Research Topics
Genomes and Genes | Anissa Abi-DarghamSummaryAffiliation: Columbia University Country: USA Publications
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Publications
Recent evidence for dopamine abnormalities in schizophreniaA Abi-Dargham
New York State Psychiatric Institute, 1051 Riverside Dr, New York, NY 10032, USA
Eur Psychiatry 17:341s-347s. 2002..A D1 receptor radiotracer that is sensitive to endogenous dopamine competition would be very valuable in the further exploration of this area...
Increased prefrontal cortical D₁ receptors in drug naive patients with schizophrenia: a PET study with [¹¹C]NNC112Anissa Abi-Dargham
Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
J Psychopharmacol 26:794-805. 2012..We conclude that upregulation of D1 receptors in schizophrenia is related to the illness itself and may be corrected and normalized by chronic antipsychotic treatment...- Do we still believe in the dopamine hypothesis? New data bring new evidenceAnissa Abi-Dargham
Department of Psychiatry, Columbia University, 1051 Riverside Drive, New York, NY 10032, USA
Int J Neuropsychopharmacol 7:S1-5. 2004..The up-regulation of D1 receptors may represent a compensatory effect of the dopamine deficit in the cortex. These findings provide evidence for a corticalsubcortical imbalance in the schizophrenic brain... - Mechanisms of action of second generation antipsychotic drugs in schizophrenia: insights from brain imaging studiesAnissa Abi-Dargham
Department of Psychiatry, New York State Psychiatric Institute, Unit 31, Columbia University College of Physicians and Surgeons, 1051 Riverside Drive, New York, NY 10032, USA
Eur Psychiatry 20:15-27. 2005.... - Prefrontal DA transmission at D1 receptors and the pathology of schizophreniaAnissa Abi-Dargham
Department of Psychiatry, Columbia University College of Physicians and Surgeons and New York State Psychiatric Institute, New York, NY 10032, USA
Neuroscientist 9:404-16. 2003..The impact of antipsychotic drugs on prefrontal DA function will also be reviewed. We will conclude with the formulation of several models of altered prefrontal DA transmission at D1 receptors in schizophrenia... - Baseline and amphetamine-stimulated dopamine activity are related in drug-naïve schizophrenic subjectsAnissa Abi-Dargham
Department of Psychiatry, New York State Psychiatric Institute, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
Biol Psychiatry 65:1091-3. 2009..We report here on the relationship between these two aspects of DA release in drug-naïve patients with schizophrenia (SCZ) and matched healthy control subjects (HC)... - Dopamine hypothesis of schizophrenia: making sense of it allMitsuru Toda
Curr Psychiatry Rep 9:329-36. 2007..We will review here its history, validation, and implications for treatment... - Prefrontal dopamine D1 receptors and working memory in schizophreniaAnissa Abi-Dargham
Department of Psychiatry, Columbia University College of Physicians and Surgeons and New York State Psychiatric Institute, New York, New York 10032, USA
J Neurosci 22:3708-19. 2002..Increased D1 receptor availability observed in patients with schizophrenia might represent a compensatory (but ineffective) upregulation secondary to sustained deficiency in mesocortical DA function... - Serotonin transporter availability in patients with schizophrenia: a positron emission tomography imaging study with [11C]DASBW Gordon Frankle
Department of Psychiatry, Columbia University College of Physicians and Surgeons and the New York State Psychiatric Institute, New York, New York 10032, USA
Biol Psychiatry 57:1510-6. 2005..The aim of this study was to compare SERT availability in vivo in patients with schizophrenia and matched control subjects... - Increased synaptic dopamine function in associative regions of the striatum in schizophreniaLawrence S Kegeles
Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, New York, USA
Arch Gen Psychiatry 67:231-9. 2010.... - Imaging human mesolimbic dopamine transmission with positron emission tomography. Part II: amphetamine-induced dopamine release in the functional subdivisions of the striatumDiana Martinez
Department of Psychiatry, Columbia University College of Physicians and Surgeons, 1051 Riverside Drive, New York, NY 10032, USA
J Cereb Blood Flow Metab 23:285-300. 2003.... - In vivo vulnerability to competition by endogenous dopamine: comparison of the D2 receptor agonist radiotracer (-)-N-[11C]propyl-norapomorphine ([11C]NPA) with the D2 receptor antagonist radiotracer [11C]-racloprideRajesh Narendran
Department of Psychiatry, Columbia University College of Physicians and Surgeons and the New York State Psychiatric Institute, New York, NY 10032, USA
Synapse 52:188-208. 2004..In conclusion, [11C]NPA might provide a superior radiotracer to probe presynaptic DA function with PET in health and disease... - Occupancy of brain serotonin transporters during treatment with paroxetine in patients with social phobia: a positron emission tomography study with 11C McN 5652Justine M Kent
New York State Psychiatry Institute, New York, NY 10032, USA
Psychopharmacology (Berl) 164:341-8. 2002.... - Comparative evaluation of serotonin transporter radioligands 11C-DASB and 11C-McN 5652 in healthy humansW Gordon Frankle
Department of Psychiatry, Columbia University College of Physicians and Surgeons, and the New York State Psychiatric Institute, New York, New York, USA
J Nucl Med 45:682-94. 2004..The purpose of this study was to compare these 2 agents in healthy humans... - Altered prefrontal dopaminergic function in chronic recreational ketamine usersRajesh Narendran
Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY, USA
Am J Psychiatry 162:2352-9. 2005..In this study, dopamine D1 receptor availability was assessed by using positron emission tomography and the selective D1 receptor radioligand [11C]NNC 112 in a group of 14 recreational chronic ketamine users and matched healthy subjects... - Effects of reduced endogenous 5-HT on the in vivo binding of the serotonin transporter radioligand 11C-DASB in healthy humansPeter S Talbot
Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York State Psychiatric Institute, New York, New York 10032, USA
Synapse 55:164-75. 2005..These results suggest that (11)C-DASB in vivo binding is not affected by reductions in endogenous 5-HT... - Striatal dopamine D(2) receptor availability in OCD with and without comorbid social anxiety disorder: preliminary findingsFranklin R Schneier
Anxiety Disorders Clinic, New York State Psychiatric Institute, New York, NY 10032, USA
Depress Anxiety 25:1-7. 2008..Prior findings of decreased D(2) receptor availability in noncomorbid OCD were not confirmed. Decreased D(2) receptor availability was also associated with trait detachment, supporting prior findings in samples of healthy subjects... 
Striatal and extrastriatal dopamine release measured with PET and [(18)F] fallyprideMark Slifstein
Columbia University, New York, NY, USA
Synapse 64:350-62. 2010....- Dose-occupancy study of striatal and extrastriatal dopamine D2 receptors by aripiprazole in schizophrenia with PET and [18F]fallyprideLawrence S Kegeles
Department of Psychiatry, New York State Psychiatric Institute, Columbia University College of Physicians and Surgeons, New York, NY, USA
Neuropsychopharmacology 33:3111-25. 2008.... - Brain serotonin transporter distribution in subjects with impulsive aggressivity: a positron emission study with [11C]McN 5652W Gordon Frankle
Department of Psychiatry, Columbia University College of Physicians and Surgeons, and the New York State Psychiatric Institute, 1051 Riverside Dr, Box 31, New York, NY 10032, USA
Am J Psychiatry 162:915-23. 2005..This study evaluated regional serotonin transporter distribution in the brain of individuals with impulsive aggression by using positron emission tomography (PET) with the serotonin transporter PET radiotracer [(11)C]McN 5652... - Alcohol dependence is associated with blunted dopamine transmission in the ventral striatumDiana Martinez
Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, USA
Biol Psychiatry 58:779-86. 2005..This study measured D2 receptors and dopamine transmission in human alcohol-dependent (AD) subjects using positron emission tomography (PET) and [11C]raclopride... - Measurement of the serotonin 1A receptor availability in patients with schizophrenia during treatment with the antipsychotic medication ziprasidoneW Gordon Frankle
Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, USA
J Psychopharmacol 25:734-43. 2011..The finding of a relationship between 5-HT(1A) binding and the degree of improvement in negative symptoms provides further support for the role of the 5-HT(1A) receptor in the pathophysiology and treatment of this symptom domain... - Striatal amphetamine-induced dopamine release in patients with schizotypal personality disorder studied with single photon emission computed tomography and [123I]iodobenzamideAnissa Abi-Dargham
Department of Psychiatry, Columbia University, and New York State Psychiatric Institute, New York, 10032, USA
Biol Psychiatry 55:1001-6. 2004..This suggests that DA dysregulation in schizophrenia spectrum disorders might have a trait component, present in remitted patients with schizophrenia and in SPD, and a state component, associated with psychotic exacerbations but not SPD... - Striatal and extrastriatal dopamine D2/D3 receptors in schizophrenia evaluated with [18F]fallypride positron emission tomographyLawrence S Kegeles
Department of Psychiatry, Columbia University College of Physicians and Surgeons, and New York State Psychiatric Institute, New York 10032, USA
Biol Psychiatry 68:634-41. 2010..We used positron emission tomography with [(18)F]fallypride to evaluate D(2)/D(3) receptors in both striatal and extrastriatal regions in schizophrenia... - Dopamine depletion and in vivo binding of PET D1 receptor radioligands: implications for imaging studies in schizophreniaNingning Guo
Department of Psychiatry, Columbia University and New York State Psychiatric Institute, New York, NY 10032, USA
Neuropsychopharmacology 28:1703-11. 2003.... - Increased serotonin 2A receptor availability in the orbitofrontal cortex of physically aggressive personality disordered patientsDaniel R Rosell
James J Peters Veterans Affairs Medical Center, Bronx, New York, NY, USA
Biol Psychiatry 67:1154-62. 2010..We have previously hypothesized that increased 5-HT(2A)R function in the OFC is a state phenomenon that promotes impulsive aggression... - Sustained recreational use of ecstasy is associated with altered pre and postsynaptic markers of serotonin transmission in neocortical areas: a PET study with [¹¹C]DASB and [¹¹C]MDL 100907Nina Bl Urban
Department of Psychiatry, Columbia University, New York State Psychiatric Institute, New York, NY 10032, USA
Neuropsychopharmacology 37:1465-73. 2012..Alterations in mood, cognition, and impulse control associated with these changes might contribute to sustain MDMA use. The reversibility of these changes upon abstinence remains to be firmly established... - Dopamine transporters, D2 receptors, and dopamine release in generalized social anxiety disorderFranklin R Schneier
Anxiety Disorders Clinic, New York State Psychiatric Institute, Unit 69, 1051 Riverside Drive, New York, NY 10032, USA
Depress Anxiety 26:411-8. 2009..D2 receptors and DAT have not previously been studied within the same GSAD subjects, however, and prior GSAD studies have not assessed dopamine release or subdivided the STR into functional subregions... - Positron emission tomography imaging of the serotonin transporter and 5-HT(1A) receptor in alcohol dependenceDiana Martinez
Department of Psychiatry, Columbia University College of Physicians and Surgeons, 1051 Riverside Drive, New York, NY 10032, USA
Biol Psychiatry 65:175-80. 2009..This is the first report of combined tracers for pre- and postsynaptic serotonergic transmission in the same alcoholic subjects and the first study of 5-HT(1A) receptors in alcoholism... - Imaging changes in glutamate transmission in vivo with the metabotropic glutamate receptor 5 tracer [11C] ABP688 and N-acetylcysteine challengeNobumi Miyake
Department of Psychiatry, Columbia University, New York, New York New York State Psychiatric Institute, New York, New York, USA
Biol Psychiatry 69:822-4. 2011..Here we demonstrate the feasibility of this approach for the first time using positron emission tomography and [(11)C] ABP688, a radiotracer for an allosteric site on the metabotropic glutamate receptor 5... - The 5-HT(2A) receptor and serotonin transporter in Asperger's disorder: A PET study with [¹¹C]MDL 100907 and [¹¹C]DASBRagy R Girgis
Department of Psychiatry, Columbia University and New York State Psychiatric Institute, New York, NY 10032, USA
Psychiatry Res 194:230-4. 2011..This study failed to find significant alterations in binding parameters of 5-HT(2A) receptors and serotonin transporters in adult subjects with Asperger's disorder... - Mechanism of action of antipsychotic drugs: from dopamine D(2) receptor antagonism to glutamate NMDA facilitationMarc Laruelle
Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
Clin Ther 27:S16-24. 2005..The fundamental pathologic processes associated with schizophrenia remain uncertain... - Biodistribution and radiation dosimetry of the dopamine D2 ligand 11C-raclopride determined from human whole-body PETMark Slifstein
Department of Psychiatry, Columbia University, New York, New York 10032, USA
J Nucl Med 47:313-9. 2006..Whole-body radiation dosimetry of 11C-raclopride was performed in healthy human volunteers... - In vivo DA D(1) receptor selectivity of NNC 112 and SCH 23390Jesper Ekelund
Department of Psychiatry, Columbia University, New York, NY, USA
Mol Imaging Biol 9:117-25. 2007..It is known that both have some affinity for serotonin 2A receptors, but previous studies have suggested this is negligible compared to D(1) affinity. We sought to verify this property in vivo... - Striatal dopamine in bulimia nervosa: a PET imaging studyAllegra Broft
Columbia College of Physicians and Surgeons, New York, NY, USA
Int J Eat Disord 45:648-56. 2012..This study utilized PET imaging to determine whether abnormalities in brain dopamine (DA) similar to those described in substance use disorders occur in BN... - Dopamine release in chronic cannabis users: a [11c]raclopride positron emission tomography studyNina B L Urban
New York State PsychiatricInstitute, Department of Psychiatry, 1051 Riverside Drive, New York, NY 10032, USA
Biol Psychiatry 71:677-83. 2012.... - Extended characterisation of the serotonin 2A (5-HT2A) receptor-selective PET radiotracer 11C-MDL100907 in humans: quantitative analysis, test-retest reproducibility, and vulnerability to endogenous 5-HT tonePeter S Talbot
Department of Psychiatry, Columbia University College of Physicians and Surgeons and the New York State Psychiatric Institute, New York, NY 10032, USA
Neuroimage 59:271-85. 2012..We present an extended characterisation in healthy human subjects... - Serotonin 2A receptors in obsessive-compulsive disorder: a positron emission tomography study with [11C]MDL 100907Helen Blair Simpson
Department of Psychiatry, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA
Biol Psychiatry 70:897-904. 2011..This study used positron emission tomography with the radioligand [11C]MDL 100907 to examine whether the distribution of serotonin 2A (5-HT(2A)) receptors is altered in OCD... - Sex differences in striatal dopamine release in young adults after oral alcohol challenge: a positron emission tomography imaging study with [¹¹C]racloprideNina B L Urban
Department of Psychiatry at New York State Psychiatric Institute and Columbia University, New York, New York 10032, USA
Biol Psychiatry 68:689-96. 2010..We used a positron emission tomography paradigm with the D2/3 radiotracer [¹¹C]raclopride and an alcohol challenge to examine the magnitude of alcohol-induced dopamine release and compare it between young men and women... - Characterization of in vivo pharmacokinetic properties of the dopamine D1 receptor agonist DAR-0100A in nonhuman primates using PET with [11C] NNC112 and [11C] racloprideMark Slifstein
Department of Psychiatry, Columbia University, New York, New York, USA
J Cereb Blood Flow Metab 31:293-304. 2011..This is the first demonstration with PET of a significant occupancy by a full D1 agonist in vivo... - [11C]NNC 112 selectivity for dopamine D1 and serotonin 5-HT(2A) receptors: a PET study in healthy human subjectsMark Slifstein
Department of Psychiatry, Columbia University, New York, New York, USA
J Cereb Blood Flow Metab 27:1733-41. 2007..These results suggest caution in interpreting data from studies using this tracer to measure cortical D(1) receptors as well as the need for more selective radioligands to assess cortical D(1) receptors... - Estimation of serotonin transporter parameters with 11C-DASB in healthy humans: reproducibility and comparison of methodsW Gordon Frankle
Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York State Psychiatric Institute, New York, NY 10032, USA
J Nucl Med 47:815-26. 2006..The aim of the present study was to define the optimal analytic method to derive accurate and reliable serotonin transporter (SERT) receptor parameters with (11)C-3-amino-4-(2-[(dimethylamino)methyl]phenylthio)benzonitrile ((11)C-DASB)... - Dopamine D1 receptors in cocaine dependence measured with PET and the choice to self-administer cocaineDiana Martinez
Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
Neuropsychopharmacology 34:1774-82. 2009.... - Dopamine mediation of positive reinforcing effects of amphetamine in stimulant naïve healthy volunteers: results from a large cohortAnissa Abi-Dargham
Department of Psychiatry, Columbia University, New York, NY, USA
Eur Neuropsychopharmacol 13:459-68. 2003..This study indicates that both a large dopaminergic response and young age during a first encounter with a drug of abuse potential contribute to higher positive reinforcing effects... - Serotonin transporters in obsessive-compulsive disorder: a positron emission tomography study with [(11)C]McN 5652H Blair Simpson
Department of Psychiatry, Columbia University, College of Physicians and Surgeons, New York, New York, USA
Biol Psychiatry 54:1414-21. 2003..CONCLUSIONS: OCD without comorbid depression, may not be associated with major changes in SERT availability in subcortical and limbic regions... - Imaging human reward processing with positron emission tomography and functional magnetic resonance imagingNina B L Urban
Department of Psychiatry at Columbia University, New York, NY 10032, USA
Psychopharmacology (Berl) 221:67-77. 2012..The lack of correlation at the ROI level may be due to the small magnitude of release or to the particular dependence of BOLD on glutamatergic signaling... - Glutamate, dopamine, and schizophrenia: from pathophysiology to treatmentMarc Laruelle
Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
Ann N Y Acad Sci 1003:138-58. 2003.... - Cognitive and brain function in schizotypal personality disorderLarry J Siever
Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, USA
Schizophr Res 54:157-67. 2002..Preliminary trials of catecholaminergic agents suggest that these agents may be able to improve these impaired cognitive functions... - In vivo binding of antipsychotics to D3 and D2 receptors: a PET study in baboons with [11C]-(+)-PHNORagy R Girgis
Department of Psychiatry, Columbia University, New York, NY, USA
Neuropsychopharmacology 36:887-95. 2011..82). These data suggest that acute doses of clozapine and haloperidol bind to D(3) receptors in vivo, and that the lack of D(3) occupancy by antipsychotics observed in some recent imaging studies may be because of other phenomena... - Impact of D2 receptor internalization on binding affinity of neuroimaging radiotracersNingning Guo
Department of Psychiatry, Columbia University, New York, NY10032, USA
Neuropsychopharmacology 35:806-17. 2010.... - Elevated prefrontal cortex γ-aminobutyric acid and glutamate-glutamine levels in schizophrenia measured in vivo with proton magnetic resonance spectroscopyLawrence S Kegeles
Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY, USA
Arch Gen Psychiatry 69:449-59. 2012..Abnormalities in these transmitters are thought to play a role in cognitive impairments in the illness... - Imaging the neurochemistry of alcohol and substance abuseDiana Martinez
Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York State Psychiatric Institute, 1051 Riverside Drive, Box 31, New York, NY 10032, USA
Neuroimaging Clin N Am 17:539-55, x. 2007..This article reviews the literature of radiochemical imaging in cocaine, alcohol, heroin, methamphetamine, MDMA, and ketamine abuse and dependence... - Neurobiology of dopamine in schizophreniaOlivier Guillin
Department of Psychiatry, Columbia College of Physicians and Surgeons, New York State Psychiatric Institute, Columbia University, New York 10032, USA
Int Rev Neurobiol 78:1-39. 2007.... - Imaging the high-affinity state of the dopamine D2 receptor in vivo: fact or fiction?Mette Skinbjerg
Department of Psychiatry, Columbia University, New York, NY, USA
Biochem Pharmacol 83:193-8. 2012.... - Presynaptic regulation of dopamine transmission in schizophreniaGholson J Lyon
Department of Psychiatry, Columbia University, New York City, NY 10032, USA
Schizophr Bull 37:108-17. 2011..New laboratory approaches are elucidating mechanisms that control the level of presynaptic DA stores, thus contributing to fundamental understanding of the basic pathophysiologic mechanism in schizophrenia... - Prediction of panic response to a respiratory stimulant by reduced orbitofrontal cerebral blood flow in panic disorderJustine M Kent
Department of Psychiatry, Unit 41, Columbia University, 1051 Riverside Drive, New York, NY 10032, USA
Am J Psychiatry 162:1379-81. 2005..The aim of this study was to examine regional cerebral blood flow changes in response to anxiety/panic provocation in subjects with panic disorder and healthy comparison subjects... - Positron emission tomography and single photon emission CT molecular imaging in schizophreniaDavid Erritzoe
Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York State Psychiatric Institute, 1051 Riverside Drive, Unit 31, New York, NY 10032, USA
Neuroimaging Clin N Am 13:817-32. 2003..Expanding the availability of PET and the current radiopharmaceutical portfolio will be critical for these predictions to become reality... - Presynaptic dopamine in schizophreniaNobumi Miyake
Department of Psychiatry, Columbia University, New York State Psychiatric Institute, New York, NY, USA
CNS Neurosci Ther 17:104-9. 2011..Understanding the etiology of this dysregulation and its consequences on the rest of the circuitry is important for future drug development... - Alterations of serotonin transmission in schizophreniaAnissa Abi Dargham
Department of Psychiatry, Columbia College of Physicians and Surgeons, New York State Psychiatric Institute, Columbia University, New York 10032, USA
Int Rev Neurobiol 78:133-64. 2007.... - The vulnerability to alcohol and substance abuse in individuals diagnosed with schizophreniaJohn H Krystal
Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
Neurotox Res 10:235-52. 2006.... - Absence of behavioral sensitization in healthy human subjects following repeated exposure to ketamineHyun-Sang Cho
Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
Psychopharmacology (Berl) 179:136-43. 2005..CONCLUSIONS: The current data do not provide evidence that repeated exposure to ketamine, albeit limited, is associated with sensitization to the behavioral effects of ketamine... - Neurochemical imaging in schizophreniaNina Urban
Department of Psychiatry, New York State Psychiatric Institute, Columbia University, New York, NY 10032, USA
Curr Top Behav Neurosci 4:215-42. 2010..As more imaging tools become available, this knowledge will expand and will lead to better detection of disease, as well as better therapeutic approaches... - Ritanserin antagonism of m-chlorophenylpiperazine effects in neuroleptic-free schizophrenics patients: support for serotonin-2 receptor modulation of schizophrenia symptomsWalid Abi-Saab
Department of Psychiatry, Yale University School of Medicine, New Haven, Conn. 06519, USA
Psychopharmacology (Berl) 162:55-62. 2002..CONCLUSIONS: These data support a contribution of 5-HT(2) receptor stimulation to symptom exacerbation in schizophrenic patients and a role for 5-HT(2) receptor antagonism in the prevention of this effect... - Comparative and interactive human psychopharmacologic effects of ketamine and amphetamine: implications for glutamatergic and dopaminergic model psychoses and cognitive functionJohn H Krystal
Department of Psychiatry and Division of Biostatistics, Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Conn 06516, USA
Arch Gen Psychiatry 62:985-94. 2005..Studying the comparative and interactive effects of these agents may provide insights into the roles of the glutamate and monoamine systems in psychosis and cognition... - Recent advances in the development of novel pharmacological agents for the treatment of cognitive impairments in schizophreniaRobert W Buchanan
Schizophr Bull 33:1120-30. 2007..This article reviews the rationale for these 3 approaches and provides an update on the development of therapeutic agents, which act through one of these 3 mechanisms... - Serotonin 1A receptor availability in patients with schizophrenia and schizo-affective disorder: a positron emission tomography imaging study with [11C]WAY 100635W Gordon Frankle
Departments of Psychiatry and Radiology, Western Psychiatric Institute and Clinic, University of Pittsburgh, Pittsburgh, PA 15213, USA
Psychopharmacology (Berl) 189:155-64. 2006..This study examines 5-HT(1A) availability in vivo in individuals with schizophrenia and schizo-affective disorder...
Research Grants
- Imaging dopamine transmission in cannabis dependenceAnissa Abi Dargham; Fiscal Year: 2007....
- Prefrontal cortical dopamine and cognition-schizophreniaAnissa Abi Dargham; Fiscal Year: 2007..abstract_text> ..
- PET Imaging of Serotonin Transmission in MDMA UsersAnissa Abi Dargham; Fiscal Year: 2005..abstract_text> ..
- DOPAMINE TRANSMISSION IN ALCOHOLISMAnissa Abi Dargham; Fiscal Year: 2002..Understanding the neurochemical abnormalities underlying vulnerability to alcoholism would guide future treatment interventions and risk prevention strategies. ..
- PREFRONTAL D1 AND 5HT1A RECEPTORS IN SCHIZOPHRENIAAnissa Abi Dargham; Fiscal Year: 2001..This study will lead to a better understanding of neurochemical abnormalities in schizophrenia, their relations to symptomatology, and their implications for treatment. ..
- Imaging dopamine transmission in cannabis dependenceAnissa Abi Dargham; Fiscal Year: 2010....