V Arango

Summary

Affiliation: Columbia University
Country: USA

Publications

  1. pmc Sex genes for genomic analysis in human brain: internal controls for comparison of probe level data extraction
    Hanga C Galfalvy
    Department of Neuroscience, New York State Psychiatric Institute, New York, NY 10032, USA
    BMC Bioinformatics 4:37. 2003
  2. ncbi request reprint Postmortem findings in suicide victims. Implications for in vivo imaging studies
    V Arango
    Department of Neuroscience, New York State Psychiatric Institute, NY 10032, USA
    Ann N Y Acad Sci 836:269-87. 1997
  3. ncbi request reprint Genetics of the serotonergic system in suicidal behavior
    Victoria Arango
    Department of Neuroscience, New York State Psychiatric Institute, New York, NY 10032, USA
    J Psychiatr Res 37:375-86. 2003
  4. ncbi request reprint Serotonin brain circuits involved in major depression and suicide
    Victoria Arango
    Department of Neuroscience, New York State Psychiatric Institute, Columbia University College of Physicians and Surgeons, New York, NY, USA
    Prog Brain Res 136:443-53. 2002
  5. ncbi request reprint The neurobiology and genetics of suicide and attempted suicide: a focus on the serotonergic system
    J J Mann
    Department of Neuroscience, New York State Psychiatric Institute, Columbia University, New York, NY, USA
    Neuropsychopharmacology 24:467-77. 2001
  6. pmc Elevated expression of tryptophan hydroxylase-2 mRNA at the neuronal level in the dorsal and median raphe nuclei of depressed suicides
    H Bach-Mizrachi
    Department of Molecular Imaging and Neuropathology, New York State Psychiatric Institute, New York, NY 10032, USA
    Mol Psychiatry 13:507-13, 465. 2008
  7. ncbi request reprint Serotonin 1A receptors, serotonin transporter binding and serotonin transporter mRNA expression in the brainstem of depressed suicide victims
    V Arango
    Department of Neuroscience, New York State Psychiatric Institute, New York, NY 10032, USA
    Neuropsychopharmacology 25:892-903. 2001
  8. ncbi request reprint Mixed models and multiple comparisons in analysis of human neurochemical maps
    S P Ellis
    Department of Neuroscience, Unit 42, New York State Psychiatric Institute and Columbia University, 1051 Riverside Drive, NY 10032, New York, USA
    Psychiatry Res 99:111-9. 2000
  9. doi request reprint Genetic architecture of the human tryptophan hydroxylase 2 Gene: existence of neural isoforms and relevance for major depression
    F Haghighi
    Columbia Genome Center, Columbia University, New York, NY, USA
    Mol Psychiatry 13:813-20. 2008
  10. ncbi request reprint Dorsal raphe nucleus serotonergic neurons innervate the rostral ventrolateral medulla in rat
    M D Underwood
    Department of Psychiatry, College of Physicians and Surgeons of Columbia University, and New York State Psychiatric Institute 10032, USA
    Brain Res 824:45-55. 1999

Collaborators

Detail Information

Publications49

  1. pmc Sex genes for genomic analysis in human brain: internal controls for comparison of probe level data extraction
    Hanga C Galfalvy
    Department of Neuroscience, New York State Psychiatric Institute, New York, NY 10032, USA
    BMC Bioinformatics 4:37. 2003
    ..We introduce the idea of using sex-chromosome genes as an alternative to spiked-in control genes or simulations for assessment of microarray data and analysis methods...
  2. ncbi request reprint Postmortem findings in suicide victims. Implications for in vivo imaging studies
    V Arango
    Department of Neuroscience, New York State Psychiatric Institute, NY 10032, USA
    Ann N Y Acad Sci 836:269-87. 1997
    ....
  3. ncbi request reprint Genetics of the serotonergic system in suicidal behavior
    Victoria Arango
    Department of Neuroscience, New York State Psychiatric Institute, New York, NY 10032, USA
    J Psychiatr Res 37:375-86. 2003
    ..The most meaningful studies combine the study of candidate genes with direct measures of related proteins as well as psychopathology...
  4. ncbi request reprint Serotonin brain circuits involved in major depression and suicide
    Victoria Arango
    Department of Neuroscience, New York State Psychiatric Institute, Columbia University College of Physicians and Surgeons, New York, NY, USA
    Prog Brain Res 136:443-53. 2002
    ..Today's informed psychiatrists will not be able to deny the role of the brain in the mental ailments that afflict their patients...
  5. ncbi request reprint The neurobiology and genetics of suicide and attempted suicide: a focus on the serotonergic system
    J J Mann
    Department of Neuroscience, New York State Psychiatric Institute, Columbia University, New York, NY, USA
    Neuropsychopharmacology 24:467-77. 2001
    ..A variety of biological indices have been generated by new approaches using postmortem tissue and in vivo imaging that will provide a rich substrate for further genetic studies...
  6. pmc Elevated expression of tryptophan hydroxylase-2 mRNA at the neuronal level in the dorsal and median raphe nuclei of depressed suicides
    H Bach-Mizrachi
    Department of Molecular Imaging and Neuropathology, New York State Psychiatric Institute, New York, NY 10032, USA
    Mol Psychiatry 13:507-13, 465. 2008
    ....
  7. ncbi request reprint Serotonin 1A receptors, serotonin transporter binding and serotonin transporter mRNA expression in the brainstem of depressed suicide victims
    V Arango
    Department of Neuroscience, New York State Psychiatric Institute, New York, NY 10032, USA
    Neuropsychopharmacology 25:892-903. 2001
    ..Less feedback inhibition of serotonin DRN firing via 5-HT(1A) autoreceptors and enhancement of serotonin action due to less uptake of serotonin, is consistent with compensatory changes in response to hypofunction in depressed suicides...
  8. ncbi request reprint Mixed models and multiple comparisons in analysis of human neurochemical maps
    S P Ellis
    Department of Neuroscience, Unit 42, New York State Psychiatric Institute and Columbia University, 1051 Riverside Drive, NY 10032, New York, USA
    Psychiatry Res 99:111-9. 2000
    ..Such an analysis is illustrated using a small autoradiographic data set. The Bonferroni method, the method of Holm, and two 'False Discovery Rate'-controlling methods for adjusting P-values for multiple comparisons are compared...
  9. doi request reprint Genetic architecture of the human tryptophan hydroxylase 2 Gene: existence of neural isoforms and relevance for major depression
    F Haghighi
    Columbia Genome Center, Columbia University, New York, NY, USA
    Mol Psychiatry 13:813-20. 2008
    ....
  10. ncbi request reprint Dorsal raphe nucleus serotonergic neurons innervate the rostral ventrolateral medulla in rat
    M D Underwood
    Department of Psychiatry, College of Physicians and Surgeons of Columbia University, and New York State Psychiatric Institute 10032, USA
    Brain Res 824:45-55. 1999
    ..These studies demonstrate that there is a descending serotonergic projection from the DRN to the RVL. This projection may mediate autonomic changes elicited by DRN stimulation...
  11. ncbi request reprint The human nucleus of the solitary tract: visceral pathways revealed with an "in vitro" postmortem tracing method
    D A Ruggiero
    Columbia University College of Physicians and Surgeons, Department of Psychiatry, New York State Psychiatric Institute, New York, NY 10032, USA
    J Auton Nerv Syst 79:181-90. 2000
    ..Axonal tracing studies predict that visceral impulses in humans may transmit over evolutionarily conserved pathways involved in autonomic feedback control and stress adaptation...
  12. ncbi request reprint Upregulation of CB1 receptors and agonist-stimulated [35S]GTPgammaS binding in the prefrontal cortex of depressed suicide victims
    B L Hungund
    New York State Psychiatric Institute, New York, NY 10962, USA
    Mol Psychiatry 9:184-90. 2004
    ..The cannabinoidergic system may be a novel therapeutic target in the treatment of depression and/or suicidal behavior...
  13. ncbi request reprint Neuronal tryptophan hydroxylase mRNA expression in the human dorsal and median raphe nuclei: major depression and suicide
    Helene Bach-Mizrachi
    Department of Neuroscience, New York State Psychiatric Institute, New York, NY 10032, USA
    Neuropsychopharmacology 31:814-24. 2006
    ..Higher TPH2 mRNA expression may explain more TPH protein observed in depressed suicides and reflect a homeostatic response to deficient brain serotonergic transmission...
  14. ncbi request reprint In vivo assessment of [11C]MRB as a prospective PET ligand for imaging the norepinephrine transporter
    Alin J Severance
    Division of Brain Imaging, Department of Neuroscience, New York State Psychiatric Institute, 1051 Riverside Drive, P O Box 42, New York, NY 10032, USA
    Eur J Nucl Med Mol Imaging 34:688-93. 2007
    ..S,S)-Methylreboxetine (MRB) is among the more promising ligands recently adapted for positron emission tomography (PET), and the present study aimed to evaluate its potential for use in higher primates...
  15. ncbi request reprint Synthesis and in vivo evaluation of [18F]-4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide as a PET imaging probe for COX-2 expression
    Jaya Prabhakaran
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Bioorg Med Chem 15:1802-7. 2007
    ..A radiolabeling method that can generate consistent high specific activity is needed for routine human use...
  16. ncbi request reprint In vitro and in vivo evaluation of [11C]MPEPy as a potential PET ligand for mGlu5 receptors
    Alin J Severance
    Division of Brain Imaging, Department of Neuroscience, New York State Psychiatric Institute, New York, NY 10032, USA
    Nucl Med Biol 33:1021-7. 2006
    ..Despite the promising in vitro results, the low signal-to-noise ratio found in vivo does not justify the use of [(11)C]MPEPy as a PET radiotracer in humans...
  17. ncbi request reprint Lower serotonin transporter binding potential in the human brain during major depressive episodes
    Ramin V Parsey
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, USA
    Am J Psychiatry 163:52-8. 2006
    ..On the basis of postmortem and imaging studies, the authors hypothesized that subjects with major depressive disorder in a major depressive episode have fewer serotonin transporter sites, compared with healthy subjects...
  18. ncbi request reprint Effect of a triallelic functional polymorphism of the serotonin-transporter-linked promoter region on expression of serotonin transporter in the human brain
    Ramin V Parsey
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, USA
    Am J Psychiatry 163:48-51. 2006
    ....
  19. ncbi request reprint Acute occupancy of brain serotonin transporter by sertraline as measured by [11C]DASB and positron emission tomography
    Ramin V Parsey
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, New York, USA
    Biol Psychiatry 59:821-8. 2006
    ..Previous studies used chronic SSRI administration that may down-regulate 5-HTT and used the cerebellum as reference region despite measurable 5-HTT. We examine the reference region and occupancy after acute sertraline dosing...
  20. pmc Brain serotonin transporter binding in depressed patients with bipolar disorder using positron emission tomography
    Maria A Oquendo
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Arch Gen Psychiatry 64:201-8. 2007
    ..Associations of serotonin transporter promoter polymorphisms and bipolarity have been reported; however, research on alterations in serotonergic neurotransmission in bipolar depression remains scant...
  21. ncbi request reprint Morphometry of dorsal raphe nucleus serotonergic neurons in alcoholism
    Mark D Underwood
    Department of Neuroscience, New York State Psychiatric Institute, New York, New York 10032, USA
    Alcohol Clin Exp Res 31:837-45. 2007
    ....
  22. pmc PET Imaging of CRF1 with [11C]R121920 and [11C]DMP696: is the target of sufficient density?
    Gregory M Sullivan
    Division of Neuroscience, Department of Psychiatry, New York State Psychiatric Institute, Columbia University, New York, NY 10032, USA
    Nucl Med Biol 34:353-61. 2007
    ..The aim of this study was to investigate the in vivo binding characteristics of [11C]R121920 and [11C]DMP696 in the nonhuman primate for application in positron emission tomography (PET) studies of CRF1...
  23. ncbi request reprint Neocortical and hippocampal neuron and glial cell numbers in the rhesus monkey
    Jeppe Romme Christensen
    Research Laboratory for Stereology and Neuroscience, Bispebjerg University Hospital, Copenhagen, Denmark
    Anat Rec (Hoboken) 290:330-40. 2007
    ..The results are phylogenetically consistent, apart from the neuron/glia ratio, which is remarkably higher than what is found in other species...
  24. ncbi request reprint Neuropathologic examination after 91 ECT treatments in a 92-year-old woman with late-onset depression
    Jason Scalia
    Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    J ECT 23:96-8. 2007
    ..Cognition in this patient was intact as indicated by a perfect score on a Mini-Mental Status Examination administered 6 days before death at the age of 92. This case adds to the considerable evidence for the safety of ECT...
  25. pmc Serotonin-1A autoreceptor binding in the dorsal raphe nucleus of depressed suicides
    Maura Boldrini
    Department of Psychiatry, Division of Neuroscience, Columbia University College of Physicians and Surgeons, New York State Psychiatric Institute, 1051 Riverside Drive, P O Box 42, New York, NY 10032, USA
    J Psychiatr Res 42:433-42. 2008
    ..More autoreceptor binding in rostral DRN might contribute to deficient serotonin release in ventromedial prefrontal cortex by lower neuronal firing...
  26. pmc Large-scale estimates of cellular origins of mRNAs: enhancing the yield of transcriptome analyses
    Etienne Sibille
    Department of Psychiatry, University of Pittsburgh, PA 15213, USA
    J Neurosci Methods 167:198-206. 2008
    ..As this approach can be applied post hoc, we provide tables of ratios for analysis of existing mouse and human brain datasets...
  27. doi request reprint Family history of alcoholism is associated with lower 5-HT2A receptor binding in the prefrontal cortex
    Mark D Underwood
    Department of Psychiatry, Columbia College of Physicians and Surgeons, New York State Psychiatric Institute, New York 10032, USA
    Alcohol Clin Exp Res 32:593-9. 2008
    ..We sought to determine postmortem whether 5-HT(2A) receptors are altered in the prefrontal cortex (PFC) of alcoholics...
  28. doi request reprint Norepinephrine and serotonin imbalance in the locus coeruleus in bipolar disorder
    Anna K Wiste
    Department of Psychiatry, Columbia College of Physicians and Surgeons, New York, NY, USA
    Bipolar Disord 10:349-59. 2008
    ....
  29. ncbi request reprint Co-registration of radiographic and pathologic infarct territory in a non-human primate model of stroke
    Ricardo J Komotar
    Department of Neurological Surgery, Columbia University, New York, NY 10032, USA
    Neurol Res 27:634-7. 2005
    ..We describe a protocol that enables co-registration of radiographic signal change and histologic ischemia in a non-human primate model of stroke...
  30. ncbi request reprint Altered serotonin 1A binding in major depression: a [carbonyl-C-11]WAY100635 positron emission tomography study
    Ramin V Parsey
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, New York, USA
    Biol Psychiatry 59:106-13. 2006
    ..We measure 5-HT(1A) in MDD, assess the effects of antidepressant exposure (AE), and examine the role of the C(-1019)G polymorphism...
  31. ncbi request reprint Higher postmortem prefrontal 5-HT2A receptor binding correlates with lifetime aggression in suicide
    Maria A Oquendo
    Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, New York, USA
    Biol Psychiatry 59:235-43. 2006
    ..We measured 5-hydroxytryptamine 2A (5-HT(2A)) receptor binding in prefrontal cortex of suicide and nonsuicide subjects and explored the relationship between 5-HT(2A) receptor binding, lifetime aggression, and suicide...
  32. ncbi request reprint Altered editing of serotonin 2C receptor pre-mRNA in the prefrontal cortex of depressed suicide victims
    Ilona Gurevich
    Mount Sinai Graduate School of Biological Sciences, New York, NY 10029, USA
    Neuron 34:349-56. 2002
    ..Thus, one outcome of fluoxetine treatment may be to reverse the abnormalities in 5-HT2C pre-mRNA editing seen in depressed suicide victims...
  33. ncbi request reprint Effects of sex, age, and aggressive traits in man on brain serotonin 5-HT1A receptor binding potential measured by PET using [C-11]WAY-100635
    Ramin V Parsey
    Division of Neuroscience, Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Brain Res 954:173-82. 2002
    ..Lower 5-HT(1A) binding in more aggressive individuals is consistent with pharmacological challenge studies. Future studies should determine whether the binding is a state or trait effect...
  34. ncbi request reprint Attenuated 5-HT1A receptor signaling in brains of suicide victims: involvement of adenylyl cyclase, phosphatidylinositol 3-kinase, Akt and mitogen-activated protein kinase
    Shu chi Hsiung
    Department of Neuroscience, New York State Psychiatric Institute, New York, USA
    J Neurochem 87:182-94. 2003
    ....
  35. ncbi request reprint Gene expression profiling of depression and suicide in human prefrontal cortex
    Etienne Sibille
    Department of Psychiatry, Columbia University, New York, NY, USA
    Neuropsychopharmacology 29:351-61. 2004
    ....
  36. ncbi request reprint Altered depression-related behaviors and functional changes in the dorsal raphe nucleus of serotonin transporter-deficient mice
    Alena Lira
    Division of Developmental Psychobiology, Columbia University, New York, New York 10032, USA
    Biol Psychiatry 54:960-71. 2003
    ..Using mice lacking the SERT (SERT KO), we examined the role of SERT function in anxiety- and depression-related behaviors and serotonergic neuron function...
  37. ncbi request reprint Absence of histological lesions in primate models of ECT and magnetic seizure therapy
    Andrew J Dwork
    Magnetic Brain Stimulation Laboratory, Department of Biological Psychiatry, New York State Psychiatric Institute, New York 10032, USA
    Am J Psychiatry 161:576-8. 2004
    ..The authors present preliminary findings from the first nonhuman primate neuropathological study of ECT to use perfusion fixation and adequate controls and the first to compare ECT with magnetic seizure therapy, to their knowledge...
  38. ncbi request reprint Volumetric analysis of the prefrontal cortex, amygdala, and hippocampus in major depression
    Ramin S Hastings
    Department of Neuroscience, New York State Psychiatric Institute, New York, NY 10032, USA
    Neuropsychopharmacology 29:952-9. 2004
    ..The biology of mood disorders in females may differ in some aspects from males, and may contribute to the higher rate of depression in women...
  39. ncbi request reprint Synthesis of [O-methyl-11C]1-(2-chlorophenyl)-5-(4-methoxyphenyl)-4-methyl-1H-pyrazole-3-carboxylic acid piperidin-1-ylamide: a potential PET ligand for CB1 receptors
    J S Dileep Kumar
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Bioorg Med Chem Lett 14:2393-6. 2004
    ..The radiotracer was found to selectively label CB(1) receptors in slide-mounted sections of postmortem human brain containing prefrontal cortex as demonstrated by in vitro autoradiography using phosphor imaging...
  40. ncbi request reprint Serotonergic and noradrenergic neurobiology of alcoholic suicide
    Mark D Underwood
    Department of Psychiatry, Columbia College of Physicians and Surgeons, New York, New York, USA
    Alcohol Clin Exp Res 28:57S-69S. 2004
    ..Altered serotonin (5-HT) function is associated with suicide and serious suicide attempts. We hypothesized patterns of abnormality associated independently with suicide and with alcoholism...
  41. ncbi request reprint More tryptophan hydroxylase in the brainstem dorsal raphe nucleus in depressed suicides
    Maura Boldrini
    Department of Neuroscience, New York State Psychiatric Institute, New York, NY 10032, USA
    Brain Res 1041:19-28. 2005
    ..More TPH may be an upregulatory homeostatic response to impaired serotonin release or less autoreceptor activation. Alternatively, the serotonin impairment in suicide may be due to hypofunctional serotonin-synthesizing enzyme...
  42. ncbi request reprint Molecular aging in human prefrontal cortex is selective and continuous throughout adult life
    Loubna Erraji-Benchekroun
    Department of Psychiatry, Columbia University, New York, New York, USA
    Biol Psychiatry 57:549-58. 2005
    ..Aging leads to morphologic and functional changes in the brain and is associated with increased risk for psychiatric and neurological disorders...
  43. ncbi request reprint Elevated levels of endocannabinoids and CB1 receptor-mediated G-protein signaling in the prefrontal cortex of alcoholic suicide victims
    K Yaragudri Vinod
    Department of Analytical Psychopharmacology, Nathan Kline Institute for Psychiatric Research, Orangeburg, New York 10962, USA
    Biol Psychiatry 57:480-6. 2005
    ..In the present study, we sought to determine whether the changes in depressed suicides would also be present in alcoholic suicides and whether the endocannabinoid (EC) system plays a role in suicide in alcoholism...
  44. ncbi request reprint Regional heterogeneity of 5-HT1A receptors in human cerebellum as assessed by positron emission tomography
    Ramin V Parsey
    Department of Neuroscience, New York State Psychiatric Institute, New York, New York 10032, USA
    J Cereb Blood Flow Metab 25:785-93. 2005
    ..With CW as a reference region, V(3)'' cannot be used to detect differences in 5-HT(1A) receptors between men and women, suggesting the need for arterial input functions to determine BP...
  45. ncbi request reprint Human 5-HT1A receptor C(-1019)G polymorphism and psychopathology
    Yung Yu Huang
    Department of Neuroscience, New York State Psychiatric Institute, New York, NY 10032, USA
    Int J Neuropsychopharmacol 7:441-51. 2004
    ..The relationship does not appear to be explained by binding differences, although we cannot rule out altered receptor affinity and transduction...
  46. ncbi request reprint Using the gene ontology for microarray data mining: a comparison of methods and application to age effects in human prefrontal cortex
    Paul Pavlidis
    Department of Biomedical Informatics and Columbia Genome Center, Columbia University, New York, New York 10032, USA
    Neurochem Res 29:1213-22. 2004
    ..quot;..
  47. ncbi request reprint Abnormalities of SNARE mechanism proteins in anterior frontal cortex in severe mental illness
    William G Honer
    Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada
    Cereb Cortex 12:349-56. 2002
    ..These abnormalities in the SNARE complex could represent a molecular substrate for abnormalities of neural connectivity in severe mental disorders...
  48. ncbi request reprint Immobilization stress elevates tryptophan hydroxylase mRNA and protein in the rat raphe nuclei
    Firas M Chamas
    Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla, NY 10595, USA
    Biol Psychiatry 55:278-83. 2004
    ..We examined the effect of immobilization stress (IMO) on gene expression of tryptophan hydroxylase (TPH), the rate-limiting enzyme in serotonin biosynthesis, and the role of cortisol in that response...
  49. ncbi request reprint Fiber order of the normal and regenerated optic tract of the frog (Rana pipiens)
    Helene Bach
    Program in Anatomy and Cell Biology, State University of New York Health Science Center at Brooklyn, Brooklyn, New York 11203, USA
    J Comp Neurol 477:43-54. 2004
    ..In contrast, the growth pattern of regenerating peripheral nasal axons would not be affected by the ephrin-A gradient in the optic tract...