Roy N Alcalay

Summary

Affiliation: Columbia University
Country: USA

Publications

  1. pmc Cognitive performance of GBA mutation carriers with early-onset PD: the CORE-PD study
    R N Alcalay
    Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    Neurology 78:1434-40. 2012
  2. pmc The association between Mediterranean diet adherence and Parkinson's disease
    Roy N Alcalay
    Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    Mov Disord 27:771-4. 2012
  3. pmc Predictors of parkin mutations in early-onset Parkinson disease: the consortium on risk for early-onset Parkinson disease study
    Karen S Marder
    Taub Institute for Research on Alzheimer s Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, 630 W 168th St, Unit 16, New York, NY 10032, USA
    Arch Neurol 67:731-8. 2010
  4. pmc Neuropsychological Profile of Parkin Mutation Carriers with and without Parkinson Disease: The CORE-PD Study
    Elise Caccappolo
    Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, New York, USA
    J Int Neuropsychol Soc 17:91-100. 2011
  5. pmc Self-report of cognitive impairment and mini-mental state examination performance in PRKN, LRRK2, and GBA carriers with early onset Parkinson's disease
    Roy N Alcalay
    Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    J Clin Exp Neuropsychol 32:775-9. 2010
  6. pmc Cognitive and motor function in long-duration PARKIN-associated Parkinson disease
    Roy N Alcalay
    Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, New York2Taub Institute for Research on Alzheimer s Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, New York
    JAMA Neurol 71:62-7. 2014
  7. pmc Frequency of known mutations in early-onset Parkinson disease: implication for genetic counseling: the consortium on risk for early onset Parkinson disease study
    Roy N Alcalay
    Department of Neurology, Columbia University, New York, NY 10032, USA
    Arch Neurol 67:1116-22. 2010
  8. pmc Age-specific Parkinson disease risk in GBA mutation carriers: information for genetic counseling
    Huma Q Rana
    Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, NY, USA
    Genet Med 15:146-9. 2013
  9. pmc Motor phenotype of LRRK2 G2019S carriers in early-onset Parkinson disease
    Roy N Alcalay
    Department of Neurology, Columbia University, New York, NY 10032, USA
    Arch Neurol 66:1517-22. 2009
  10. pmc Parkinson disease phenotype in Ashkenazi Jews with and without LRRK2 G2019S mutations
    Roy N Alcalay
    Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, New York, USA Taub Institute for Research on Alzheimer s Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, New York, USA
    Mov Disord 28:1966-71. 2013

Collaborators

Detail Information

Publications21

  1. pmc Cognitive performance of GBA mutation carriers with early-onset PD: the CORE-PD study
    R N Alcalay
    Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    Neurology 78:1434-40. 2012
    ..To assess the cognitive phenotype of glucocerebrosidase (GBA) mutation carriers with early-onset Parkinson disease (PD)...
  2. pmc The association between Mediterranean diet adherence and Parkinson's disease
    Roy N Alcalay
    Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    Mov Disord 27:771-4. 2012
    ..Recent studies have demonstrated an association between a Mediterranean-type diet and Alzheimer's risk. We assessed the association between Mediterranean-type diet adherence and Parkinson's disease (PD) status...
  3. pmc Predictors of parkin mutations in early-onset Parkinson disease: the consortium on risk for early-onset Parkinson disease study
    Karen S Marder
    Taub Institute for Research on Alzheimer s Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, 630 W 168th St, Unit 16, New York, NY 10032, USA
    Arch Neurol 67:731-8. 2010
    ..Mutations in the parkin gene are the most common genetic cause of early-onset Parkinson disease (PD). Results from a multicenter study of patients with PD systematically sampled by age at onset have not been reported to date...
  4. pmc Neuropsychological Profile of Parkin Mutation Carriers with and without Parkinson Disease: The CORE-PD Study
    Elise Caccappolo
    Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, New York, USA
    J Int Neuropsychol Soc 17:91-100. 2011
    ..Carriers of parkin mutations, whether or not they have PD, do not perform differently on neuropsychological measures as compared to noncarriers. The cognitive functioning of parkin carriers over time warrants further study...
  5. pmc Self-report of cognitive impairment and mini-mental state examination performance in PRKN, LRRK2, and GBA carriers with early onset Parkinson's disease
    Roy N Alcalay
    Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    J Clin Exp Neuropsychol 32:775-9. 2010
    ..GBA carriers reported more impairment, but MMSE performance did not differ among genetic groups. Detailed neuropsychological testing is required to explore the association between cognitive impairment and GBA mutations...
  6. pmc Cognitive and motor function in long-duration PARKIN-associated Parkinson disease
    Roy N Alcalay
    Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, New York2Taub Institute for Research on Alzheimer s Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, New York
    JAMA Neurol 71:62-7. 2014
    ..Data on the long-term cognitive outcomes of patients with PARKIN-associated Parkinson disease (PD) are unknown but may be useful when counseling these patients...
  7. pmc Frequency of known mutations in early-onset Parkinson disease: implication for genetic counseling: the consortium on risk for early onset Parkinson disease study
    Roy N Alcalay
    Department of Neurology, Columbia University, New York, NY 10032, USA
    Arch Neurol 67:1116-22. 2010
    ..To assess the frequency and clinical characteristics of carriers of previously identified mutations in 6 genes associated with early-onset Parkinson disease (PD) and provide empirical data that can be used to inform genetic counseling...
  8. pmc Age-specific Parkinson disease risk in GBA mutation carriers: information for genetic counseling
    Huma Q Rana
    Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, NY, USA
    Genet Med 15:146-9. 2013
    ..We sought to estimate age-specific risk of Parkinson disease in relatives of patients with Gaucher disease, who are obligate carriers of GBA mutations and who were not ascertained by family history of Parkinson disease...
  9. pmc Motor phenotype of LRRK2 G2019S carriers in early-onset Parkinson disease
    Roy N Alcalay
    Department of Neurology, Columbia University, New York, NY 10032, USA
    Arch Neurol 66:1517-22. 2009
    ....
  10. pmc Parkinson disease phenotype in Ashkenazi Jews with and without LRRK2 G2019S mutations
    Roy N Alcalay
    Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, New York, USA Taub Institute for Research on Alzheimer s Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, New York, USA
    Mov Disord 28:1966-71. 2013
    ..PD in AJ LRRK2 G2019S mutation carriers is similar to idiopathic PD but is characterized by more frequent lower extremity involvement at onset and PIGD without the associated cognitive impairment...
  11. pmc Lack of association between cancer history and PARKIN genotype: a family based study in PARKIN/Parkinson's families
    Roy N Alcalay
    Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Genes Chromosomes Cancer 51:1109-13. 2012
    ..We conclude that although Parkin may exert a suppressive effect in mice, further studies are required prior to assigning a TS function to PARKIN in humans...
  12. doi request reprint Tremor severity and age: a cross-sectional, population-based study of 2,524 young and midlife normal adults
    Elan D Louis
    GH Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, New York, USA
    Mov Disord 26:1515-20. 2011
    ..These data suggest that age-dependent increase in tremor amplitude is not restricted to older people but occurs in all adult age groups...
  13. pmc Comparison of Parkinson risk in Ashkenazi Jewish patients with Gaucher disease and GBA heterozygotes
    Roy N Alcalay
    The Taub Institute, Department of Neurology, Columbia University Medical Center, New York, New York
    JAMA Neurol 71:752-7. 2014
    ....
  14. pmc Prevalence and features of unreported dystonia in a family study of "pure" essential tremor
    Elan D Louis
    GH Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    Parkinsonism Relat Disord 19:359-62. 2013
    ..We sought to determine the prevalence and clinical features of unreported dystonia in a family study of "pure" ET...
  15. pmc Clinical and pathological characteristics of LRRK2 G2019S patients with PD
    Markos Poulopoulos
    Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    J Mol Neurosci 47:139-43. 2012
    ..However, the extent of cortical involvement is variable. Larger longitudinal follow-up of LRRK2 G2019S mutation carriers is required to assess for risk factors for cortical involvement and dementia...
  16. pmc Knowledge of and interest in genetic results among Parkinson disease patients and caregivers
    Karina Sakanaka
    Department of Neurology, College of Physicians and Surgeons, Columbia University Medical Center, New York, NY, USA
    J Genet Couns 23:114-20. 2014
    ..6 % of caregivers knew that "scientists have identified genes associated with a higher risk of developing PD." PD patients may benefit from education and genetic counseling on the implications of genetic testing. ..
  17. ncbi request reprint Parkinson's disease with Lewy bodies associated with a heterozygous PARKIN dosage mutation
    Madeleine E Sharp
    Department of Neurology, Columbia University, New York, New York, USA
    Mov Disord 29:566-8. 2014
    ..Only one other heterozygote PARKIN carrier with autopsy findings has been described. Our case adds to the broadening pathological and clinical phenotype of PARKIN-related disease...
  18. pmc The neuropathology of genetic Parkinson's disease
    Markos Poulopoulos
    Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    Mov Disord 27:831-42. 2012
    ..In particular, there is a need for larger, unbiased pathological studies. Differential association of Lewy pathology with specific mutations may reflect heterogeneity in pathogenic mechanisms among the different PD-related genes...
  19. pmc Postural and Intention Tremors: A Detailed Clinical Study of Essential Tremor vs. Parkinson's Disease
    Eliezer J Sternberg
    Gertrude H Sergievsky Center, College of Physicians and Surgeons, Columbia University New York, NY, USA Tufts University School of Medicine Boston, MA, USA
    Front Neurol 4:51. 2013
    ..We hope that detailed phenomenological data on tremor in ET and PD will help practicing physicians delineate the two diseases...
  20. pmc Prevalence of essential tremor in Araihazar, Bangladesh: a population-based study
    Elan D Louis
    GH Sergievsky Center, Columbia University, New York, NY, USA EDL2 columbia edu
    Neuroepidemiology 36:71-6. 2011
    ..Few prevalence studies have been conducted in South Asia, and none in Bangladesh, one of the most populated countries in the world. We estimated the prevalence of ET in a population-based study in Araihazar, Bangladesh...
  21. pmc Mutations in the Parkinson's disease genes, Leucine Rich Repeat Kinase 2 (LRRK2) and Glucocerebrosidase (GBA), are not associated with essential tremor
    Lorraine N Clark
    Taub Institute for Research on Alzheimer s Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, NY, NY 10032, USA
    Parkinsonism Relat Disord 16:132-5. 2010
    ..Furthermore, a similar frequency of GBA mutations in AJ ET cases and controls suggests that GBA is not a common cause of ET either...