylphorbol-13-acetate (TPA) in mice
    Shakilur Rahman
    Department of Medical Elementology and Toxicology, Jamia Hamdard, Hamdard University, New Delhi 110 062, India
    Chem Biol Interact 172:195-205. 2008
    ..These results confirm the efficacy of vitamin E against early inflammatory and oxidative stress responses, which are hallmark of tumor promotion and provide rational basis for chemopreventive action of vitamin E in skin cancer...
  36. ncbi request reprint Catechin prevents tamoxifen-induced oxidative stress and biochemical perturbations in mice
    Suhel Parvez
    Immunotoxicology Laboratory, Department of Medical Elementology and Toxicology, Jamia Hamdard Hamdard University, New Delhi 110062, India
    Toxicology 225:109-18. 2006
    ..The results of the study show that catechin supplementation might be helpful in abrogation of TAM toxicity during chemotherapy. Additionally, it makes it a prophylactic and preventive agent of anticancer drug-induced oxidative stress...
  37. ncbi request reprint Inhibitory effect of 18beta-glycyrrhetinic acid on 12-O-tetradecanoyl phorbol-13-acetate-induced cutaneous oxidative stress and tumor promotion in mice
    Mukesh Kumar Agarwal
    Department of Medical Elementology and Toxicology, Faculty of Science, Jamia Hamdard, Hamdard University, New Delhi, India
    Redox Rep 10:151-7. 2005
    ..05) and 62% (P < 0.05), respectively. These results suggest that glycyrrhetinic acid, an antioxidant, is a potential chemopreventive agent that can inhibit DMBA/TPA-induced cutaneous oxidative stress and tumor promotion...
  38. ncbi request reprint Role of p38 MAPK in UVB-induced inflammatory responses in the skin of SKH-1 hairless mice
    Arianna L Kim
    Department of Dermatology, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    J Invest Dermatol 124:1318-25. 2005
    ..Blockade of the p38 MAPK pathway may offer an effective approach to reducing or preventing skin damage resulting from acute solar radiation...
  39. pmc Metformin, an antidiabetic agent reduces growth of cutaneous squamous cell carcinoma by targeting mTOR signaling pathway
    Sandeep C Chaudhary
    Department of Dermatology, University of Alabama at Birmingham, Birmingham, AL, USA
    Photochem Photobiol 88:1149-56. 2012
    ..Consistently, decreased phosphorylation of GSK3β, which is carried out by AKT kinases was also observed. These results suggest that metformin blocks SCC growth by dampening NFkB and mTOR signaling pathways...
  40. ncbi request reprint Evaluation of antioxidant activity of Salix caprea flowers
    M Sarwar Alam
    Department of Chemistry, Faculty of Science, Jamia Hamdard, Hamdard Nagar, New Delhi 110062, India
    Phytother Res 20:479-83. 2006
    ..The present study indicates that the flowers of S. caprea possess a significant antioxidant and hepatoprotective property, the former being implicated in the latter...
  41. ncbi request reprint Vitamin E inhibits hepatic oxidative stress, toxicity and hyperproliferation in rats treated with the renal carcinogen ferric nitrilotriacetate
    Mukesh Kumar Agarwal
    Department of Medical Elementology and Toxicology, Faculty of Science, Jamia Hamdard, Hamdard University, New Delhi, India
    Redox Rep 10:62-70. 2005
    ..Taken together, our results suggest that vitamin E may afford substantial protection against the damage caused by Fe-NTA exposure and can serve as a potent preventive agent to suppress oxidant-induced tissue injury...
  42. pmc Slit2 inhibits growth and metastasis of fibrosarcoma and squamous cell carcinoma
    Hee Kyung Kim
    Department of Dermatology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Neoplasia 10:1411-20. 2008
    ....
  43. ncbi request reprint Cyclooxygenase-2 expression in murine and human nonmelanoma skin cancers: implications for therapeutic approaches
    Kathy P An
    Department of Dermatology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Photochem Photobiol 76:73-80. 2002
    ..In summary, enhanced COX-2 expression serves as a marker of epidermal UVB exposure for murine and human NMSC. These results suggest that COX-2 inhibitors could have potent anticarcinogenic effects in UVB-induced skin cancer...
  44. ncbi request reprint Cyclooxygenases in the skin: pharmacological and toxicological implications
    Juliette L Lee
    Departments of Dermatology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Toxicol Appl Pharmacol 192:294-306. 2003
    ..Selective COX-2 inhibitors have a more favorable side-effect profile. Topical formulations of COX-2 inhibitors are being developed as a novel pharmacologic approach for the treatment of COX-2 mediated skin diseases...
  45. ncbi request reprint Ultraviolet-B-induced G1 arrest is mediated by downregulation of cyclin-dependent kinase 4 in transformed keratinocytes lacking functional p53
    Arianna L Kim
    Department of Dermatology, College of Physicians and Surgeons, Columbia University, New York, New York, USA
    J Invest Dermatol 118:818-24. 2002
    ..This identifies a novel pathway for G1 cell cycle arrest in transformed keratinocytes following ultraviolet-B irradiation...
  46. pmc Procarcinogenic effects of cyclosporine A are mediated through the activation of TAK1/TAB1 signaling pathway
    Jianmin Xu
    Department of Dermatology, University of Alabama at Birmingham, AL 35294, USA
    Biochem Biophys Res Commun 408:363-8. 2011
    ..Activation of both NFκB and p38 MAP kinase provide mitogenic stimuli to augment the growth of SCCs...
  47. pmc Resveratrol: a review of preclinical studies for human cancer prevention
    Mohammad Athar
    Department of Dermatology, College of Physicians and Surgeons, Columbia University, 630 West 168th Street VC15 204, New York, NY 10032, USA
    Toxicol Appl Pharmacol 224:274-83. 2007
    ..This review discusses the current preclinical and mechanistic data available and assesses resveratrol's anticancer effects to support its potential as an anticancer agent in human populations...
  48. pmc Combined inhibition of p38 and Akt signaling pathways abrogates cyclosporine A-mediated pathogenesis of aggressive skin SCCs
    Aadithya Arumugam
    Department of Dermatology, University of Alabama at Birmingham, Birmingham, AL 35294 0019, USA
    Biochem Biophys Res Commun 425:177-81. 2012
    ..These data provide first important combinatorial pharmacological approach to block the pathogenesis of CsA-induced highly aggressive cutaneous neoplasm in OTRs...
  49. ncbi request reprint Tocotrienol-rich fraction of palm oil activates p53, modulates Bax/Bcl2 ratio and induces apoptosis independent of cell cycle association
    Mukesh K Agarwal
    Department of Medical Elementology and Toxicology, Hamdard University, New Delhi, India
    Cell Cycle 3:205-11. 2004
    ..Our data suggest that TRF-induced apoptosis in colon carcinoma cells is mediated by p53 signaling network which appears to be independent of cell cycle association...
  50. pmc Rapamycin and mTORC1 inhibition in the mouse: skin cancer prevention
    Mohammad Athar
    Department of Dermatology, Skin Diseases Research Center and UAB Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Cancer Prev Res (Phila) 4:957-61. 2011
    ....
  51. ncbi request reprint Oxidative stress in the pathogenesis of skin disease
    David R Bickers
    Department of Dermatology, Columbia University Medical Center, New York, New York, USA
    J Invest Dermatol 126:2565-75. 2006
    ..Although many antioxidants have shown substantive efficacy in cell culture systems and in animal models of oxidant injury, unequivocal confirmation of their beneficial effects in human populations has proven elusive...
  52. pmc Loss of hairless confers susceptibility to UVB-induced tumorigenesis via disruption of NF-kappaB signaling
    Hyunmi Kim
    Department of Genetics and Development, Columbia University, College of Physicians and Surgeons, New York, New York, United States of America
    PLoS ONE 7:e39691. 2012
    ..Instead, Hr is a crucial UVB response gene and its loss creates a permissive environment that potentiates increased tumorigenesis...
  53. pmc Prospects for skin cancer treatment and prevention: the potential contribution of an engineered virus
    Jennifer A Cafardi
    Department of Dermatology, University of Alabama at Birmingham, Birmingham, Alabama, USA
    J Invest Dermatol 131:559-61. 2011
    ..These results suggest that such an enzyme may be incorporated into regimens for the chemoprevention of skin cancers...
  54. ncbi request reprint Mitochondrial damage mediates genotoxicity of arsenic in mammalian cells
    Su Xian Liu
    Center for Radiological Research, Department of Neurology, Columbia University, 630 West 168th Street, New York, NY 10032, USA
    Cancer Res 65:3236-42. 2005
    ....
  55. ncbi request reprint Stage-specific alterations of cyclin expression during UVB-induced murine skin tumor development
    Arianna L Kim
    Department of Dermatology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Photochem Photobiol 75:58-67. 2002
    ..Cyclin D1 and p53 overexpression were coupled with the development of tumors, and these changes are likely to be relevant to the pathogenesis of these lesions...
  56. pmc Immunoprevention of basal cell carcinomas with recombinant hedgehog-interacting protein
    Annika Vogt
    Department of Dermatology, University of California San Francisco, 94143, USA
    J Exp Med 199:753-61. 2004
    ....
  57. pmc The other end of the rainbow: infrared and skin
    Aton M Holzer
    Department of Dermatology, University of Alabama at Birmingham, 1530 3rd Avenue S, Birmingham, AL 35294, USA
    J Invest Dermatol 130:1496-9. 2010
    ..Their work paves the way for new research directions in IRA photobiology and raises important clinical questions regarding photoprotection and IRR-based dermatotherapy...
  58. pmc Pharmacological activation of p53 in cancer cells
    Mohammad Athar
    Department of Dermatology, The University of Alabama at Birmingham, Volker Hall, Room 509, 1530 3rd Avenue South, Birmingham, Alabama 35294 0019, USA
    Curr Pharm Des 17:631-9. 2011
    ..This review provides a description of various pharmacological approaches tested to activate p53 (both wild-type and mutant) and to assess the effects of activated p53 on neoplastic progression...
  59. pmc Targeting ornithine decarboxylase for the prevention of nonmelanoma skin cancer in humans
    Craig A Elmets
    Department of Dermatology, UAB Skin Diseases Research Center and UAB Comprehensive Cancer Center, The University of Alabama at Birmingham, 35294 0019, USA
    Cancer Prev Res (Phila) 3:8-11. 2010
    ..discusses our knowledge of the contribution of polyamines to BCC pathogenesis, how this knowledge advanced the development of a new method to prevent BCCs, and prospects for future studies of DFMO in BCC prevention...
  60. ncbi request reprint Palm oil alleviates 12-O-tetradecanoyl-phorbol-13-acetate-induced tumor promotion response in murine skin
    Hina Kausar
    Department of Medical Elementology and Toxicology, Faculty of Science, Hamdard University, 110062, New Delhi, India
    Cancer Lett 192:151-60. 2003
    ....
  61. pmc Liver kinase B1 (LKB1) in the pathogenesis of epithelial cancers
    Jennifer L Herrmann
    Department of Dermatology, University of Alabama at Birmingham, USA
    Cancer Lett 306:1-9. 2011
    ..In short, LKB1 is a tissue and context-specific kinase. This review aims to summarize our current understanding of its role in the pathogenesis of epithelial cancers...
  62. doi request reprint Geraniol inhibits murine skin tumorigenesis by modulating COX-2 expression, Ras-ERK1/2 signaling pathway and apoptosis
    Sandeep Chand Chaudhary
    Department of Medical Elementology and Toxicology, Faculty of Science, Jamia Hamdard Hamdard University, Hamdard Nagar, New Delhi 110062, India
    J Appl Toxicol 33:828-37. 2013
    ..Thus, it was concluded that GOH inhibits DMBA/TPA-mediated skin tumorigenesis by attenuating the Ras proliferation pathway and inducing pro-apoptotic state via inhibition of oxidative stress response and inflammation...
  63. ncbi request reprint Protoporphyrin-IX accumulation and cutaneous tumor regression in mice using a ferrochelatase inhibitor
    Gayatri Bhasin
    Department of Medical Elementology and Toxicology, Hamdard University, New Delhi 110062, India
    Cancer Lett 187:9-16. 2002
    ..Since the ferrochelatase inhibitor (lead) used in the present study is toxic, the search must continue for a safe, non-toxic inhibitor to enhance sensitizer-mediated PDT...
  64. ncbi request reprint Glyceryl trinitrate, a nitric oxide donor, abrogates ferric nitrilotriacetate-induced oxidative stress and renal damage
    Ayesha Rahman
    Department of Medical Elementology and Toxicology, Faculty of Science, Jamia Hamdard Hamdard University, New Delhi, India
    Arch Biochem Biophys 418:71-9. 2003
    ..Overall, the study suggests that NO administration subsequent to Fe-NTA affords protection against ROS-mediated damage induced by Fe-NTA...
  65. ncbi request reprint Antiinflammatory evaluation of alcoholic extract of galls of Quercus infectoria
    Gurpreet Kaur
    Department of Medical Elementology and Toxicology, Jamia Hamdard, Hamdard Nagar, New Delhi 110062, India
    J Ethnopharmacol 90:285-92. 2004
    ..These results suggest that alcoholic extract of galls of Q. infectoria exerts in vivo antiinflammatory activity after oral or topical administration and also has the ability to prevent the production of some inflammatory mediators...
  66. ncbi request reprint Iron augments stage-I and stage-II tumor promotion in murine skin
    Gayatri Bhasin
    Department of Medical Elementology and Toxicology, Hamdard University, 110062, New Delhi, India
    Cancer Lett 183:113-22. 2002
    ..Besides this, cutaneous iron levels were higher in iron-overloaded mice. Thus, we conclude from this study that iron-overload augments stage-I and stage-II of tumor promotion in murine skin...
  67. ncbi request reprint Molecular target-based therapy of pancreatic cancer
    Irina V Lebedeva
    Department of Pathology, Herbert Irving Comprehensive Cancer Center, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA
    Cancer Res 66:2403-13. 2006
    ..Our study provides support for a "dual molecular targeted therapy" involving oncogene inhibition and selective cancer apoptosis-inducing gene expression with potential for effectively treating an invariably fatal cancer...
  68. ncbi request reprint Roles of catalase and hydrogen peroxide in green tea polyphenol-induced chemopreventive effects
    Tetsuya Yamamoto
    Kochi Medical School, Japan
    J Pharmacol Exp Ther 308:317-23. 2004
    ..In conclusion, although endogenous catalase may play a role in response to H2O2-induced cytotoxicity, the EGCG-induced cytotoxic effects on tumor cells mainly result from sources other than H2O2...
  69. ncbi request reprint Green tea polyphenol targets the mitochondria in tumor cells inducing caspase 3-dependent apoptosis
    Stephen Hsu
    Department of Oral Biology and Maxillofacial Pathology, School of Dentistry, AD1443 Medical College of Georgia, Augusta, GA 30912 1126, USA
    Anticancer Res 23:1533-9. 2003
    ....
  70. ncbi request reprint Antioxidants prevent UV-induced apoptosis by inhibiting mitochondrial cytochrome c release and caspase activation in Spodoptera frugiperda (Sf9) cells
    Manjari Mohan
    Laboratory of Molecular and Cellular Biology, Centre for DNA Fingerprinting and Diagnostics, Hyderabad 500076, India
    Cell Biol Int 27:483-90. 2003
    ....
  71. ncbi request reprint Induction of p57 is required for cell survival when exposed to green tea polyphenols
    Stephen Hsu
    Department of Oral Biology and Maxillofacial Pathology, School of Dentistry, AD1443, Medical College of Georgia, Augusta, GA 30912 1126, USA
    Anticancer Res 22:4115-20. 2002
    ..Our results suggest that p57/KIP2 is a determinant pro-survival factor for cell protection from green tea polyphenol-induced apoptosis...
  72. ncbi request reprint Elevated polyamines lead to selective induction of apoptosis and inhibition of tumorigenesis by (-)-epigallocatechin-3-gallate (EGCG) in ODC/Ras transgenic mice
    Barry Paul
    Lankenau Institute for Medical Research, 100 Lancaster Avenue, Wynnewood, PA 19096, USA
    Carcinogenesis 26:119-24. 2005
    ..These results suggest that EGCG may be an effective chemopreventive agent in individuals with early, pre-neoplastic stages of cancer having higher levels of polyamines...
  73. ncbi request reprint Endothelial nitric oxide synthase gene variants contribute to oxidative stress in COPD
    Ehtesham Arif
    Functional Genomics Unit, Institute of Genomics and Integrative Biology, Delhi 110 007, India
    Biochem Biophys Res Commun 361:182-8. 2007
    ..The variants and their combinations of four polymorphisms of eNOS contribute to disturbed pulmonary function and oxidative stress in COPD...
  74. ncbi request reprint Baculoviral p35 inhibits oxidant-induced activation of mitochondrial apoptotic pathway
    Sudhir Sahdev
    Laboratory of Molecular and Cellular Biology, CDFD, Hyderabad 500076, India
    Biochem Biophys Res Commun 307:483-90. 2003
    ..p35 expression also inhibited cytochrome c release from the mitochondria of oxidant-exposed cells and blocked caspase-3 activation...