Diane Ordway

Summary

Affiliation: Colorado State University
Country: USA

Publications

  1. ncbi request reprint Intracellular activity of clinical concentrations of phenothiazines including thioridiazine against phagocytosed Staphylococcus aureus
    Diane Ordway
    Unit of Mycobacteriology, Department of Mycobacteriology, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa, Rua da Junqueira 96, 1349 019 Lisboa, Portugal
    Int J Antimicrob Agents 20:34-43. 2002
  2. ncbi request reprint Increased Interleukin-4 production by CD8 and gammadelta T cells in health-care workers is associated with the subsequent development of active tuberculosis
    Diane J Ordway
    Centro de Malaria e Outras Doencas Tropicais, Unit of Mycobacteriology Instituto de Higiene e Medicina Tropical, Universidade de Lisboa, Hospital Egas Moniz, Lisbon, Portugal
    J Infect Dis 190:756-66. 2004
  3. ncbi request reprint Enhanced macrophage activity in granulomatous lesions of immune mice challenged with Mycobacterium tuberculosis
    Diane Ordway
    Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523, USA
    J Immunol 176:4931-9. 2006
  4. ncbi request reprint Foamy macrophages within lung granulomas of mice infected with Mycobacterium tuberculosis express molecules characteristic of dendritic cells and antiapoptotic markers of the TNF receptor-associated factor family
    Diane Ordway
    Mycobacteria Research Laboratories, Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO 80523, USA
    J Immunol 175:3873-81. 2005
  5. ncbi request reprint Gamma delta T cell responses associated with the development of tuberculosis in health care workers
    Diane J Ordway
    Centro de Malaria e Outras Doencas Tropicais, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa, Rua da Junqueira 96, 1394 008 Lisbon, Portugal
    FEMS Immunol Med Microbiol 43:339-50. 2005
  6. ncbi request reprint Thioridazine reduces resistance of methicillin-resistant staphylococcus aureus by inhibiting a reserpine-sensitive efflux pump
    Malthe M Kristiansen
    Unit of Mycobacteriology, UPMM, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa, Rua da Junqueira 96, 1349 008 Lisboa, Portugal
    In Vivo 20:361-6. 2006
  7. pmc Influence of Mycobacterium bovis BCG vaccination on cellular immune response of guinea pigs challenged with Mycobacterium tuberculosis
    Diane Ordway
    Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523 1682, USA
    Clin Vaccine Immunol 15:1248-58. 2008
  8. ncbi request reprint Clinical concentrations of thioridazine enhance the killing of intracellular methicillin-resistant Staphylococcus aureus: an in vivo, ex vivo and electron microscopy study
    Marta Martins
    Unit of Mycobacteriology, UPMM, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa, 1349 019 Lisboa, Portugal
    In Vivo 18:787-94. 2004
  9. pmc Post-exposure vaccination against Mycobacterium tuberculosis
    Marcela Henao-Tamayo
    Colorado State University, Fort Collins, CO 80523 1682, USA
    Tuberculosis (Edinb) 89:142-8. 2009
  10. ncbi request reprint XCL1 (lymphotactin) chemokine produced by activated CD8 T cells during the chronic stage of infection with Mycobacterium tuberculosis negatively affects production of IFN-gamma by CD4 T cells and participates in granuloma stability
    Diane Ordway
    Mycobacteria Research Laboratories, Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO 80523 1682, USA
    J Leukoc Biol 82:1221-9. 2007

Collaborators

Detail Information

Publications24

  1. ncbi request reprint Intracellular activity of clinical concentrations of phenothiazines including thioridiazine against phagocytosed Staphylococcus aureus
    Diane Ordway
    Unit of Mycobacteriology, Department of Mycobacteriology, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa, Rua da Junqueira 96, 1349 019 Lisboa, Portugal
    Int J Antimicrob Agents 20:34-43. 2002
    ..These results suggest that TZ induces intracellular bactericidal activities independent of the capacity to generate Type 1 responses against S. aureus...
  2. ncbi request reprint Increased Interleukin-4 production by CD8 and gammadelta T cells in health-care workers is associated with the subsequent development of active tuberculosis
    Diane J Ordway
    Centro de Malaria e Outras Doencas Tropicais, Unit of Mycobacteriology Instituto de Higiene e Medicina Tropical, Universidade de Lisboa, Hospital Egas Moniz, Lisbon, Portugal
    J Infect Dis 190:756-66. 2004
    ..HCWs who remained healthy showed increased median percentages of CD8+IFN- gamma+ (25.0%) and gammadelta +IFN- gamma+ (8.0%) and lower percentages of CD8+IL-4+ (0.05%) and gammadelta +IL-4+ (0.03%) T cells...
  3. ncbi request reprint Enhanced macrophage activity in granulomatous lesions of immune mice challenged with Mycobacterium tuberculosis
    Diane Ordway
    Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523, USA
    J Immunol 176:4931-9. 2006
    ..tuberculosis by aerosol exposure, immune mice develop a protective granulomatous lesion by increasing macrophage numbers and reduced expression of protective and inflammatory cytokines...
  4. ncbi request reprint Foamy macrophages within lung granulomas of mice infected with Mycobacterium tuberculosis express molecules characteristic of dendritic cells and antiapoptotic markers of the TNF receptor-associated factor family
    Diane Ordway
    Mycobacteria Research Laboratories, Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO 80523, USA
    J Immunol 175:3873-81. 2005
    ..These data indicate that in addition to the central role of DCs in initiating the acquired immune response against M. tuberculosis infection, they also participate in the granulomatous response...
  5. ncbi request reprint Gamma delta T cell responses associated with the development of tuberculosis in health care workers
    Diane J Ordway
    Centro de Malaria e Outras Doencas Tropicais, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa, Rua da Junqueira 96, 1394 008 Lisbon, Portugal
    FEMS Immunol Med Microbiol 43:339-50. 2005
    ..Our results suggest that HCWs who developed TB show an early compensatory mechanism involving an increase in lytic responses of gammadelta TCR+ cells which did not prevent TB...
  6. ncbi request reprint Thioridazine reduces resistance of methicillin-resistant staphylococcus aureus by inhibiting a reserpine-sensitive efflux pump
    Malthe M Kristiansen
    Unit of Mycobacteriology, UPMM, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa, Rua da Junqueira 96, 1349 008 Lisboa, Portugal
    In Vivo 20:361-6. 2006
    ..The phenothiazines have been shown, by others, to inhibit the efflux pumps of bacteria and the mechanism by which MRSA are rendered more susceptible to oxacillin in the presence of TZ is believed to be due to a similar efflux pump...
  7. pmc Influence of Mycobacterium bovis BCG vaccination on cellular immune response of guinea pigs challenged with Mycobacterium tuberculosis
    Diane Ordway
    Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523 1682, USA
    Clin Vaccine Immunol 15:1248-58. 2008
    ....
  8. ncbi request reprint Clinical concentrations of thioridazine enhance the killing of intracellular methicillin-resistant Staphylococcus aureus: an in vivo, ex vivo and electron microscopy study
    Marta Martins
    Unit of Mycobacteriology, UPMM, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa, 1349 019 Lisboa, Portugal
    In Vivo 18:787-94. 2004
    ....
  9. pmc Post-exposure vaccination against Mycobacterium tuberculosis
    Marcela Henao-Tamayo
    Colorado State University, Fort Collins, CO 80523 1682, USA
    Tuberculosis (Edinb) 89:142-8. 2009
    ....
  10. ncbi request reprint XCL1 (lymphotactin) chemokine produced by activated CD8 T cells during the chronic stage of infection with Mycobacterium tuberculosis negatively affects production of IFN-gamma by CD4 T cells and participates in granuloma stability
    Diane Ordway
    Mycobacteria Research Laboratories, Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO 80523 1682, USA
    J Leukoc Biol 82:1221-9. 2007
    ..Additionally, we also describe for the first time that during Mtb infection, activated CD8 T cells in the lungs produce XCL1 and that this chemokine is capable of controlling IFN-gamma production by CD4 T cells...
  11. ncbi request reprint Inhibition of the Carpobrotus edulis methanol extract on the growth of phagocytosed multidrug-resistant Mycobacterium tuberculosis and methicillin-resistant Staphylococcus aureus
    Marta Martins
    Unit of Mycobacteriology, UPMM, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa, Rua da Junqueira 96, 1349 008, Lisboa, Portugal
    Fitoterapia 76:96-9. 2005
    ....
  12. pmc A mutant of Mycobacterium tuberculosis lacking the 19-kDa lipoprotein Rv3763 is highly attenuated in vivo but retains potent vaccinogenic properties
    Marcela Henao-Tamayo
    Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80524, USA
    Vaccine 25:7153-9. 2007
    ..These data show that despite being highly attenuated, the Delta 19 mutant strongly retained vaccinogenic properties...
  13. ncbi request reprint Phenothiazines alter resistance of methicillin-resistant strains of Staphylococcus aureus (MRSA) to oxacillin in vitro
    Malthe M Kristiansen
    Unit of Mycobacteriology, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa, Rua da Junqueira 96, 1349 008 Lisbon, Portugal
    Int J Antimicrob Agents 22:250-3. 2003
    ..Reserpine, an inhibitor of antibiotic efflux pumps also reduced the resistance of MRSA strains to oxacillin suggesting the presence of an efflux pump that contributes to antibiotic resistance of MRSA strains...
  14. doi request reprint Animal model of Mycobacterium abscessus lung infection
    Diane Ordway
    Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523 1682, USA
    J Leukoc Biol 83:1502-11. 2008
    ..In conclusion, IFN-gamma is critically important in the host defense against M. abscessus. As the number of effective drugs against M. abscessus is limited, the GKO mice provide a model for in vivo testing of novel drugs...
  15. pmc Clinical concentrations of thioridazine kill intracellular multidrug-resistant Mycobacterium tuberculosis
    Diane Ordway
    Unit of Mycobacteriology, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa, 1349 008 Lisbon, Portugal
    Antimicrob Agents Chemother 47:917-22. 2003
    ..tuberculosis isolates. Nevertheless, we must await the outcomes of clinical trials to determine whether TZ itself may be safely and effectively used as an antituberculosis agent...
  16. pmc A Toll-like receptor-2-directed fusion protein vaccine against tuberculosis
    Baolin Wang
    Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523, USA
    Clin Vaccine Immunol 14:902-6. 2007
    ....
  17. ncbi request reprint The hypervirulent Mycobacterium tuberculosis strain HN878 induces a potent TH1 response followed by rapid down-regulation
    Diane Ordway
    Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523, USA
    J Immunol 179:522-31. 2007
    ..This association may explain the paradoxical initial emergence of a TH1 response in these mice but their relatively short time of survival...
  18. ncbi request reprint The cellular immune response to Mycobacterium tuberculosis infection in the guinea pig
    Diane Ordway
    Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523, USA
    J Immunol 179:2532-41. 2007
    ..These data reveal new information about the cellular phenotypes which mediate protective immunity or host immunopathogenesis during M. tuberculosis infection in this key animal model...
  19. ncbi request reprint Carpobrotus edulis methanol extract inhibits the MDR efflux pumps, enhances killing of phagocytosed S. aureus and promotes immune modulation
    Diane Ordway
    Unit of Mycobacteriology, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa, Rua da Junqueira 96, 1349 008 Lisboa, Portugal
    Phytother Res 17:512-9. 2003
    ..It is supposed that the resistance modifier and immunomodulatory effect of this plant extract can be exploited in the experimental chemotherapy of cancer and bacterial or viral infections...
  20. doi request reprint Cigarette smoke increases susceptibility to tuberculosis--evidence from in vivo and in vitro models
    Shaobin Shang
    Mycobacteria Research Laboratories, Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO, USA
    J Infect Dis 203:1240-8. 2011
    ..Cigarette smoke (CS) exposure is an epidemiological risk factor for tuberculosis, although the biological basis has not been elucidated...
  21. ncbi request reprint Chlorpromazine has intracellular killing activity against phagocytosed Staphylococcus aureus at clinical concentrations
    Diane Ordway
    Unit of Mycobacteriology, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa, Rua da Junqueira 96, 1349 019 Lisbon, Portugal
    J Infect Chemother 8:227-31. 2002
    ..Therefore, CPZ may have a role in the management of intracellular staphylococcal infections that normally require the use of antibiotics whose potential toxicity exceeds that associated with short-term management with CPZ...
  22. pmc Inducement and reversal of tetracycline resistance in Escherichia coli K-12 and expression of proton gradient-dependent multidrug efflux pump genes
    Miguel Viveiros
    Unit of Mycobacteriology, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa, Rua Junqueira 96, 1349 008 Lisbon, Portugal
    Antimicrob Agents Chemother 49:3578-82. 2005
    ..All transporter genes were overexpressed after induced resistance with acrF being 80-fold more expressed in the DeltaacrAB tetracycline-induced strain...
  23. pmc T lymphocyte surface expression of exhaustion markers as biomarkers of the efficacy of chemotherapy for tuberculosis
    Marcela Henao-Tamayo
    Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins CO 80523, USA
    Tuberculosis (Edinb) 91:308-13. 2011
    ..While there is no guarantee these changes would also be seen on T cells in the blood, this approach should be further investigated...
  24. pmc Isoniazid-induced transient high-level resistance in Mycobacterium tuberculosis
    Miguel Viveiros
    Unit of Mycobacteriology, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa, P 1349 008 Lisbon, Portugal
    Antimicrob Agents Chemother 46:2804-10. 2002
    ..These results collectively suggest that high-level resistance to INH can be induced in INH-susceptible M. tuberculosis strains by the induction of a reserpine-sensitive efflux mechanism...

Research Grants1

  1. Immune modulation by highly virulent clinical isolates of M.tuberculosis
    Diane Ordway; Fiscal Year: 2009
    ..Such information is critical to rational vaccine design. ..