Research Topics
Species | Diane OrdwaySummaryAffiliation: Colorado State University Country: USA Publications
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Publications
Mycobacterium bovis BCG-mediated protection against W-Beijing strains of Mycobacterium tuberculosis is diminished concomitant with the emergence of regulatory T cellsDiane J Ordway
Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523 1682
Clin Vaccine Immunol 18:1527-35. 2011....
The cellular immune response to Mycobacterium tuberculosis infection in the guinea pigDiane Ordway
Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523, USA
J Immunol 179:2532-41. 2007..These data reveal new information about the cellular phenotypes which mediate protective immunity or host immunopathogenesis during M. tuberculosis infection in this key animal model...- The hypervirulent Mycobacterium tuberculosis strain HN878 induces a potent TH1 response followed by rapid down-regulationDiane Ordway
Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523, USA
J Immunol 179:522-31. 2007..This association may explain the paradoxical initial emergence of a TH1 response in these mice but their relatively short time of survival... 
Animal model of Mycobacterium abscessus lung infectionDiane Ordway
Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523 1682, USA
J Leukoc Biol 83:1502-11. 2008..In conclusion, IFN-gamma is critically important in the host defense against M. abscessus. As the number of effective drugs against M. abscessus is limited, the GKO mice provide a model for in vivo testing of novel drugs...- Influence of Mycobacterium bovis BCG vaccination on cellular immune response of guinea pigs challenged with Mycobacterium tuberculosisDiane Ordway
Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523 1682, USA
Clin Vaccine Immunol 15:1248-58. 2008.... - Evaluation of standard chemotherapy in the guinea pig model of tuberculosisDiane J Ordway
Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO 80523 1682, USA
Antimicrob Agents Chemother 54:1820-33. 2010..Chemotherapy also prevented the emergence in lung tissues of high levels of interleukin-10 and Foxp3-positive cells, known markers of regulatory T cells... - Post-exposure vaccination against Mycobacterium tuberculosisMarcela Henao-Tamayo
Colorado State University, Fort Collins, CO 80523 1682, USA
Tuberculosis (Edinb) 89:142-8. 2009.... - XCL1 (lymphotactin) chemokine produced by activated CD8 T cells during the chronic stage of infection with Mycobacterium tuberculosis negatively affects production of IFN-gamma by CD4 T cells and participates in granuloma stabilityDiane Ordway
Mycobacteria Research Laboratories, Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO 80523 1682, USA
J Leukoc Biol 82:1221-9. 2007..Additionally, we also describe for the first time that during Mtb infection, activated CD8 T cells in the lungs produce XCL1 and that this chemokine is capable of controlling IFN-gamma production by CD4 T cells... - Enhanced macrophage activity in granulomatous lesions of immune mice challenged with Mycobacterium tuberculosisDiane Ordway
Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523, USA
J Immunol 176:4931-9. 2006..tuberculosis by aerosol exposure, immune mice develop a protective granulomatous lesion by increasing macrophage numbers and reduced expression of protective and inflammatory cytokines... - A mutant of Mycobacterium tuberculosis lacking the 19-kDa lipoprotein Rv3763 is highly attenuated in vivo but retains potent vaccinogenic propertiesMarcela Henao-Tamayo
Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80524, USA
Vaccine 25:7153-9. 2007..These data show that despite being highly attenuated, the Delta 19 mutant strongly retained vaccinogenic properties... - A Toll-like receptor-2-directed fusion protein vaccine against tuberculosisBaolin Wang
Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523, USA
Clin Vaccine Immunol 14:902-6. 2007.... - Cigarette smoke increases susceptibility to tuberculosis--evidence from in vivo and in vitro modelsShaobin Shang
Mycobacteria Research Laboratories, Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO, USA
J Infect Dis 203:1240-8. 2011..Cigarette smoke (CS) exposure is an epidemiological risk factor for tuberculosis, although the biological basis has not been elucidated... - T lymphocyte surface expression of exhaustion markers as biomarkers of the efficacy of chemotherapy for tuberculosisMarcela Henao-Tamayo
Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins CO 80523, USA
Tuberculosis (Edinb) 91:308-13. 2011..While there is no guarantee these changes would also be seen on T cells in the blood, this approach should be further investigated... - Foamy macrophages within lung granulomas of mice infected with Mycobacterium tuberculosis express molecules characteristic of dendritic cells and antiapoptotic markers of the TNF receptor-associated factor familyDiane Ordway
Mycobacteria Research Laboratories, Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO 80523, USA
J Immunol 175:3873-81. 2005..These data indicate that in addition to the central role of DCs in initiating the acquired immune response against M. tuberculosis infection, they also participate in the granulomatous response... - Activities of TMC207, rifampin, and pyrazinamide against Mycobacterium tuberculosis infection in guinea pigsShaobin Shang
Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO 80523, USA
Antimicrob Agents Chemother 55:124-31. 2011..These data indicate that TMC207 could be a useful addition to current treatment regimens for tuberculosis... - Intracellular activity of clinical concentrations of phenothiazines including thioridiazine against phagocytosed Staphylococcus aureusDiane Ordway
Unit of Mycobacteriology, Department of Mycobacteriology, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa, Rua da Junqueira 96, 1349-019 Lisboa, Portugal
Int J Antimicrob Agents 20:34-43. 2002..These results suggest that TZ induces intracellular bactericidal activities independent of the capacity to generate Type 1 responses against S. aureus... - Clinical concentrations of thioridazine enhance the killing of intracellular methicillin-resistant Staphylococcus aureus: an in vivo, ex vivo and electron microscopy studyMarta Martins
Unit of Mycobacteriology, UPMM, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa, 1349-019 Lisboa, Portugal
In Vivo 18:787-94. 2004.... - Isoniazid-induced transient high-level resistance in Mycobacterium tuberculosisMiguel Viveiros
Unit of Mycobacteriology, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa, P-1349-008 Lisbon, Portugal
Antimicrob Agents Chemother 46:2804-10. 2002..These results collectively suggest that high-level resistance to INH can be induced in INH-susceptible M. tuberculosis strains by the induction of a reserpine-sensitive efflux mechanism... - Chlorpromazine has intracellular killing activity against phagocytosed Staphylococcus aureus at clinical concentrationsDiane Ordway
Unit of Mycobacteriology, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa, Rua da Junqueira 96, 1349-019 Lisbon, Portugal
J Infect Chemother 8:227-31. 2002..Therefore, CPZ may have a role in the management of intracellular staphylococcal infections that normally require the use of antibiotics whose potential toxicity exceeds that associated with short-term management with CPZ... - Clinical concentrations of thioridazine kill intracellular multidrug-resistant Mycobacterium tuberculosisDiane Ordway
Unit of Mycobacteriology, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa, 1349-008 Lisbon, Portugal
Antimicrob Agents Chemother 47:917-22. 2003..tuberculosis isolates. Nevertheless, we must await the outcomes of clinical trials to determine whether TZ itself may be safely and effectively used as an antituberculosis agent... - Carpobrotus edulis methanol extract inhibits the MDR efflux pumps, enhances killing of phagocytosed S. aureus and promotes immune modulationDiane Ordway
Unit of Mycobacteriology, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa, Rua da Junqueira 96, 1349 008 Lisboa, Portugal
Phytother Res 17:512-9. 2003..It is supposed that the resistance modifier and immunomodulatory effect of this plant extract can be exploited in the experimental chemotherapy of cancer and bacterial or viral infections... - Inhibition of the Carpobrotus edulis methanol extract on the growth of phagocytosed multidrug-resistant Mycobacterium tuberculosis and methicillin-resistant Staphylococcus aureusMarta Martins
Unit of Mycobacteriology, UPMM, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa, Rua da Junqueira 96, 1349-008, Lisboa, Portugal
Fitoterapia 76:96-9. 2005.... - Thioridazine reduces resistance of methicillin-resistant staphylococcus aureus by inhibiting a reserpine-sensitive efflux pumpMalthe M Kristiansen
Unit of Mycobacteriology, UPMM, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa, Rua da Junqueira 96, 1349-008 Lisboa, Portugal
In Vivo 20:361-6. 2006..The phenothiazines have been shown, by others, to inhibit the efflux pumps of bacteria and the mechanism by which MRSA are rendered more susceptible to oxacillin in the presence of TZ is believed to be due to a similar efflux pump...