Ronald Tjalkens

Summary

Affiliation: Colorado State University
Country: USA

Publications

  1. doi request reprint Neuroprotective efficacy and pharmacokinetic behavior of novel anti-inflammatory para-phenyl substituted diindolylmethanes in a mouse model of Parkinson's disease
    Briana R De Miranda
    Center for Environmental Medicine, Department of Environmental and Radiological Health Sciences, Animal Cancer Center, Colorado State University, Fort Collins, Colorado 80523 1680, USA
    J Pharmacol Exp Ther 345:125-38. 2013
  2. ncbi request reprint The peroxisome proliferator-activated receptor-gamma agonist 1,1-bis(3'-indolyl)-1-(p-trifluoromethylphenyl)methane suppresses manganese-induced production of nitric oxide in astrocytes and inhibits apoptosis in cocultured PC12 cells
    Ronald B Tjalkens
    Department of Veterinary Integrative Biosciences, Texas A and M University, College Station, Texas
    J Neurosci Res 86:618-29. 2008
  3. ncbi request reprint Manganese suppresses ATP-dependent intercellular calcium waves in astrocyte networks through alteration of mitochondrial and endoplasmic reticulum calcium dynamics
    Ronald B Tjalkens
    Molecular, Cellular, and Integrative Neuroscience, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80523 1680, USA
    Brain Res 1113:210-9. 2006
  4. ncbi request reprint NF-kappaB-dependent production of nitric oxide by astrocytes mediates apoptosis in differentiated PC12 neurons following exposure to manganese and cytokines
    Xuhong Liu
    Molecular, Cellular, and Integrative Neuroscience, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, 1680 Campus Delivery, Fort Collins, CO 80526 1680, USA
    Brain Res Mol Brain Res 141:39-47. 2005
  5. pmc Suppression of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced nitric-oxide synthase 2 expression in astrocytes by a novel diindolylmethane analog protects striatal neurons against apoptosis
    David L Carbone
    Department of Environmental and Radiological Health Sciences, Colorado State University, Collins, CO 80523, USA
    Mol Pharmacol 75:35-43. 2009
  6. doi request reprint Manganese potentiates nuclear factor-kappaB-dependent expression of nitric oxide synthase 2 in astrocytes by activating soluble guanylate cyclase and extracellular responsive kinase signaling pathways
    Julie A Moreno
    Cell and Molecular Biology Program, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, Colorado 80523, USA
    J Neurosci Res 86:2028-38. 2008
  7. pmc Modulation of intercellular calcium signaling by melatonin in avian and mammalian astrocytes is brain region-specific
    Jennifer L Peters
    Department of Biology and Center Research on Biological Clocks, Texas A and M University, College Station, 77843, USA
    J Comp Neurol 493:370-80. 2005
  8. ncbi request reprint Manganese potentiates lipopolysaccharide-induced expression of NOS2 in C6 glioma cells through mitochondrial-dependent activation of nuclear factor kappaB
    Rola Barhoumi
    Department of Anatomy, Neuroscience Program, College of Veterinary Medicine, Texas A and M University, MS 4458 TAMU, College Station, TX 77843 4458, USA
    Brain Res Mol Brain Res 122:167-79. 2004
  9. ncbi request reprint Manganese-induced neurotoxicity: the role of astroglial-derived nitric oxide in striatal interneuron degeneration
    Xuhong Liu
    Toxicology Program, Department of Integrative Biosciences, Texas A and M University, College Station, Texas 77843, USA
    Toxicol Sci 91:521-31. 2006
  10. pmc Nuclear factor kappa-B mediates selective induction of neuronal nitric oxide synthase in astrocytes during low-level inflammatory stimulation with MPTP
    David L Carbone
    Program in Molecular, Cellular, and Integrative Neuroscience, Colorado State University, Fort Collins, CO 80523, USA
    Brain Res 1217:1-9. 2008

Research Grants

  1. Manganese and basal ganglia dysfunction: role of NO
    Ronald Tjalkens; Fiscal Year: 2007
  2. Manganese and basal ganglia dysfunction: role of NO
    Ronald B Tjalkens; Fiscal Year: 2010

Collaborators

  • S Safe
  • David L Carbone
  • Jennifer L Peters
  • ROBERT STEPHEN CHAPKIN
  • R P Erickson
  • Charlene A McQueen
  • Julie A Moreno
  • Xuhong Liu
  • Kelly A Sullivan
  • Briana R De Miranda
  • Rola Barhoumi
  • Amanda K Ashley
  • Karin M Streifel
  • Marie E Legare
  • William H Hanneman
  • Yeevoon Ng
  • Terry J Miller
  • Ryan J Hansen
  • Dorothy Colagiovanni
  • Paul J Lunghofer
  • James A Miller
  • Daniel L Gustafson
  • Takeshi Katoh
  • Ashley Pollack
  • Elizabeth C Yeomans
  • Bryan L Brattin
  • Robert J Taylor
  • James E Madl
  • Marie Legare
  • Satya Kolar
  • Yang Yi Fan
  • Naisyin Wang
  • Joanne R Lupton
  • Julie A Buffington
  • Jennifer Faske
  • Martin A Philbert
  • Amanda D Phelka
  • Lloyd A Dethloff

Detail Information

Publications18

  1. doi request reprint Neuroprotective efficacy and pharmacokinetic behavior of novel anti-inflammatory para-phenyl substituted diindolylmethanes in a mouse model of Parkinson's disease
    Briana R De Miranda
    Center for Environmental Medicine, Department of Environmental and Radiological Health Sciences, Animal Cancer Center, Colorado State University, Fort Collins, Colorado 80523 1680, USA
    J Pharmacol Exp Ther 345:125-38. 2013
    ....
  2. ncbi request reprint The peroxisome proliferator-activated receptor-gamma agonist 1,1-bis(3'-indolyl)-1-(p-trifluoromethylphenyl)methane suppresses manganese-induced production of nitric oxide in astrocytes and inhibits apoptosis in cocultured PC12 cells
    Ronald B Tjalkens
    Department of Veterinary Integrative Biosciences, Texas A and M University, College Station, Texas
    J Neurosci Res 86:618-29. 2008
    ..These data suggest that PPARgamma may be an effective target for limiting inflammatory activation of astrocytes during neurologic injury...
  3. ncbi request reprint Manganese suppresses ATP-dependent intercellular calcium waves in astrocyte networks through alteration of mitochondrial and endoplasmic reticulum calcium dynamics
    Ronald B Tjalkens
    Molecular, Cellular, and Integrative Neuroscience, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80523 1680, USA
    Brain Res 1113:210-9. 2006
    ....
  4. ncbi request reprint NF-kappaB-dependent production of nitric oxide by astrocytes mediates apoptosis in differentiated PC12 neurons following exposure to manganese and cytokines
    Xuhong Liu
    Molecular, Cellular, and Integrative Neuroscience, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, 1680 Campus Delivery, Fort Collins, CO 80526 1680, USA
    Brain Res Mol Brain Res 141:39-47. 2005
    ..It is concluded that Mn- and cytokine-dependent apoptosis in PC12 neurons requires astroglial-derived NO and NF-kappaB-dependent expression of NOS2...
  5. pmc Suppression of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced nitric-oxide synthase 2 expression in astrocytes by a novel diindolylmethane analog protects striatal neurons against apoptosis
    David L Carbone
    Department of Environmental and Radiological Health Sciences, Colorado State University, Collins, CO 80523, USA
    Mol Pharmacol 75:35-43. 2009
    ....
  6. doi request reprint Manganese potentiates nuclear factor-kappaB-dependent expression of nitric oxide synthase 2 in astrocytes by activating soluble guanylate cyclase and extracellular responsive kinase signaling pathways
    Julie A Moreno
    Cell and Molecular Biology Program, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, Colorado 80523, USA
    J Neurosci Res 86:2028-38. 2008
    ..These data indicate that near-physiological concentrations of Mn potentiate cytokine-induced expression of NOS2 and production of NO in astrocytes via activation of sGC, which promotes ERK-dependent enhancement of NF-kappaB signaling...
  7. pmc Modulation of intercellular calcium signaling by melatonin in avian and mammalian astrocytes is brain region-specific
    Jennifer L Peters
    Department of Biology and Center Research on Biological Clocks, Texas A and M University, College Station, 77843, USA
    J Comp Neurol 493:370-80. 2005
    ..These results suggest multiple roles for melatonin receptors in the regulation of astroglial function, impacting specific brain regions differentially...
  8. ncbi request reprint Manganese potentiates lipopolysaccharide-induced expression of NOS2 in C6 glioma cells through mitochondrial-dependent activation of nuclear factor kappaB
    Rola Barhoumi
    Department of Anatomy, Neuroscience Program, College of Veterinary Medicine, Texas A and M University, MS 4458 TAMU, College Station, TX 77843 4458, USA
    Brain Res Mol Brain Res 122:167-79. 2004
    ..These data indicate that Mn augments LPS-induced expression of NOS2 in C6 cells by increasing mitochondrial ROS and activation of NF-kappaB...
  9. ncbi request reprint Manganese-induced neurotoxicity: the role of astroglial-derived nitric oxide in striatal interneuron degeneration
    Xuhong Liu
    Toxicology Program, Department of Integrative Biosciences, Texas A and M University, College Station, Texas 77843, USA
    Toxicol Sci 91:521-31. 2006
    ..These data suggest a role for astrocyte-derived NO in injury to striatal-pallidal interneurons from Mn intoxication...
  10. pmc Nuclear factor kappa-B mediates selective induction of neuronal nitric oxide synthase in astrocytes during low-level inflammatory stimulation with MPTP
    David L Carbone
    Program in Molecular, Cellular, and Integrative Neuroscience, Colorado State University, Fort Collins, CO 80523, USA
    Brain Res 1217:1-9. 2008
    ..The data presented here thus demonstrate a role for NF-kappaB in selective induction of NOS1 during early inflammatory activation of astrocytes stimulated by low-dose MPTP and inflammatory cytokines...
  11. ncbi request reprint Regional variation in the activation threshold for 1,3-DNB-induced mitochondrial permeability transition in brainstem and cortical astrocytes
    Ronald B Tjalkens
    Department of Integrative Biosciences, Interdisciplinary Faculty of Toxicology, Texas A and M University, College Station, TX, USA
    Neurotoxicology 24:391-401. 2003
    ....
  12. doi request reprint Analysis of targeted mutation in DJ-1 on cellular function in primary astrocytes
    Amanda K Ashley
    Cell and Molecular Biology Graduate Program, Colorado State University, Fort Collins, CO 80523, United States
    Toxicol Lett 184:186-91. 2009
    ..Our DJ-1 knockout mouse provides an exciting tool for exploring the molecular and physiological roles of DJ-1 to further explicate its functions in neurodegeneration...
  13. pmc Developmental exposure to manganese increases adult susceptibility to inflammatory activation of glia and neuronal protein nitration
    Julie A Moreno
    Center for Environmental Medicine, Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, Colorado 80523, USA
    Toxicol Sci 112:405-15. 2009
    ..These data indicate that subchronic exposure to Mn during development leads to temporally distinct patterns of glial activation that result in elevated nitrosative stress in distinct populations of basal ganglia neurons...
  14. pmc Age-dependent susceptibility to manganese-induced neurological dysfunction
    Julie A Moreno
    Department of Environmental and Radiological Health Sciences, Center for Environmental Medicine, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, Colorado 80523, USA
    Toxicol Sci 112:394-404. 2009
    ..These results reveal that developing mice are more sensitive to Mn than adult animals and that Mn exposure during development enhances behavioral and neurochemical dysfunction relative to adult animals without juvenile exposure...
  15. ncbi request reprint The role of docosahexaenoic acid in mediating mitochondrial membrane lipid oxidation and apoptosis in colonocytes
    Yeevoon Ng
    Faculty of Nutrition, Texas A and M University, College Station, TX 77843, USA
    Carcinogenesis 26:1914-21. 2005
    ..These data indicate that DHA and butyrate potentiate mitochondrial lipid oxidation and the dissipation of MP which contribute to the induction of apoptosis...
  16. ncbi request reprint The effects of genetic variation in N-acetyltransferases on 4-aminobiphenyl genotoxicity in mouse liver
    Charlene A McQueen
    Department of Pharmacology and Toxicology, College of Pharmacy, The University of Arizona, PO Box 210207, Tucson, AZ 85721, USA
    Chem Biol Interact 146:51-60. 2003
    ..Mouse models with variation in both isoforms are needed to adequately assess the role of variation in NATs in susceptibility to 4ABP genotoxicity...
  17. ncbi request reprint Prenatal expression of N-acetyltransferases in C57Bl/6 mice
    Charlene A McQueen
    Department of Pharmacology and Toxicology, College of Pharmacy, The University of Arizona, PO Box 210207, Tucson, AZ 85721, USA
    Chem Biol Interact 145:77-87. 2003
    ..These data support the possible in situ generation of reactive products by the conceptus. The relative contributions of maternal activation of 4ABP and that by the conceptus remain to be determined...
  18. ncbi request reprint CI-1010 induced opening of the mitochondrial permeability transition pore precedes oxidative stress and apoptosis in SY5Y neuroblastoma cells
    Terry J Miller
    Toxicology Program, Department of Environmental Health Sciences, The University of Michigan, 1420 Washington Heights, SPH II Ann Arbor, MI 48109 2029, USA
    Brain Res 963:43-56. 2003
    ..This study evaluates intracellular oxidative stress associated with pore opening prior to apoptosis and provides evidence in support of a mitochondrial mechanism of CI-1010-induced neuronal cell death...

Research Grants7

  1. Manganese and basal ganglia dysfunction: role of NO
    Ronald Tjalkens; Fiscal Year: 2007
    ..abstract_text> ..
  2. Manganese and basal ganglia dysfunction: role of NO
    Ronald B Tjalkens; Fiscal Year: 2010
    ..abstract_text> ..