Anissa Abi-Dargham

Summary

Affiliation: Columbia University
Country: USA

Publications

  1. ncbi request reprint Recent evidence for dopamine abnormalities in schizophrenia
    A Abi-Dargham
    New York State Psychiatric Institute, 1051 Riverside Dr, New York, NY 10032, USA
    Eur Psychiatry 17:341s-347s. 2002
  2. doi request reprint Increased prefrontal cortical D₁ receptors in drug naive patients with schizophrenia: a PET study with [¹¹C]NNC112
    Anissa Abi-Dargham
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    J Psychopharmacol 26:794-805. 2012
  3. doi request reprint Baseline and amphetamine-stimulated dopamine activity are related in drug-naïve schizophrenic subjects
    Anissa Abi-Dargham
    Department of Psychiatry, New York State Psychiatric Institute, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Biol Psychiatry 65:1091-3. 2009
  4. ncbi request reprint Prefrontal DA transmission at D1 receptors and the pathology of schizophrenia
    Anissa Abi-Dargham
    Department of Psychiatry, Columbia University College of Physicians and Surgeons and New York State Psychiatric Institute, New York, NY 10032, USA
    Neuroscientist 9:404-16. 2003
  5. ncbi request reprint Do we still believe in the dopamine hypothesis? New data bring new evidence
    Anissa Abi-Dargham
    Department of Psychiatry, Columbia University, 1051 Riverside Drive, New York, NY 10032, USA
    Int J Neuropsychopharmacol 7:S1-5. 2004
  6. ncbi request reprint Dopamine hypothesis of schizophrenia: making sense of it all
    Mitsuru Toda
    Curr Psychiatry Rep 9:329-36. 2007
  7. ncbi request reprint Prefrontal dopamine D1 receptors and working memory in schizophrenia
    Anissa Abi-Dargham
    Department of Psychiatry, Columbia University College of Physicians and Surgeons and New York State Psychiatric Institute, New York, New York 10032, USA
    J Neurosci 22:3708-19. 2002
  8. ncbi request reprint Mechanisms of action of second generation antipsychotic drugs in schizophrenia: insights from brain imaging studies
    Anissa Abi-Dargham
    Department of Psychiatry, New York State Psychiatric Institute, Unit 31, Columbia University College of Physicians and Surgeons, 1051 Riverside Drive, New York, NY 10032, USA
    Eur Psychiatry 20:15-27. 2005
  9. doi request reprint Increased synaptic dopamine function in associative regions of the striatum in schizophrenia
    Lawrence S Kegeles
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, New York, USA
    Arch Gen Psychiatry 67:231-9. 2010
  10. ncbi request reprint Serotonin transporter availability in patients with schizophrenia: a positron emission tomography imaging study with [11C]DASB
    W Gordon Frankle
    Department of Psychiatry, Columbia University College of Physicians and Surgeons and the New York State Psychiatric Institute, New York, New York 10032, USA
    Biol Psychiatry 57:1510-6. 2005

Research Grants

  1. Imaging dopamine transmission in cannabis dependence
    Anissa Abi Dargham; Fiscal Year: 2007
  2. Prefrontal cortical dopamine and cognition-schizophrenia
    Anissa Abi Dargham; Fiscal Year: 2007
  3. PET Imaging of Serotonin Transmission in MDMA Users
    Anissa Abi Dargham; Fiscal Year: 2005
  4. DOPAMINE TRANSMISSION IN ALCOHOLISM
    Anissa Abi Dargham; Fiscal Year: 2002
  5. PREFRONTAL D1 AND 5HT1A RECEPTORS IN SCHIZOPHRENIA
    Anissa Abi Dargham; Fiscal Year: 2001
  6. Imaging dopamine transmission in cannabis dependence
    Anissa Abi Dargham; Fiscal Year: 2010

Detail Information

Publications68

  1. ncbi request reprint Recent evidence for dopamine abnormalities in schizophrenia
    A Abi-Dargham
    New York State Psychiatric Institute, 1051 Riverside Dr, New York, NY 10032, USA
    Eur Psychiatry 17:341s-347s. 2002
    ..A D1 receptor radiotracer that is sensitive to endogenous dopamine competition would be very valuable in the further exploration of this area...
  2. doi request reprint Increased prefrontal cortical D₁ receptors in drug naive patients with schizophrenia: a PET study with [¹¹C]NNC112
    Anissa Abi-Dargham
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    J Psychopharmacol 26:794-805. 2012
    ..We conclude that upregulation of D1 receptors in schizophrenia is related to the illness itself and may be corrected and normalized by chronic antipsychotic treatment...
  3. doi request reprint Baseline and amphetamine-stimulated dopamine activity are related in drug-naïve schizophrenic subjects
    Anissa Abi-Dargham
    Department of Psychiatry, New York State Psychiatric Institute, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Biol Psychiatry 65:1091-3. 2009
    ..We report here on the relationship between these two aspects of DA release in drug-naïve patients with schizophrenia (SCZ) and matched healthy control subjects (HC)...
  4. ncbi request reprint Prefrontal DA transmission at D1 receptors and the pathology of schizophrenia
    Anissa Abi-Dargham
    Department of Psychiatry, Columbia University College of Physicians and Surgeons and New York State Psychiatric Institute, New York, NY 10032, USA
    Neuroscientist 9:404-16. 2003
    ..The impact of antipsychotic drugs on prefrontal DA function will also be reviewed. We will conclude with the formulation of several models of altered prefrontal DA transmission at D1 receptors in schizophrenia...
  5. ncbi request reprint Do we still believe in the dopamine hypothesis? New data bring new evidence
    Anissa Abi-Dargham
    Department of Psychiatry, Columbia University, 1051 Riverside Drive, New York, NY 10032, USA
    Int J Neuropsychopharmacol 7:S1-5. 2004
    ..The up-regulation of D1 receptors may represent a compensatory effect of the dopamine deficit in the cortex. These findings provide evidence for a corticalsubcortical imbalance in the schizophrenic brain...
  6. ncbi request reprint Dopamine hypothesis of schizophrenia: making sense of it all
    Mitsuru Toda
    Curr Psychiatry Rep 9:329-36. 2007
    ..We will review here its history, validation, and implications for treatment...
  7. ncbi request reprint Prefrontal dopamine D1 receptors and working memory in schizophrenia
    Anissa Abi-Dargham
    Department of Psychiatry, Columbia University College of Physicians and Surgeons and New York State Psychiatric Institute, New York, New York 10032, USA
    J Neurosci 22:3708-19. 2002
    ..Increased D1 receptor availability observed in patients with schizophrenia might represent a compensatory (but ineffective) upregulation secondary to sustained deficiency in mesocortical DA function...
  8. ncbi request reprint Mechanisms of action of second generation antipsychotic drugs in schizophrenia: insights from brain imaging studies
    Anissa Abi-Dargham
    Department of Psychiatry, New York State Psychiatric Institute, Unit 31, Columbia University College of Physicians and Surgeons, 1051 Riverside Drive, New York, NY 10032, USA
    Eur Psychiatry 20:15-27. 2005
    ....
  9. doi request reprint Increased synaptic dopamine function in associative regions of the striatum in schizophrenia
    Lawrence S Kegeles
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, New York, USA
    Arch Gen Psychiatry 67:231-9. 2010
    ....
  10. ncbi request reprint Serotonin transporter availability in patients with schizophrenia: a positron emission tomography imaging study with [11C]DASB
    W Gordon Frankle
    Department of Psychiatry, Columbia University College of Physicians and Surgeons and the New York State Psychiatric Institute, New York, New York 10032, USA
    Biol Psychiatry 57:1510-6. 2005
    ..The aim of this study was to compare SERT availability in vivo in patients with schizophrenia and matched control subjects...
  11. ncbi request reprint Imaging human mesolimbic dopamine transmission with positron emission tomography. Part II: amphetamine-induced dopamine release in the functional subdivisions of the striatum
    Diana Martinez
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, 1051 Riverside Drive, New York, NY 10032, USA
    J Cereb Blood Flow Metab 23:285-300. 2003
    ....
  12. ncbi request reprint In vivo vulnerability to competition by endogenous dopamine: comparison of the D2 receptor agonist radiotracer (-)-N-[11C]propyl-norapomorphine ([11C]NPA) with the D2 receptor antagonist radiotracer [11C]-raclopride
    Rajesh Narendran
    Department of Psychiatry, Columbia University College of Physicians and Surgeons and the New York State Psychiatric Institute, New York, NY 10032, USA
    Synapse 52:188-208. 2004
    ..In conclusion, [11C]NPA might provide a superior radiotracer to probe presynaptic DA function with PET in health and disease...
  13. ncbi request reprint Altered prefrontal dopaminergic function in chronic recreational ketamine users
    Rajesh Narendran
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY, USA
    Am J Psychiatry 162:2352-9. 2005
    ..In this study, dopamine D1 receptor availability was assessed by using positron emission tomography and the selective D1 receptor radioligand [11C]NNC 112 in a group of 14 recreational chronic ketamine users and matched healthy subjects...
  14. ncbi request reprint Occupancy of brain serotonin transporters during treatment with paroxetine in patients with social phobia: a positron emission tomography study with 11C McN 5652
    Justine M Kent
    New York State Psychiatry Institute, New York, NY 10032, USA
    Psychopharmacology (Berl) 164:341-8. 2002
    ....
  15. ncbi request reprint Comparative evaluation of serotonin transporter radioligands 11C-DASB and 11C-McN 5652 in healthy humans
    W Gordon Frankle
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, and the New York State Psychiatric Institute, New York, New York, USA
    J Nucl Med 45:682-94. 2004
    ..The purpose of this study was to compare these 2 agents in healthy humans...
  16. ncbi request reprint Effects of reduced endogenous 5-HT on the in vivo binding of the serotonin transporter radioligand 11C-DASB in healthy humans
    Peter S Talbot
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York State Psychiatric Institute, New York, New York 10032, USA
    Synapse 55:164-75. 2005
    ..These results suggest that (11)C-DASB in vivo binding is not affected by reductions in endogenous 5-HT...
  17. ncbi request reprint Striatal dopamine D(2) receptor availability in OCD with and without comorbid social anxiety disorder: preliminary findings
    Franklin R Schneier
    Anxiety Disorders Clinic, New York State Psychiatric Institute, New York, NY 10032, USA
    Depress Anxiety 25:1-7. 2008
    ..Prior findings of decreased D(2) receptor availability in noncomorbid OCD were not confirmed. Decreased D(2) receptor availability was also associated with trait detachment, supporting prior findings in samples of healthy subjects...
  18. doi request reprint Dose-occupancy study of striatal and extrastriatal dopamine D2 receptors by aripiprazole in schizophrenia with PET and [18F]fallypride
    Lawrence S Kegeles
    Department of Psychiatry, New York State Psychiatric Institute, Columbia University College of Physicians and Surgeons, New York, NY, USA
    Neuropsychopharmacology 33:3111-25. 2008
    ....
  19. pmc Striatal and extrastriatal dopamine release measured with PET and [(18)F] fallypride
    Mark Slifstein
    Columbia University, New York, NY, USA
    Synapse 64:350-62. 2010
    ....
  20. doi request reprint Measurement of the serotonin 1A receptor availability in patients with schizophrenia during treatment with the antipsychotic medication ziprasidone
    W Gordon Frankle
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, USA
    J Psychopharmacol 25:734-43. 2011
    ..The finding of a relationship between 5-HT(1A) binding and the degree of improvement in negative symptoms provides further support for the role of the 5-HT(1A) receptor in the pathophysiology and treatment of this symptom domain...
  21. pmc Striatal and extrastriatal dopamine D2/D3 receptors in schizophrenia evaluated with [18F]fallypride positron emission tomography
    Lawrence S Kegeles
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, and New York State Psychiatric Institute, New York 10032, USA
    Biol Psychiatry 68:634-41. 2010
    ..We used positron emission tomography with [(18)F]fallypride to evaluate D(2)/D(3) receptors in both striatal and extrastriatal regions in schizophrenia...
  22. ncbi request reprint Brain serotonin transporter distribution in subjects with impulsive aggressivity: a positron emission study with [11C]McN 5652
    W Gordon Frankle
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, and the New York State Psychiatric Institute, 1051 Riverside Dr, Box 31, New York, NY 10032, USA
    Am J Psychiatry 162:915-23. 2005
    ..This study evaluated regional serotonin transporter distribution in the brain of individuals with impulsive aggression by using positron emission tomography (PET) with the serotonin transporter PET radiotracer [(11)C]McN 5652...
  23. ncbi request reprint Striatal amphetamine-induced dopamine release in patients with schizotypal personality disorder studied with single photon emission computed tomography and [123I]iodobenzamide
    Anissa Abi-Dargham
    Department of Psychiatry, Columbia University, and New York State Psychiatric Institute, New York, 10032, USA
    Biol Psychiatry 55:1001-6. 2004
    ..Schizotypal personality disorder (SPD) is a schizophrenia spectrum disorder, genetically related to schizophrenia. The goal of this study was to investigate striatal DA function in patients with SPD...
  24. ncbi request reprint Alcohol dependence is associated with blunted dopamine transmission in the ventral striatum
    Diana Martinez
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, USA
    Biol Psychiatry 58:779-86. 2005
    ..This study measured D2 receptors and dopamine transmission in human alcohol-dependent (AD) subjects using positron emission tomography (PET) and [11C]raclopride...
  25. ncbi request reprint Dopamine depletion and in vivo binding of PET D1 receptor radioligands: implications for imaging studies in schizophrenia
    Ningning Guo
    Department of Psychiatry, Columbia University and New York State Psychiatric Institute, New York, NY 10032, USA
    Neuropsychopharmacology 28:1703-11. 2003
    ....
  26. pmc Increased serotonin 2A receptor availability in the orbitofrontal cortex of physically aggressive personality disordered patients
    Daniel R Rosell
    James J Peters Veterans Affairs Medical Center, Bronx, New York, NY, USA
    Biol Psychiatry 67:1154-62. 2010
    ..We have previously hypothesized that increased 5-HT(2A)R function in the OFC is a state phenomenon that promotes impulsive aggression...
  27. pmc Sustained recreational use of ecstasy is associated with altered pre and postsynaptic markers of serotonin transmission in neocortical areas: a PET study with [¹¹C]DASB and [¹¹C]MDL 100907
    Nina Bl Urban
    Department of Psychiatry, Columbia University, New York State Psychiatric Institute, New York, NY 10032, USA
    Neuropsychopharmacology 37:1465-73. 2012
    ..Alterations in mood, cognition, and impulse control associated with these changes might contribute to sustain MDMA use. The reversibility of these changes upon abstinence remains to be firmly established...
  28. pmc Dopamine transporters, D2 receptors, and dopamine release in generalized social anxiety disorder
    Franklin R Schneier
    Anxiety Disorders Clinic, New York State Psychiatric Institute, Unit 69, 1051 Riverside Drive, New York, NY 10032, USA
    Depress Anxiety 26:411-8. 2009
    ..D2 receptors and DAT have not previously been studied within the same GSAD subjects, however, and prior GSAD studies have not assessed dopamine release or subdivided the STR into functional subregions...
  29. pmc Positron emission tomography imaging of the serotonin transporter and 5-HT(1A) receptor in alcohol dependence
    Diana Martinez
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, 1051 Riverside Drive, New York, NY 10032, USA
    Biol Psychiatry 65:175-80. 2009
    ..This is the first report of combined tracers for pre- and postsynaptic serotonergic transmission in the same alcoholic subjects and the first study of 5-HT(1A) receptors in alcoholism...
  30. doi request reprint Imaging changes in glutamate transmission in vivo with the metabotropic glutamate receptor 5 tracer [11C] ABP688 and N-acetylcysteine challenge
    Nobumi Miyake
    Department of Psychiatry, Columbia University, New York, New York New York State Psychiatric Institute, New York, New York, USA
    Biol Psychiatry 69:822-4. 2011
    ..Here we demonstrate the feasibility of this approach for the first time using positron emission tomography and [(11)C] ABP688, a radiotracer for an allosteric site on the metabotropic glutamate receptor 5...
  31. ncbi request reprint In vivo DA D(1) receptor selectivity of NNC 112 and SCH 23390
    Jesper Ekelund
    Department of Psychiatry, Columbia University, New York, NY, USA
    Mol Imaging Biol 9:117-25. 2007
    ..It is known that both have some affinity for serotonin 2A receptors, but previous studies have suggested this is negligible compared to D(1) affinity. We sought to verify this property in vivo...
  32. pmc The 5-HT(2A) receptor and serotonin transporter in Asperger's disorder: A PET study with [¹¹C]MDL 100907 and [¹¹C]DASB
    Ragy R Girgis
    Department of Psychiatry, Columbia University and New York State Psychiatric Institute, New York, NY 10032, USA
    Psychiatry Res 194:230-4. 2011
    ..This study failed to find significant alterations in binding parameters of 5-HT(2A) receptors and serotonin transporters in adult subjects with Asperger's disorder...
  33. ncbi request reprint Mechanism of action of antipsychotic drugs: from dopamine D(2) receptor antagonism to glutamate NMDA facilitation
    Marc Laruelle
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Clin Ther 27:S16-24. 2005
    ..The fundamental pathologic processes associated with schizophrenia remain uncertain...
  34. ncbi request reprint Biodistribution and radiation dosimetry of the dopamine D2 ligand 11C-raclopride determined from human whole-body PET
    Mark Slifstein
    Department of Psychiatry, Columbia University, New York, New York 10032, USA
    J Nucl Med 47:313-9. 2006
    ..Whole-body radiation dosimetry of 11C-raclopride was performed in healthy human volunteers...
  35. pmc Striatal dopamine in bulimia nervosa: a PET imaging study
    Allegra Broft
    Columbia College of Physicians and Surgeons, New York, NY, USA
    Int J Eat Disord 45:648-56. 2012
    ..This study utilized PET imaging to determine whether abnormalities in brain dopamine (DA) similar to those described in substance use disorders occur in BN...
  36. pmc Dopamine release in chronic cannabis users: a [11c]raclopride positron emission tomography study
    Nina B L Urban
    New York State PsychiatricInstitute, Department of Psychiatry, 1051 Riverside Drive, New York, NY 10032, USA
    Biol Psychiatry 71:677-83. 2012
    ....
  37. doi request reprint Serotonin 2A receptors in obsessive-compulsive disorder: a positron emission tomography study with [11C]MDL 100907
    Helen Blair Simpson
    Department of Psychiatry, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA
    Biol Psychiatry 70:897-904. 2011
    ..This study used positron emission tomography with the radioligand [11C]MDL 100907 to examine whether the distribution of serotonin 2A (5-HT(2A)) receptors is altered in OCD...
  38. pmc Extended characterisation of the serotonin 2A (5-HT2A) receptor-selective PET radiotracer 11C-MDL100907 in humans: quantitative analysis, test-retest reproducibility, and vulnerability to endogenous 5-HT tone
    Peter S Talbot
    Department of Psychiatry, Columbia University College of Physicians and Surgeons and the New York State Psychiatric Institute, New York, NY 10032, USA
    Neuroimage 59:271-85. 2012
    ..We present an extended characterisation in healthy human subjects...
  39. pmc Characterization of in vivo pharmacokinetic properties of the dopamine D1 receptor agonist DAR-0100A in nonhuman primates using PET with [11C] NNC112 and [11C] raclopride
    Mark Slifstein
    Department of Psychiatry, Columbia University, New York, New York, USA
    J Cereb Blood Flow Metab 31:293-304. 2011
    ..This is the first demonstration with PET of a significant occupancy by a full D1 agonist in vivo...
  40. pmc Sex differences in striatal dopamine release in young adults after oral alcohol challenge: a positron emission tomography imaging study with [¹¹C]raclopride
    Nina B L Urban
    Department of Psychiatry at New York State Psychiatric Institute and Columbia University, New York, New York 10032, USA
    Biol Psychiatry 68:689-96. 2010
    ..We used a positron emission tomography paradigm with the D2/3 radiotracer [¹¹C]raclopride and an alcohol challenge to examine the magnitude of alcohol-induced dopamine release and compare it between young men and women...
  41. ncbi request reprint [11C]NNC 112 selectivity for dopamine D1 and serotonin 5-HT(2A) receptors: a PET study in healthy human subjects
    Mark Slifstein
    Department of Psychiatry, Columbia University, New York, New York, USA
    J Cereb Blood Flow Metab 27:1733-41. 2007
    ..These results suggest caution in interpreting data from studies using this tracer to measure cortical D(1) receptors as well as the need for more selective radioligands to assess cortical D(1) receptors...
  42. ncbi request reprint Estimation of serotonin transporter parameters with 11C-DASB in healthy humans: reproducibility and comparison of methods
    W Gordon Frankle
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York State Psychiatric Institute, New York, NY 10032, USA
    J Nucl Med 47:815-26. 2006
    ..The aim of the present study was to define the optimal analytic method to derive accurate and reliable serotonin transporter (SERT) receptor parameters with (11)C-3-amino-4-(2-[(dimethylamino)methyl]phenylthio)benzonitrile ((11)C-DASB)...
  43. pmc Dopamine D1 receptors in cocaine dependence measured with PET and the choice to self-administer cocaine
    Diana Martinez
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Neuropsychopharmacology 34:1774-82. 2009
    ....
  44. ncbi request reprint Serotonin transporters in obsessive-compulsive disorder: a positron emission tomography study with [(11)C]McN 5652
    H Blair Simpson
    Department of Psychiatry, Columbia University, College of Physicians and Surgeons, New York, New York, USA
    Biol Psychiatry 54:1414-21. 2003
    ..This study examined whether brain serotonin transporter (SERT) availability is altered in OCD using positron emission tomography (PET) and the SERT PET radiotracer [(11)C]McN 5652...
  45. ncbi request reprint Dopamine mediation of positive reinforcing effects of amphetamine in stimulant naïve healthy volunteers: results from a large cohort
    Anissa Abi-Dargham
    Department of Psychiatry, Columbia University, New York, NY, USA
    Eur Neuropsychopharmacol 13:459-68. 2003
    ..This study indicates that both a large dopaminergic response and young age during a first encounter with a drug of abuse potential contribute to higher positive reinforcing effects...
  46. doi request reprint In vivo binding of the dopamine-1 receptor PET tracers [¹¹C]NNC112 and [¹¹C]SCH23390: a comparison study in individuals with schizophrenia
    Eline M P Poels
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY, USA
    Psychopharmacology (Berl) 228:167-74. 2013
    ..However, the results from positron emission tomography imaging studies of D1 receptor levels in individuals with schizophrenia are mixed...
  47. doi request reprint Imaging human reward processing with positron emission tomography and functional magnetic resonance imaging
    Nina B L Urban
    Department of Psychiatry at Columbia University, New York, NY 10032, USA
    Psychopharmacology (Berl) 221:67-77. 2012
    ..The lack of correlation at the ROI level may be due to the small magnitude of release or to the particular dependence of BOLD on glutamatergic signaling...
  48. pmc Impact of D2 receptor internalization on binding affinity of neuroimaging radiotracers
    Ningning Guo
    Department of Psychiatry, Columbia University, New York, NY10032, USA
    Neuropsychopharmacology 35:806-17. 2010
    ....
  49. ncbi request reprint Glutamate, dopamine, and schizophrenia: from pathophysiology to treatment
    Marc Laruelle
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Ann N Y Acad Sci 1003:138-58. 2003
    ....
  50. pmc In vivo binding of antipsychotics to D3 and D2 receptors: a PET study in baboons with [11C]-(+)-PHNO
    Ragy R Girgis
    Department of Psychiatry, Columbia University, New York, NY, USA
    Neuropsychopharmacology 36:887-95. 2011
    ..82). These data suggest that acute doses of clozapine and haloperidol bind to D(3) receptors in vivo, and that the lack of D(3) occupancy by antipsychotics observed in some recent imaging studies may be because of other phenomena...
  51. ncbi request reprint Cognitive and brain function in schizotypal personality disorder
    Larry J Siever
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, USA
    Schizophr Res 54:157-67. 2002
    ..Preliminary trials of catecholaminergic agents suggest that these agents may be able to improve these impaired cognitive functions...
  52. doi request reprint Elevated prefrontal cortex γ-aminobutyric acid and glutamate-glutamine levels in schizophrenia measured in vivo with proton magnetic resonance spectroscopy
    Lawrence S Kegeles
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY, USA
    Arch Gen Psychiatry 69:449-59. 2012
    ..Abnormalities in these transmitters are thought to play a role in cognitive impairments in the illness...
  53. ncbi request reprint Prediction of panic response to a respiratory stimulant by reduced orbitofrontal cerebral blood flow in panic disorder
    Justine M Kent
    Department of Psychiatry, Unit 41, Columbia University, 1051 Riverside Drive, New York, NY 10032, USA
    Am J Psychiatry 162:1379-81. 2005
    ..The aim of this study was to examine regional cerebral blood flow changes in response to anxiety/panic provocation in subjects with panic disorder and healthy comparison subjects...
  54. ncbi request reprint Imaging the neurochemistry of alcohol and substance abuse
    Diana Martinez
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York State Psychiatric Institute, 1051 Riverside Drive, Box 31, New York, NY 10032, USA
    Neuroimaging Clin N Am 17:539-55, x. 2007
    ..This article reviews the literature of radiochemical imaging in cocaine, alcohol, heroin, methamphetamine, MDMA, and ketamine abuse and dependence...
  55. ncbi request reprint Neurobiology of dopamine in schizophrenia
    Olivier Guillin
    Department of Psychiatry, Columbia College of Physicians and Surgeons, New York State Psychiatric Institute, Columbia University, New York 10032, USA
    Int Rev Neurobiol 78:1-39. 2007
    ....
  56. pmc Imaging the high-affinity state of the dopamine D2 receptor in vivo: fact or fiction?
    Mette Skinbjerg
    Department of Psychiatry, Columbia University, New York, NY, USA
    Biochem Pharmacol 83:193-8. 2012
    ....
  57. pmc Presynaptic regulation of dopamine transmission in schizophrenia
    Gholson J Lyon
    Department of Psychiatry, Columbia University, New York City, NY 10032, USA
    Schizophr Bull 37:108-17. 2011
    ..New laboratory approaches are elucidating mechanisms that control the level of presynaptic DA stores, thus contributing to fundamental understanding of the basic pathophysiologic mechanism in schizophrenia...
  58. doi request reprint Glutamatergic abnormalities in schizophrenia: a review of proton MRS findings
    Eline M P Poels
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY, USA New York State Psychiatric Institute, New York, NY, USA
    Schizophr Res 152:325-32. 2014
    ..We will review the contribution of (1)H-MRS studies to our knowledge about glutamatergic abnormalities in the brains of individuals with SCZ and discuss the implications for future research and clinical care. ..
  59. doi request reprint Presynaptic dopamine in schizophrenia
    Nobumi Miyake
    Department of Psychiatry, Columbia University, New York State Psychiatric Institute, New York, NY, USA
    CNS Neurosci Ther 17:104-9. 2011
    ..Understanding the etiology of this dysregulation and its consequences on the rest of the circuitry is important for future drug development...
  60. ncbi request reprint Positron emission tomography and single photon emission CT molecular imaging in schizophrenia
    David Erritzoe
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York State Psychiatric Institute, 1051 Riverside Drive, Unit 31, New York, NY 10032, USA
    Neuroimaging Clin N Am 13:817-32. 2003
    ..Expanding the availability of PET and the current radiopharmaceutical portfolio will be critical for these predictions to become reality...
  61. ncbi request reprint Alterations of serotonin transmission in schizophrenia
    Anissa Abi Dargham
    Department of Psychiatry, Columbia College of Physicians and Surgeons, New York State Psychiatric Institute, Columbia University, New York 10032, USA
    Int Rev Neurobiol 78:133-64. 2007
    ....
  62. ncbi request reprint The vulnerability to alcohol and substance abuse in individuals diagnosed with schizophrenia
    John H Krystal
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
    Neurotox Res 10:235-52. 2006
    ..The focus on distinctions between motivation and reward with respect to substance abuse risk by schizophrenic patients suggests a need for a reconsideration of the construct of "negative symptoms" for this dually-diagnosed patient group...
  63. ncbi request reprint Absence of behavioral sensitization in healthy human subjects following repeated exposure to ketamine
    Hyun Sang Cho
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
    Psychopharmacology (Berl) 179:136-43. 2005
    ....
  64. ncbi request reprint Ritanserin antagonism of m-chlorophenylpiperazine effects in neuroleptic-free schizophrenics patients: support for serotonin-2 receptor modulation of schizophrenia symptoms
    Walid Abi-Saab
    Department of Psychiatry, Yale University School of Medicine, New Haven, Conn 06519, USA
    Psychopharmacology (Berl) 162:55-62. 2002
    ..Objectives: In order to test this hypothesis this study evaluated the capacity of pretreatment with the 5-HT(2) receptor antagonist ritanserin to attenuate the effects of the 5-HT agonist, m-chlorophenylpiperazine (mCPP)...
  65. ncbi request reprint Neurochemical imaging in schizophrenia
    Nina Urban
    Department of Psychiatry, New York State Psychiatric Institute, Columbia University, New York, NY 10032, USA
    Curr Top Behav Neurosci 4:215-42. 2010
    ..As more imaging tools become available, this knowledge will expand and will lead to better detection of disease, as well as better therapeutic approaches...
  66. pmc Recent advances in the development of novel pharmacological agents for the treatment of cognitive impairments in schizophrenia
    Robert W Buchanan
    Schizophr Bull 33:1120-30. 2007
    ..This article reviews the rationale for these 3 approaches and provides an update on the development of therapeutic agents, which act through one of these 3 mechanisms...
  67. ncbi request reprint Serotonin 1A receptor availability in patients with schizophrenia and schizo-affective disorder: a positron emission tomography imaging study with [11C]WAY 100635
    W Gordon Frankle
    Departments of Psychiatry and Radiology, Western Psychiatric Institute and Clinic, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Psychopharmacology (Berl) 189:155-64. 2006
    ..This study examines 5-HT(1A) availability in vivo in individuals with schizophrenia and schizo-affective disorder...
  68. ncbi request reprint Comparative and interactive human psychopharmacologic effects of ketamine and amphetamine: implications for glutamatergic and dopaminergic model psychoses and cognitive function
    John H Krystal
    Department of Psychiatry and Division of Biostatistics, Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Conn 06516, USA
    Arch Gen Psychiatry 62:985-94. 2005
    ..Studying the comparative and interactive effects of these agents may provide insights into the roles of the glutamate and monoamine systems in psychosis and cognition...

Research Grants13

  1. Imaging dopamine transmission in cannabis dependence
    Anissa Abi Dargham; Fiscal Year: 2007
    ....
  2. Prefrontal cortical dopamine and cognition-schizophrenia
    Anissa Abi Dargham; Fiscal Year: 2007
    ..abstract_text> ..
  3. PET Imaging of Serotonin Transmission in MDMA Users
    Anissa Abi Dargham; Fiscal Year: 2005
    ..abstract_text> ..
  4. DOPAMINE TRANSMISSION IN ALCOHOLISM
    Anissa Abi Dargham; Fiscal Year: 2002
    ..Understanding the neurochemical abnormalities underlying vulnerability to alcoholism would guide future treatment interventions and risk prevention strategies. ..
  5. PREFRONTAL D1 AND 5HT1A RECEPTORS IN SCHIZOPHRENIA
    Anissa Abi Dargham; Fiscal Year: 2001
    ..This study will lead to a better understanding of neurochemical abnormalities in schizophrenia, their relations to symptomatology, and their implications for treatment. ..
  6. Imaging dopamine transmission in cannabis dependence
    Anissa Abi Dargham; Fiscal Year: 2010
    ....