Henry J Thompson

Summary

Affiliation: Colorado State University
Country: USA

Publications

  1. doi request reprint Excess weight gain accelerates 1-methyl-1-nitrosourea-induced mammary carcinogenesis in a rat model of premenopausal breast cancer
    Shawna B Matthews
    111 Shepardson Building, 1173 Campus Delivery, Colorado State University, Fort Collins, CO 80523 1173
    Cancer Prev Res (Phila) 7:310-8. 2014
  2. ncbi request reprint A systems pharmacokinetic and pharmacodynamic approach to identify opportunities and pitfalls in energy stress-mediated chemoprevention: the use of metformin and other biguanides
    Matthew D Thompson
    Cancer Prevention Fellowship Program, National Cancer Institute, Bethesda, MD, USA
    Curr Drug Targets 13:1876-84. 2012
  3. pmc Effect of dietary patterns differing in carbohydrate and fat content on blood lipid and glucose profiles based on weight-loss success of breast-cancer survivors
    Henry J Thompson
    Cancer Prevention Laboratory, Colorado State University, Fort Collins, CO 80523, USA
    Breast Cancer Res 14:R1. 2012
  4. ncbi request reprint Targeting angiogenesis for mammary cancer prevention: factors to consider in experimental design and analysis
    Henry J Thompson
    Cancer Prevention Laboratory, Colorado State University, Fort Collins, 80523 1173, USA
    Cancer Epidemiol Biomarkers Prev 13:1173-84. 2004
  5. ncbi request reprint DNA oxidation products, antioxidant status, and cancer prevention
    Henry J Thompson
    Colorado State University, Fort Collins, CO 80523, USA
    J Nutr 134:3186S-3187S. 2004
  6. ncbi request reprint Weight control and breast cancer prevention: are the effects of reduced energy intake equivalent to those of increased energy expenditure?
    Henry J Thompson
    Cancer Prevention Laboratory, Colorado State University, Fort Collins, CO 80523, USA
    J Nutr 134:3407S-3411S. 2004
  7. pmc Evaluation of diversity among common beans (Phaseolus vulgaris L.) from two centers of domestication using 'omics' technologies
    Meghan M Mensack
    Cancer Prevention Laboratory, Department of Horticulture, Colorado State Univ, Fort Collins, CO 80523 1173, USA
    BMC Genomics 11:686. 2010
  8. pmc Wheel running-induced changes in plasma biomarkers and carcinogenic response in the 1-methyl-1-nitrosourea-induced rat model for breast cancer
    Henry J Thompson
    Cancer Prevention Laboratory, Colorado State University, Fort Collins, Colorado 80523, USA
    Cancer Prev Res (Phila) 3:1484-92. 2010
  9. ncbi request reprint In vivo investigation of changes in biomarkers of oxidative stress induced by plant food rich diets
    Henry J Thompson
    Colorado State University, Fort Collins, Colorado 80523, and AMC Cancer Research Center, Denver, Colorado 80214, USA
    J Agric Food Chem 53:6126-32. 2005
  10. ncbi request reprint 8-Isoprostane F2alpha excretion is reduced in women by increased vegetable and fruit intake
    Henry J Thompson
    Colorado State University, Fort Collins, CO 80523, USA
    Am J Clin Nutr 82:768-76. 2005

Research Grants

  1. SELENIUM AND LUNG CANCER RISK
    Henry Thompson; Fiscal Year: 2004
  2. ENERGY RESTRICTION AND MAMMARY CANCER
    Henry Thompson; Fiscal Year: 2007
  3. Exercise, Breast Cancer Prevention, and Mechanisms
    Henry Thompson; Fiscal Year: 2007
  4. Diet Composition, Weight Control and Breast Carcinogenesis
    Henry Thompson; Fiscal Year: 2007
  5. Exercise, Breast Cancer Prevention, and Mechanisms
    Henry Thompson; Fiscal Year: 2009
  6. Energy Restrction and Mammary Cancer
    Henry Thompson; Fiscal Year: 2009
  7. Exercise, Breast Cancer Prevention, and Mechanisms
    Henry J Thompson; Fiscal Year: 2010
  8. Diet Composition, Weight Control and Breast Carcinogenesis
    Henry J Thompson; Fiscal Year: 2010
  9. SELENIUM AND LUNG CANCER RISK
    Henry Thompson; Fiscal Year: 2003
  10. SELENIUM AND LUNG CANCER RISK
    Henry Thompson; Fiscal Year: 2002

Collaborators

Detail Information

Publications60

  1. doi request reprint Excess weight gain accelerates 1-methyl-1-nitrosourea-induced mammary carcinogenesis in a rat model of premenopausal breast cancer
    Shawna B Matthews
    111 Shepardson Building, 1173 Campus Delivery, Colorado State University, Fort Collins, CO 80523 1173
    Cancer Prev Res (Phila) 7:310-8. 2014
    ..Cancer Prev Res; 7(3); 310-8. ©2014 AACR. ..
  2. ncbi request reprint A systems pharmacokinetic and pharmacodynamic approach to identify opportunities and pitfalls in energy stress-mediated chemoprevention: the use of metformin and other biguanides
    Matthew D Thompson
    Cancer Prevention Fellowship Program, National Cancer Institute, Bethesda, MD, USA
    Curr Drug Targets 13:1876-84. 2012
    ....
  3. pmc Effect of dietary patterns differing in carbohydrate and fat content on blood lipid and glucose profiles based on weight-loss success of breast-cancer survivors
    Henry J Thompson
    Cancer Prevention Laboratory, Colorado State University, Fort Collins, CO 80523, USA
    Breast Cancer Res 14:R1. 2012
    ....
  4. ncbi request reprint Targeting angiogenesis for mammary cancer prevention: factors to consider in experimental design and analysis
    Henry J Thompson
    Cancer Prevention Laboratory, Colorado State University, Fort Collins, 80523 1173, USA
    Cancer Epidemiol Biomarkers Prev 13:1173-84. 2004
    ....
  5. ncbi request reprint DNA oxidation products, antioxidant status, and cancer prevention
    Henry J Thompson
    Colorado State University, Fort Collins, CO 80523, USA
    J Nutr 134:3186S-3187S. 2004
  6. ncbi request reprint Weight control and breast cancer prevention: are the effects of reduced energy intake equivalent to those of increased energy expenditure?
    Henry J Thompson
    Cancer Prevention Laboratory, Colorado State University, Fort Collins, CO 80523, USA
    J Nutr 134:3407S-3411S. 2004
    ..Additional research is needed to investigate the equivalence of DER, PA, and their combination in breast cancer prevention under comparable conditions of energy balance...
  7. pmc Evaluation of diversity among common beans (Phaseolus vulgaris L.) from two centers of domestication using 'omics' technologies
    Meghan M Mensack
    Cancer Prevention Laboratory, Department of Horticulture, Colorado State Univ, Fort Collins, CO 80523 1173, USA
    BMC Genomics 11:686. 2010
    ..Yet, little is known about whether these traits, which distinguish among genetically distinct types of common bean, can be evaluated using omics technologies...
  8. pmc Wheel running-induced changes in plasma biomarkers and carcinogenic response in the 1-methyl-1-nitrosourea-induced rat model for breast cancer
    Henry J Thompson
    Cancer Prevention Laboratory, Colorado State University, Fort Collins, Colorado 80523, USA
    Cancer Prev Res (Phila) 3:1484-92. 2010
    ..Identification of such biomarkers is critical in clinical studies for which evaluating the effects of physical activity on cancer outcomes (diagnosis, recurrence, or mortality) is not possible...
  9. ncbi request reprint In vivo investigation of changes in biomarkers of oxidative stress induced by plant food rich diets
    Henry J Thompson
    Colorado State University, Fort Collins, Colorado 80523, and AMC Cancer Research Center, Denver, Colorado 80214, USA
    J Agric Food Chem 53:6126-32. 2005
    ..Null findings do not necessarily indicate that an antioxidant compound lacks in vivo activity...
  10. ncbi request reprint 8-Isoprostane F2alpha excretion is reduced in women by increased vegetable and fruit intake
    Henry J Thompson
    Colorado State University, Fort Collins, CO 80523, USA
    Am J Clin Nutr 82:768-76. 2005
    ..However, in vivo evidence that VF actually reduce markers of oxidative stress is limited...
  11. ncbi request reprint Dietary botanical diversity affects the reduction of oxidative biomarkers in women due to high vegetable and fruit intake
    Henry J Thompson
    Colorado State University, Fort Collins, CO 80523, USA
    J Nutr 136:2207-12. 2006
    ....
  12. ncbi request reprint Pre-clinical investigations of physical activity and cancer: a brief review and analysis
    Henry J Thompson
    Cancer Prevention Laboratory, Colorado State University, Fort Collins, CO 80523, USA
    Carcinogenesis 27:1946-9. 2006
    ..This brief review and analysis is intended to focus attention on the issues and opportunities associated with the pre-clinical investigations of PA and cancer...
  13. ncbi request reprint Oxidative DNA damage and cancer risk assessment
    Henry J Thompson
    Cancer Prevention Laboratory, Colorado State University, Fort Collins, CO 80523, USA
    J Nutr 136:2693S-4S. 2006
  14. doi request reprint Candidate mechanisms accounting for effects of physical activity on breast carcinogenesis
    Henry J Thompson
    Cancer Prevention Laboratory, Colorado State University, Fort Collins, CO 80523, USA
    IUBMB Life 61:895-901. 2009
    ....
  15. ncbi request reprint Effect of dietary energy restriction on vascular density during mammary carcinogenesis
    Henry J Thompson
    Cancer Prevention Laboratory, Colorado State University, Fort Collins, Colorado 80523, USA
    Cancer Res 64:5643-50. 2004
    ..The factors that account for the failure of dietary energy restriction to limit intratumoral vascularization are not obvious and merit additional investigation...
  16. pmc Collection of epithelial cells from rodent mammary gland via laser capture microdissection yielding high-quality RNA suitable for microarray analysis
    John N McGinley
    Cancer Prevention Laboratory, Colorado State University, 1173 Campus Delivery, Fort Collins, CO 80523, USA
    Biol Proced Online 12:9026. 2010
    ..The results showed that the quality of RNA isolated from epithelial cells of both mammary gland and mammary adenocarcinomas was high with a probe set present call rate of 65% and a high signal-to-noise ratio...
  17. pmc A method for serial tissue processing and parallel analysis of aberrant crypt morphology, mucin depletion, and Beta-catenin staining in an experimental model of colon carcinogenesis
    John N McGinley
    Cancer Prevention Laboratory, Colorado State University, 1173 Campus Delivery, Fort Collins, CO 80523, USA
    Biol Proced Online 12:9032. 2010
    ..The subsequent evaluation of ACF for beta-catenin staining is also demonstrated. The methods described are particularly relevant to the screening of compounds for cancer chemopreventive activity...
  18. pmc Quantitative assessment of mammary gland density in rodents using digital image analysis
    John N McGinley
    Cancer Prevention Laboratory, Colorado State University, 1173 Campus Delivery, Fort Collins, CO 80523, USA
    Biol Proced Online 13:4. 2011
    ..abstract:..
  19. pmc Weight cycling and cancer: weighing the evidence of intermittent caloric restriction and cancer risk
    Henry J Thompson
    Cancer Prevention Laboratory, Colorado State University, 1173 Campus Delivery, Fort Collins, CO 80523, USA
    Cancer Prev Res (Phila) 4:1736-42. 2011
    ....
  20. ncbi request reprint Identification of the apoptosis activation cascade induced in mammary carcinomas by energy restriction
    Henry J Thompson
    Cancer Prevention Laboratory, Colorado State University, 1173 Campus Delivery, Fort Collins, CO 80523, USA
    Cancer Res 64:1541-5. 2004
    ..Additional studies revealed that Akt phosphorylation (activation) was reduced in mammary carcinomas from ER rats. Thus, it appears that ER induces apoptosis in mammary carcinomas via a cell survival factor-dependent pathway...
  21. ncbi request reprint Dietary energy restriction in breast cancer prevention
    Henry J Thompson
    Cancer Prevention Laboratory, Colorado State University, Fort Collins, Colorado 80523, USA
    J Mammary Gland Biol Neoplasia 8:133-42. 2003
    ..Mechanistic studies hold the promise of leading to the identification of DER mimetic approaches that can be used in the prevention and control of breast cancer...
  22. ncbi request reprint Effect of energy restriction on cell cycle machinery in 1-methyl-1-nitrosourea-induced mammary carcinomas in rats
    Weiqin Jiang
    Center for Nutrition in the Prevention of Disease, AMC Cancer Research Center, Denver, Colorado 80214, USA
    Cancer Res 63:1228-34. 2003
    ....
  23. ncbi request reprint Mechanisms by which energy restriction inhibits rat mammary carcinogenesis: in vivo effects of corticosterone on cell cycle machinery in mammary carcinomas
    Zongjian Zhu
    Cancer Prevention Laboratory, Colorado State University, Fort Collins, 111 Shepardson, 1173 Campus Delivery, Fort Collins, CO 80523 1173, USA
    Carcinogenesis 24:1225-31. 2003
    ....
  24. pmc Effect of a low fat versus a low carbohydrate weight loss dietary intervention on biomarkers of long term survival in breast cancer patients ('CHOICE'): study protocol
    Scot M Sedlacek
    Cancer Prevention Laboratory, Colorado State University, Fort Collins, CO, USA
    BMC Cancer 11:287. 2011
    ..The study will also determine how much weight must be lost for biomarkers to change in a favorable direction...
  25. pmc Dietary energy restriction modulates the activity of AMP-activated protein kinase, Akt, and mammalian target of rapamycin in mammary carcinomas, mammary gland, and liver
    Weiqin Jiang
    Cancer Prevention Laboratory, Colorado State University, Fort Collins, Colorado 80523, USA
    Cancer Res 68:5492-9. 2008
    ....
  26. doi request reprint In vitro measures used to predict anticancer activity of apple cultivars and their comparison to outcomes from a rat model of experimentally induced breast cancer
    Matthew D Thompson
    Colorado State University, Fort Collins, Colorado, USA
    Nutr Cancer 61:510-7. 2009
    ..001), whereas the apoptotic rate did not. These findings suggest altered methodology for screening apples for anticancer activity and that more diverse apple cultivars with higher phytochemical content should be evaluated...
  27. ncbi request reprint Mechanisms of energy restriction: effects of corticosterone on cell growth, cell cycle machinery, and apoptosis
    Weiqin Jiang
    Centers for Nutrition in the Prevention of Disease, AMC Cancer Research Center, 1600 Pierce Street, Denver, CO 80214, USA
    Cancer Res 62:5280-7. 2002
    ..These data provide evidence for a role of corticosterone on some but not all of the cellular activities associated with ER-mediated inhibition of mammary carcinogenesis...
  28. pmc Energetics and mammary carcinogenesis: effects of moderate-intensity running and energy intake on cellular processes and molecular mechanisms in rats
    Zongjian Zhu
    Cancer Prevention Laboratory, Colorado State University, Fort Collins, Colorado 80523, USA
    J Appl Physiol (1985) 106:911-8. 2009
    ....
  29. pmc Effects of limiting energy availability via diet and physical activity on mammalian target of rapamycin-related signaling in rat mammary carcinomas
    Weiqin Jiang
    Cancer Prevention Laboratory, Colorado State University, Fort Collins, CO 80523, USA
    Carcinogenesis 34:378-87. 2013
    ..Given the modest effects observed on the LKB1/AMP-activated protein kinase regulatory node, NADH and NADPH rather than ATP may be more limiting for tumor growth when LEA is 15%...
  30. ncbi request reprint Effects of dietary energy repletion and IGF-1 infusion on the inhibition of mammary carcinogenesis by dietary energy restriction
    Zongjian Zhu
    Cancer Prevention Laboratory, Colorado State University, Fort Collins, Colorado 80523, USA
    Mol Carcinog 42:170-6. 2005
    ..Thus, an 8-d period of refeeding following chronic DER (DER-REP) reversed the anticancer effects of DER, and 8 d of IGF-1 infusion without refeeding (INF) did not mimic the effects of the DER-REP on the carcinogenic response...
  31. doi request reprint Mechanisms associated with dose-dependent inhibition of rat mammary carcinogenesis by dry bean (Phaseolus vulgaris, L.)
    Matthew D Thompson
    Cancer Prevention Laboratory, Department of Horticulture, Colorado State University, Fort Collins, CO 80523, USA
    J Nutr 138:2091-7. 2008
    ....
  32. pmc Effect of nonmotorized wheel running on mammary carcinogenesis: circulating biomarkers, cellular processes, and molecular mechanisms in rats
    Zongjian Zhu
    Cancer Prevention Laboratory, Colorado State University, 1173 Campus Delivery, Fort Collins, CO 80523, USA
    Cancer Epidemiol Biomarkers Prev 17:1920-9. 2008
    ..Collectively, these findings provide a rationale for additional studies of energy-sensing pathways in the elucidation of mechanisms that account for the inhibition of carcinogenesis by physical activity...
  33. doi request reprint Edible dry bean consumption (Phaseolus vulgaris L.) modulates cardiovascular risk factors and diet-induced obesity in rats and mice
    Zongjian Zhu
    Cancer Prevention Laboratory, Colorado State University, 1173 Campus Delivery, Fort Collins, CO 80523, USA
    Br J Nutr 108:S66-73. 2012
    ..These same assays can be used to identify the bioactive components of bean that account for the observed effects...
  34. doi request reprint Identification of a molecular signature underlying inhibition of mammary carcinoma growth by dietary N-3 fatty acids
    Weiqin Jiang
    Cancer Prevention Laboratory, Colorado State University, Fort Collins, CO 80523, USA
    Cancer Res 72:3795-806. 2012
    ..This study identifies the pathways modulated by dietary fatty acid ratios in a rat model of breast cancer, with implications for cancer prevention...
  35. ncbi request reprint An experimental paradigm for studying the cellular and molecular mechanisms of cancer inhibition by energy restriction
    Zongjian Zhu
    Center for Nutrition in the Prevention of Disease, AMC Cancer Research Center, Denver, Colorado 80214, USA
    Mol Carcinog 35:51-6. 2002
    ..However, a similar pattern of change in the energy-regulated hormone leptin indicated that its role in cancer inhibition also merits consideration...
  36. ncbi request reprint Effects of dietary energy restriction on gene regulation in mammary epithelial cells
    Zongjian Zhu
    Cancer Prevention Laboratory, Colorado State University, Fort Collins, Colorado 80523, USA
    Cancer Res 67:12018-25. 2007
    ....
  37. doi request reprint Modulation of the activities of AMP-activated protein kinase, protein kinase B, and mammalian target of rapamycin by limiting energy availability with 2-deoxyglucose
    Weiqin Jiang
    Cancer Prevention Laboratory, Colorado State University, Fort Collins, Colorado 80523, USA
    Mol Carcinog 47:616-28. 2008
    ..This work indicates that AMPK, Akt, and mTOR are candidate targets for efforts to inhibit the carcinogenic process by limiting energy availability...
  38. ncbi request reprint Weight change patterns and breast cancer risk: a brief review and analysis
    Mary C Playdon
    Cancer Prevention Laboratory, Colorado State University, Fort Collins, Colorado 80523, USA
    Crit Rev Eukaryot Gene Expr 23:159-69. 2013
    ....
  39. ncbi request reprint Adrenalectomy does not block the inhibition of mammary carcinogenesis by dietary energy restriction in rats
    Weiqin Jiang
    Cancer Prevention Laboratory, Colorado State University, Fort Collins, CO 80523, USA
    J Nutr 134:1152-6. 2004
    ..If circulation-borne factors such as corticosterone or IGF-1 are involved in the inhibition of mammary carcinogenesis by DER, IGF-1 is likely to play a greater role than corticosterone...
  40. pmc Effects of energy restriction and wheel running on mammary carcinogenesis and host systemic factors in a rat model
    Zongjian Zhu
    Cancer Prevention Laboratory, Colorado State University, 1173 Campus Delivery, Fort Collins, CO 80523, USA
    Cancer Prev Res (Phila) 5:414-22. 2012
    ..The plasma biomarkers of greatest value in predicting the carcinogenic response were adiponectin > IGF-1/IGFBP-3 > IGFBP-3 > leptin > IGF-1...
  41. doi request reprint Effects of physical activity and restricted energy intake on chemically induced mammary carcinogenesis
    Weiqin Jiang
    Cancer Prevention Laboratory, Colorado State University, Fort Collins, CO 80523, USA
    Cancer Prev Res (Phila) 2:338-44. 2009
    ..05). It was observed that these effects may be mediated, in part, by activation of AMP-activated protein kinase and down-regulation of protein kinase B and the mammalian target of rapamycin...
  42. ncbi request reprint Vascular density profile of rat mammary carcinomas induced by 1-methyl-1-nitrosourea: implications for the investigation of angiogenesis
    Henry J Thompson
    Center for Nutrition in the Prevention of Disease, AMC Cancer Research Center, 1600 Pierce Street, Denver, CO 80214, USA
    Carcinogenesis 23:847-54. 2002
    ..Collectively, the data provide a complete description of vascularization in autochthonously growing mammary tumors, and a reference for comparison in studies of various cancer preventive agents that modulate the angiogenic process...
  43. pmc Wheel running, skeletal muscle aerobic capacity and 1-methyl-1-nitrosourea induced mammary carcinogenesis in the rat
    Phillip B Mann
    Cancer Prevention Laboratory, Colorado State University, 1173 Campus Delivery, Fort Collins, CO 80523, USA
    Carcinogenesis 31:1279-83. 2010
    ..The multifaceted nature of intrinsic and inducible aerobic capacity limits the usefulness of citrate synthase activity alone in elucidating the relationship between aerobic capacity and the carcinogenic response...
  44. ncbi request reprint 2-Deoxyglucose as an energy restriction mimetic agent: effects on mammary carcinogenesis and on mammary tumor cell growth in vitro
    Zongjian Zhu
    Cancer Prevention Laboratory, Colorado State University, Fort Collins, Colorado 80523, USA
    Cancer Res 65:7023-30. 2005
    ..05). These studies support the hypothesis that DER inhibits carcinogenesis, in part, by limiting glucose availability and that energy metabolism is a target for the development of ERMA for chemoprevention...
  45. doi request reprint Mammary gland density predicts the cancer inhibitory activity of the N-3 to N-6 ratio of dietary fat
    Zongjian Zhu
    Cancer Prevention Laboratory, Colorado State University, Fort Collins, 80523, USA
    Cancer Prev Res (Phila) 4:1675-85. 2011
    ....
  46. doi request reprint Defining the role of histone deacetylases in the inhibition of mammary carcinogenesis by dietary energy restriction (DER): effects of suberoylanilide hydroxamic acid (SAHA) and DER in a rat model
    Zongjian Zhu
    Cancer Prevention Laboratory, Colorado State University, 1173 Campus Delivery, Fort Collins, CO 80523, USA
    Cancer Prev Res (Phila) 6:290-8. 2013
    ..05), consistent with apoptosis-mediated cell deletion. These findings support further investigation of the hypothesis that HDAC induction by DER blunts its anti-carcinogenic impact...
  47. doi request reprint Dietary dry bean effects on hepatic expression of stress and toxicity-related genes in rats
    Erica L Daniell
    Cancer Prevention Laboratory, Colorado State University, 1173 Campus Delivery, Fort Collins, CO 80523, USA
    Br J Nutr 108:S37-45. 2012
    ..These candidate genes may contribute to the health benefits attributed to increased bean consumption...
  48. ncbi request reprint Effect of cytological fixative and environmental conditions on nuclear morphometric characteristics of squamous epithelial cells in sputum
    E Brigitte Gottschall
    National Jewish Medical and Research Center, Denver, Colorado, USA
    Cytometry B Clin Cytom 67:19-26. 2005
    ..We examined whether the type of cytological fixative and exposure to different environmental conditions introduces artifacts that affect cytological analysis...
  49. ncbi request reprint Protection against cancer by energy restriction: all experimental approaches are not equal
    Henry J Thompson
    Center for Nutrition in the Prevention of Disease, AMC Cancer Research Center, Denver, CO 80214, USA
    J Nutr 132:1047-9. 2002
  50. ncbi request reprint Using nuclear morphometry to discriminate the tumorigenic potential of cells: a comparison of statistical methods
    Pamela Wolfe
    Cancer Prevention Laboratory, Colorado State University, 111 Shepardson Building, 1173 Campus Delivery, Fort Collins, CO 80523, USA
    Cancer Epidemiol Biomarkers Prev 13:976-88. 2004
    ....
  51. ncbi request reprint Semi-automated method of quantifying vasculature of 1-methyl-1-nitrosourea-induced rat mammary carcinomas using immunohistochemical detection
    John N McGinley
    Center for Nutrition in the Prevention of Disease, AMC Cancer Research Center, Denver, Colorado 80214, USA
    J Histochem Cytochem 50:213-22. 2002
    ....
  52. pmc Characterization of low molecular weight chemical fractions of dry bean (Phaseolus vulgaris) for bioactivity using Caenorhabditis elegans longevity and metabolite fingerprinting
    Meghan M Mensack
    Cancer Prevention Laboratory, Department of Horticulture, Colorado State University, Fort Collins, Colorado 80523, USA
    J Agric Food Chem 58:6697-705. 2010
    ..Metabolite fingerprinting revealed distinguishing spectral differences among the four chemical fractions evaluated and demonstrated that within each fraction chemical composition differed significantly based on dry bean genetic heritage...
  53. ncbi request reprint Mechanisms of cell cycle arrest by methylseleninic acid
    Zongjian Zhu
    Center for Nutrition in the Prevention of Disease, AMC Cancer Research Center, Lakewood, Colorado 80214, USA
    Cancer Res 62:156-64. 2002
    ..This effect may be induced by MSA via its modulation of insulin-like growth factor-I-mediated signal transduction leading to inhibition of Akt activation and limitation of cyclin D1-CDK4-mediated phosphorylation of Rb...
  54. ncbi request reprint Increased urinary 8-isoprostaglandin F(2)alpha is associated with lower plasma selenium levels and lower vegetable and fruit intake in an asbestos-exposed cohort at risk for lung cancer
    E Brigitte Gottschall
    National Jewish Medical and Research Center, Denver, CO, USA
    Chest 125:83S. 2004
  55. pmc Metabolite profiling of a diverse collection of wheat lines using ultraperformance liquid chromatography coupled with time-of-flight mass spectrometry
    Shawna B Matthews
    Cancer Prevention Laboratory and Department of Horticulture, Colorado State University, Fort Collins, Colorado, United States of America
    PLoS ONE 7:e44179. 2012
    ..This work provides a foundation for identification of metabolite profiles associated with desirable agronomic and human health traits and for assessing how environmental factors impact these characteristics...
  56. doi request reprint Metabolomic analysis of the effects of edible dry beans (Phaseolus vulgaris L.) on tissue lipid metabolism and carcinogenesis in rats
    Meghan M Mensack
    Cancer Prevention Laboratory, Colorado State University, Fort Collins, CO 80523, USA
    Br J Nutr 108:S155-65. 2012
    ....
  57. pmc Metformin as an energy restriction mimetic agent for breast cancer prevention
    Zongjian Zhu
    Cancer Prevention Laboratory, Colorado State University, Fort Collins, CO, 80523, USA
    J Carcinog 10:17. 2011
    ..To begin to delineate clinically relevant mechanisms for breast cancer prevention, metformin was also studied along with dietary energy restriction...
  58. doi request reprint Adaptation of the AOAC 2011.25 integrated total dietary fiber assay to determine the dietary fiber and oligosaccharide content of dry edible beans
    Adrienne E Kleintop
    Department of Soil and Crop Sciences and Department of Horticulture and Landscape Architecture, Colorado State University, Fort Collins, Colorado 80523, United States
    J Agric Food Chem 61:9719-26. 2013
    ..25 method were suitable for estimating DF in cooked dry edible beans. ..
  59. ncbi request reprint Association between the T27C polymorphism in the cytochrome P450 c17alpha (CYP17) gene and risk factors for breast cancer
    Chi Chen Hong
    Division of Epidemiology and Statistics, Ontario Cancer Institute, 610 University Avenue, Toronto, Ontario, M5G 2M9, Canada
    Breast Cancer Res Treat 88:217-30. 2004
    ..Our findings suggest that the CYP17 A2 allele is associated with hormone levels, and interacts with insulin levels and diet to affect breast density levels and potentially breast cancer risk...
  60. ncbi request reprint Val158Met Polymorphism in catechol-O-methyltransferase gene associated with risk factors for breast cancer
    Chi Chen Hong
    Division of Epidemiology and Statistics, Ontario Cancer Institute, Toronto, Ontario, M5G 2M9 Canada
    Cancer Epidemiol Biomarkers Prev 12:838-47. 2003
    ..These findings indicate that COMT genotype is associated with several risk factors for breast cancer and suggest that the low-activity COMT*2 allele is associated with a reduced risk of breast cancer among premenopausal women...

Research Grants35

  1. SELENIUM AND LUNG CANCER RISK
    Henry Thompson; Fiscal Year: 2004
    ..In addition, this work has the potential to provide new biomarkers with which to assess lung cancer risk and its modulation. ..
  2. ENERGY RESTRICTION AND MAMMARY CANCER
    Henry Thompson; Fiscal Year: 2007
    ..abstract_text> ..
  3. Exercise, Breast Cancer Prevention, and Mechanisms
    Henry Thompson; Fiscal Year: 2007
    ..These data should facilitate the translation of pre-clinical and clinical research to public health recommendations for cancer risk reduction. ..
  4. Diet Composition, Weight Control and Breast Carcinogenesis
    Henry Thompson; Fiscal Year: 2007
    ....
  5. Exercise, Breast Cancer Prevention, and Mechanisms
    Henry Thompson; Fiscal Year: 2009
    ..The data obtained has the potential to facilitate the translation of pre-clinical and clinical research to public health guidelines for PA directed to cancer prevention and control. ..
  6. Energy Restrction and Mammary Cancer
    Henry Thompson; Fiscal Year: 2009
    ....
  7. Exercise, Breast Cancer Prevention, and Mechanisms
    Henry J Thompson; Fiscal Year: 2010
    ..The data obtained has the potential to facilitate the translation of pre-clinical and clinical research to public health guidelines for PA directed to cancer prevention and control. ..
  8. Diet Composition, Weight Control and Breast Carcinogenesis
    Henry J Thompson; Fiscal Year: 2010
    ....
  9. SELENIUM AND LUNG CANCER RISK
    Henry Thompson; Fiscal Year: 2003
    ..Furthermore, our study addresses the question of whether the much-discussed antioxidant activity of selenium is a relevant mechanism of chemopreventive action. ..
  10. SELENIUM AND LUNG CANCER RISK
    Henry Thompson; Fiscal Year: 2002
    ..Level of MDA and 8-EPG in sputum also will determined. The project proposed will contribute to understanding whether intermediate biomarkers for lung cancer can be reserved by selenium, a finding of potential public health importance. ..
  11. ENERGY RESTRICTION AND MAMMARY CARCINOGENESIS
    Henry Thompson; Fiscal Year: 1993
    ....
  12. ENERGY RESTRICTION AND MAMMARY CARCINOGENESIS
    Henry Thompson; Fiscal Year: 2002
    ..abstract_text> ..
  13. Energy Restrction and Mammary Cancer
    Henry J Thompson; Fiscal Year: 2010
    ....