Toni R Pak

Summary

Affiliation: Colorado State University
Country: USA

Publications

  1. ncbi request reprint Steroidal modulation of in vitro gonadotropin secretion in prepubertal and adult male Siberian hamsters
    Toni R Pak
    Department of Environmental, Population and Organismic Biology, University of Colorado, Boulder, Colorado 80309, USA
    J Exp Zool A Comp Exp Biol 298:53-9. 2003
  2. ncbi request reprint Disruption of pubertal onset by exogenous testosterone and estrogen in two species of rodents
    Toni R Pak
    Department of Environmental, Population and Organismic Biology, University of Colorado, Boulder 80309, USA
    Am J Physiol Endocrinol Metab 284:E206-12. 2003
  3. ncbi request reprint Estrogen accelerates gonadal recrudescence in photo-regressed male siberian hamsters
    Toni R Pak
    Department of Environmental, Population and Organismic Biology, University of Colorado, Boulder 80309 0334, USA
    Endocrinology 143:4131-4. 2002
  4. ncbi request reprint Differential alteration of the reproductive axis by testosterone and estrogen in peripubertal and adult male Siberian hamsters (Phodopus sungorus)
    Toni R Pak
    Department of Environmental, Population, and Organismic Biology, University of Colorado, Boulder, Colorado 80309, USA
    Biol Reprod 67:706-11. 2002
  5. ncbi request reprint Progestin receptor expression in the developing rat brain depends upon activation of estrogen receptor alpha and not estrogen receptor beta
    Wilson C J Chung
    Department of Biomedical Sciences, Colorado State University, Fort Collins, 80523, USA
    Brain Res 1082:50-60. 2006
  6. ncbi request reprint Ligand-independent effects of estrogen receptor beta on mouse gonadotropin-releasing hormone promoter activity
    Toni R Pak
    Department of Biomedical Sciences, College of Veterinary Medicine, Colorado State University, Fort Collins, 80523, USA
    Endocrinology 147:1924-31. 2006
  7. ncbi request reprint The androgen metabolite, 5alpha-androstane-3beta, 17beta-diol, is a potent modulator of estrogen receptor-beta1-mediated gene transcription in neuronal cells
    Toni R Pak
    Department of Biomedical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, Colorado 80523, USA
    Endocrinology 146:147-55. 2005
  8. pmc An alternate pathway for androgen regulation of brain function: activation of estrogen receptor beta by the metabolite of dihydrotestosterone, 5alpha-androstane-3beta,17beta-diol
    Robert J Handa
    Department of Biomedical Sciences Neurosciences Division, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80523, USA
    Horm Behav 53:741-52. 2008
  9. ncbi request reprint Targeted expression of a dominant-negative fibroblast growth factor (FGF) receptor in gonadotropin-releasing hormone (GnRH) neurons reduces FGF responsiveness and the size of GnRH neuronal population
    Pei San Tsai
    Department of Integrative Physiology and the Center for Neuroscience, University of Colorado, 114 Clare Small, Boulder, Colorado 80309 0354, USA
    Mol Endocrinol 19:225-36. 2005
  10. ncbi request reprint Estrogen receptor-beta mediates dihydrotestosterone-induced stimulation of the arginine vasopressin promoter in neuronal cells
    Toni R Pak
    Department of Biomedical Science, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins 80523, USA
    Endocrinology 148:3371-82. 2007

Research Grants

Detail Information

Publications11

  1. ncbi request reprint Steroidal modulation of in vitro gonadotropin secretion in prepubertal and adult male Siberian hamsters
    Toni R Pak
    Department of Environmental, Population and Organismic Biology, University of Colorado, Boulder, Colorado 80309, USA
    J Exp Zool A Comp Exp Biol 298:53-9. 2003
    ....
  2. ncbi request reprint Disruption of pubertal onset by exogenous testosterone and estrogen in two species of rodents
    Toni R Pak
    Department of Environmental, Population and Organismic Biology, University of Colorado, Boulder 80309, USA
    Am J Physiol Endocrinol Metab 284:E206-12. 2003
    ..Despite the highly varied effects of T and E(2) in these two species, the ability of steroid hormones to disrupt the onset of puberty appears to be a feature common to many rodents...
  3. ncbi request reprint Estrogen accelerates gonadal recrudescence in photo-regressed male siberian hamsters
    Toni R Pak
    Department of Environmental, Population and Organismic Biology, University of Colorado, Boulder 80309 0334, USA
    Endocrinology 143:4131-4. 2002
    ..Further, we demonstrated a novel role of E(2) in the initiation of spermatogenesis, possibly via a mechanism independent of FSH...
  4. ncbi request reprint Differential alteration of the reproductive axis by testosterone and estrogen in peripubertal and adult male Siberian hamsters (Phodopus sungorus)
    Toni R Pak
    Department of Environmental, Population, and Organismic Biology, University of Colorado, Boulder, Colorado 80309, USA
    Biol Reprod 67:706-11. 2002
    ....
  5. ncbi request reprint Progestin receptor expression in the developing rat brain depends upon activation of estrogen receptor alpha and not estrogen receptor beta
    Wilson C J Chung
    Department of Biomedical Sciences, Colorado State University, Fort Collins, 80523, USA
    Brain Res 1082:50-60. 2006
    ..In the lateral bed nucleus of the stria terminalis (BSTL), neither PPT nor DPN affected PR expression, suggesting the presence of a gonadal hormone-independent PR regulatory mechanism...
  6. ncbi request reprint Ligand-independent effects of estrogen receptor beta on mouse gonadotropin-releasing hormone promoter activity
    Toni R Pak
    Department of Biomedical Sciences, College of Veterinary Medicine, Colorado State University, Fort Collins, 80523, USA
    Endocrinology 147:1924-31. 2006
    ..Overall, our data suggest that ERbeta functions as a basic transcription factor in GnRH neurons and demonstrate a potential molecular mechanism for the negative feedback effects of E(2) on GnRH...
  7. ncbi request reprint The androgen metabolite, 5alpha-androstane-3beta, 17beta-diol, is a potent modulator of estrogen receptor-beta1-mediated gene transcription in neuronal cells
    Toni R Pak
    Department of Biomedical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, Colorado 80523, USA
    Endocrinology 146:147-55. 2005
    ..These data provide evidence for activation of ER signaling pathways by an androgen metabolite in neuronal cells...
  8. pmc An alternate pathway for androgen regulation of brain function: activation of estrogen receptor beta by the metabolite of dihydrotestosterone, 5alpha-androstane-3beta,17beta-diol
    Robert J Handa
    Department of Biomedical Sciences Neurosciences Division, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80523, USA
    Horm Behav 53:741-52. 2008
    ..These novel findings compel us to re-evaluate the interpretation of past studies and the design of future experiments aimed at elucidating the specific effects of androgen receptor signaling pathways...
  9. ncbi request reprint Targeted expression of a dominant-negative fibroblast growth factor (FGF) receptor in gonadotropin-releasing hormone (GnRH) neurons reduces FGF responsiveness and the size of GnRH neuronal population
    Pei San Tsai
    Department of Integrative Physiology and the Center for Neuroscience, University of Colorado, 114 Clare Small, Boulder, Colorado 80309 0354, USA
    Mol Endocrinol 19:225-36. 2005
    ..Overall, our results are the first to show, at the level of the organism, that FGFs are one of the important components involved in the formation and maintenance of the GnRH system...
  10. ncbi request reprint Estrogen receptor-beta mediates dihydrotestosterone-induced stimulation of the arginine vasopressin promoter in neuronal cells
    Toni R Pak
    Department of Biomedical Science, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins 80523, USA
    Endocrinology 148:3371-82. 2007
    ..Our results demonstrate that DHT and its metabolite 5alpha-androstane-3beta,17beta-diol stimulate AVP promoter activity through ERbeta in a neuronal cell line...
  11. ncbi request reprint Detection and localization of an estrogen receptor beta splice variant protein (ERbeta2) in the adult female rat forebrain and midbrain regions
    Wilson C J Chung
    Department of Biomedical Sciences, Colorado State University, Fort Collins, Colorado 80309 0354, USA
    J Comp Neurol 505:249-67. 2007
    ....

Research Grants1

  1. Estrogen regulation of GnRH neurons in male mice
    Toni Pak; Fiscal Year: 2006
    ..Overall these studies will provide important information about the mechanisms regulating puberty in male mammals. ..