Diane Ordway

Summary

Affiliation: Colorado State University
Country: USA

Publications

  1. pmc Mycobacterium bovis BCG-mediated protection against W-Beijing strains of Mycobacterium tuberculosis is diminished concomitant with the emergence of regulatory T cells
    Diane J Ordway
    Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523 1682
    Clin Vaccine Immunol 18:1527-35. 2011
  2. ncbi request reprint The cellular immune response to Mycobacterium tuberculosis infection in the guinea pig
    Diane Ordway
    Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523, USA
    J Immunol 179:2532-41. 2007
  3. ncbi request reprint The hypervirulent Mycobacterium tuberculosis strain HN878 induces a potent TH1 response followed by rapid down-regulation
    Diane Ordway
    Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523, USA
    J Immunol 179:522-31. 2007
  4. ncbi request reprint Animal model of Mycobacterium abscessus lung infection
    Diane Ordway
    Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523 1682, USA
    J Leukoc Biol 83:1502-11. 2008
  5. pmc Influence of Mycobacterium bovis BCG vaccination on cellular immune response of guinea pigs challenged with Mycobacterium tuberculosis
    Diane Ordway
    Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523 1682, USA
    Clin Vaccine Immunol 15:1248-58. 2008
  6. pmc Evaluation of standard chemotherapy in the guinea pig model of tuberculosis
    Diane J Ordway
    Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO 80523 1682, USA
    Antimicrob Agents Chemother 54:1820-33. 2010
  7. pmc Post-exposure vaccination against Mycobacterium tuberculosis
    Marcela Henao-Tamayo
    Colorado State University, Fort Collins, CO 80523 1682, USA
    Tuberculosis (Edinb) 89:142-8. 2009
  8. ncbi request reprint XCL1 (lymphotactin) chemokine produced by activated CD8 T cells during the chronic stage of infection with Mycobacterium tuberculosis negatively affects production of IFN-gamma by CD4 T cells and participates in granuloma stability
    Diane Ordway
    Mycobacteria Research Laboratories, Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO 80523 1682, USA
    J Leukoc Biol 82:1221-9. 2007
  9. ncbi request reprint Enhanced macrophage activity in granulomatous lesions of immune mice challenged with Mycobacterium tuberculosis
    Diane Ordway
    Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523, USA
    J Immunol 176:4931-9. 2006
  10. pmc A mutant of Mycobacterium tuberculosis lacking the 19-kDa lipoprotein Rv3763 is highly attenuated in vivo but retains potent vaccinogenic properties
    Marcela Henao-Tamayo
    Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80524, USA
    Vaccine 25:7153-9. 2007

Collaborators

Detail Information

Publications23

  1. pmc Mycobacterium bovis BCG-mediated protection against W-Beijing strains of Mycobacterium tuberculosis is diminished concomitant with the emergence of regulatory T cells
    Diane J Ordway
    Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523 1682
    Clin Vaccine Immunol 18:1527-35. 2011
    ....
  2. ncbi request reprint The cellular immune response to Mycobacterium tuberculosis infection in the guinea pig
    Diane Ordway
    Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523, USA
    J Immunol 179:2532-41. 2007
    ..These data reveal new information about the cellular phenotypes which mediate protective immunity or host immunopathogenesis during M. tuberculosis infection in this key animal model...
  3. ncbi request reprint The hypervirulent Mycobacterium tuberculosis strain HN878 induces a potent TH1 response followed by rapid down-regulation
    Diane Ordway
    Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523, USA
    J Immunol 179:522-31. 2007
    ..This association may explain the paradoxical initial emergence of a TH1 response in these mice but their relatively short time of survival...
  4. ncbi request reprint Animal model of Mycobacterium abscessus lung infection
    Diane Ordway
    Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523 1682, USA
    J Leukoc Biol 83:1502-11. 2008
    ..In conclusion, IFN-gamma is critically important in the host defense against M. abscessus. As the number of effective drugs against M. abscessus is limited, the GKO mice provide a model for in vivo testing of novel drugs...
  5. pmc Influence of Mycobacterium bovis BCG vaccination on cellular immune response of guinea pigs challenged with Mycobacterium tuberculosis
    Diane Ordway
    Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523 1682, USA
    Clin Vaccine Immunol 15:1248-58. 2008
    ....
  6. pmc Evaluation of standard chemotherapy in the guinea pig model of tuberculosis
    Diane J Ordway
    Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO 80523 1682, USA
    Antimicrob Agents Chemother 54:1820-33. 2010
    ..Chemotherapy also prevented the emergence in lung tissues of high levels of interleukin-10 and Foxp3-positive cells, known markers of regulatory T cells...
  7. pmc Post-exposure vaccination against Mycobacterium tuberculosis
    Marcela Henao-Tamayo
    Colorado State University, Fort Collins, CO 80523 1682, USA
    Tuberculosis (Edinb) 89:142-8. 2009
    ....
  8. ncbi request reprint XCL1 (lymphotactin) chemokine produced by activated CD8 T cells during the chronic stage of infection with Mycobacterium tuberculosis negatively affects production of IFN-gamma by CD4 T cells and participates in granuloma stability
    Diane Ordway
    Mycobacteria Research Laboratories, Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO 80523 1682, USA
    J Leukoc Biol 82:1221-9. 2007
    ..Additionally, we also describe for the first time that during Mtb infection, activated CD8 T cells in the lungs produce XCL1 and that this chemokine is capable of controlling IFN-gamma production by CD4 T cells...
  9. ncbi request reprint Enhanced macrophage activity in granulomatous lesions of immune mice challenged with Mycobacterium tuberculosis
    Diane Ordway
    Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523, USA
    J Immunol 176:4931-9. 2006
    ..tuberculosis by aerosol exposure, immune mice develop a protective granulomatous lesion by increasing macrophage numbers and reduced expression of protective and inflammatory cytokines...
  10. pmc A mutant of Mycobacterium tuberculosis lacking the 19-kDa lipoprotein Rv3763 is highly attenuated in vivo but retains potent vaccinogenic properties
    Marcela Henao-Tamayo
    Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80524, USA
    Vaccine 25:7153-9. 2007
    ..These data show that despite being highly attenuated, the Delta 19 mutant strongly retained vaccinogenic properties...
  11. pmc A Toll-like receptor-2-directed fusion protein vaccine against tuberculosis
    Baolin Wang
    Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523, USA
    Clin Vaccine Immunol 14:902-6. 2007
    ....
  12. doi request reprint Cigarette smoke increases susceptibility to tuberculosis--evidence from in vivo and in vitro models
    Shaobin Shang
    Mycobacteria Research Laboratories, Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO, USA
    J Infect Dis 203:1240-8. 2011
    ..Cigarette smoke (CS) exposure is an epidemiological risk factor for tuberculosis, although the biological basis has not been elucidated...
  13. pmc T lymphocyte surface expression of exhaustion markers as biomarkers of the efficacy of chemotherapy for tuberculosis
    Marcela Henao-Tamayo
    Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins CO 80523, USA
    Tuberculosis (Edinb) 91:308-13. 2011
    ..While there is no guarantee these changes would also be seen on T cells in the blood, this approach should be further investigated...
  14. ncbi request reprint Foamy macrophages within lung granulomas of mice infected with Mycobacterium tuberculosis express molecules characteristic of dendritic cells and antiapoptotic markers of the TNF receptor-associated factor family
    Diane Ordway
    Mycobacteria Research Laboratories, Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO 80523, USA
    J Immunol 175:3873-81. 2005
    ..These data indicate that in addition to the central role of DCs in initiating the acquired immune response against M. tuberculosis infection, they also participate in the granulomatous response...
  15. pmc Activities of TMC207, rifampin, and pyrazinamide against Mycobacterium tuberculosis infection in guinea pigs
    Shaobin Shang
    Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO 80523, USA
    Antimicrob Agents Chemother 55:124-31. 2011
    ..These data indicate that TMC207 could be a useful addition to current treatment regimens for tuberculosis...
  16. ncbi request reprint Intracellular activity of clinical concentrations of phenothiazines including thioridiazine against phagocytosed Staphylococcus aureus
    Diane Ordway
    Unit of Mycobacteriology, Department of Mycobacteriology, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa, Rua da Junqueira 96, 1349 019 Lisboa, Portugal
    Int J Antimicrob Agents 20:34-43. 2002
    ..These results suggest that TZ induces intracellular bactericidal activities independent of the capacity to generate Type 1 responses against S. aureus...
  17. ncbi request reprint Clinical concentrations of thioridazine enhance the killing of intracellular methicillin-resistant Staphylococcus aureus: an in vivo, ex vivo and electron microscopy study
    Marta Martins
    Unit of Mycobacteriology, UPMM, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa, 1349 019 Lisboa, Portugal
    In Vivo 18:787-94. 2004
    ....
  18. pmc Isoniazid-induced transient high-level resistance in Mycobacterium tuberculosis
    Miguel Viveiros
    Unit of Mycobacteriology, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa, P 1349 008 Lisbon, Portugal
    Antimicrob Agents Chemother 46:2804-10. 2002
    ..These results collectively suggest that high-level resistance to INH can be induced in INH-susceptible M. tuberculosis strains by the induction of a reserpine-sensitive efflux mechanism...
  19. ncbi request reprint Chlorpromazine has intracellular killing activity against phagocytosed Staphylococcus aureus at clinical concentrations
    Diane Ordway
    Unit of Mycobacteriology, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa, Rua da Junqueira 96, 1349 019 Lisbon, Portugal
    J Infect Chemother 8:227-31. 2002
    ..Therefore, CPZ may have a role in the management of intracellular staphylococcal infections that normally require the use of antibiotics whose potential toxicity exceeds that associated with short-term management with CPZ...
  20. pmc Clinical concentrations of thioridazine kill intracellular multidrug-resistant Mycobacterium tuberculosis
    Diane Ordway
    Unit of Mycobacteriology, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa, 1349 008 Lisbon, Portugal
    Antimicrob Agents Chemother 47:917-22. 2003
    ..tuberculosis isolates. Nevertheless, we must await the outcomes of clinical trials to determine whether TZ itself may be safely and effectively used as an antituberculosis agent...
  21. ncbi request reprint Carpobrotus edulis methanol extract inhibits the MDR efflux pumps, enhances killing of phagocytosed S. aureus and promotes immune modulation
    Diane Ordway
    Unit of Mycobacteriology, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa, Rua da Junqueira 96, 1349 008 Lisboa, Portugal
    Phytother Res 17:512-9. 2003
    ..It is supposed that the resistance modifier and immunomodulatory effect of this plant extract can be exploited in the experimental chemotherapy of cancer and bacterial or viral infections...
  22. ncbi request reprint Inhibition of the Carpobrotus edulis methanol extract on the growth of phagocytosed multidrug-resistant Mycobacterium tuberculosis and methicillin-resistant Staphylococcus aureus
    Marta Martins
    Unit of Mycobacteriology, UPMM, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa, Rua da Junqueira 96, 1349 008, Lisboa, Portugal
    Fitoterapia 76:96-9. 2005
    ....
  23. ncbi request reprint Thioridazine reduces resistance of methicillin-resistant staphylococcus aureus by inhibiting a reserpine-sensitive efflux pump
    Malthe M Kristiansen
    Unit of Mycobacteriology, UPMM, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa, Rua da Junqueira 96, 1349 008 Lisboa, Portugal
    In Vivo 20:361-6. 2006
    ..The phenothiazines have been shown, by others, to inhibit the efflux pumps of bacteria and the mechanism by which MRSA are rendered more susceptible to oxacillin in the presence of TZ is believed to be due to a similar efflux pump...