H Ahsan

Summary

Affiliation: Columbia University
Country: USA

Publications

  1. pmc No major association between TGFBR1*6A and prostate cancer
    Virginia Kaklamani
    Cancer Genetics Program, Division of Hematology Oncology, Department of Medicine, Robert H Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA
    BMC Genet 5:28. 2004
  2. pmc Variants in estrogen-biosynthesis genes CYP17 and CYP19 and breast cancer risk: a family-based genetic association study
    Habibul Ahsan
    Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York, USA
    Breast Cancer Res 7:R71-81. 2005
  3. ncbi request reprint Associations between drinking water and urinary arsenic levels and skin lesions in Bangladesh
    H Ahsan
    Division of Epidemiology, Room PH 18 130, Columbia University Medical Center, 622 West 168th Street, New York, NY 10032, USA
    J Occup Environ Med 42:1195-201. 2000
  4. ncbi request reprint A family-based genetic association study of variants in estrogen-metabolism genes COMT and CYP1B1 and breast cancer risk
    Habibul Ahsan
    Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY 10032, USA
    Breast Cancer Res Treat 85:121-31. 2004
  5. pmc Variability in aflatoxin-albumin adduct levels and effects of hepatitis B and C virus infection and glutathione S-transferase M1 and T1 genotype
    H Ahsan
    Department of Epidemiology, Columbia University, New York, New York, USA
    Environ Health Perspect 109:833-7. 2001
  6. ncbi request reprint Relative risk for genetic associations: the case-parent triad as a variant of case-cohort design
    Habibul Ahsan
    Department of Epidemiology, Joseph L Mailman School of Public Health, New York, NY, USA
    Int J Epidemiol 31:669-78. 2002
  7. ncbi request reprint Associations of plasma aflatoxin B1-albumin adduct level with plasma selenium level and genetic polymorphisms of glutathione S-transferase M1 and T1
    S Y Chen
    Columbia University School of Public Health, New York, NY 10032, USA
    Nutr Cancer 38:179-85. 2000
  8. ncbi request reprint Association of aflatoxin B(1)-albumin adduct levels with hepatitis B surface antigen status among adolescents in Taiwan
    S Y Chen
    Department of Environmental Health Sciences, Mailman School of Public Health of Columbia University, New York, New York 10032, USA
    Cancer Epidemiol Biomarkers Prev 10:1223-6. 2001
  9. ncbi request reprint Serum levels of the extracellular domain of the epidermal growth factor receptor in individuals exposed to arsenic in drinking water in Bangladesh
    Y Li
    Mailman School of Public Health, Columbia University, New York, NY 10032, USA
    Biomarkers 12:256-65. 2007
  10. ncbi request reprint Arsenic metabolism, genetic susceptibility, and risk of premalignant skin lesions in Bangladesh
    Habibul Ahsan
    Departments of Epidemiology, Columbia University, USA
    Cancer Epidemiol Biomarkers Prev 16:1270-8. 2007

Detail Information

Publications81

  1. pmc No major association between TGFBR1*6A and prostate cancer
    Virginia Kaklamani
    Cancer Genetics Program, Division of Hematology Oncology, Department of Medicine, Robert H Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA
    BMC Genet 5:28. 2004
    ..080) but the differences in TGFBR1*6A genotype distribution between cases and controls did not reach statistical significance (p = 0.67). Our data suggest that TGFBR1*6A does not contribute to the development of prostate cancer...
  2. pmc Variants in estrogen-biosynthesis genes CYP17 and CYP19 and breast cancer risk: a family-based genetic association study
    Habibul Ahsan
    Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York, USA
    Breast Cancer Res 7:R71-81. 2005
    ....
  3. ncbi request reprint Associations between drinking water and urinary arsenic levels and skin lesions in Bangladesh
    H Ahsan
    Division of Epidemiology, Room PH 18 130, Columbia University Medical Center, 622 West 168th Street, New York, NY 10032, USA
    J Occup Environ Med 42:1195-201. 2000
    ..The study suggests that arsenic exposure is associated with skin lesions in the Bangladesh population and that urinary arsenic may be a stronger predictor of skin lesions than arsenic in drinking water in this population...
  4. ncbi request reprint A family-based genetic association study of variants in estrogen-metabolism genes COMT and CYP1B1 and breast cancer risk
    Habibul Ahsan
    Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY 10032, USA
    Breast Cancer Res Treat 85:121-31. 2004
    ....
  5. pmc Variability in aflatoxin-albumin adduct levels and effects of hepatitis B and C virus infection and glutathione S-transferase M1 and T1 genotype
    H Ahsan
    Department of Epidemiology, Columbia University, New York, New York, USA
    Environ Health Perspect 109:833-7. 2001
    ..g., hepatitis B/C viral infection or GST M1/T1 genetic status)...
  6. ncbi request reprint Relative risk for genetic associations: the case-parent triad as a variant of case-cohort design
    Habibul Ahsan
    Department of Epidemiology, Joseph L Mailman School of Public Health, New York, NY, USA
    Int J Epidemiol 31:669-78. 2002
    ..Also, by allowing the potential sources of selection bias to be revealed more easily the design is made more accessible both conceptually and practically to epidemiologists...
  7. ncbi request reprint Associations of plasma aflatoxin B1-albumin adduct level with plasma selenium level and genetic polymorphisms of glutathione S-transferase M1 and T1
    S Y Chen
    Columbia University School of Public Health, New York, NY 10032, USA
    Nutr Cancer 38:179-85. 2000
    ..This study provides insight into the dietary and genetic factors influencing AFB1-albumin adduct formation in an isolated population with high liver cancer mortality...
  8. ncbi request reprint Association of aflatoxin B(1)-albumin adduct levels with hepatitis B surface antigen status among adolescents in Taiwan
    S Y Chen
    Department of Environmental Health Sciences, Mailman School of Public Health of Columbia University, New York, New York 10032, USA
    Cancer Epidemiol Biomarkers Prev 10:1223-6. 2001
    ..The association between HBsAg status and AFB(1)-albumin adducts remained after multivariate adjustment. This finding additionally supports the synergetic interaction between HBV and AFB(1), but the mechanism remains to be elucidated...
  9. ncbi request reprint Serum levels of the extracellular domain of the epidermal growth factor receptor in individuals exposed to arsenic in drinking water in Bangladesh
    Y Li
    Mailman School of Public Health, Columbia University, New York, NY 10032, USA
    Biomarkers 12:256-65. 2007
    ..These results suggest that serum EGFR ECD levels may be a potential biomarker of effect of arsenic exposure and may indicate those exposed individuals at greatest risk for the development of arsenic-induced skin lesions...
  10. ncbi request reprint Arsenic metabolism, genetic susceptibility, and risk of premalignant skin lesions in Bangladesh
    Habibul Ahsan
    Departments of Epidemiology, Columbia University, USA
    Cancer Epidemiol Biomarkers Prev 16:1270-8. 2007
    ....
  11. ncbi request reprint Consumption of folate-related nutrients and metabolism of arsenic in Bangladesh
    Julia E Heck
    Department of Epidemiology, Mailman School of Public Health and Institute for Social and Economic Research and Policy, Columbia University, New York, NY, USA
    Am J Clin Nutr 85:1367-74. 2007
    ..Previous studies suggest that persons with more complete methylation, characterized as greater proportions of DMA and lesser proportions of MMA and InAs in urine, have a lower risk of adverse arsenic-related health outcomes...
  12. ncbi request reprint Polycyclic aromatic hydrocarbon-DNA adducts in liver tissues of hepatocellular carcinoma patients and controls
    Shu Yuan Chen
    Department of Environmental Health Sciences, Mailman School of Public Health of Columbia University, New York, NY 10032, USA
    Int J Cancer 99:14-21. 2002
    ..2-187.2) compared to those who had low DNA adduct levels. These results suggest that PAHs may play a role in human hepatocarcinogenesis in conjunction with HBsAg carrier status, GSTM1 and GSTP1 genotypes and exposure to 4-ABP and AFB(1)...
  13. ncbi request reprint Urinary 8-oxodeoxyguanosine, aflatoxin B1 exposure and hepatitis B virus infection and hepatocellular carcinoma in Taiwan
    Hui Chen Wu
    Departments of Environmental Health Sciences, Mailman School of Public Health of Columbia University, New York, NY 10032, USA
    Carcinogenesis 28:995-9. 2007
    ..These results suggest that elevated levels of urinary 8-oxodG may be related to increasing level of aflatoxin exposure but may also indicate enhanced repair of oxidative DNA damage and therefore lower risk of HCC...
  14. ncbi request reprint Genomic methylation of peripheral blood leukocyte DNA: influences of arsenic and folate in Bangladeshi adults
    J Richard Pilsner
    Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, 60 Haven Avenue, B1, New York, NY 10032, USA
    Am J Clin Nutr 86:1179-86. 2007
    ..It is not known whether arsenic exposure influences genomic DNA methylation in human populations chronically exposed to arsenic-contaminated drinking water...
  15. pmc Influence of cobalamin on arsenic metabolism in Bangladesh
    Megan N Hall
    Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York 10032, USA
    Environ Health Perspect 117:1724-9. 2009
    ..Although DMA(V) is the least toxic metabolite, increasing evidence suggests that MMA(III) may be the most cytotoxic and genotoxic As intermediary metabolite...
  16. doi request reprint Arsenic exposure at low-to-moderate levels and skin lesions, arsenic metabolism, neurological functions, and biomarkers for respiratory and cardiovascular diseases: review of recent findings from the Health Effects of Arsenic Longitudinal Study (HEALS) in
    Yu Chen
    Departments of Environmental Medicine and Medicine and New York University Cancer Institute, New York University School of Medicine, New York, NY, USA
    Toxicol Appl Pharmacol 239:184-92. 2009
    ....
  17. ncbi request reprint Silencing of glutathione S-transferase P1 by promoter hypermethylation and its relationship to environmental chemical carcinogens in hepatocellular carcinoma
    Yu Jing Zhang
    Department of Environmental Health Sciences, Mailman School of Public Health of Columbia University, 701 West 168th Street, New York, NY 10032, USA
    Cancer Lett 221:135-43. 2005
    ..The mechanism by which environmental exposures induce epigenetic changes in HCC needs further analysis...
  18. doi request reprint Arsenic exposure and anemia in Bangladesh: a population-based study
    Julia E Heck
    Department of Epidemiology, Mailman School of Public Health, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    J Occup Environ Med 50:80-7. 2008
    ..The purpose of this study was to examine the association between arsenic exposure and anemia, based on blood hemoglobin concentration...
  19. pmc Changes in gene expression profiles in response to selenium supplementation among individuals with arsenic-induced pre-malignant skin lesions
    Muhammad G Kibriya
    Department of Epidemiology, Mailman School of Public Health, Columbia University, USA
    Toxicol Lett 169:162-76. 2007
    ..Additionally, this study suggests that long-term selenium supplementation may revert some of the gene expression changes presumably induced by chronic As exposure in individuals with pre-malignant skin lesions...
  20. ncbi request reprint Arsenic exposure from drinking water, dietary intakes of B vitamins and folate, and risk of high blood pressure in Bangladesh: a population-based, cross-sectional study
    Yu Chen
    Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA
    Am J Epidemiol 165:541-52. 2007
    ..Future research is needed to evaluate the effect of low-level arsenic exposure on specific cardiovascular outcomes...
  21. pmc Do placental genes affect maternal breast cancer? Association between offspring's CGB5 and CSH1 gene variants and maternal breast cancer risk
    Yu Chen
    Department of Environmental Medicine, New York University Cancer Institute, New York University School of Medicine, New York, NY, USA
    Cancer Res 68:9729-34. 2008
    ..90; 95% CI, 0.53-1.51; P for interaction=0.04). The findings suggest that placental CGB5 genotype may be predictive of maternal post-pregnancy breast cancer risk among women who give birth early in life...
  22. ncbi request reprint Modification of risk of arsenic-induced skin lesions by sunlight exposure, smoking, and occupational exposures in Bangladesh
    Yu Chen
    Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York 10032, USA
    Epidemiology 17:459-67. 2006
    ..The risk of skin lesions associated with arsenic exposure from drinking water in Bangladesh is considerably greater in men than in women...
  23. ncbi request reprint Arsenic exposure from drinking-water and carotid artery intima-medial thickness in healthy young adults in Bangladesh
    Yu Chen
    Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, 10032, USA
    J Health Popul Nutr 24:253-7. 2006
    ....
  24. ncbi request reprint Blood arsenic as a biomarker of arsenic exposure: results from a prospective study
    Marni Hall
    Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University Medical Center, 60 Haven Avenue B1, New York, NY 10032, USA
    Toxicology 225:225-33. 2006
    ..This prospective study confirms the increased risk of skin lesions in relation to As concentrations in blood, urine and water and also establishes that BAs is a useful biomarker of As exposure in this study population...
  25. pmc Prevalence of arsenic exposure from drinking water and awareness of its health risks in a Bangladeshi population: results from a large population-based study
    Faruque Parvez
    Mailman School of Public Health, Columbia University, New York, New York 10032, USA
    Environ Health Perspect 114:355-9. 2006
    ..Increasing knowledge of the health consequences of As may be an important element in facilitating remediation...
  26. ncbi request reprint Covariate adjustment in family-based association studies
    Alice S Whittemore
    Division of Epidemiology, Department of Health Research and Policy, Stanford University School of Medicine, Stanford, California, USA
    Genet Epidemiol 28:244-55. 2005
    ..e., data for which multiple logistic regression of matched sibships would have little power. Software for performing the covariate-adjusted tests is available at http://www.stanford.edu/dept/HRP/epidemiology/COVTDT...
  27. pmc Aflatoxin B1 exposure, hepatitis B virus infection, and hepatocellular carcinoma in Taiwan
    Hui Chen Wu
    Department of Environmental Health Sciences, Mailman School of Public Health of Columbia University, 630 West 168th Street, RM19 418, New York, NY 10032, USA
    Cancer Epidemiol Biomarkers Prev 18:846-53. 2009
    ..However, in this larger study, the effect of combined AFB1 exposure and HBV infection is more consistent with an additive than a multiplicative model...
  28. pmc Protective effects of B vitamins and antioxidants on the risk of arsenic-related skin lesions in Bangladesh
    Lydia B Zablotska
    Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York, USA
    Environ Health Perspect 116:1056-62. 2008
    ..The mitigating effects of diet on arsenic-related premalignant skin lesions are largely unknown...
  29. doi request reprint Effect of selenium and vitamin e supplementation on plasma protein carbonyl levels in patients with arsenic-related skin lesions
    Julie Mahata
    Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY, USA
    Nutr Cancer 60:55-60. 2008
    ....
  30. pmc Urinary 15-F2t-isoprostane, aflatoxin B1 exposure and hepatitis B virus infection and hepatocellular carcinoma in Taiwan
    Hui Chen Wu
    Department of Environmental Health Sciences, Mailman School of Public Health of Columbia University, New York, NY 10032, USA
    Carcinogenesis 29:971-6. 2008
    ..These results suggest that elevated levels of urinary 15-F(2t)-IsoP may be related to increasing level of aflatoxin exposure and are associated with an increased risk of HCC...
  31. ncbi request reprint A CYP19 (aromatase) polymorphism is associated with increased premenopausal breast cancer risk
    Kathryn E Talbott
    Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, 10032, USA
    Breast Cancer Res Treat 111:481-7. 2008
    ..The finding supports the potential role of variation in estrogen biosynthesis genes in premenopausal breast cancer risk...
  32. ncbi request reprint Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation and its relationship to aflatoxin B1-DNA adducts and p53 mutation in hepatocellular carcinoma
    Yu Jing Zhang
    Departments of Environmental Health Sciences and Epidemiology, Mailman School of Public Health, Columbia University, 700 West 168th Street, New York, NY 10032, USA
    Int J Cancer 103:440-4. 2003
    ..The role of chemical carcinogens in hypermethylation needs further investigation...
  33. pmc Nonmalignant respiratory effects of chronic arsenic exposure from drinking water among never-smokers in Bangladesh
    Faruque Parvez
    Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY, USA
    Environ Health Perspect 116:190-5. 2008
    ..The association with nonmalignant respiratory illnesses has not been well established because the assessments of respiratory symptoms may be influenced by recall bias or interviewer bias because participants had visible skin lesions...
  34. doi request reprint Estrogen-biosynthesis gene CYP17 and its interactions with reproductive, hormonal and lifestyle factors in breast cancer risk: results from the Long Island Breast Cancer Study Project
    Yu Chen
    Department of Environmental Medicine and New York University Cancer Institute, New York University School of Medicine, New York, NY 10016, USA
    Carcinogenesis 29:766-71. 2008
    ..In conclusion, the findings suggest that the CYP17 variant C allele may increase breast cancer risk in conjunction with long-term HRT use and high BMI in postmenopausal women...
  35. pmc Folate deficiency, hyperhomocysteinemia, low urinary creatinine, and hypomethylation of leukocyte DNA are risk factors for arsenic-induced skin lesions
    J Richard Pilsner
    Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, 60 Haven Ave, B1, New York, NY 10032 USA
    Environ Health Perspect 117:254-60. 2009
    ..Clinical manifestations of As toxicity vary considerably among individuals and populations, and poor methylation capacity is thought to confer greater susceptibility...
  36. ncbi request reprint Nutritional influence on risk of high blood pressure in Bangladesh: a population-based cross-sectional study
    Yu Chen
    Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA
    Am J Clin Nutr 84:1224-32. 2006
    ..The nutritional determinants of hypertension in Bangladesh and other low-income countries are largely unknown...
  37. pmc Association between arsenic exposure from drinking water and plasma levels of soluble cell adhesion molecules
    Yu Chen
    Departments of Environmental Medicine and Medicine, and New York University Cancer Institute, New York University School of Medicine, New York, New York 10016, USA
    Environ Health Perspect 115:1415-20. 2007
    ..Epidemiologic studies of cardiovascular disease risk factors and appropriate biomarkers in populations exposed to a wide range of arsenic levels are a public health research priority...
  38. pmc Reduction in urinary arsenic levels in response to arsenic mitigation efforts in Araihazar, Bangladesh
    Yu Chen
    Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York, USA
    Environ Health Perspect 115:917-23. 2007
    ..There is a need to identify and evaluate an effective mitigation program for arsenic exposure from drinking water in Bangladesh...
  39. ncbi request reprint Gene expression profiles in peripheral lymphocytes by arsenic exposure and skin lesion status in a Bangladeshi population
    Maria Argos
    Department of Epidemiology, Mailman School of Public Health, Columbia University Medical Center, New York, NY 10032, USA
    Cancer Epidemiol Biomarkers Prev 15:1367-75. 2006
    ..Genes identified from this analysis may provide insights into the underlying processes of arsenic-induced disease and represent potential targets for chemoprevention studies to reduce arsenic-induced skin cancer in this population...
  40. pmc A prospective study of blood selenium levels and the risk of arsenic-related premalignant skin lesions
    Yu Chen
    Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA
    Cancer Epidemiol Biomarkers Prev 16:207-13. 2007
    ..The findings support the hypothesis that dietary selenium intake may reduce the incidence of arsenic-related premalignant skin lesions among populations exposed to arsenic exposure from drinking water...
  41. ncbi request reprint Evaluation of 4-aminobiphenyl-DNA adducts in human breast cancer: the influence of tobacco smoke
    Beatrice Faraglia
    Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, 701 West 168th Street, New York, NY 10032, USA
    Carcinogenesis 24:719-25. 2003
    ..In this study, genetic polymorphisms did not significantly affect the formation of 4-ABP-DNA adducts in breast cancer cases, perhaps due to the small number of samples...
  42. ncbi request reprint A randomized, double-blind placebo-controlled trial evaluating the effects of vitamin E and selenium on arsenic-induced skin lesions in Bangladesh
    Wendy J Verret
    Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York 10032, USA
    J Occup Environ Med 47:1026-35. 2005
    ..We sought to determine whether supplementation of vitamin E (alpha-tocopherol), selenium (L-selenomethionine), or their combination improves arsenical skin lesions...
  43. ncbi request reprint High frequency of promoter hypermethylation of RASSF1A and p16 and its relationship to aflatoxin B1-DNA adduct levels in human hepatocellular carcinoma
    Yu Jing Zhang
    Department of Environmental Health Sciences, Mailman School of Public Health of Columbia University, New York, New York 10032, USA
    Mol Carcinog 35:85-92. 2002
    ..No association was found between methylation status and p53 status. These results suggest the hypothesis that exposure to environmental carcinogens may be involved in altered methylation of genes involved in cancer development...
  44. ncbi request reprint Reliability of a commercial kit to test groundwater for arsenic in Bangladesh
    A van Geen
    Lamont Doherty Earth Observatory of Columbia University, Palisades, New York 10964, USA
    Environ Sci Technol 39:299-303. 2005
    ....
  45. pmc Promotion of well-switching to mitigate the current arsenic crisis in Bangladesh
    Alexander van Geen
    Lamont Doherty Earth Observatory, Columbia University, Palisades, New York 10964, USA
    Bull World Health Organ 80:732-7. 2002
    ..To survey tube wells and households in Araihazar upazila, Bangladesh, to set the stage for a long-term epidemiological study of the consequences of chronic arsenic exposure...
  46. pmc Association between manganese exposure through drinking water and infant mortality in Bangladesh
    Danella Hafeman
    Mailman School of Public Health, Columbia University, New York, New York 10032, USA
    Environ Health Perspect 115:1107-12. 2007
    ..In this cross-sectional study we assessed the association between water manganese and all-cause infant mortality in the offspring of female participants in the Health Effects of Arsenic Longitudinal Study Cohort...
  47. pmc Cancer screening practices of Asian American physicians in New York City
    Ethan E Bodle
    Asian American Network for Cancer Awareness, Research, and Training, Mailman School of Public Health, Columbia University, New York, NY, USA
    J Immigr Minor Health 10:239-46. 2008
    ..About 70% recommend screening for hepatitis B. Gender and ethnicity of the physician were found to be significant predictors for cancer screening practice...
  48. ncbi request reprint Predicting asthma morbidity in Harlem emergency department patients
    Gene R Pesola
    Harlem Lung Center and Hospital Emergency Department, Columbia University, New York, NY, USA
    Acad Emerg Med 11:944-50. 2004
    ..To determine predictors of asthma morbidity in African American patients with asthma. Proxies for asthma morbidity were emergency department (ED) visits for asthma and hospitalizations for asthma...
  49. pmc Folic acid supplementation lowers blood arsenic
    Mary V Gamble
    Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY 10032, USA
    Am J Clin Nutr 86:1202-9. 2007
    ..Methylation of ingested inorganic arsenic (InAs) to monomethylarsonic (MMAs) and dimethylarsinic (DMAs) acids relies on folate-dependent one-carbon metabolism and facilitates urinary arsenic elimination...
  50. pmc Cancer burden from arsenic in drinking water in Bangladesh
    Yu Chen
    Department of Epidemiology, Mailman School of Public Health, Columbia University, 722 W 168th Street, New York, NY 10032, USA
    Am J Public Health 94:741-4. 2004
    ..Results indicated at least a doubling of lifetime mortality risk from liver, bladder, and lung cancers (229.6 vs 103.5 per 100 000 population) in Bangladesh owing to arsenic in drinking water...
  51. ncbi request reprint Measures of genotype versus gene products: promise and pitfalls in cancer prevention
    Habibul Ahsan
    Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, USA
    Carcinogenesis 24:1429-34. 2003
    ..Finally, we offer some specific recommendations for future research directions in this area...
  52. ncbi request reprint DNA repair gene XPD and susceptibility to arsenic-induced hyperkeratosis
    Habibul Ahsan
    Department of Epidemiology, Mailman School of Public Health, Columbia University, Room 18 129, 622 West 168th Street, New York, NY 10032, USA
    Toxicol Lett 143:123-31. 2003
    ..Future larger studies are needed to confirm this novel finding and investigate how combinations of different candidate genes and/or other host and environmental factors may influence the risk of arsenic induced skin and other cancers...
  53. doi request reprint A prospective study of respiratory symptoms associated with chronic arsenic exposure in Bangladesh: findings from the Health Effects of Arsenic Longitudinal Study (HEALS)
    Faruque Parvez
    Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, New York, USA
    Thorax 65:528-33. 2010
    ..A total of 7.31, 9.95 and 2.03% of the 11 746 participants completing 4 years of active follow-up reported having a chronic cough, breathing problem or blood in their sputum, respectively, as assessed by trained physicians...
  54. doi request reprint Dyspnea reproducibility in a rural Bangladesh population
    Gene Raymond Pesola
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Harlem Hospital Center, Columbia University, New York, NY 10037, USA
    Clin Respir J 3:222-8. 2009
    ..Dyspnea screening would only be valid if reproducible. The study aim was to determine the reliability (reproducibility) of assessing dyspnea through a simple questionnaire among a rural population...
  55. pmc Methods for assessing familial aggregation: family history measures and confounding in the standard cohort, reconstructed cohort and case-control designs
    Regina Zimmerman
    Department of Epidemiology, Mailman School of Public Health, New York, NY, USA
    Hum Hered 68:201-8. 2009
    ..In addition, we test if the definition of family history affects the accuracy of results obtained from either design. We use simulated data, which allows us to know the true data origin...
  56. ncbi request reprint Placental genes and breast cancer: can the offspring's or father's genotypes predict mother's risk?
    Habibul Ahsan
    Department of Epidemiology, Mailman School of Public Health and Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY 10032, USA
    Epidemiology 14:251-3. 2003
    ....
  57. pmc Water arsenic exposure and children's intellectual function in Araihazar, Bangladesh
    Gail A Wasserman
    Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, New York, USA
    Environ Health Perspect 112:1329-33. 2004
    ..5 microg/L. The association was generally stronger for well-water As than for urinary As...
  58. ncbi request reprint Further development of the case-only design for assessing gene-environment interaction: evaluation of and adjustment for bias
    Nicolle M Gatto
    Department of Epidemiology, Mailman School of Public Health at Columbia University in the City of New York, NY, USA
    Int J Epidemiol 33:1014-24. 2004
    ..Our work investigates to what extent this approach is appropriate and how non-independence can be accounted for in case-only analyses...
  59. ncbi request reprint Susceptibility to arsenic-induced hyperkeratosis and oxidative stress genes myeloperoxidase and catalase
    Habibul Ahsan
    Department of Epidemiology, Mailman School of Public Health, Columfbia University, Room 720G, 722 West 168th Street, New York, NY 10032, USA
    Cancer Lett 201:57-65. 2003
    ..Our findings, although based on small numbers, suggest that the oxidative stress genes MPO and CAT may influence the risk of arsenic-induced premalignant hyperkeratotic skin lesions...
  60. ncbi request reprint Health Effects of Arsenic Longitudinal Study (HEALS): description of a multidisciplinary epidemiologic investigation
    Habibul Ahsan
    Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY 10032, USA
    J Expo Sci Environ Epidemiol 16:191-205. 2006
    ..HEALS is a valuable resource for examining novel research questions on the health effects of As exposure...
  61. pmc Folate, homocysteine, and arsenic metabolism in arsenic-exposed individuals in Bangladesh
    Mary V Gamble
    Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY 10032, USA
    Environ Health Perspect 113:1683-8. 2005
    ..This may be particularly relevant in Bangladesh, where the prevalence of hyperhomocysteinemia is extremely high...
  62. pmc Folate and arsenic metabolism: a double-blind, placebo-controlled folic acid-supplementation trial in Bangladesh
    Mary V Gamble
    Departments of Environmental Health Sciences, Columbia University, New York, NY, USA
    Am J Clin Nutr 84:1093-101. 2006
    ..Consequently, folate nutritional status may influence arsenic methylation and toxicity...
  63. pmc Water manganese exposure and children's intellectual function in Araihazar, Bangladesh
    Gail A Wasserman
    Department of Psychiatry, College of Physicians and Surgeons, Columbia University, and New York State Psychiatric Institute, New York, New York 10032, USA
    Environ Health Perspect 114:124-9. 2006
    ..S. Environmental Protection Agency lifetime health advisory level. We conclude that in both Bangladesh and the United States, some children are at risk for Mn-induced neurotoxicity...
  64. pmc Water arsenic exposure and intellectual function in 6-year-old children in Araihazar, Bangladesh
    Gail A Wasserman
    Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    Environ Health Perspect 115:285-9. 2007
    ..We recently reported results of a cross-sectional investigation of intellectual function in 10-year-olds in Bangladesh, who had been exposed to arsenic from drinking water in their home wells...
  65. ncbi request reprint Variants in estrogen metabolism and biosynthesis genes and urinary estrogen metabolites in women with a family history of breast cancer
    Heather Greenlee
    Department of Epidemiology, Mailman School of Public Health, Columbia University, 722 West 168th Street, 7th Floor, New York, NY 10032, USA
    Breast Cancer Res Treat 102:111-7. 2007
    ....
  66. ncbi request reprint Aflatoxin B1 and polycyclic aromatic hydrocarbon adducts, p53 mutations and p16 methylation in liver tissue and plasma of hepatocellular carcinoma patients
    Yu Jing Zhang
    Department of Environmental Health Science, Mailman School of Public Health of Columbia University, New York, NY 10032, USA
    Int J Cancer 119:985-91. 2006
    ..These data suggest that genetic, epigenetic and environmental exposure biomarkers in plasma may help in estimating the risk for the development of HCC...
  67. ncbi request reprint Predicting hepatocellular carcinoma by detection of aberrant promoter methylation in serum DNA
    Yu Jing Zhang
    Department of Environmental Health Sciences, Mailman School of Public Health of Columbia University, New York, New York 10032, USA
    Clin Cancer Res 13:2378-84. 2007
    ..We explored the possible diagnostic value of aberrant promoter hypermethylation of three tumor suppressor genes in serum DNA for early detection of HCC...
  68. pmc Folate and cobalamin deficiencies and hyperhomocysteinemia in Bangladesh
    Mary V Gamble
    Department of Environmental Health Sciences, School of Public Health, Columbia University, New York, NY 10032, USA
    Am J Clin Nutr 81:1372-7. 2005
    ..This has been largely attributed to dietary deficiencies in cobalamin associated with vegetarianism among these Indian Asians...
  69. pmc Polycyclic aromatic hydrocarbon- and aflatoxin-albumin adducts, hepatitis B virus infection and hepatocellular carcinoma in Taiwan
    Hui Chen Wu
    Department of Environmental Health Sciences, Mailman School of Public Health of Columbia University, New York, NY, USA
    Cancer Lett 252:104-14. 2007
    ..Environmental PAH exposure seems to enhance the hepatocarcinogenicity of chronic HBV infection...
  70. doi request reprint Expression of cytochrome P450 1A1/2 and 3A4 in liver tissues of hepatocellular carcinoma cases and controls from Taiwan and their relationship to hepatitis B virus and aflatoxin B1-and 4-aminobiphenyl-DNA adducts
    Y J Zhang
    Division of Environmental Health Sciences, Mailman School of Public Health of Columbia University, New York, NY 10032, USA E mail
    Biomarkers 5:295-306. 2000
    ..These results suggest that one factor influencing carcinogen-DNA adducts is levels of specific P450 enzymes. However, adduct formation in vivo is a complex processes dependent upon numerous genetic and environmental factors. ..
  71. pmc Body mass, tobacco smoking, alcohol drinking and risk of cancer of the small intestine--a pooled analysis of over 500,000 subjects in the Asia Cohort Consortium
    P Boffetta
    The Tisch Cancer Institute and Institute for Translational Epidemiology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Ann Oncol 23:1894-8. 2012
    ..The evidence for a role of tobacco smoking, alcohol drinking, and body mass index (BMI) in the etiology of small intestine cancer is based mainly on case-control studies from Europe and United States...
  72. ncbi request reprint PTEN/MMAC1 mutations in hepatocellular carcinomas
    Y J Yao
    Department of Dermatology, School of Public Health, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA
    Oncogene 18:3181-5. 1999
    ..Additionally, we identified a silent mutation (P96P) in exon 5 of the PTEN/MMAC1 gene from HCC sample B6-22. These data provide the first evidence that the PTEN/MMAC1 gene is mutated in a subset of HCC samples...
  73. ncbi request reprint Variations in the use of adjuvant chemotherapy for node-positive colon cancer in the elderly: a population-based study
    V Sundararajan
    Division of Epidemiology, Joseph L. Mailman School of Public Health, PH-18-127, 630 West 168th Street, New York, NY 10032, USA
    Cancer J 7:213-8. 2001
    ..Efforts are needed to ensure that elderly and non-Hispanic black patients receive appropriate treatment...
  74. ncbi request reprint Arsenic exposure from drinking water and risk of premalignant skin lesions in Bangladesh: baseline results from the Health Effects of Arsenic Longitudinal Study
    Habibul Ahsan
    Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY 10032, USA
    Am J Epidemiol 163:1138-48. 2006
    ..53, 5.44), and 5.39 (95% CI: 3.69, 7.86), respectively. The effect seemed to be influenced by gender, age, and body mass index. These findings provide information that should be considered in future research and policy decisions...
  75. pmc Socioeconomic status and risk for arsenic-related skin lesions in Bangladesh
    Maria Argos
    Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA
    Am J Public Health 97:825-31. 2007
    ..In this study, we explored the association between socioeconomic status and arsenic toxicity...
  76. ncbi request reprint Preferential distal radius fracture in right-handed individuals presenting to an ED
    Gene R Pesola
    Department of Emergency Medicine, St Vincent s Hospital, Academic Medical Center of New York Medical College, New York, NY, USA
    Am J Emerg Med 21:552-5. 2003
    ..If this data holds up, finding the etiology/mechanism of this predisposition might help in designing environments to minimize the impact of this injury pattern in the slightly older individual...
  77. ncbi request reprint Combined genetic assessment of transforming growth factor-beta signaling pathway variants may predict breast cancer risk
    Virginia G Kaklamani
    Cancer Genetics Program, Division of Hematology Oncology, Department of Medicine, Feinberg School of Medicine and Robert H Lurie Comprehensive Cancer Center, Northwestern University, 676 North St Clair Street, Chicago, IL 60611, USA
    Cancer Res 65:3454-61. 2005
    ..25-3.87). This is the first study assessing the TGF-beta signaling pathway through two common and functionally relevant TGFBR1 and TGFB1 variants. This approach may predict breast cancer risk in a large subset of the population...
  78. ncbi request reprint Polycyclic aromatic hydrocarbon-DNA adducts among rickshaw drivers in Dhaka City, Bangladesh
    M Hafizur Rahman
    Department of Biochemistry, Bangabandhu Sheikh Mujib Medical University BSMMU, Dhaka, Bangladesh
    Int Arch Occup Environ Health 76:533-8. 2003
    ..In conclusion, the results suggest that urban residents who are occupationally exposed to traffic pollution in Dhaka are at potentially higher risk of health effects from exposure to carcinogenic PAH compounds...
  79. ncbi request reprint New York AANCART: using participatory research to address the health needs of South Asian and Korean Americans in New York City
    Nadia Islam
    Center for the Study of Asian American Health, New York University School of Medicine, New York, New York 10032, USA
    Cancer 104:2931-6. 2005
    ..Using case studies from two community-based partnerships that were developed by NY AANCART, the current report describes how the principles of CBPR were applied in two rapidly growing Asian-American communities in New York City...
  80. ncbi request reprint Design options for molecular epidemiology research within cohort studies
    Andrew G Rundle
    Department of Epidemiology, Mailman School of Public Health and Herbert Irving Comprehensive Cancer Center, Columbia University, 722 West 168th, Room 730, New York, NY 10032, USA
    Cancer Epidemiol Biomarkers Prev 14:1899-907. 2005
    ..However, in total, of the two designs, the nested case-control study is better suited for studying biomarkers that can be influenced by analytic batch, long-term storage, and freeze-thaw cycles...
  81. pmc Variants of the adiponectin and adiponectin receptor 1 genes and breast cancer risk
    Virginia G Kaklamani
    Division of Hematology Oncology, Department of Medicine, Robert H Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Cancer Res 68:3178-84. 2008
    ..89; P(trend) = 0.001). This is the first report of an association between functionally relevant variants of the adiponectin pathway and breast cancer risk. The results warrant further studies of the adiponectin pathway in breast cancer...