A Abi Dargham

Summary

Affiliation: Columbia University
Country: USA

Publications

  1. ncbi Increased striatal dopamine transmission in schizophrenia: confirmation in a second cohort
    A Abi-Dargham
    Department of Psychiatry, Yale University, New Haven, Conn, USA
    Am J Psychiatry 155:761-7. 1998
  2. ncbi Alterations of benzodiazepine receptors in type II alcoholic subjects measured with SPECT and [123I]iomazenil
    A Abi-Dargham
    Department of Psychiatry, Yale University School of Medicine, New Haven, Conn, USA
    Am J Psychiatry 155:1550-5. 1998
  3. ncbi PET studies of binding competition between endogenous dopamine and the D1 radiotracer [11C]NNC 756
    A Abi-Dargham
    Department of Psychiatry, Columbia University, College of Physicians and Surgeons, New York State Psychiatric Institute, New York 10032, USA
    Synapse 32:93-109. 1999
  4. pmc Increased baseline occupancy of D2 receptors by dopamine in schizophrenia
    A Abi-Dargham
    Departments of Psychiatry and Radiology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 97:8104-9. 2000
  5. ncbi Occupancy of dopamine D2 receptors by the atypical antipsychotic drugs risperidone and olanzapine: theoretical implications
    W G Frankle
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY, 10032, USA
    Psychopharmacology (Berl) 175:473-80. 2004
  6. doi COMT genotype predicts cortical-limbic D1 receptor availability measured with [11C]NNC112 and PET
    M Slifstein
    Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Mol Psychiatry 13:821-7. 2008

Collaborators

Detail Information

Publications6

  1. ncbi Increased striatal dopamine transmission in schizophrenia: confirmation in a second cohort
    A Abi-Dargham
    Department of Psychiatry, Yale University, New Haven, Conn, USA
    Am J Psychiatry 155:761-7. 1998
    ..The purpose of this study was to replicate this finding in a new cohort of schizophrenic patients and healthy subjects...
  2. ncbi Alterations of benzodiazepine receptors in type II alcoholic subjects measured with SPECT and [123I]iomazenil
    A Abi-Dargham
    Department of Psychiatry, Yale University School of Medicine, New Haven, Conn, USA
    Am J Psychiatry 155:1550-5. 1998
    ..The authors attempted to replicate these findings using single photon emission computed tomography and the benzodiazepine receptor radiotracer [123I]iomazenil...
  3. ncbi PET studies of binding competition between endogenous dopamine and the D1 radiotracer [11C]NNC 756
    A Abi-Dargham
    Department of Psychiatry, Columbia University, College of Physicians and Surgeons, New York State Psychiatric Institute, New York 10032, USA
    Synapse 32:93-109. 1999
    ..These findings may also imply that a simple binding competition model is inadequate to account for the effects of manipulation of endogenous DA levels on the in vivo binding of radiolabeled antagonists...
  4. pmc Increased baseline occupancy of D2 receptors by dopamine in schizophrenia
    A Abi-Dargham
    Departments of Psychiatry and Radiology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 97:8104-9. 2000
    ..This finding provides direct evidence of increased stimulation of D(2) receptors by dopamine in schizophrenia, consistent with increased phasic activity of dopaminergic neurons...
  5. ncbi Occupancy of dopamine D2 receptors by the atypical antipsychotic drugs risperidone and olanzapine: theoretical implications
    W G Frankle
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY, 10032, USA
    Psychopharmacology (Berl) 175:473-80. 2004
    ..To examine the D2 occupancy of two commonly used antipsychotic medications and relate this to the D2 occupancy by endogenous dopamine in schizophrenia...
  6. doi COMT genotype predicts cortical-limbic D1 receptor availability measured with [11C]NNC112 and PET
    M Slifstein
    Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Mol Psychiatry 13:821-7. 2008
    ..These results confirm the prominent role of COMT in regulating DA transmission in cortex but not striatum, and the reliability of [11C]NNC 112 as a marker for low DA tone as previously suggested by studies in patients with schizophrenia...