Mark Zabel

Summary

Affiliation: Colorado State University
Country: USA

Publications

  1. doi request reprint Lipopeptide delivery of siRNA to the central nervous system
    Mark D Zabel
    Department of Microbiology, Immunology and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO, USA
    Methods Mol Biol 948:251-62. 2013
  2. ncbi request reprint Stromal complement receptor CD21/35 facilitates lymphoid prion colonization and pathogenesis
    Mark D Zabel
    Institute for Neuropathology, University Hospital of Zurich, Zurich, Switzerland
    J Immunol 179:6144-52. 2007
  3. pmc Perturbation of T-cell development by insertional mutation of a PrP transgene
    Mark Zabel
    Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, USA
    Immunology 127:226-36. 2009
  4. pmc Detection of chronic wasting disease prions in salivary, urinary, and intestinal tissues of deer: potential mechanisms of prion shedding and transmission
    Nicholas J Haley
    Department of Microbiology, Immunology, and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80523, USA
    J Virol 85:6309-18. 2011
  5. ncbi request reprint Complement receptors CD21/35 link innate and protective immunity during Streptococcus pneumoniae infection by regulating IgG3 antibody responses
    Karen M Haas
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    Immunity 17:713-23. 2002
  6. ncbi request reprint Depletion of Lyn kinase from the BCR complex and inhibition of B cell activation by excess CD21 ligation
    Leena Chakravarty
    Division of Cell Biology and Immunology, Department of Pathology, University of Utah, School of Medicine, 50 N Medical Drive, Salt Lake City, UT 84132, USA
    Int Immunol 14:139-46. 2002
  7. ncbi request reprint Yin Yang 1, Oct1, and NFAT-4 form repeating, cyclosporin-sensitive regulatory modules within the murine CD21 intronic control region
    Mark D Zabel
    Department of Pathology, Division of Cell Biology and Immunology, University of Utah School of Medicine, Salt Lake City, UT 84132, USA
    J Immunol 168:3341-50. 2002
  8. pmc Efficient in vitro amplification of chronic wasting disease PrPRES
    Timothy D Kurt
    Department of Microbiology, Immunology, and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80523, USA
    J Virol 81:9605-8. 2007

Collaborators

Detail Information

Publications8

  1. doi request reprint Lipopeptide delivery of siRNA to the central nervous system
    Mark D Zabel
    Department of Microbiology, Immunology and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO, USA
    Methods Mol Biol 948:251-62. 2013
    ..When injected intravenously, these liposome-siRNA-peptide complexes resist serum degradation, effectively cross the BBB, and deliver siRNA to AchR-expressing cells to suppress protein expression in the CNS...
  2. ncbi request reprint Stromal complement receptor CD21/35 facilitates lymphoid prion colonization and pathogenesis
    Mark D Zabel
    Institute for Neuropathology, University Hospital of Zurich, Zurich, Switzerland
    J Immunol 179:6144-52. 2007
    ..Because both PrP(C) and CD21/35 are highly expressed on follicular dendritic cells, CD21/35 appears to be involved in targeting prions to follicular dendritic cells and expediting neuroinvasion following peripheral exposure to prions...
  3. pmc Perturbation of T-cell development by insertional mutation of a PrP transgene
    Mark Zabel
    Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, USA
    Immunology 127:226-36. 2009
    ..We propose that the immune cell phenotype of tga20 mice may be caused by the insertional mutation of the Prnp transgene into the pTalpha gene or its regulatory elements...
  4. pmc Detection of chronic wasting disease prions in salivary, urinary, and intestinal tissues of deer: potential mechanisms of prion shedding and transmission
    Nicholas J Haley
    Department of Microbiology, Immunology, and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80523, USA
    J Virol 85:6309-18. 2011
    ..These findings offer unique insights into the transmission of CWD in particular and prion infection and trafficking overall...
  5. ncbi request reprint Complement receptors CD21/35 link innate and protective immunity during Streptococcus pneumoniae infection by regulating IgG3 antibody responses
    Karen M Haas
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    Immunity 17:713-23. 2002
    ..Thus, CD21/35 expression is critical for early protective antibody responses to lethal pathogens that rapidly multiply and quickly overwhelm the immune system...
  6. ncbi request reprint Depletion of Lyn kinase from the BCR complex and inhibition of B cell activation by excess CD21 ligation
    Leena Chakravarty
    Division of Cell Biology and Immunology, Department of Pathology, University of Utah, School of Medicine, 50 N Medical Drive, Salt Lake City, UT 84132, USA
    Int Immunol 14:139-46. 2002
    ..Localization of other kinases integral for B cell activation is not altered. These data suggest that excess CD21 ligand binding can negatively impact B cell activation by sequestering Lyn kinase away from the BCR complex...
  7. ncbi request reprint Yin Yang 1, Oct1, and NFAT-4 form repeating, cyclosporin-sensitive regulatory modules within the murine CD21 intronic control region
    Mark D Zabel
    Department of Pathology, Division of Cell Biology and Immunology, University of Utah School of Medicine, Salt Lake City, UT 84132, USA
    J Immunol 168:3341-50. 2002
    ....
  8. pmc Efficient in vitro amplification of chronic wasting disease PrPRES
    Timothy D Kurt
    Department of Microbiology, Immunology, and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80523, USA
    J Virol 81:9605-8. 2007
    ..5 x 10(9)-fold amplification after six rounds. Highly efficient in vitro amplification of PrP(CWD) is a significant step toward detection of PrP(CWD) in the body fluids or excreta of CWD-susceptible species...

Research Grants2

  1. Key molecular mechanisms of extraneural pathogenesis and transmission of TSEs
    Mark Zabel; Fiscal Year: 2009
    ..Determining mechanisms of transmission of scrapie and CWD, which exhibit incredibly efficient Intraspecies transmission, is vital to ensuring the safety of the nation's food supply and, therefore, public health. ..
  2. Key molecular mechanisms of extraneural pathogenesis and transmission of TSEs
    Mark D Zabel; Fiscal Year: 2010
    ..Determining mechanisms of transmission of scrapie and CWD, which exhibit incredibly efficient Intraspecies transmission, is vital to ensuring the safety of the nation's food supply and, therefore, public health. ..