Ying Zhang

Summary

Affiliation: Colorado State University
Country: USA

Publications

  1. ncbi request reprint Signaling by the Mpl receptor involves IKK and NF-kappaB
    Ying Zhang
    Department of Biochemistry, Whitaker Cardiovascular Institute, Cancer Research Center, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Cell Biochem 85:523-35. 2002
  2. pmc Phosphatidylinositol 3-kinase/protein kinase Czeta-induced phosphorylation of Sp1 and p107 repressor release have a critical role in histone deacetylase inhibitor-mediated derepression [corrected] of transcription of the luteinizing hormone receptor gene
    Ying Zhang
    Section on Molecular Endocrinology, Endocrinology and Reproduction Research Branch, National Institute of Child Health and Human Development NIH, 49 Convent Drive MSC 4510, Bethesda, MD 20892 4510, USA
    Mol Cell Biol 26:6748-61. 2006
  3. doi request reprint Deficiencies of double-strand break repair factors and effects on mutagenesis in directly gamma-irradiated and medium-mediated bystander human lymphoblastoid cells
    Ying Zhang
    Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, Colorado, USA
    Radiat Res 169:197-206. 2008
  4. ncbi request reprint The effects of NBS1 knockdown by small interfering RNA on the ionizing radiation-induced apoptosis in human lymphoblastoid cells with different p53 status
    Ying Zhang
    Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO 80523, USA
    Toxicol Lett 171:50-9. 2007
  5. ncbi request reprint NBS1 knockdown by small interfering RNA increases ionizing radiation mutagenesis and telomere association in human cells
    Ying Zhang
    Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, Colorado 80523, USA
    Cancer Res 65:5544-53. 2005
  6. ncbi request reprint Partial deficiency of DNA-PKcs increases ionizing radiation-induced mutagenesis and telomere instability in human cells
    Ying Zhang
    Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO 80521, USA
    Cancer Lett 250:63-73. 2007
  7. ncbi request reprint The role of NBS1 in DNA double strand break repair, telomere stability, and cell cycle checkpoint control
    Ying Zhang
    Department of Environmental and Radiological Health Science, Colorado State University, Fort Collins, 80523, USA
    Cell Res 16:45-54. 2006
  8. pmc High level glucose increases mutagenesis in human lymphoblastoid cells
    Ying Zhang
    Department of Environmental, Radiological Health Science, Colorado State University, Fort Collins, Colorado 80521, USA
    Int J Biol Sci 3:375-9. 2007
  9. pmc The role of NBS1 in the modulation of PIKK family proteins ATM and ATR in the cellular response to DNA damage
    Junqing Zhou
    Department of Environmental and Radiological Health Science, Colorado State University, Fort Collins, CO 80521, USA
    Cancer Lett 243:9-15. 2006
  10. pmc Ionizing radiation-induced bystander mutagenesis and adaptation: quantitative and temporal aspects
    Ying Zhang
    Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO 80523, USA
    Mutat Res 671:20-5. 2009

Collaborators

Detail Information

Publications63

  1. ncbi request reprint Signaling by the Mpl receptor involves IKK and NF-kappaB
    Ying Zhang
    Department of Biochemistry, Whitaker Cardiovascular Institute, Cancer Research Center, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Cell Biochem 85:523-35. 2002
    ....
  2. pmc Phosphatidylinositol 3-kinase/protein kinase Czeta-induced phosphorylation of Sp1 and p107 repressor release have a critical role in histone deacetylase inhibitor-mediated derepression [corrected] of transcription of the luteinizing hormone receptor gene
    Ying Zhang
    Section on Molecular Endocrinology, Endocrinology and Reproduction Research Branch, National Institute of Child Health and Human Development NIH, 49 Convent Drive MSC 4510, Bethesda, MD 20892 4510, USA
    Mol Cell Biol 26:6748-61. 2006
    ..These studies have revealed a novel mechanism of TSA action through derecruitment of a repressor from the LHR gene promoter in a PI3K/PKCzeta-induced Sp1 phosphorylation-dependent manner...
  3. doi request reprint Deficiencies of double-strand break repair factors and effects on mutagenesis in directly gamma-irradiated and medium-mediated bystander human lymphoblastoid cells
    Ying Zhang
    Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, Colorado, USA
    Radiat Res 169:197-206. 2008
    ..Studies with extracellular catalase confirmed the involvement of H2O2 in bystander signaling. Our results demonstrate that DSB repair factors have different roles in mediating mutagenesis in irradiated and bystander cells...
  4. ncbi request reprint The effects of NBS1 knockdown by small interfering RNA on the ionizing radiation-induced apoptosis in human lymphoblastoid cells with different p53 status
    Ying Zhang
    Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO 80523, USA
    Toxicol Lett 171:50-9. 2007
    ..The impaired apoptosis response to DNA damage in NBS1 deficient cells might be one of the important mechanisms of cancer predisposition in NBS patients...
  5. ncbi request reprint NBS1 knockdown by small interfering RNA increases ionizing radiation mutagenesis and telomere association in human cells
    Ying Zhang
    Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, Colorado 80523, USA
    Cancer Res 65:5544-53. 2005
    ....
  6. ncbi request reprint Partial deficiency of DNA-PKcs increases ionizing radiation-induced mutagenesis and telomere instability in human cells
    Ying Zhang
    Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO 80521, USA
    Cancer Lett 250:63-73. 2007
    ..Taken together, our results suggest that even partial deficiency of DNA repair proteins may represent a considerable risk to genomic stability...
  7. ncbi request reprint The role of NBS1 in DNA double strand break repair, telomere stability, and cell cycle checkpoint control
    Ying Zhang
    Department of Environmental and Radiological Health Science, Colorado State University, Fort Collins, 80523, USA
    Cell Res 16:45-54. 2006
    ..Emphasis is placed on the role of NBS1 in the DNA double strand repair, modulation of the DNA damage sensing and signaling, cell cycle checkpoint control and maintenance of telomere stability...
  8. pmc High level glucose increases mutagenesis in human lymphoblastoid cells
    Ying Zhang
    Department of Environmental, Radiological Health Science, Colorado State University, Fort Collins, Colorado 80521, USA
    Int J Biol Sci 3:375-9. 2007
    ..This study is the first to indicate that HG is able to induce gene mutation which may be one of the important mechanisms of diabetes-associated carcinogenesis...
  9. pmc The role of NBS1 in the modulation of PIKK family proteins ATM and ATR in the cellular response to DNA damage
    Junqing Zhou
    Department of Environmental and Radiological Health Science, Colorado State University, Fort Collins, CO 80521, USA
    Cancer Lett 243:9-15. 2006
    ..In this mini-review, we would emphasize the requirement of NBS1 as an upstream mediator for the modulation of PIKK family proteins ATM and ATR...
  10. pmc Ionizing radiation-induced bystander mutagenesis and adaptation: quantitative and temporal aspects
    Ying Zhang
    Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO 80523, USA
    Mutat Res 671:20-5. 2009
    ....
  11. ncbi request reprint Wild-type p53 reduces radiation hypermutability in p53-mutated human lymphoblast cells
    Qinming Zhang
    Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO 80523, USA
    Mutagenesis 22:329-34. 2007
    ..These results indicate that wild-type p53 can reduce the apparent gain-of-function hypermutable effects of a particular p53 gene mutation and thereby help maintain genomic stability...
  12. ncbi request reprint Cell cycle dependent apoptosis and cell cycle blocks induced by hyperthermia in HL-60 cells
    Chang Uk Lim
    Cell and Molecular Biology Graduate Program, Colorado State University, Fort Collins, CO 80523, USA
    Int J Hyperthermia 22:77-91. 2006
    ..0 degrees C. Survival based on a clonogenic assay was much lower than survival based only on apoptotic index at all times for HL-60 cells. HWC-2 cells did not undergo apoptosis and also had a higher clonogenic survival than HL-60 cells...
  13. ncbi request reprint The notch regulator MAML1 interacts with p53 and functions as a coactivator
    Yongtong Zhao
    Division of Cancer Biology, Department of Medicine, ENH Research Institute, Feinberg School of Medicine, Northwestern University, Evanston, Illinois 60201, USA
    J Biol Chem 282:11969-81. 2007
    ..elegans p53 homolog Cep-1. Thus, we present evidence for a novel coactivator function of MAML1 for p53, independent of its function as a coactivator of Notch signaling pathway...
  14. ncbi request reprint TTK kinase is essential for the centrosomal localization of TACC2
    Zhen Dou
    Hefei National Laboratory for Physical Sciences at Micro scale, Hefei 230027, China
    FEBS Lett 572:51-6. 2004
    ..The inter-relationship between TTK and TACC2 established here provides new avenue to study centrosome and spindle dynamics underlying cell divisional control...
  15. ncbi request reprint Dividing roles of prion protein in staurosporine-mediated apoptosis
    Ying Zhang
    Institute of Basic Medical Sciences, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100005, People s Republic of China
    Biochem Biophys Res Commun 349:759-68. 2006
    ..Together, our data suggest that physiological level of endogenous PrPC plays a protective role against STS-mediated cellular stress. Loss of this protection could render cells more prone to cellular insults such as STS...
  16. ncbi request reprint Coordinated regulation of AIB1 transcriptional activity by sumoylation and phosphorylation
    Huijian Wu
    Department of Biochemistry and Molecular Biology, Peking University Health Science Center, 38 Xue Yuan Road, Beijing 100083, China
    J Biol Chem 281:21848-56. 2006
    ....
  17. ncbi request reprint Dynamic interactions of cortactin and membrane type 1 matrix metalloproteinase at invadopodia: defining the stages of invadopodia formation and function
    Vira V Artym
    Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical School, Washington, District of Columbia 20057 1469, USA
    Cancer Res 66:3034-43. 2006
    ..Based on these results, we propose a stepwise model of invadopodia formation and function...
  18. ncbi request reprint Alpha 1,3-fucosyltransferase-VII regulates the signaling molecules of the insulin receptor pathway
    Qiu Yan Wang
    Key Laboratory of Glycoconjugate Research, Shanghai Medical College, Fudan University, Shanghai, China
    FEBS J 274:526-38. 2007
    ..These effects are likely mediated by its product, SLe(x), on the glycans of the InR. This is the first study to report that changes in the terminal structure of glycans on a surface receptor can modify cell signaling...
  19. ncbi request reprint Allelic expression imbalance of human mu opioid receptor (OPRM1) caused by variant A118G
    Ying Zhang
    Program in Pharmacogenomics, Department of Pharmacology, College of Medicine and Public Health, The Ohio State University, Columbus, Ohio 43210, USA
    J Biol Chem 280:32618-24. 2005
    ..Clarifying the functional relevance of polymorphisms associated with susceptibility to a complex disorder such as drug addiction provides a foundation for clinical association studies...
  20. ncbi request reprint Stable inhibition of hepatitis B virus expression and replication by expressed siRNA
    Guang Li Ren
    The State Key Discipline and Diagnosis and Treatment Center of Infectious Diseases of Chinese People Liberation Army, Tang Du Hospital, Fourth Military Medical University, Xin Yi Road, Fang Zhi District, Xi an 710038, China
    Biochem Biophys Res Commun 335:1051-9. 2005
    ..In conclusion, the specific siRNA can knock down the HBV gene expression and replication in vitro, and the silence effects have no relationship with interferon response...
  21. ncbi request reprint Bcl-xL overexpression restricts gamma-radiation-induced apoptosis
    Zi Bing Wang
    Department of Immunology, Beijing Institute of Radiation Medicine, 27 Taiping Road, 100850 Beijing, China
    Cell Biol Int 30:15-20. 2006
    ..These results possess a vital significance for insights into a new strategy for gene therapy of radiation-induced immune injury...
  22. ncbi request reprint Human aurora-B binds to a proteasome alpha-subunit HC8 and undergoes degradation in a proteasome-dependent manner
    Fengjue Shu
    State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Science, Fudan University, Shanghai, PR China
    Mol Cell Biochem 254:157-62. 2003
    ..The Aurora-B protein level increased in HeLa cells cultured with proteasome inhibitor ALLN. Our data suggest that Aurora-B might undergo degradation by binding to HC8 in a proteasome-dependent manner during mitosis...
  23. ncbi request reprint Crystal structure of a Rad51 filament
    Adam B Conway
    Department of Biochemistry and Molecular Biology, The University of Chicago, 920 East 58th Street, Chicago, Illinois 60637, USA
    Nat Struct Mol Biol 11:791-6. 2004
    ..Additionally, we show that mutation of His352, which lies at this new interface, markedly disrupts DNA binding...
  24. ncbi request reprint Silencing of transcription of the human luteinizing hormone receptor gene by histone deacetylase-mSin3A complex
    Ying Zhang
    Section on Molecular Endocrinology, Endocrinology and Reproduction Research Branch, NICHD, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 277:33431-8. 2002
    ....
  25. ncbi request reprint Apoptosis of mortal human fibroblasts transformed by the bovine papillomavirus E5 oncoprotein
    Ying Zhang
    Center for Immunology and Microbial Disease, Albany Medical College, Albany, NY 12208, USA
    Mol Cancer Res 1:122-36. 2002
    ..Thus, an atypical apoptotic pathway is activated in mortal human fibroblasts in response to transformation induced by sustained receptor tyrosine kinase activation...
  26. ncbi request reprint Insulin/protein kinase B signalling pathway upregulates metastasis-related phenotypes and molecules in H7721 human hepatocarcinoma cell line
    Hui Ling Qi
    Department of Biochemistry, Shanghai Medical College of Fu Dan University, Shanghai, China
    Eur J Biochem 270:3795-805. 2003
    ..Taken together, the insulin/PKB signalling pathway participated in the enhancement of metastatic potential of H7721 cells, which was mediated by the upregulation of the expression of SLe(x) and alpha-1,3 FucT-VII...
  27. pmc Transcriptional repression of c-Myb and GATA-2 is involved in the biologic effects of C/EBPalpha in p210BCR/ABL-expressing cells
    Angela Rachele Soliera
    Department of Cancer Biology, Kimmel Cancer Center, Thomas Jefferson Medical College, Philadelphia, PA 19107, USA
    Blood 112:1942-50. 2008
    ..Since perturbation of c-Myb and GATA-2 expression has nonidentical consequences for proliferation and differentiation of K562 cells, the effects of C/EBPalpha appear to involve dif-ferent transcription-regulated targets...
  28. ncbi request reprint Forskolin up-regulates metastasis-related phenotypes and molecules via protein kinase B, but not PI-3K, in H7721 human hepato-carcinoma cell line
    Shi liang WU
    Key Laboratory of Glycoconjugate Research, Ministry of Health, Department of Biochemistry, Shanghai Medical College of Fu Dan University, Shanghai, China
    Mol Cell Biochem 254:193-202. 2003
    ..It can be concluded that FSK shows a metastasis-promoting effect ex vivo...
  29. doi request reprint alpha1,3 fucosyltransferase-VII up-regulates the mRNA of alpha5 integrin and its biological function
    Qiu Yan Wang
    Key Laboratory of Glycoconjugate Research, Ministry of Health, Department of Biochemistry, Shanghai Medical College, Fudan University, Shanghai 200032, China
    J Cell Biochem 104:2078-90. 2008
    ..This is the first time to report that alpha1,3FucT-VII can regulate the mRNA expression of integrin...
  30. doi request reprint Phosphorylation of eIF-4E positively regulates formation of the eIF-4F translation initiation complex following DNA damage
    Ying Zhang
    The Division of Basic Biomedical Sciences, University of South Dakota, Sanford School of Medicine, 414 E Clark Street, Lee Medical Building, Vermillion, SD 57069, USA
    Biochem Biophys Res Commun 367:54-9. 2008
    ..Our results provide the first evidence indicating that phosphorylation of eIF-4E by Mnk, possibly mediated by JNK or JNK-like kinases, is critical for formation of the translational initiation complex eIF-4F following DNA damage...
  31. ncbi request reprint [Adenovirus-delivered tissue inhibitor of metalloproteinases-3 transfection increases the sensitivity of cervical cancer cells to cisplatin]
    Ying Zhang
    Beijing Obstetrics and Gynecologic Hospital, Capital Medical University, Beijing 100006, China
    Zhonghua Zhong Liu Za Zhi 29:25-9. 2007
    ....
  32. ncbi request reprint Reactive oxygen species, but not mitochondrial membrane potential, is associated with radiation-induced apoptosis of AHH-1 human lymphoblastoid cells
    Zi Bing Wang
    Department of Immunology, Beijing Institute of Radiation Medicine, 27 Taiping Road, Beijing 100850, P R China
    Cell Biol Int 31:1353-8. 2007
    ..Moreover, the results might cast doubts on those studies using Rhodamine 123 which hypothesized that the fall in MMP is one of the early events of apoptosis...
  33. ncbi request reprint SCC-112, a novel cell cycle-regulated molecule, exhibits reduced expression in human renal carcinomas
    Deepak Kumar
    Department of Radiation Medicine, Lombardi Cancer Center, Georgetown University, E208, Research Building, 3970 Reservoir Road, NW, Washington, DC 20007, USA
    Gene 328:187-96. 2004
    ..2-fold to>10-fold, n=18). Taken together, these findings suggest that the SCC-112 gene expression is likely to be associated with normal cell growth and proliferation...
  34. ncbi request reprint Long-chain fatty acyl-coenzyme A-induced inhibition of glucokinase in pancreatic islets from rats depleted in long-chain polyunsaturated omega3 fatty acids
    Ying Zhang
    Laboratories of Experimental Hormonology and Surgery, Brussels Free University, Brussels, Belgium
    Cell Biochem Funct 26:233-7. 2008
    ....
  35. pmc SIP, a novel ankyrin repeat containing protein, sequesters steroid receptor coactivators in the cytoplasm
    Ying Zhang
    Department of Biochemistry and Molecular Biology, Peking University Health Science Center, Beijing, China
    EMBO J 26:2645-57. 2007
    ....
  36. pmc Unlocking repression of the human luteinizing hormone receptor gene by trichostatin A-induced cell-specific phosphatase release
    Ying Zhang
    Section on Molecular Endocrinology, Endocrinology and Reproduction Research Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development NIH, 49 Convent Drive, Bethesda, MD 20892 4510, USA
    J Biol Chem 283:24039-46. 2008
    ....
  37. pmc Disruption of sarcolemmal ATP-sensitive potassium channel activity impairs the cardiac response to systolic overload
    Xinli Hu
    Cardiovascular Division, Department of Medicine, Universityof Minnesota Medical School, Minneapolis, MN 55455, USA
    Circ Res 103:1009-17. 2008
    ..These data indicate that K(ATP) channels facilitate the cardiac response to stress by regulating PGC-1alpha and its target genes, at least partially through the FOXO1 pathway...
  38. pmc The catalytic subunit of the proteasome is engaged in the entire process of estrogen receptor-regulated transcription
    Hua Zhang
    Department of Biochemistry and Molecular Biology, Peking University Health Science Center, Beijing, China
    EMBO J 25:4223-33. 2006
    ..These results revealed a mechanism by which the proteasome machinery is recruited in ER-mediated gene transcription. Our experiments also provided evidence implicating SRC coactivators in gene transcription elongation...
  39. pmc Integration of estrogen and Wnt signaling circuits by the polycomb group protein EZH2 in breast cancer cells
    Bin Shi
    Department of Biochemistry and Molecular Biology, Peking University Health Science Center, 38 Xue Yuan Road, Beijing 100083, China
    Mol Cell Biol 27:5105-19. 2007
    ..Our experiments indicated that EZH2 is a dual function transcription regulator with a dynamic activity, and we provide a mechanism for EZH2 in tumorigenesis...
  40. pmc Activation of the PTEN/mTOR/STAT3 pathway in breast cancer stem-like cells is required for viability and maintenance
    Jiangbing Zhou
    Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 104:16158-63. 2007
    ..This study suggests the existence of prosurvival signaling pathways critical for cancer stem-like cell maintenance, which could be selectively targeted for inhibiting cancer stem-like cells for improved treatment...
  41. ncbi request reprint Alpha1,3 Fucosyltransferase-VII modifies the susceptibility of apoptosis induced by ultraviolet and retinoic acid in human hepatocarcinoma cells
    Hao Wang
    Key Laboratory of Glycoconjugate Research, Ministry of Health, Department of Biochemistry, Shanghai Medical College, Fudan University, Shanghai, 200032, People s Republic of China
    Glycoconj J 24:207-20. 2007
    ....
  42. ncbi request reprint Proliferation, viability, and metabolism of human tumor and normal cells cultured in microcapsule
    Xulang Zhang
    Laboratory of Biomedical Material Engineering, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian 116023, China
    Appl Biochem Biotechnol 134:61-76. 2006
    ..In addition, it lays a solid foundation for the use of microencapsulation in cell culture in vitro and cell implantation in vivo...
  43. ncbi request reprint [Apoptosis and modulatory mechanism of human AHH-1 T lymphocytes induced by gamma-irradiation]
    Yu fang Cui
    Department of Immunology, Institute of Radiation Medicine, Beijing 100850, China
    Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 20:39-41. 2004
    ..To explore the apoptotic characteristics and modulatory mechanism of human AHH-1 T lymphoblast induced by ionizing radiation and provide an experimental basis for preventing and treating immune damage in acute radiation sickness...
  44. ncbi request reprint Effect of N-acetylglucosaminyltransferase V on the expressions of other glycosyltransferases
    Peng Guo
    Key Laboratory of Glycoconjugate Research, Ministry of Health, Department of Biochemistry, Shanghai Medical College, Fudan University, Shanghai 200032, PR China
    FEBS Lett 562:93-8. 2004
    ..However, it did not cause the increase of SLe(x) synthesis. Transfection of antisense GnTV into H7721 cells showed entirely opposite effects on the expression of above-mentioned SLe(x) and glycosyltransferases as the sense GnTV...
  45. ncbi request reprint [CIK cells acquired multidrug resistance and maintained cytotoxic activity to tumor cells after mdr1 gene transfection]
    Yong hong Yang
    Beijing University First Hospital, Beijing 100034, China
    Zhonghua Xue Ye Xue Za Zhi 24:617-20. 2003
    ..To investigate whether the cytokine-induced killer (CIK) cells could acquire multidrug resistance and maintain the original cytotoxic activity after multidrug resistance (mdr1) genes transfection...
  46. ncbi request reprint Aberrant quantity and localization of Aurora-B/AIM-1 and survivin during megakaryocyte polyploidization and the consequences of Aurora-B/AIM-1-deregulated expression
    Ying Zhang
    Department of Biochemistry, Boston University School of Medicine, 715 Albany St, K225, Boston, MA 02118
    Blood 103:3717-26. 2004
    ..Future studies will examine the impact of survivin restoration on mouse megakaryocyte polyploidization...
  47. ncbi request reprint Potent, selective and cell-mediated inhibition of human herpesvirus 6 at an early stage of viral replication by the non-nucleoside compound CMV423
    Leen De Bolle
    Rega Institute for Medical Research, Katholieke Universiteit Leuven, 3000, Leuven, Belgium
    Biochem Pharmacol 67:325-36. 2004
    ..We, therefore, conclude that CMV423 exerts its activity against HHV-6 through inhibition of a cellular process that is critical at early stages of viral replication and that may affect protein tyrosine kinase activity...
  48. ncbi request reprint Stat5a is tyrosine phosphorylated and nuclear localized in a high proportion of human breast cancers
    Ion Cotarla
    Department of Oncology, Georgetown University, Washington, DC 20057, USA
    Int J Cancer 108:665-71. 2004
    ..As its role in human breast cancer progression and response to therapy is defined, Stat5a could become a new molecular target for breast cancer therapy...
  49. ncbi request reprint Phosphorylation of threonine 276 in Smad4 is involved in transforming growth factor-beta-induced nuclear accumulation
    Bernard A J Roelen
    Program in Membrane Biology and Renal Unit, Massachusetts General Hospital, and Department of Medicine, Harvard Medical School, Charlestown, MA 02129, USA
    Am J Physiol Cell Physiol 285:C823-30. 2003
    ..Our results suggest that MAP kinase can phosphorylate Thr276 of Smad4 and that phosphorylation can lead to enhanced TGF-beta-induced nuclear accumulation and, as a consequence, enhanced transcriptional activity of Smad4...
  50. ncbi request reprint Gene expression profile of human endothelial cells exposed to sustained fluid shear stress
    Scott M Wasserman
    Millennium Pharmaceuticals, Inc, South San Francisco 94080, USA
    Physiol Genomics 12:13-23. 2002
    ..Thus these data identify a limited set of flow-responsive genes expressed in the endothelium that may be responsible for the establishment and maintenance of the flow-adapted endothelial phenotype in vivo...
  51. ncbi request reprint Dissimilar effects of D-mannoheptulose on the phosphorylation of alpha- versus beta-D-glucose by either hexokinase or glucokinase
    Ying Zhang
    Laboratory of Experimental Hormonology, Brussels Free University, 808 Route de Lennik, B 1070 Brussels, Belgium
    Int J Mol Med 14:107-12. 2004
    ..These findings thus document anomeric specificity in terms of the inhibitory action of D-mannoheptulose upon alpha- versus beta-D-glucose phosphorylation by either hexokinase or glucokinase...
  52. ncbi request reprint Relations of the type and branch of surface N-glycans to cell adhesion, migration and integrin expressions
    Ying Zhang
    Key Laboratory of Glycoconjugate Research, Ministry of Health, Department of Biochemistry, School of Medicine, Fudan University, Shanghai, China
    Mol Cell Biochem 260:137-46. 2004
    ..This findings suggest that both the structure of N-glycan and the expression of integrin on cell surface are two of the important factors in the determination of cell adhesion to Fn, a complex biological process...
  53. ncbi request reprint Activation of signal transducer and activator of transcription 5 in human prostate cancer is associated with high histological grade
    Hongzhen Li
    Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, NRB E508, 3970 Reservoir Road NW, Washington, DC 20057, USA
    Cancer Res 64:4774-82. 2004
    ..The results further suggest that Jak2 is the principal Stat5 tyrosine kinase in human prostate cancer, possibly activated by autocrine/paracrine Prl...
  54. ncbi request reprint Role of CDK5 in neuroprotection from serum deprivation by mu-opioid receptor agonist
    Ying Wang
    Neuroscience Research Institute and Department of Neurobiology, Key Laboratory for Neuroscience, Peking University, 38 Xueyuan Rd, Beijing 100083, PR China
    Exp Neurol 202:313-23. 2006
    ....
  55. ncbi request reprint Repression of cap-dependent translation attenuates the transformed phenotype in non-small cell lung cancer both in vitro and in vivo
    Blake A Jacobson
    Department of Medicine, University of Minnesota, Minneapolis 55455, USA
    Cancer Res 66:4256-62. 2006
    ....
  56. ncbi request reprint Morphine promotes Jurkat cell apoptosis through pro-apoptotic FADD/P53 and anti-apoptotic PI3K/Akt/NF-kappaB pathways
    Deling Yin
    Department of Internal Medicine, James Quillen College of Medicine, East Tennessee State University, P O Box 70622, Johnson City, TN 37614, United States
    J Neuroimmunol 174:101-7. 2006
    ..Our study thus demonstrates that morphine induces Jurkat cell apoptosis through FADD/p53, anti-apoptotic PI3K/Akt and NF-kappaB pathways...
  57. ncbi request reprint Fructokinase activity in rat liver, ileum, parotid gland, pancreas, pancreatic islet, B and non-B islet cell homogenates
    Marie Helene Giroix
    Laboratory of Nutrition Physiopathology, CNRS UMR 7059, University of Paris 7, France
    Int J Mol Med 17:517-22. 2006
    ..Relative to paired hexokinase activity, no obvious difference was found for fructokinase activity in B versus non-B islet cells...
  58. ncbi request reprint Microarray-based pncA genotyping of pyrazinamide-resistant strains of Mycobacterium tuberculosis
    Steven Denkin
    Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland 21205, USA
    J Med Microbiol 54:1127-31. 2005
    ..It is concluded that the microarray method is a valuable tool for the rapid screening and genetic identification of potential PZA-resistant M. tuberculosis strains...
  59. ncbi request reprint Recognition and ubiquitination of Salmonella type III effector SopA by a ubiquitin E3 ligase, HsRMA1
    Ying Zhang
    Department of Biological Sciences, Purdue University, West Lafayette, Indiana 47907, USA
    J Biol Chem 280:38682-8. 2005
    ..Our data suggest that efficient bacterial escape into the cytosol of epithelial cells requires HsRMA1-mediated SopA ubiquitination and contributes to Salmonella-induced enteropathogenicity...
  60. ncbi request reprint Inhibiting the expression of CD28 costimulatory molecule on human lymphocytes by special siRNA
    Kai Lin Xu
    Department of Hematology, Affiliated Hospital of Xuzhou Medical College, Xuzhou 221002, China
    Chin Med J (Engl) 118:480-6. 2005
    ..In this study, we investigated the RNA interference (RNAi) effect induced by small interfering RNA (siRNA) targeting CD28 mRNA on human lymphocytes and its specificity...
  61. ncbi request reprint The nuclear receptor coactivator AIB1 mediates insulin-like growth factor I-induced phenotypic changes in human breast cancer cells
    Annabell Oh
    Department of Oncology, Vincent T Lombardi Cancer Center, Georgetown University, Washington, District of Columbia 20057, USA
    Cancer Res 64:8299-308. 2004
    ..We conclude that AIB1 is required for IGF-I-induced proliferation, signaling, cell survival, and gene expression in human breast cancer cells, independent of its role in estrogen receptor signaling...
  62. ncbi request reprint Progressive loss of Syk and abnormal proliferation in breast cancer cells
    Maria Moroni
    Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical School, USA
    Cancer Res 64:7346-54. 2004
    ..Because of its progressive and early loss during tumor onset and development, monitoring of Syk loss in breast epithelial cells by noninvasive techniques such as ductal lavage may be a powerful tool for screening purposes...
  63. ncbi request reprint Development of anti-tumor immunity against a non-immunogenic mammary carcinoma through in vivo somatic GM-CSF, IL-2, and HSVtk combination gene therapy
    Dirk G Brockstedt
    Aventis Gencell, 3825 Bay Center Place, Hayward, California 94520, USA
    Mol Ther 6:627-36. 2002
    ..These data indicate that the coexpression of GM-CSF and IL-2 can augment the effect of HSVtk suicide gene therapy...