Anne J M Lenaerts

Summary

Affiliation: Colorado State University
Country: USA

Publications

  1. pmc Rapid in vivo screening of experimental drugs for tuberculosis using gamma interferon gene-disrupted mice
    Anne J M Lenaerts
    Department of Microbiology, Colorado State University, Fort Collins, Colorado 80523, USA
    Antimicrob Agents Chemother 47:783-5. 2003
  2. pmc Location of intra- and extracellular M. tuberculosis populations in lungs of mice and guinea pigs during disease progression and after drug treatment
    Donald R Hoff
    Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, Colorado, United States of America
    PLoS ONE 6:e17550. 2011
  3. pmc Evaluation of a 2-pyridone, KRQ-10018, against Mycobacterium tuberculosis in vitro and in vivo
    Anne J Lenaerts
    Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523, USA
    Antimicrob Agents Chemother 52:1513-5. 2008
  4. pmc Location of persisting mycobacteria in a Guinea pig model of tuberculosis revealed by r207910
    Anne J Lenaerts
    Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523, USA
    Antimicrob Agents Chemother 51:3338-45. 2007
  5. ncbi request reprint Significant increases in the levels of liver enzymes in mice treated with anti-tuberculosis drugs
    Anne J Lenaerts
    Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523, USA
    Int J Antimicrob Agents 26:152-8. 2005
  6. pmc Preclinical testing of the nitroimidazopyran PA-824 for activity against Mycobacterium tuberculosis in a series of in vitro and in vivo models
    Anne J Lenaerts
    Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523, USA
    Antimicrob Agents Chemother 49:2294-301. 2005
  7. ncbi request reprint Statistical limitations to the Cornell model of latent tuberculosis infection for the study of relapse rates
    Anne J Lenaerts
    Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523, USA
    Tuberculosis (Edinb) 84:361-4. 2004
  8. pmc Metronidazole lacks antibacterial activity in guinea pigs infected with Mycobacterium tuberculosis
    Donald R Hoff
    Department of Microbiology, Colorado State University, Fort Collins, Colorado 80523, USA
    Antimicrob Agents Chemother 52:4137-40. 2008
  9. doi request reprint Preclinical testing of new drugs for tuberculosis: current challenges
    Anne J Lenaerts
    Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523, USA
    Trends Microbiol 16:48-54. 2008
  10. pmc In vivo adaptation of the Wayne model of latent tuberculosis
    Lisa Woolhiser
    Mycobacteria Research Laboratories, Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO 80523, USA
    Infect Immun 75:2621-5. 2007

Collaborators

Detail Information

Publications21

  1. pmc Rapid in vivo screening of experimental drugs for tuberculosis using gamma interferon gene-disrupted mice
    Anne J M Lenaerts
    Department of Microbiology, Colorado State University, Fort Collins, Colorado 80523, USA
    Antimicrob Agents Chemother 47:783-5. 2003
    ..To validate this model, several fluoroquinolones, including ciprofloxacin, levofloxacin, moxifloxacin, and gatifloxacin, were tested in parallel...
  2. pmc Location of intra- and extracellular M. tuberculosis populations in lungs of mice and guinea pigs during disease progression and after drug treatment
    Donald R Hoff
    Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, Colorado, United States of America
    PLoS ONE 6:e17550. 2011
    ..Drug development should be designed to target this bacillary population and should evaluate drug regimens in the appropriate animal models...
  3. pmc Evaluation of a 2-pyridone, KRQ-10018, against Mycobacterium tuberculosis in vitro and in vivo
    Anne J Lenaerts
    Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523, USA
    Antimicrob Agents Chemother 52:1513-5. 2008
    ..tuberculosis versus moxifloxacin. In vivo efficacy of KRQ-10018 at 300 mg/kg of body weight was similar to that of isoniazid at 25 mg/kg, but showed less activity than moxifloxacin at 300 mg/kg...
  4. pmc Location of persisting mycobacteria in a Guinea pig model of tuberculosis revealed by r207910
    Anne J Lenaerts
    Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523, USA
    Antimicrob Agents Chemother 51:3338-45. 2007
    ..These results show that this acellular rim may, therefore, be a primary location of persisting bacilli withstanding drug treatment...
  5. ncbi request reprint Significant increases in the levels of liver enzymes in mice treated with anti-tuberculosis drugs
    Anne J Lenaerts
    Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523, USA
    Int J Antimicrob Agents 26:152-8. 2005
    ..The data obtained indicate that changes in serum enzyme levels in mice after extensive exposure to tuberculosis drugs could be useful as an initial indicator of drug-related hepatotoxicity...
  6. pmc Preclinical testing of the nitroimidazopyran PA-824 for activity against Mycobacterium tuberculosis in a series of in vitro and in vivo models
    Anne J Lenaerts
    Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523, USA
    Antimicrob Agents Chemother 49:2294-301. 2005
    ..These data indicate that there is significant potential for effective oral delivery of PA-824 for the treatment of tuberculosis...
  7. ncbi request reprint Statistical limitations to the Cornell model of latent tuberculosis infection for the study of relapse rates
    Anne J Lenaerts
    Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523, USA
    Tuberculosis (Edinb) 84:361-4. 2004
    ..When the objective of the experiment is confirmation of an effect through establishment of statistical significance, power calculations are critical in order to assure that the sample size will be sufficient to meet that objective...
  8. pmc Metronidazole lacks antibacterial activity in guinea pigs infected with Mycobacterium tuberculosis
    Donald R Hoff
    Department of Microbiology, Colorado State University, Fort Collins, Colorado 80523, USA
    Antimicrob Agents Chemother 52:4137-40. 2008
    ..Metronidazole treatment (for 6 weeks at 100 mg/kg of body weight) resulted in no reduction in the bacillary burden and significantly worsened lesion inflammation...
  9. doi request reprint Preclinical testing of new drugs for tuberculosis: current challenges
    Anne J Lenaerts
    Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523, USA
    Trends Microbiol 16:48-54. 2008
    ....
  10. pmc In vivo adaptation of the Wayne model of latent tuberculosis
    Lisa Woolhiser
    Mycobacteria Research Laboratories, Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO 80523, USA
    Infect Immun 75:2621-5. 2007
    ..Preimmunization of mice with a panel of selected vaccine candidates slowed or prevented this event. This simple model has potential for identifying vaccines targeting latent tuberculosis...
  11. pmc Testing of experimental compounds in a relapse model of tuberculosis using granulocyte-macrophage colony-stimulating factor gene-disrupted mice
    Lisa K Woolhiser
    Department of Microbiology, Colorado State University, Fort Collins, Colorado 80523, USA
    Antimicrob Agents Chemother 53:306-8. 2009
    ..A subsequent treatment with individual drugs was performed to assess their activity on the 1% of remaining bacilli and disease relapse...
  12. pmc Evaluation of standard chemotherapy in the guinea pig model of tuberculosis
    Diane J Ordway
    Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO 80523 1682, USA
    Antimicrob Agents Chemother 54:1820-33. 2010
    ..Chemotherapy also prevented the emergence in lung tissues of high levels of interleukin-10 and Foxp3-positive cells, known markers of regulatory T cells...
  13. pmc Oral therapy using nanoparticle-encapsulated antituberculosis drugs in guinea pigs infected with Mycobacterium tuberculosis
    Christine M Johnson
    Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, 80523 1682, USA
    Antimicrob Agents Chemother 49:4335-8. 2005
    ..Both treatments significantly reduced the bacterial count and lung histopathology, suggesting that the nanoparticle drug delivery system has potential in intermitted treatment of tuberculosis...
  14. pmc Comparative studies evaluating mouse models used for efficacy testing of experimental drugs against Mycobacterium tuberculosis
    Mary A De Groote
    Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523, USA
    Antimicrob Agents Chemother 55:1237-47. 2011
    ....
  15. pmc Rapid microbiologic and pharmacologic evaluation of experimental compounds against Mycobacterium tuberculosis
    Veronica Gruppo
    Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523, USA
    Antimicrob Agents Chemother 50:1245-50. 2006
    ....
  16. pmc Activities of TMC207, rifampin, and pyrazinamide against Mycobacterium tuberculosis infection in guinea pigs
    Shaobin Shang
    Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO 80523, USA
    Antimicrob Agents Chemother 55:124-31. 2011
    ..These data indicate that TMC207 could be a useful addition to current treatment regimens for tuberculosis...
  17. pmc Multiple M. tuberculosis phenotypes in mouse and guinea pig lung tissue revealed by a dual-staining approach
    Gavin J Ryan
    Department of Microbiology, Colorado State University, Fort Collins, Colorado, United States of America
    PLoS ONE 5:e11108. 2010
    ..This is relevant information for approaches that study bacillary characteristics in pooled samples (using lipidomics and proteomics) as well as in M. tuberculosis drug development...
  18. pmc Discovery of novel isoxazolines as anti-tuberculosis agents
    Rajendra P Tangallapally
    Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    Bioorg Med Chem Lett 17:6638-42. 2007
    ..This led to the discovery of novel isoxazoline 12 as anti-tuberculosis agent with a MIC(90) value of 1.56microg/mL...
  19. pmc Synthesis and evaluation of cyclic secondary amine substituted phenyl and benzyl nitrofuranyl amides as novel antituberculosis agents
    Rajendra P Tangallapally
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
    J Med Chem 48:8261-9. 2005
    ..This study led to the successful discovery of novel compounds with increased antituberculosis activity in vitro and a better understanding of the requisite pharmacological properties to advance this class...
  20. ncbi request reprint Synthesis and evaluation of nitrofuranylamides as novel antituberculosis agents
    Rajendra P Tangallapally
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, 847 Monroe Avenue, Room 327, Memphis, TN 38163, USA
    J Med Chem 47:5276-83. 2004
    ..On the basis of these results, four compounds were selected for in vivo testing in a mouse model of tuberculosis infection, and of these compounds one showed significant antituberculosis activity...
  21. ncbi request reprint Synthesis of new and potent analogues of anti-tuberculosis agent 5-nitro-furan-2-carboxylic acid 4-(4-benzyl-piperazin-1-yl)-benzylamide with improved bioavailability
    Rajendra P Tangallapally
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, 847 Monroe Ave, Rm 327, Memphis, TN 38163, USA
    Bioorg Med Chem Lett 16:2584-9. 2006
    ..These modifications retained strong activity and in some case gained superior anti-tuberculosis activity, increased absorption, and serum half life...