Research Topics
Species | V ArangoSummaryAffiliation: Columbia University Country: USA Publications
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Publications
Sex genes for genomic analysis in human brain: internal controls for comparison of probe level data extractionHanga C Galfalvy
Department of Neuroscience, New York State Psychiatric Institute, New York, NY 10032, USA
BMC Bioinformatics 4:37. 2003..We introduce the idea of using sex-chromosome genes as an alternative to spiked-in control genes or simulations for assessment of microarray data and analysis methods...
Postmortem findings in suicide victims. Implications for in vivo imaging studiesV Arango
Department of Neuroscience, New York State Psychiatric Institute, NY 10032, USA
Ann N Y Acad Sci 836:269-87. 1997....- Genetics of the serotonergic system in suicidal behaviorVictoria Arango
Department of Neuroscience, New York State Psychiatric Institute, New York, NY 10032, USA
J Psychiatr Res 37:375-86. 2003..The most meaningful studies combine the study of candidate genes with direct measures of related proteins as well as psychopathology... - Serotonin brain circuits involved in major depression and suicideVictoria Arango
Department of Neuroscience, New York State Psychiatric Institute, Columbia University College of Physicians and Surgeons, New York, NY, USA
Prog Brain Res 136:443-53. 2002..Today's informed psychiatrists will not be able to deny the role of the brain in the mental ailments that afflict their patients... - The neurobiology and genetics of suicide and attempted suicide: a focus on the serotonergic systemJ J Mann
Department of Neuroscience, New York State Psychiatric Institute, Columbia University, New York, NY, USA
Neuropsychopharmacology 24:467-77. 2001..A variety of biological indices have been generated by new approaches using postmortem tissue and in vivo imaging that will provide a rich substrate for further genetic studies... - Elevated expression of tryptophan hydroxylase-2 mRNA at the neuronal level in the dorsal and median raphe nuclei of depressed suicidesH Bach-Mizrachi
Department of Molecular Imaging and Neuropathology, New York State Psychiatric Institute, New York, NY 10032, USA
Mol Psychiatry 13:507-13, 465. 2008.... - Serotonin 1A receptors, serotonin transporter binding and serotonin transporter mRNA expression in the brainstem of depressed suicide victimsV Arango
Department of Neuroscience, New York State Psychiatric Institute, New York, NY 10032, USA
Neuropsychopharmacology 25:892-903. 2001..Less feedback inhibition of serotonin DRN firing via 5-HT(1A) autoreceptors and enhancement of serotonin action due to less uptake of serotonin, is consistent with compensatory changes in response to hypofunction in depressed suicides... - Mixed models and multiple comparisons in analysis of human neurochemical mapsS P Ellis
Department of Neuroscience, Unit 42, New York State Psychiatric Institute and Columbia University, 1051 Riverside Drive, NY 10032, New York, USA
Psychiatry Res 99:111-9. 2000..Such an analysis is illustrated using a small autoradiographic data set. The Bonferroni method, the method of Holm, and two 'False Discovery Rate'-controlling methods for adjusting P-values for multiple comparisons are compared... 
Genetic architecture of the human tryptophan hydroxylase 2 Gene: existence of neural isoforms and relevance for major depressionF Haghighi
Columbia Genome Center, Columbia University, New York, NY, USA
Mol Psychiatry 13:813-20. 2008....- Dorsal raphe nucleus serotonergic neurons innervate the rostral ventrolateral medulla in ratM D Underwood
Department of Psychiatry, College of Physicians and Surgeons of Columbia University, and New York State Psychiatric Institute 10032, USA
Brain Res 824:45-55. 1999..These studies demonstrate that there is a descending serotonergic projection from the DRN to the RVL. This projection may mediate autonomic changes elicited by DRN stimulation... - The human nucleus of the solitary tract: visceral pathways revealed with an "in vitro" postmortem tracing methodD A Ruggiero
Columbia University College of Physicians and Surgeons, Department of Psychiatry, New York State Psychiatric Institute, New York, NY 10032, USA
J Auton Nerv Syst 79:181-90. 2000..Axonal tracing studies predict that visceral impulses in humans may transmit over evolutionarily conserved pathways involved in autonomic feedback control and stress adaptation... - Upregulation of CB1 receptors and agonist-stimulated [35S]GTPgammaS binding in the prefrontal cortex of depressed suicide victimsB L Hungund
New York State Psychiatric Institute, New York, NY 10962, USA
Mol Psychiatry 9:184-90. 2004..The cannabinoidergic system may be a novel therapeutic target in the treatment of depression and/or suicidal behavior... - Neuronal tryptophan hydroxylase mRNA expression in the human dorsal and median raphe nuclei: major depression and suicideHelene Bach-Mizrachi
Department of Neuroscience, New York State Psychiatric Institute, New York, NY 10032, USA
Neuropsychopharmacology 31:814-24. 2006..Higher TPH2 mRNA expression may explain more TPH protein observed in depressed suicides and reflect a homeostatic response to deficient brain serotonergic transmission... - In vivo assessment of [11C]MRB as a prospective PET ligand for imaging the norepinephrine transporterAlin J Severance
Division of Brain Imaging, Department of Neuroscience, New York State Psychiatric Institute, 1051 Riverside Drive, P O Box 42, New York, NY 10032, USA
Eur J Nucl Med Mol Imaging 34:688-93. 2007..S,S)-Methylreboxetine (MRB) is among the more promising ligands recently adapted for positron emission tomography (PET), and the present study aimed to evaluate its potential for use in higher primates... - Synthesis and in vivo evaluation of [18F]-4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide as a PET imaging probe for COX-2 expressionJaya Prabhakaran
Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
Bioorg Med Chem 15:1802-7. 2007..A radiolabeling method that can generate consistent high specific activity is needed for routine human use... - In vitro and in vivo evaluation of [11C]MPEPy as a potential PET ligand for mGlu5 receptorsAlin J Severance
Division of Brain Imaging, Department of Neuroscience, New York State Psychiatric Institute, New York, NY 10032, USA
Nucl Med Biol 33:1021-7. 2006..Despite the promising in vitro results, the low signal-to-noise ratio found in vivo does not justify the use of [(11)C]MPEPy as a PET radiotracer in humans... - Lower serotonin transporter binding potential in the human brain during major depressive episodesRamin V Parsey
Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, USA
Am J Psychiatry 163:52-8. 2006..On the basis of postmortem and imaging studies, the authors hypothesized that subjects with major depressive disorder in a major depressive episode have fewer serotonin transporter sites, compared with healthy subjects... - Effect of a triallelic functional polymorphism of the serotonin-transporter-linked promoter region on expression of serotonin transporter in the human brainRamin V Parsey
Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, USA
Am J Psychiatry 163:48-51. 2006.... - Acute occupancy of brain serotonin transporter by sertraline as measured by [11C]DASB and positron emission tomographyRamin V Parsey
Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, New York, USA
Biol Psychiatry 59:821-8. 2006..Previous studies used chronic SSRI administration that may down-regulate 5-HTT and used the cerebellum as reference region despite measurable 5-HTT. We examine the reference region and occupancy after acute sertraline dosing... - Brain serotonin transporter binding in depressed patients with bipolar disorder using positron emission tomographyMaria A Oquendo
Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
Arch Gen Psychiatry 64:201-8. 2007..Associations of serotonin transporter promoter polymorphisms and bipolarity have been reported; however, research on alterations in serotonergic neurotransmission in bipolar depression remains scant... - Morphometry of dorsal raphe nucleus serotonergic neurons in alcoholismMark D Underwood
Department of Neuroscience, New York State Psychiatric Institute, New York, New York 10032, USA
Alcohol Clin Exp Res 31:837-45. 2007.... - PET Imaging of CRF1 with [11C]R121920 and [11C]DMP696: is the target of sufficient density?Gregory M Sullivan
Division of Neuroscience, Department of Psychiatry, New York State Psychiatric Institute, Columbia University, New York, NY 10032, USA
Nucl Med Biol 34:353-61. 2007..The aim of this study was to investigate the in vivo binding characteristics of [11C]R121920 and [11C]DMP696 in the nonhuman primate for application in positron emission tomography (PET) studies of CRF1... - Neocortical and hippocampal neuron and glial cell numbers in the rhesus monkeyJeppe Romme Christensen
Research Laboratory for Stereology and Neuroscience, Bispebjerg University Hospital, Copenhagen, Denmark
Anat Rec (Hoboken) 290:330-40. 2007..The results are phylogenetically consistent, apart from the neuron/glia ratio, which is remarkably higher than what is found in other species... - Neuropathologic examination after 91 ECT treatments in a 92-year-old woman with late-onset depressionJason Scalia
Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
J ECT 23:96-8. 2007..Cognition in this patient was intact as indicated by a perfect score on a Mini-Mental Status Examination administered 6 days before death at the age of 92. This case adds to the considerable evidence for the safety of ECT... - Serotonin-1A autoreceptor binding in the dorsal raphe nucleus of depressed suicidesMaura Boldrini
Department of Psychiatry, Division of Neuroscience, Columbia University College of Physicians and Surgeons, New York State Psychiatric Institute, 1051 Riverside Drive, P O Box 42, New York, NY 10032, USA
J Psychiatr Res 42:433-42. 2008..More autoreceptor binding in rostral DRN might contribute to deficient serotonin release in ventromedial prefrontal cortex by lower neuronal firing... - Large-scale estimates of cellular origins of mRNAs: enhancing the yield of transcriptome analysesEtienne Sibille
Department of Psychiatry, University of Pittsburgh, PA 15213, USA
J Neurosci Methods 167:198-206. 2008..As this approach can be applied post hoc, we provide tables of ratios for analysis of existing mouse and human brain datasets... - Family history of alcoholism is associated with lower 5-HT2A receptor binding in the prefrontal cortexMark D Underwood
Department of Psychiatry, Columbia College of Physicians and Surgeons, New York State Psychiatric Institute, New York 10032, USA
Alcohol Clin Exp Res 32:593-9. 2008..We sought to determine postmortem whether 5-HT(2A) receptors are altered in the prefrontal cortex (PFC) of alcoholics... - Norepinephrine and serotonin imbalance in the locus coeruleus in bipolar disorderAnna K Wiste
Department of Psychiatry, Columbia College of Physicians and Surgeons, New York, NY, USA
Bipolar Disord 10:349-59. 2008.... - Co-registration of radiographic and pathologic infarct territory in a non-human primate model of strokeRicardo J Komotar
Department of Neurological Surgery, Columbia University, New York, NY 10032, USA
Neurol Res 27:634-7. 2005..We describe a protocol that enables co-registration of radiographic signal change and histologic ischemia in a non-human primate model of stroke... - Altered serotonin 1A binding in major depression: a [carbonyl-C-11]WAY100635 positron emission tomography studyRamin V Parsey
Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, New York, USA
Biol Psychiatry 59:106-13. 2006..We measure 5-HT(1A) in MDD, assess the effects of antidepressant exposure (AE), and examine the role of the C(-1019)G polymorphism... - Higher postmortem prefrontal 5-HT2A receptor binding correlates with lifetime aggression in suicideMaria A Oquendo
Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, New York, USA
Biol Psychiatry 59:235-43. 2006..We measured 5-hydroxytryptamine 2A (5-HT(2A)) receptor binding in prefrontal cortex of suicide and nonsuicide subjects and explored the relationship between 5-HT(2A) receptor binding, lifetime aggression, and suicide... - Altered editing of serotonin 2C receptor pre-mRNA in the prefrontal cortex of depressed suicide victimsIlona Gurevich
Mount Sinai Graduate School of Biological Sciences, New York, NY 10029, USA
Neuron 34:349-56. 2002..Thus, one outcome of fluoxetine treatment may be to reverse the abnormalities in 5-HT2C pre-mRNA editing seen in depressed suicide victims... - Effects of sex, age, and aggressive traits in man on brain serotonin 5-HT1A receptor binding potential measured by PET using [C-11]WAY-100635Ramin V Parsey
Division of Neuroscience, Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
Brain Res 954:173-82. 2002..Lower 5-HT(1A) binding in more aggressive individuals is consistent with pharmacological challenge studies. Future studies should determine whether the binding is a state or trait effect... - Attenuated 5-HT1A receptor signaling in brains of suicide victims: involvement of adenylyl cyclase, phosphatidylinositol 3-kinase, Akt and mitogen-activated protein kinaseShu chi Hsiung
Department of Neuroscience, New York State Psychiatric Institute, New York, USA
J Neurochem 87:182-94. 2003.... - Gene expression profiling of depression and suicide in human prefrontal cortexEtienne Sibille
Department of Psychiatry, Columbia University, New York, NY, USA
Neuropsychopharmacology 29:351-61. 2004.... - Altered depression-related behaviors and functional changes in the dorsal raphe nucleus of serotonin transporter-deficient miceAlena Lira
Division of Developmental Psychobiology, Columbia University, New York, New York 10032, USA
Biol Psychiatry 54:960-71. 2003..Using mice lacking the SERT (SERT KO), we examined the role of SERT function in anxiety- and depression-related behaviors and serotonergic neuron function... - Absence of histological lesions in primate models of ECT and magnetic seizure therapyAndrew J Dwork
Magnetic Brain Stimulation Laboratory, Department of Biological Psychiatry, New York State Psychiatric Institute, New York 10032, USA
Am J Psychiatry 161:576-8. 2004..The authors present preliminary findings from the first nonhuman primate neuropathological study of ECT to use perfusion fixation and adequate controls and the first to compare ECT with magnetic seizure therapy, to their knowledge... - Volumetric analysis of the prefrontal cortex, amygdala, and hippocampus in major depressionRamin S Hastings
Department of Neuroscience, New York State Psychiatric Institute, New York, NY 10032, USA
Neuropsychopharmacology 29:952-9. 2004..The biology of mood disorders in females may differ in some aspects from males, and may contribute to the higher rate of depression in women... - Synthesis of [O-methyl-11C]1-(2-chlorophenyl)-5-(4-methoxyphenyl)-4-methyl-1H-pyrazole-3-carboxylic acid piperidin-1-ylamide: a potential PET ligand for CB1 receptorsJ S Dileep Kumar
Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
Bioorg Med Chem Lett 14:2393-6. 2004..The radiotracer was found to selectively label CB(1) receptors in slide-mounted sections of postmortem human brain containing prefrontal cortex as demonstrated by in vitro autoradiography using phosphor imaging... - Serotonergic and noradrenergic neurobiology of alcoholic suicideMark D Underwood
Department of Psychiatry, Columbia College of Physicians and Surgeons, New York, New York, USA
Alcohol Clin Exp Res 28:57S-69S. 2004..Altered serotonin (5-HT) function is associated with suicide and serious suicide attempts. We hypothesized patterns of abnormality associated independently with suicide and with alcoholism... - More tryptophan hydroxylase in the brainstem dorsal raphe nucleus in depressed suicidesMaura Boldrini
Department of Neuroscience, New York State Psychiatric Institute, New York, NY 10032, USA
Brain Res 1041:19-28. 2005..More TPH may be an upregulatory homeostatic response to impaired serotonin release or less autoreceptor activation. Alternatively, the serotonin impairment in suicide may be due to hypofunctional serotonin-synthesizing enzyme... - Molecular aging in human prefrontal cortex is selective and continuous throughout adult lifeLoubna Erraji-Benchekroun
Department of Psychiatry, Columbia University, New York, New York, USA
Biol Psychiatry 57:549-58. 2005.... - Elevated levels of endocannabinoids and CB1 receptor-mediated G-protein signaling in the prefrontal cortex of alcoholic suicide victimsK Yaragudri Vinod
Department of Analytical Psychopharmacology, Nathan Kline Institute for Psychiatric Research, Orangeburg, New York 10962, USA
Biol Psychiatry 57:480-6. 2005..EC system may be a novel therapeutic target for the treatment of suicidal behavior... - Regional heterogeneity of 5-HT1A receptors in human cerebellum as assessed by positron emission tomographyRamin V Parsey
Department of Neuroscience, New York State Psychiatric Institute, New York, New York 10032, USA
J Cereb Blood Flow Metab 25:785-93. 2005..With CW as a reference region, V(3)'' cannot be used to detect differences in 5-HT(1A) receptors between men and women, suggesting the need for arterial input functions to determine BP... - Human 5-HT1A receptor C(-1019)G polymorphism and psychopathologyYung Yu Huang
Department of Neuroscience, New York State Psychiatric Institute, New York, NY 10032, USA
Int J Neuropsychopharmacol 7:441-51. 2004..The relationship does not appear to be explained by binding differences, although we cannot rule out altered receptor affinity and transduction... - Using the gene ontology for microarray data mining: a comparison of methods and application to age effects in human prefrontal cortexPaul Pavlidis
Department of Biomedical Informatics and Columbia Genome Center, Columbia University, New York, New York 10032, USA
Neurochem Res 29:1213-22. 2004..quot;.. - Abnormalities of SNARE mechanism proteins in anterior frontal cortex in severe mental illnessWilliam G Honer
Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada
Cereb Cortex 12:349-56. 2002..These abnormalities in the SNARE complex could represent a molecular substrate for abnormalities of neural connectivity in severe mental disorders... - Immobilization stress elevates tryptophan hydroxylase mRNA and protein in the rat raphe nucleiFiras M Chamas
Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla, NY 10595, USA
Biol Psychiatry 55:278-83. 2004..We examined the effect of immobilization stress (IMO) on gene expression of tryptophan hydroxylase (TPH), the rate-limiting enzyme in serotonin biosynthesis, and the role of cortisol in that response... - Fiber order of the normal and regenerated optic tract of the frog (Rana pipiens)Helene Bach
Program in Anatomy and Cell Biology, State University of New York Health Science Center at Brooklyn, Brooklyn, New York 11203, USA
J Comp Neurol 477:43-54. 2004..In contrast, the growth pattern of regenerating peripheral nasal axons would not be affected by the ephrin-A gradient in the optic tract...