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Species | Ying ZhangSummaryAffiliation: Colorado State University Country: USA Publications
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Publications
Phosphatidylinositol 3-kinase/protein kinase Czeta-induced phosphorylation of Sp1 and p107 repressor release have a critical role in histone deacetylase inhibitor-mediated derepression [corrected] of transcription of the luteinizing hormone receptor geneYing Zhang
Section on Molecular Endocrinology, Endocrinology and Reproduction Research Branch, National Institute of Child Health and Human Development NIH, 49 Convent Drive MSC 4510, Bethesda, MD 20892 4510, USA
Mol Cell Biol 26:6748-61. 2006..These studies have revealed a novel mechanism of TSA action through derecruitment of a repressor from the LHR gene promoter in a PI3K/PKCzeta-induced Sp1 phosphorylation-dependent manner...
Signaling by the Mpl receptor involves IKK and NF-kappaBYing Zhang
Department of Biochemistry, Whitaker Cardiovascular Institute, Cancer Research Center, Boston University School of Medicine, Boston, Massachusetts 02118, USA
J Cell Biochem 85:523-35. 2002....
Deficiencies of double-strand break repair factors and effects on mutagenesis in directly gamma-irradiated and medium-mediated bystander human lymphoblastoid cellsYing Zhang
Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, Colorado, USA
Radiat Res 169:197-206. 2008..Studies with extracellular catalase confirmed the involvement of H2O2 in bystander signaling. Our results demonstrate that DSB repair factors have different roles in mediating mutagenesis in irradiated and bystander cells...- The effects of NBS1 knockdown by small interfering RNA on the ionizing radiation-induced apoptosis in human lymphoblastoid cells with different p53 statusYing Zhang
Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO 80523, USA
Toxicol Lett 171:50-9. 2007..The impaired apoptosis response to DNA damage in NBS1 deficient cells might be one of the important mechanisms of cancer predisposition in NBS patients... - NBS1 knockdown by small interfering RNA increases ionizing radiation mutagenesis and telomere association in human cellsYing Zhang
Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, Colorado 80523, USA
Cancer Res 65:5544-53. 2005.... - Partial deficiency of DNA-PKcs increases ionizing radiation-induced mutagenesis and telomere instability in human cellsYing Zhang
Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO 80521, USA
Cancer Lett 250:63-73. 2007..Taken together, our results suggest that even partial deficiency of DNA repair proteins may represent a considerable risk to genomic stability... - The role of NBS1 in DNA double strand break repair, telomere stability, and cell cycle checkpoint controlYing Zhang
Department of Environmental and Radiological Health Science, Colorado State University, Fort Collins, 80523, USA
Cell Res 16:45-54. 2006..Emphasis is placed on the role of NBS1 in the DNA double strand repair, modulation of the DNA damage sensing and signaling, cell cycle checkpoint control and maintenance of telomere stability... - High level glucose increases mutagenesis in human lymphoblastoid cellsYing Zhang
Department of Environmental, Radiological Health Science, Colorado State University, Fort Collins, Colorado 80521, USA
Int J Biol Sci 3:375-9. 2007..This study is the first to indicate that HG is able to induce gene mutation which may be one of the important mechanisms of diabetes-associated carcinogenesis... - The role of NBS1 in the modulation of PIKK family proteins ATM and ATR in the cellular response to DNA damageJunqing Zhou
Department of Environmental and Radiological Health Science, Colorado State University, Fort Collins, CO 80521, USA
Cancer Lett 243:9-15. 2006..In this mini-review, we would emphasize the requirement of NBS1 as an upstream mediator for the modulation of PIKK family proteins ATM and ATR... - Ionizing radiation-induced bystander mutagenesis and adaptation: quantitative and temporal aspectsYing Zhang
Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO 80523, USA
Mutat Res 671:20-5. 2009.... - Wild-type p53 reduces radiation hypermutability in p53-mutated human lymphoblast cellsQinming Zhang
Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO 80523, USA
Mutagenesis 22:329-34. 2007..These results indicate that wild-type p53 can reduce the apparent gain-of-function hypermutable effects of a particular p53 gene mutation and thereby help maintain genomic stability... - Cell cycle dependent apoptosis and cell cycle blocks induced by hyperthermia in HL-60 cellsChang-Uk Lim
Cell and Molecular Biology Graduate Program, Colorado State University, Fort Collins, CO 80523, USA
Int J Hyperthermia 22:77-91. 2006..0 degrees C. Survival based on a clonogenic assay was much lower than survival based only on apoptotic index at all times for HL-60 cells. HWC-2 cells did not undergo apoptosis and also had a higher clonogenic survival than HL-60 cells... - The notch regulator MAML1 interacts with p53 and functions as a coactivatorYongtong Zhao
Division of Cancer Biology, Department of Medicine, ENH Research Institute, Feinberg School of Medicine, Northwestern University, Evanston, Illinois 60201, USA
J Biol Chem 282:11969-81. 2007..elegans p53 homolog Cep-1. Thus, we present evidence for a novel coactivator function of MAML1 for p53, independent of its function as a coactivator of Notch signaling pathway... - TTK kinase is essential for the centrosomal localization of TACC2Zhen Dou
Hefei National Laboratory for Physical Sciences at Micro scale, Hefei 230027, China
FEBS Lett 572:51-6. 2004..The inter-relationship between TTK and TACC2 established here provides new avenue to study centrosome and spindle dynamics underlying cell divisional control... - Dividing roles of prion protein in staurosporine-mediated apoptosisYing Zhang
Institute of Basic Medical Sciences, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100005, People s Republic of China
Biochem Biophys Res Commun 349:759-68. 2006..Together, our data suggest that physiological level of endogenous PrPC plays a protective role against STS-mediated cellular stress. Loss of this protection could render cells more prone to cellular insults such as STS... - Coordinated regulation of AIB1 transcriptional activity by sumoylation and phosphorylationHuijian Wu
Department of Biochemistry and Molecular Biology, Peking University Health Science Center, 38 Xue Yuan Road, Beijing 100083, China
J Biol Chem 281:21848-56. 2006.... - Dynamic interactions of cortactin and membrane type 1 matrix metalloproteinase at invadopodia: defining the stages of invadopodia formation and functionVira V Artym
Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical School, Washington, District of Columbia 20057-1469, USA
Cancer Res 66:3034-43. 2006..Based on these results, we propose a stepwise model of invadopodia formation and function... - Alpha 1,3-fucosyltransferase-VII regulates the signaling molecules of the insulin receptor pathwayQiu Yan Wang
Key Laboratory of Glycoconjugate Research, Shanghai Medical College, Fudan University, Shanghai, China
FEBS J 274:526-38. 2007..These effects are likely mediated by its product, SLe(x), on the glycans of the InR. This is the first study to report that changes in the terminal structure of glycans on a surface receptor can modify cell signaling... - Allelic expression imbalance of human mu opioid receptor (OPRM1) caused by variant A118GYing Zhang
Program in Pharmacogenomics, Department of Pharmacology, College of Medicine and Public Health, The Ohio State University, Columbus, Ohio 43210, USA
J Biol Chem 280:32618-24. 2005..Clarifying the functional relevance of polymorphisms associated with susceptibility to a complex disorder such as drug addiction provides a foundation for clinical association studies... - Stable inhibition of hepatitis B virus expression and replication by expressed siRNAGuang Li Ren
The State Key Discipline and Diagnosis and Treatment Center of Infectious Diseases of Chinese People Liberation Army, Tang Du Hospital, Fourth Military Medical University, Xin Yi Road, Fang Zhi District, Xi an 710038, China
Biochem Biophys Res Commun 335:1051-9. 2005..In conclusion, the specific siRNA can knock down the HBV gene expression and replication in vitro, and the silence effects have no relationship with interferon response... - Bcl-xL overexpression restricts gamma-radiation-induced apoptosisZi Bing Wang
Department of Immunology, Beijing Institute of Radiation Medicine, 27 Taiping Road, 100850 Beijing, China
Cell Biol Int 30:15-20. 2006..These results possess a vital significance for insights into a new strategy for gene therapy of radiation-induced immune injury... - Human aurora-B binds to a proteasome alpha-subunit HC8 and undergoes degradation in a proteasome-dependent mannerFengjue Shu
State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Science, Fudan University, Shanghai, PR China
Mol Cell Biochem 254:157-62. 2003..The Aurora-B protein level increased in HeLa cells cultured with proteasome inhibitor ALLN. Our data suggest that Aurora-B might undergo degradation by binding to HC8 in a proteasome-dependent manner during mitosis... - Crystal structure of a Rad51 filamentAdam B Conway
Department of Biochemistry and Molecular Biology, The University of Chicago, 920 East 58th Street, Chicago, Illinois 60637, USA
Nat Struct Mol Biol 11:791-6. 2004..Additionally, we show that mutation of His352, which lies at this new interface, markedly disrupts DNA binding... - Silencing of transcription of the human luteinizing hormone receptor gene by histone deacetylase-mSin3A complexYing Zhang
Section on Molecular Endocrinology, Endocrinology and Reproduction Research Branch, NICHD, National Institutes of Health, Bethesda, Maryland 20892, USA
J Biol Chem 277:33431-8. 2002.... - Apoptosis of mortal human fibroblasts transformed by the bovine papillomavirus E5 oncoproteinYing Zhang
Center for Immunology and Microbial Disease, Albany Medical College, Albany, NY 12208, USA
Mol Cancer Res 1:122-36. 2002..Thus, an atypical apoptotic pathway is activated in mortal human fibroblasts in response to transformation induced by sustained receptor tyrosine kinase activation... - Insulin/protein kinase B signalling pathway upregulates metastasis-related phenotypes and molecules in H7721 human hepatocarcinoma cell lineHui-Ling Qi
Department of Biochemistry, Shanghai Medical College of Fu-Dan University, Shanghai, China
Eur J Biochem 270:3795-805. 2003..Taken together, the insulin/PKB signalling pathway participated in the enhancement of metastatic potential of H7721 cells, which was mediated by the upregulation of the expression of SLe(x) and alpha-1,3 FucT-VII... - Transcriptional repression of c-Myb and GATA-2 is involved in the biologic effects of C/EBPalpha in p210BCR/ABL-expressing cellsAngela Rachele Soliera
Department of Cancer Biology, Kimmel Cancer Center, Thomas Jefferson Medical College, Philadelphia, PA 19107, USA
Blood 112:1942-50. 2008..Since perturbation of c-Myb and GATA-2 expression has nonidentical consequences for proliferation and differentiation of K562 cells, the effects of C/EBPalpha appear to involve dif-ferent transcription-regulated targets... - Forskolin up-regulates metastasis-related phenotypes and molecules via protein kinase B, but not PI-3K, in H7721 human hepato-carcinoma cell lineShi-liang Wu
Key Laboratory of Glycoconjugate Research, Ministry of Health, Department of Biochemistry, Shanghai Medical College of Fu-Dan University, Shanghai, China
Mol Cell Biochem 254:193-202. 2003..It can be concluded that FSK shows a metastasis-promoting effect ex vivo... - alpha1,3 fucosyltransferase-VII up-regulates the mRNA of alpha5 integrin and its biological functionQiu Yan Wang
Key Laboratory of Glycoconjugate Research, Ministry of Health, Department of Biochemistry, Shanghai Medical College, Fudan University, Shanghai 200032, China
J Cell Biochem 104:2078-90. 2008..This is the first time to report that alpha1,3FucT-VII can regulate the mRNA expression of integrin... - Phosphorylation of eIF-4E positively regulates formation of the eIF-4F translation initiation complex following DNA damageYing Zhang
The Division of Basic Biomedical Sciences, University of South Dakota, Sanford School of Medicine, 414 E Clark Street, Lee Medical Building, Vermillion, SD 57069, USA
Biochem Biophys Res Commun 367:54-9. 2008..Our results provide the first evidence indicating that phosphorylation of eIF-4E by Mnk, possibly mediated by JNK or JNK-like kinases, is critical for formation of the translational initiation complex eIF-4F following DNA damage... - [Adenovirus-delivered tissue inhibitor of metalloproteinases-3 transfection increases the sensitivity of cervical cancer cells to cisplatin]Ying Zhang
Beijing Obstetrics and Gynecologic Hospital, Capital Medical University, Beijing 100006, China
Zhonghua Zhong Liu Za Zhi 29:25-9. 2007.... - Reactive oxygen species, but not mitochondrial membrane potential, is associated with radiation-induced apoptosis of AHH-1 human lymphoblastoid cellsZi Bing Wang
Department of Immunology, Beijing Institute of Radiation Medicine, 27 Taiping Road, Beijing 100850, P R China
Cell Biol Int 31:1353-8. 2007..Moreover, the results might cast doubts on those studies using Rhodamine 123 which hypothesized that the fall in MMP is one of the early events of apoptosis... - SCC-112, a novel cell cycle-regulated molecule, exhibits reduced expression in human renal carcinomasDeepak Kumar
Department of Radiation Medicine, Lombardi Cancer Center, Georgetown University, E208, Research Building, 3970 Reservoir Road, NW, Washington, DC 20007, USA
Gene 328:187-96. 2004..2-fold to>10-fold, n=18). Taken together, these findings suggest that the SCC-112 gene expression is likely to be associated with normal cell growth and proliferation... - Long-chain fatty acyl-coenzyme A-induced inhibition of glucokinase in pancreatic islets from rats depleted in long-chain polyunsaturated omega3 fatty acidsYing Zhang
Laboratories of Experimental Hormonology and Surgery, Brussels Free University, Brussels, Belgium
Cell Biochem Funct 26:233-7. 2008.... - SIP, a novel ankyrin repeat containing protein, sequesters steroid receptor coactivators in the cytoplasmYing Zhang
Department of Biochemistry and Molecular Biology, Peking University Health Science Center, Beijing, China
EMBO J 26:2645-57. 2007.... - Unlocking repression of the human luteinizing hormone receptor gene by trichostatin A-induced cell-specific phosphatase releaseYing Zhang
Section on Molecular Endocrinology, Endocrinology and Reproduction Research Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development NIH, 49 Convent Drive, Bethesda, MD 20892 4510, USA
J Biol Chem 283:24039-46. 2008.... - Disruption of sarcolemmal ATP-sensitive potassium channel activity impairs the cardiac response to systolic overloadXinli Hu
Cardiovascular Division, Department of Medicine, Universityof Minnesota Medical School, Minneapolis, MN 55455, USA
Circ Res 103:1009-17. 2008..These data indicate that K(ATP) channels facilitate the cardiac response to stress by regulating PGC-1alpha and its target genes, at least partially through the FOXO1 pathway... - The catalytic subunit of the proteasome is engaged in the entire process of estrogen receptor-regulated transcriptionHua Zhang
Department of Biochemistry and Molecular Biology, Peking University Health Science Center, Beijing, China
EMBO J 25:4223-33. 2006..These results revealed a mechanism by which the proteasome machinery is recruited in ER-mediated gene transcription. Our experiments also provided evidence implicating SRC coactivators in gene transcription elongation... - Integration of estrogen and Wnt signaling circuits by the polycomb group protein EZH2 in breast cancer cellsBin Shi
Department of Biochemistry and Molecular Biology, Peking University Health Science Center, 38 Xue Yuan Road, Beijing 100083, China
Mol Cell Biol 27:5105-19. 2007..Our experiments indicated that EZH2 is a dual function transcription regulator with a dynamic activity, and we provide a mechanism for EZH2 in tumorigenesis... - Activation of the PTEN/mTOR/STAT3 pathway in breast cancer stem-like cells is required for viability and maintenanceJiangbing Zhou
Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, MD 21205, USA
Proc Natl Acad Sci U S A 104:16158-63. 2007..This study suggests the existence of prosurvival signaling pathways critical for cancer stem-like cell maintenance, which could be selectively targeted for inhibiting cancer stem-like cells for improved treatment... - Alpha1,3 Fucosyltransferase-VII modifies the susceptibility of apoptosis induced by ultraviolet and retinoic acid in human hepatocarcinoma cellsHao Wang
Key Laboratory of Glycoconjugate Research, Ministry of Health, Department of Biochemistry, Shanghai Medical College, Fudan University, Shanghai, 200032, People s Republic of China
Glycoconj J 24:207-20. 2007.... - Proliferation, viability, and metabolism of human tumor and normal cells cultured in microcapsuleXulang Zhang
Laboratory of Biomedical Material Engineering, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian 116023, China
Appl Biochem Biotechnol 134:61-76. 2006..In addition, it lays a solid foundation for the use of microencapsulation in cell culture in vitro and cell implantation in vivo... - [Apoptosis and modulatory mechanism of human AHH-1 T lymphocytes induced by gamma-irradiation]Yu fang Cui
Department of Immunology, Institute of Radiation Medicine, Beijing 100850, China
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 20:39-41. 2004..To explore the apoptotic characteristics and modulatory mechanism of human AHH-1 T lymphoblast induced by ionizing radiation and provide an experimental basis for preventing and treating immune damage in acute radiation sickness... - Effect of N-acetylglucosaminyltransferase V on the expressions of other glycosyltransferasesPeng Guo
Key Laboratory of Glycoconjugate Research, Ministry of Health, Department of Biochemistry, Shanghai Medical College, Fudan University, Shanghai 200032, PR China
FEBS Lett 562:93-8. 2004..However, it did not cause the increase of SLe(x) synthesis. Transfection of antisense GnTV into H7721 cells showed entirely opposite effects on the expression of above-mentioned SLe(x) and glycosyltransferases as the sense GnTV... - [CIK cells acquired multidrug resistance and maintained cytotoxic activity to tumor cells after mdr1 gene transfection]Yong-hong Yang
Beijing University First Hospital, Beijing 100034, China
Zhonghua Xue Ye Xue Za Zhi 24:617-20. 2003..05). CONCLUSION: It demonstrated that CIK cells transfected with mdr1 gene via electroporation could express multidrug resistance successfully without changes of cytotoxic activity... - Aberrant quantity and localization of Aurora-B/AIM-1 and survivin during megakaryocyte polyploidization and the consequences of Aurora-B/AIM-1-deregulated expressionYing Zhang
Department of Biochemistry, Boston University School of Medicine, 715 Albany St, K225, Boston, MA 02118
Blood 103:3717-26. 2004..Future studies will examine the impact of survivin restoration on mouse megakaryocyte polyploidization... - Potent, selective and cell-mediated inhibition of human herpesvirus 6 at an early stage of viral replication by the non-nucleoside compound CMV423Leen De Bolle
Rega Institute for Medical Research, Katholieke Universiteit Leuven, 3000, Leuven, Belgium
Biochem Pharmacol 67:325-36. 2004..We, therefore, conclude that CMV423 exerts its activity against HHV-6 through inhibition of a cellular process that is critical at early stages of viral replication and that may affect protein tyrosine kinase activity... - Stat5a is tyrosine phosphorylated and nuclear localized in a high proportion of human breast cancersIon Cotarla
Department of Oncology, Georgetown University, Washington, DC 20057, USA
Int J Cancer 108:665-71. 2004..As its role in human breast cancer progression and response to therapy is defined, Stat5a could become a new molecular target for breast cancer therapy... - Phosphorylation of threonine 276 in Smad4 is involved in transforming growth factor-beta-induced nuclear accumulationBernard A J Roelen
Program in Membrane Biology and Renal Unit, Massachusetts General Hospital, and Department of Medicine, Harvard Medical School, Charlestown, MA 02129, USA
Am J Physiol Cell Physiol 285:C823-30. 2003..Our results suggest that MAP kinase can phosphorylate Thr276 of Smad4 and that phosphorylation can lead to enhanced TGF-beta-induced nuclear accumulation and, as a consequence, enhanced transcriptional activity of Smad4... - Gene expression profile of human endothelial cells exposed to sustained fluid shear stressScott M Wasserman
Millennium Pharmaceuticals, Inc, South San Francisco 94080, USA
Physiol Genomics 12:13-23. 2002..Thus these data identify a limited set of flow-responsive genes expressed in the endothelium that may be responsible for the establishment and maintenance of the flow-adapted endothelial phenotype in vivo... - Dissimilar effects of D-mannoheptulose on the phosphorylation of alpha- versus beta-D-glucose by either hexokinase or glucokinaseYing Zhang
Laboratory of Experimental Hormonology, Brussels Free University, 808 Route de Lennik, B 1070 Brussels, Belgium
Int J Mol Med 14:107-12. 2004..These findings thus document anomeric specificity in terms of the inhibitory action of D-mannoheptulose upon alpha- versus beta-D-glucose phosphorylation by either hexokinase or glucokinase... - Relations of the type and branch of surface N-glycans to cell adhesion, migration and integrin expressionsYing Zhang
Key Laboratory of Glycoconjugate Research, Ministry of Health, Department of Biochemistry, School of Medicine, Fudan University, Shanghai, China
Mol Cell Biochem 260:137-46. 2004..This findings suggest that both the structure of N-glycan and the expression of integrin on cell surface are two of the important factors in the determination of cell adhesion to Fn, a complex biological process... - Activation of signal transducer and activator of transcription 5 in human prostate cancer is associated with high histological gradeHongzhen Li
Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, NRB E508, 3970 Reservoir Road NW, Washington, DC 20057, USA
Cancer Res 64:4774-82. 2004..The results further suggest that Jak2 is the principal Stat5 tyrosine kinase in human prostate cancer, possibly activated by autocrine/paracrine Prl... - Role of CDK5 in neuroprotection from serum deprivation by mu-opioid receptor agonistYing Wang
Neuroscience Research Institute and Department of Neurobiology, Key Laboratory for Neuroscience, Peking University, 38 Xueyuan Rd, Beijing 100083, PR China
Exp Neurol 202:313-23. 2006.... - Repression of cap-dependent translation attenuates the transformed phenotype in non-small cell lung cancer both in vitro and in vivoBlake A Jacobson
Department of Medicine, University of Minnesota, Minneapolis 55455, USA
Cancer Res 66:4256-62. 2006.... - Morphine promotes Jurkat cell apoptosis through pro-apoptotic FADD/P53 and anti-apoptotic PI3K/Akt/NF-kappaB pathwaysDeling Yin
Department of Internal Medicine, James Quillen College of Medicine, East Tennessee State University, P O Box 70622, Johnson City, TN 37614, United States
J Neuroimmunol 174:101-7. 2006..Our study thus demonstrates that morphine induces Jurkat cell apoptosis through FADD/p53, anti-apoptotic PI3K/Akt and NF-kappaB pathways... - Fructokinase activity in rat liver, ileum, parotid gland, pancreas, pancreatic islet, B and non-B islet cell homogenatesMarie Helene Giroix
Laboratory of Nutrition Physiopathology, CNRS UMR 7059, University of Paris 7, France
Int J Mol Med 17:517-22. 2006..Relative to paired hexokinase activity, no obvious difference was found for fructokinase activity in B versus non-B islet cells... - Microarray-based pncA genotyping of pyrazinamide-resistant strains of Mycobacterium tuberculosisSteven Denkin
Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland 21205, USA
J Med Microbiol 54:1127-31. 2005..It is concluded that the microarray method is a valuable tool for the rapid screening and genetic identification of potential PZA-resistant M. tuberculosis strains... - Recognition and ubiquitination of Salmonella type III effector SopA by a ubiquitin E3 ligase, HsRMA1Ying Zhang
Department of Biological Sciences, Purdue University, West Lafayette, Indiana 47907, USA
J Biol Chem 280:38682-8. 2005..Our data suggest that efficient bacterial escape into the cytosol of epithelial cells requires HsRMA1-mediated SopA ubiquitination and contributes to Salmonella-induced enteropathogenicity... - Inhibiting the expression of CD28 costimulatory molecule on human lymphocytes by special siRNAKai Lin Xu
Department of Hematology, Affiliated Hospital of Xuzhou Medical College, Xuzhou 221002, China
Chin Med J (Engl) 118:480-6. 2005..In this study, we investigated the RNA interference (RNAi) effect induced by small interfering RNA (siRNA) targeting CD28 mRNA on human lymphocytes and its specificity... - The nuclear receptor coactivator AIB1 mediates insulin-like growth factor I-induced phenotypic changes in human breast cancer cellsAnnabell Oh
Department of Oncology, Vincent T Lombardi Cancer Center, Georgetown University, Washington, District of Columbia 20057, USA
Cancer Res 64:8299-308. 2004..We conclude that AIB1 is required for IGF-I-induced proliferation, signaling, cell survival, and gene expression in human breast cancer cells, independent of its role in estrogen receptor signaling... - Progressive loss of Syk and abnormal proliferation in breast cancer cellsMaria Moroni
Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical School, USA
Cancer Res 64:7346-54. 2004..Because of its progressive and early loss during tumor onset and development, monitoring of Syk loss in breast epithelial cells by noninvasive techniques such as ductal lavage may be a powerful tool for screening purposes... - Development of anti-tumor immunity against a non-immunogenic mammary carcinoma through in vivo somatic GM-CSF, IL-2, and HSVtk combination gene therapyDirk G Brockstedt
Aventis Gencell, 3825 Bay Center Place, Hayward, California 94520, USA
Mol Ther 6:627-36. 2002..These data indicate that the coexpression of GM-CSF and IL-2 can augment the effect of HSVtk suicide gene therapy...