Cory Abate-Shen

Summary

Affiliation: Columbia University
Country: USA

Publications

  1. ncbi request reprint FGF signaling in prostate tumorigenesis--new insights into epithelial-stromal interactions
    Cory Abate-Shen
    Department of Urology, Columbia University College of Physicians and Surgeons, Herbert Irving Comprehensive Cancer Center, New York, NY 10032, USA
    Cancer Cell 12:495-7. 2007
  2. pmc The MSX1 homeoprotein recruits G9a methyltransferase to repressed target genes in myoblast cells
    Jingqiang Wang
    Department of Urology and Herbert Irving Comprehensive Cancer Center, Columbia University College of Physicians and Surgeons, New York, New York, United States of America
    PLoS ONE 7:e37647. 2012
  3. pmc Preclinical analyses of intravesical chemotherapy for prevention of bladder cancer progression
    Joan C Delto
    Department of Urology, Columbia University Medical Center, New York, NY, USA
    Oncotarget 4:269-76. 2013
  4. pmc Integrating differentiation and cancer: the Nkx3.1 homeobox gene in prostate organogenesis and carcinogenesis
    Cory Abate-Shen
    Department of Urology, Columbia University, College of Physicians and Surgeons, Herbert Irving Comprehensive Cancer Center, New York, NY, USA
    Differentiation 76:717-27. 2008
  5. pmc The untapped potential of genetically engineered mouse models in chemoprevention research: opportunities and challenges
    Cory Abate-Shen
    Department of Urology, Herbert Irving Comprehensive Cancer Center, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Cancer Prev Res (Phila) 1:161-6. 2008
  6. pmc Intravesical delivery of rapamycin suppresses tumorigenesis in a mouse model of progressive bladder cancer
    Catherine M Seager
    Departments of Urology and Pathology and Cell Biology, Herbert Irving Comprehensive Cancer Center, 1130 St Nicholas Street, Room 217a, New York, NY 10032
    Cancer Prev Res (Phila) 2:1008-14. 2009
  7. pmc Lineage analysis of basal epithelial cells reveals their unexpected plasticity and supports a cell-of-origin model for prostate cancer heterogeneity
    Zhu A Wang
    Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Nat Cell Biol 15:274-83. 2013
  8. pmc ETV4 promotes metastasis in response to activation of PI3-kinase and Ras signaling in a mouse model of advanced prostate cancer
    Alvaro Aytes
    Department of Urology and Department of Pathology and Cell Biology, Herbert Irving Comprehensive Cancer Center, Department of Systems Biology, and Department of Medicine and Department of Genetics and Development, Columbia University Medical Center, New York, NY 10032
    Proc Natl Acad Sci U S A 110:E3506-15. 2013
  9. pmc B-Raf activation cooperates with PTEN loss to drive c-Myc expression in advanced prostate cancer
    Jingqiang Wang
    Department of Urology and Pathology and Cell Biology, Columbia University Medical Center, New York, New York 10031, USA
    Cancer Res 72:4765-76. 2012
  10. pmc A luminal epithelial stem cell that is a cell of origin for prostate cancer
    Xi Wang
    Department of Medicine, Herbert Irving Comprehensive Cancer Center, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Nature 461:495-500. 2009

Research Grants

  1. MSXL (HOX 7.1) IN MURINE EMBRYOGENESIS
    Cory Abate Shen; Fiscal Year: 2002
  2. NKX31 AND PROSTATE DEVELOPMENT AND CANCER
    Cory Abate Shen; Fiscal Year: 1999
  3. Roles of Nkx3.1 in prostate development and cancer
    Cory Abate Shen; Fiscal Year: 2004
  4. NKX31 AND PROSTATE DEVELOPMENT AND CANCER
    Cory Abate Shen; Fiscal Year: 2002
  5. Roles for MSX1 in vertebrate embryogenesis
    Cory Abate Shen; Fiscal Year: 2003
  6. Roles of Nkx3.1 in prostate development and cancer
    Cory Abate Shen; Fiscal Year: 2005
  7. Roles for MSX1 in vertebrate embryogenesis
    Cory Abate Shen; Fiscal Year: 2006
  8. MSXL (HOX 7.1) IN MURINE EMBRYOGENESIS
    Cory Abate Shen; Fiscal Year: 1999
  9. Roles of Nkx3.1 in prostate development and cancer
    Cory Abate Shen; Fiscal Year: 2003
  10. GENE EXPRESSION IN MURINE NEUROGENESIS--HOX 7.1
    Cory Abate Shen; Fiscal Year: 1992

Collaborators

Detail Information

Publications27

  1. ncbi request reprint FGF signaling in prostate tumorigenesis--new insights into epithelial-stromal interactions
    Cory Abate-Shen
    Department of Urology, Columbia University College of Physicians and Surgeons, Herbert Irving Comprehensive Cancer Center, New York, NY 10032, USA
    Cancer Cell 12:495-7. 2007
    ....
  2. pmc The MSX1 homeoprotein recruits G9a methyltransferase to repressed target genes in myoblast cells
    Jingqiang Wang
    Department of Urology and Herbert Irving Comprehensive Cancer Center, Columbia University College of Physicians and Surgeons, New York, New York, United States of America
    PLoS ONE 7:e37647. 2012
    ..We propose that regulation of chromatin status by Msx1 recruitment of G9a and other histone modifying enzymes to regulatory regions of target genes represents an important means of regulating the gene expression during development...
  3. pmc Preclinical analyses of intravesical chemotherapy for prevention of bladder cancer progression
    Joan C Delto
    Department of Urology, Columbia University Medical Center, New York, NY, USA
    Oncotarget 4:269-76. 2013
    ....
  4. pmc Integrating differentiation and cancer: the Nkx3.1 homeobox gene in prostate organogenesis and carcinogenesis
    Cory Abate-Shen
    Department of Urology, Columbia University, College of Physicians and Surgeons, Herbert Irving Comprehensive Cancer Center, New York, NY, USA
    Differentiation 76:717-27. 2008
    ..Here, we review recent findings concerning the roles of Nkx3.1 in development and discuss how its normal function is disrupted in processes of early prostate carcinogenesis...
  5. pmc The untapped potential of genetically engineered mouse models in chemoprevention research: opportunities and challenges
    Cory Abate-Shen
    Department of Urology, Herbert Irving Comprehensive Cancer Center, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Cancer Prev Res (Phila) 1:161-6. 2008
    ..Here we discuss opportunities and challenges for the application of GEM models in prevention research, as well as strategies to maximize their relevance for human cancer...
  6. pmc Intravesical delivery of rapamycin suppresses tumorigenesis in a mouse model of progressive bladder cancer
    Catherine M Seager
    Departments of Urology and Pathology and Cell Biology, Herbert Irving Comprehensive Cancer Center, 1130 St Nicholas Street, Room 217a, New York, NY 10032
    Cancer Prev Res (Phila) 2:1008-14. 2009
    ....
  7. pmc Lineage analysis of basal epithelial cells reveals their unexpected plasticity and supports a cell-of-origin model for prostate cancer heterogeneity
    Zhu A Wang
    Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Nat Cell Biol 15:274-83. 2013
    ..Our results reveal the inherent plasticity of basal cells, and support a model in which different cells of origin generate distinct molecular subtypes of prostate cancer...
  8. pmc ETV4 promotes metastasis in response to activation of PI3-kinase and Ras signaling in a mouse model of advanced prostate cancer
    Alvaro Aytes
    Department of Urology and Department of Pathology and Cell Biology, Herbert Irving Comprehensive Cancer Center, Department of Systems Biology, and Department of Medicine and Department of Genetics and Development, Columbia University Medical Center, New York, NY 10032
    Proc Natl Acad Sci U S A 110:E3506-15. 2013
    ..Our findings indicate that ETV4 promotes metastasis in prostate tumors that have activation of PI3-kinase and Ras signaling, and therefore, ETV4 represents a potential target of therapeutic intervention for metastatic prostate cancer. ..
  9. pmc B-Raf activation cooperates with PTEN loss to drive c-Myc expression in advanced prostate cancer
    Jingqiang Wang
    Department of Urology and Pathology and Cell Biology, Columbia University Medical Center, New York, New York 10031, USA
    Cancer Res 72:4765-76. 2012
    ..Together, our findings suggest a generalized therapeutic approach to target c-Myc activation in prostate cancer by combinatorial targeting of the PI3K → Akt → mTOR and ERK1/2 MAPK signaling pathways...
  10. pmc A luminal epithelial stem cell that is a cell of origin for prostate cancer
    Xi Wang
    Department of Medicine, Herbert Irving Comprehensive Cancer Center, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Nature 461:495-500. 2009
    ..These observations indicate that CARNs represent a new luminal stem cell population that is an efficient target for oncogenic transformation in prostate cancer...
  11. pmc Cross-species regulatory network analysis identifies a synergistic interaction between FOXM1 and CENPF that drives prostate cancer malignancy
    Alvaro Aytes
    Department of Urology, Columbia University Medical Center, New York, NY 10032, USA Translational Research Laboratory, Catalan Institute of Oncology, Bellvitge Institute for Biomedical Research, L Hospitalet de Llobregat, Barcelona 08907, Spain
    Cancer Cell 25:638-51. 2014
    ..Thus, genome-wide cross-species interrogation of regulatory networks represents a valuable strategy to identify causal mechanisms of human cancer. ..
  12. pmc Canonical Wnt signaling regulates Nkx3.1 expression and luminal epithelial differentiation during prostate organogenesis
    Marianna Kruithof-de Julio
    Departments of Medicine and Genetics and Development, Columbia University Medical Center, New York, New York Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, New York
    Dev Dyn 242:1160-71. 2013
    ..However, the identity of the signaling factors that mediate these interactions is largely unknown...
  13. pmc Dual targeting of the Akt/mTOR signaling pathway inhibits castration-resistant prostate cancer in a genetically engineered mouse model
    Nicolas Floc'h
    Department of Urology and Pathology and Cell Biology, Columbia University Medical Center, New York, NY 10031, USA
    Cancer Res 72:4483-93. 2012
    ..Our findings suggest that dual targeting of the Akt and mTOR signaling pathways using MK-2206 and ridaforolimus (MK-8669) may be effective for treatment of CRPC, particularly for patients with deregulated Rb pathway activity...
  14. pmc Targeting AKT/mTOR and ERK MAPK signaling inhibits hormone-refractory prostate cancer in a preclinical mouse model
    Carolyn Waugh Kinkade
    Department of Urology, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    J Clin Invest 118:3051-64. 2008
    ..We therefore propose that combination therapy targeting AKT/mTOR and ERK MAPK signaling pathways may be an effective treatment for patients with advanced prostate cancer, in particular those with hormone-refractory disease...
  15. pmc Inactivation of p53 and Pten promotes invasive bladder cancer
    Anna M Puzio-Kuter
    Department of Urology, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA
    Genes Dev 23:675-80. 2009
    ..Our integrated analyses of mouse and human bladder cancer provide a rationale for investigating mTOR inhibition for treatment of patients with invasive disease...
  16. pmc Simultaneous haploinsufficiency of Pten and Trp53 tumor suppressor genes accelerates tumorigenesis in a mouse model of prostate cancer
    Suzana S Couto
    Laboratory of Comparative Pathology, Memorial Sloan Kettering Cancer Center, NY, USA
    Differentiation 77:103-11. 2009
    ..In conclusion, simultaneous heterozygosity of Pten and Trp53 accelerates prostatic tumorigenesis in this mouse model of prostate cancer independently of loss of heterozygosity of either gene...
  17. pmc A molecular signature predictive of indolent prostate cancer
    Shazia Irshad
    Department of Urology, Columbia University Medical Center, New York, NY 10029, USA
    Sci Transl Med 5:202ra122. 2013
    ..We propose that this signature may be incorporated into prognostic assays for monitoring patients on active surveillance to facilitate appropriate courses of treatment...
  18. pmc ARF regulates the stability of p16 protein via REGγ-dependent proteasome degradation
    Takashi Kobayashi
    Columbia University Medical Center, 1130 St Nicholas Ave, New York, NY 10031, USA
    Mol Cancer Res 11:828-33. 2013
    ..Thus, our findings have uncovered a novel crosstalk of 2 key tumor suppressors mediated by a REGγ-dependent mechanism. The ability of ARF to control p16 stability may influence cell-cycle function...
  19. pmc Mouse models of human bladder cancer as a tool for drug discovery
    Catherine Seager
    Department of Urology, Columbia University Medical Center, Herbert Irving Comprehensive Cancer Center, New York, New York, USA
    Curr Protoc Pharmacol . 2010
    ..Protocols are also provided on the use of these models for the preclinical evaluation of new chemical entities, with mTOR inhibitors shown as an example...
  20. pmc Molecular genetics of prostate cancer: new prospects for old challenges
    Michael M Shen
    Department of Medicine, Columbia University Medical Center, New York, New York 10032, USA
    Genes Dev 24:1967-2000. 2010
    ..Overall, we highlight the tremendous research progress made in recent years, and underscore the challenges that lie ahead...
  21. doi request reprint Clinical outcomes after radical prostatectomy in diabetic patients treated with metformin
    Trushar Patel
    Department of Urology, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA
    Urology 76:1240-4. 2010
    ..To investigate the relationship between diabetes and metformin use with outcomes after radical prostatectomy (RP) for clinically localized cancer...
  22. pmc The Msx1 Homeoprotein Recruits Polycomb to the Nuclear Periphery during Development
    Jingqiang Wang
    Departments of Urology and Pathology and Cell Biology, Herbert Irving Comprehensive Cancer Center, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA
    Dev Cell 21:575-88. 2011
    ..Our findings illustrate a hitherto unappreciated spatial coordination of transcription factors with the Polycomb complex for appropriate regulation of gene expression programs during development...
  23. ncbi request reprint Analyses of tumor-suppressor genes in germline mouse models of cancer
    Jingqiang Wang
    Departments of Urology and Pathology and Cell Biology, Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, New York 10032
    Cold Spring Harb Protoc 2014:pdb.top069773. 2014
    ....
  24. pmc Modeling prostate cancer in mice: something old, something new, something premalignant, something metastatic
    Shazia Irshad
    Herbert Irving Comprehensive Cancer Center, Departments of Urology and Pathology and Cell Biology, Columbia University College of Physicians and Surgeons, New York, NY, USA
    Cancer Metastasis Rev 32:109-22. 2013
    ..This review describes these GEM models, focusing on their relevance for human prostate cancer and highlighting their strengths and limitations, as well as opportunities for the future...
  25. pmc Transcriptional repression by the Msx1 homeoprotein is associated with global redistribution of the H3K27me3 repressive mark to the nuclear periphery
    Jingqiang Wang
    Herbert Irving Comprehensive Cancer Center, Columbia University, College of Physicians and Surgeons, New York, NY, USA
    Nucleus 3:155-61. 2012
    ..Here we discuss the implications of our recent work showing that transcriptional repression by the Msx1 homeoprotein is associated with global redistribution of the H3K27me3 repressive mark to the nuclear periphery during development...
  26. ncbi request reprint Dlx genes integrate positive and negative signals during feather bud development
    Iaroslava Rouzankina
    Howard Hughes Medical Institute and Developmental Biology Program, Sloan Kettering Institute and Weill Graduate School of Medical Sciences of Cornell University, New York, NY 10021, USA
    Dev Biol 265:219-33. 2004
    ..Our results suggest that DLX transcription factors serve to integrate and transduce feather patterning signals to downstream effector molecules...

Research Grants33

  1. MSXL (HOX 7.1) IN MURINE EMBRYOGENESIS
    Cory Abate Shen; Fiscal Year: 2002
    ..More useful for the present proposal is her observation that injection at stage 17 blocks differentiation of feather follicles. Abate proposes to develop this overexpression phenotype as a quantitative assay for function. ..
  2. NKX31 AND PROSTATE DEVELOPMENT AND CANCER
    Cory Abate Shen; Fiscal Year: 1999
    ..1 in development will be analyzed by investigating its role in the male urogenital system, by examining its cell autonomy, and its over-expression in reconstituted prostatic tissue. ..
  3. Roles of Nkx3.1 in prostate development and cancer
    Cory Abate Shen; Fiscal Year: 2004
    ..1 protein expression. These mice will provide a valuable model for exploring the reversibility of prostate carcinogenesis in vivo. ..
  4. NKX31 AND PROSTATE DEVELOPMENT AND CANCER
    Cory Abate Shen; Fiscal Year: 2002
    ..1 in development will be analyzed by investigating its role in the male urogenital system, by examining its cell autonomy, and its over-expression in reconstituted prostatic tissue. ..
  5. Roles for MSX1 in vertebrate embryogenesis
    Cory Abate Shen; Fiscal Year: 2003
    ..Taken together, our focused analyses of Msx homeoproteins will provide general paradigms for addressing the functional specificities of other homeoproteins in vivo. ..
  6. Roles of Nkx3.1 in prostate development and cancer
    Cory Abate Shen; Fiscal Year: 2005
    ..1 protein expression. These mice will provide a valuable model for exploring the reversibility of prostate carcinogenesis in vivo. ..
  7. Roles for MSX1 in vertebrate embryogenesis
    Cory Abate Shen; Fiscal Year: 2006
    ..Taken together, our focused analyses of Msx homeoproteins will provide general paradigms for addressing the functional specificities of other homeoproteins in vivo. ..
  8. MSXL (HOX 7.1) IN MURINE EMBRYOGENESIS
    Cory Abate Shen; Fiscal Year: 1999
    ..More useful for the present proposal is her observation that injection at stage 17 blocks differentiation of feather follicles. Abate proposes to develop this overexpression phenotype as a quantitative assay for function. ..
  9. Roles of Nkx3.1 in prostate development and cancer
    Cory Abate Shen; Fiscal Year: 2003
    ..1 protein expression. These mice will provide a valuable model for exploring the reversibility of prostate carcinogenesis in vivo. ..
  10. GENE EXPRESSION IN MURINE NEUROGENESIS--HOX 7.1
    Cory Abate Shen; Fiscal Year: 1992
    ..1 in the regulation of gene expression in the developing murine CNS and will also provide general insight into the molecular mechanisms that control gene transcription during mammalian neurogenesis...
  11. GENE EXPRESSION IN NEUROGENESIS--HOX 7.1
    Cory Abate Shen; Fiscal Year: 1993
    ..1 in the regulation of gene expression in the developing murine CNS and will also provide general insight into the molecular mechanisms that control gene transcription during mammalian neurogenesis...
  12. Roles of Nkx3.1 in prostate development and cancer
    Cory Abate Shen; Fiscal Year: 2007
    ..1 protein expression. These mice will provide a valuable model for exploring the reversibility of prostate carcinogenesis in vivo. ..
  13. Modeling androgen-independent prostate cancer in mutant mice
    Cory Abate Shen; Fiscal Year: 2009
    ..Therefore, it is of the utmost clinical significance to understand the evolution of androgen-independent prostate cancer and to delineate the underlying molecular pathways. ..
  14. Roles for MSX1 in vertebrate embryogenesis
    Cory Abate Shen; Fiscal Year: 2007
    ..Taken together, our focused analyses of Msx homeoproteins will provide general paradigms for addressing the functional specificities of other homeoproteins in vivo. ..
  15. Roles for MSX1 in vertebrate embryogenesis
    Cory Abate Shen; Fiscal Year: 2007
    ..Taken together, our focused analyses of Msx homeoproteins will provide general paradigms for addressing the functional specificities of other homeoproteins in vivo. ..
  16. Roles of Nkx3.1 in prostate development and cancer
    Cory Abate Shen; Fiscal Year: 2007
    ..1 protein expression. These mice will provide a valuable model for exploring the reversibility of prostate carcinogenesis in vivo. ..
  17. Roles of Nkx3.1 in prostate development and cancer
    Cory Abate Shen; Fiscal Year: 2006
    ..1 protein expression. These mice will provide a valuable model for exploring the reversibility of prostate carcinogenesis in vivo. ..
  18. MSXL (HOX 7.1) IN MURINE EMBRYOGENESIS
    Cory Abate Shen; Fiscal Year: 2000
    ..More useful for the present proposal is her observation that injection at stage 17 blocks differentiation of feather follicles. Abate proposes to develop this overexpression phenotype as a quantitative assay for function. ..
  19. NKX31 AND PROSTATE DEVELOPMENT AND CANCER
    Cory Abate Shen; Fiscal Year: 2000
    ..1 in development will be analyzed by investigating its role in the male urogenital system, by examining its cell autonomy, and its over-expression in reconstituted prostatic tissue. ..
  20. MSXL (HOX 7.1) IN MURINE EMBRYOGENESIS
    Cory Abate Shen; Fiscal Year: 2001
    ..More useful for the present proposal is her observation that injection at stage 17 blocks differentiation of feather follicles. Abate proposes to develop this overexpression phenotype as a quantitative assay for function. ..
  21. NKX31 AND PROSTATE DEVELOPMENT AND CANCER
    Cory Abate Shen; Fiscal Year: 2001
    ..1 in development will be analyzed by investigating its role in the male urogenital system, by examining its cell autonomy, and its over-expression in reconstituted prostatic tissue. ..
  22. Modeling androgen-independent prostate cancer in mutant mice
    Cory Abate Shen; Fiscal Year: 2010
    ..Therefore, it is of the utmost clinical significance to understand the evolution of androgen-independent prostate cancer and to delineate the underlying molecular pathways. ..