Angelo A Izzo

Summary

Affiliation: Colorado State University
Country: USA

Publications

  1. ncbi request reprint A matrix metalloproteinase inhibitor promotes granuloma formation during the early phase of Mycobacterium tuberculosis pulmonary infection
    A A Izzo
    Department of Microbiology, Midwestern University, Downers Grove, IL 60515, USA
    Tuberculosis (Edinb) 84:387-96. 2004
  2. ncbi request reprint NIH pre-clinical screening program: overview and current status
    Angelo Izzo
    Department of Microbiology, Colorado State University, Immunology and Pathology, Mycobacterial Research Laboratories, 1682 Campus Delivery, Fort Collins 80523 1682, USA
    Tuberculosis (Edinb) 85:25-8. 2005
  3. pmc The protective effect of the Mycobacterium bovis BCG vaccine is increased by coadministration with the Mycobacterium tuberculosis 72-kilodalton fusion polyprotein Mtb72F in M. tuberculosis-infected guinea pigs
    Lise Brandt
    Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins 80523, USA
    Infect Immun 72:6622-32. 2004
  4. ncbi request reprint Decreased survival of guinea pigs infected with Mycobacterium tuberculosis after multiple BCG vaccinations
    Randall J Basaraba
    Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523, USA
    Vaccine 24:280-6. 2006
  5. pmc Tracking antigen-specific CD8 T lymphocytes in the lungs of mice vaccinated with the Mtb72F polyprotein
    Scott M Irwin
    Mycobacterial Research Laboratories, Department of Microbiology, Immunology, and Pathology, Colorado State University, 1682 Campus Delivery, Fort Collins, CO 80523 1682, USA
    Infect Immun 73:5809-16. 2005
  6. pmc HspX-mediated protection against tuberculosis depends on its chaperoning of a mycobacterial molecule
    Jennifer L Taylor
    Department of Microbiology, Mycobacteria Research Laboratories, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523 1682, USA
    Immunol Cell Biol 90:945-54. 2012
  7. pmc BCG sub-strains induce variable protection against virulent pulmonary Mycobacterium tuberculosis infection, with the capacity to drive Th2 immunity
    Andrew Keyser
    Department of Microbiology, Immunology and Pathology, Colorado State University, 1682 Campus Delivery, Fort Collins, CO 80523, USA
    Vaccine 29:9308-15. 2011
  8. pmc Role for matrix metalloproteinase 9 in granuloma formation during pulmonary Mycobacterium tuberculosis infection
    Jennifer L Taylor
    Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, 200 West Lake Street, 1682 Campus Delivery, Fort Collins, CO 80523 1682, USA
    Infect Immun 74:6135-44. 2006
  9. doi request reprint Mycobacterial infection induces the secretion of high-mobility group box 1 protein
    Ajay Grover
    Department of Microbiology, Colorado State University, Fort Collins, CO 80523, USA
    Cell Microbiol 10:1390-404. 2008
  10. pmc Lack of alpha-1 integrin alters lesion morphology during pulmonary Mycobacterium tuberculosis infection
    Jennifer L Taylor
    Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523, USA
    Tuberculosis (Edinb) 88:444-52. 2008

Research Grants

Collaborators

Detail Information

Publications29

  1. ncbi request reprint A matrix metalloproteinase inhibitor promotes granuloma formation during the early phase of Mycobacterium tuberculosis pulmonary infection
    A A Izzo
    Department of Microbiology, Midwestern University, Downers Grove, IL 60515, USA
    Tuberculosis (Edinb) 84:387-96. 2004
    ..Granuloma formation requires immune cell infiltration and concurrent extensive remodeling of pulmonary tissue which we hypothesize to be the result of increased matrix metalloproteinases (MMP) activity...
  2. ncbi request reprint NIH pre-clinical screening program: overview and current status
    Angelo Izzo
    Department of Microbiology, Colorado State University, Immunology and Pathology, Mycobacterial Research Laboratories, 1682 Campus Delivery, Fort Collins 80523 1682, USA
    Tuberculosis (Edinb) 85:25-8. 2005
    ..The current screening program at Colorado State University has tested a wide range of novel vaccine candidates...
  3. pmc The protective effect of the Mycobacterium bovis BCG vaccine is increased by coadministration with the Mycobacterium tuberculosis 72-kilodalton fusion polyprotein Mtb72F in M. tuberculosis-infected guinea pigs
    Lise Brandt
    Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins 80523, USA
    Infect Immun 72:6622-32. 2004
    ..Collectively, these data suggest that enhancing BCG is a valid vaccination strategy for tuberculosis that is worthy of clinical evaluation...
  4. ncbi request reprint Decreased survival of guinea pigs infected with Mycobacterium tuberculosis after multiple BCG vaccinations
    Randall J Basaraba
    Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523, USA
    Vaccine 24:280-6. 2006
    ..These data indicate that multiple BCG vaccination, which is akin to super-infection with the living vaccine, leads to major organ failure pathology...
  5. pmc Tracking antigen-specific CD8 T lymphocytes in the lungs of mice vaccinated with the Mtb72F polyprotein
    Scott M Irwin
    Mycobacterial Research Laboratories, Department of Microbiology, Immunology, and Pathology, Colorado State University, 1682 Campus Delivery, Fort Collins, CO 80523 1682, USA
    Infect Immun 73:5809-16. 2005
    ..These data support the hypothesis that M. tuberculosis-specific CD8 T cells can be targeted by vaccination with the Mtb72F polyprotein...
  6. pmc HspX-mediated protection against tuberculosis depends on its chaperoning of a mycobacterial molecule
    Jennifer L Taylor
    Department of Microbiology, Mycobacteria Research Laboratories, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523 1682, USA
    Immunol Cell Biol 90:945-54. 2012
    ..These data suggest the possibility that the native form may chaperone an immunogenic and protective antigen that is mycobacteria-specific...
  7. pmc BCG sub-strains induce variable protection against virulent pulmonary Mycobacterium tuberculosis infection, with the capacity to drive Th2 immunity
    Andrew Keyser
    Department of Microbiology, Immunology and Pathology, Colorado State University, 1682 Campus Delivery, Fort Collins, CO 80523, USA
    Vaccine 29:9308-15. 2011
    ..tuberculosis...
  8. pmc Role for matrix metalloproteinase 9 in granuloma formation during pulmonary Mycobacterium tuberculosis infection
    Jennifer L Taylor
    Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, 200 West Lake Street, 1682 Campus Delivery, Fort Collins, CO 80523 1682, USA
    Infect Immun 74:6135-44. 2006
    ....
  9. doi request reprint Mycobacterial infection induces the secretion of high-mobility group box 1 protein
    Ajay Grover
    Department of Microbiology, Colorado State University, Fort Collins, CO 80523, USA
    Cell Microbiol 10:1390-404. 2008
    ..We conclude that HMGB1 is secreted by macrophages during tuberculosis and it may act as a signal of tissue or cellular injury and enhances immune response...
  10. pmc Lack of alpha-1 integrin alters lesion morphology during pulmonary Mycobacterium tuberculosis infection
    Jennifer L Taylor
    Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523, USA
    Tuberculosis (Edinb) 88:444-52. 2008
    ..tuberculosis infected lungs, it does play a role in granuloma structure and integrity during the chronic phase of infection...
  11. pmc Memory T lymphocytes generated by Mycobacterium bovis BCG vaccination reside within a CD4 CD44lo CD62 Ligandhi population
    Andre Kipnis
    Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523, USA
    Infect Immun 73:7759-64. 2005
    ..Upon cell transfer, however, cells expressing a resting/naïve phenotype (CD44lo CD62Lhi) were capable of protecting the recipients from a virulent challenge infection, suggesting the emergence of T-cell memory from within this subset...
  12. pmc BAT3 regulates Mycobacterium tuberculosis protein ESAT-6-mediated apoptosis of macrophages
    Ajay Grover
    Departments of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado, United States of America
    PLoS ONE 7:e40836. 2012
    ..Taken together, the data suggest that BAT3 plays a role in the early immune response to M. tuberculosis infection and may be a key protein associated with the fate of antigen presenting cells during infection...
  13. ncbi request reprint Disruption of granulocyte macrophage-colony stimulating factor production in the lungs severely affects the ability of mice to control Mycobacterium tuberculosis infection
    Mercedes Gonzalez-Juarrero
    Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, 80523, USA
    J Leukoc Biol 77:914-22. 2005
    ..tuberculosis bacterial growth...
  14. pmc Magnetic resonance imaging of pulmonary lesions in guinea pigs infected with Mycobacterium tuberculosis
    Susan L Kraft
    Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, Colorado 80523, USA
    Infect Immun 72:5963-71. 2004
    ..Further development of this technical approach could be very useful in tracking lesion size, number, and progression in the search for new tuberculosis vaccines...
  15. pmc Kinetics of the immune response profile in guinea pigs after vaccination with Mycobacterium bovis BCG and infection with Mycobacterium tuberculosis
    Ajay Grover
    Colorado State University, Department of Microbiology, Immunology, and Pathology, 1682 Campus Delivery, Fort Collins, CO 80523, USA
    Infect Immun 77:4837-46. 2009
    ..Our data suggest that day 40 postinfection may be a pivotal time point in determining vaccine efficacy and prolonged survival and that BCG promotes the capacity of T cells in the lungs to respond to infection...
  16. ncbi request reprint Efficient immunization and cross-priming by vaccine adjuvants containing TLR3 or TLR9 agonists complexed to cationic liposomes
    Karen Zaks
    Department of Microbiology, Immunology, and Pathology, University of Cincinnati College of Medicine and Cincinnati Children s Hospital, OH 45229, USA
    J Immunol 176:7335-45. 2006
    ..tuberculosis. These results suggest that certain TLR agonists can be combined with cationic liposomes to produce uniquely effective vaccine adjuvants capable of eliciting strong T cell responses against protein and peptide Ags...
  17. pmc Mycobacterium bovis BCG vaccine strains lack narK2 and narX induction and exhibit altered phenotypes during dormancy
    Ryan W Honaker
    University of Colorado Denver, School of Medicine, Department of Microbiology, P18 9115, 12800 East 19th Avenue, P O Box 6511, Aurora, CO 80045, USA
    Infect Immun 76:2587-93. 2008
    ..These findings demonstrate defects in DosR regulon expression during dormancy and phenotypic variation between commonly used BCG vaccine strains...
  18. ncbi request reprint Oral immunogenicity of a plant-made, subunit, tuberculosis vaccine
    M Manuela Rigano
    The Biodesign Institute at Arizona State University, School of Life Sciences, Arizona State University, Tempe, AZ 85287 4501, USA
    Vaccine 24:691-5. 2006
    ..In addition, a Th2 response was induced in the Peyer's patch. This is the first report of an orally delivered, subunit, tuberculosis vaccine priming an antigen-specific, Th1 response...
  19. ncbi request reprint The gastrointestinal pharmacology of cannabinoids: an update
    Angela A Coutts
    School of Medical Sciences, College of Life Sciences and Medicine, University of Aberdeen, Institute of Medical Sciences, Foresterhill, Aberdeen AB25 2ZD, Scotland
    Curr Opin Pharmacol 4:572-9. 2004
    ..Endocannabinoids also activate cannabinoid CB(2) and vanilloid VR1 receptors in certain inflammatory states. Thus endocannabinoid metabolism could provide a useful therapeutic target for many gastrointestinal disorders...
  20. ncbi request reprint Identification of novel resident pulmonary stem cells: form and function of the lung side population
    Susan M Majka
    Department of Medicine, Cardiovascular Pulmonary Research Section, University of Colorado Health Sciences Center, 4200 East 9th Avenue, SOM 3811, mail stop B 133, Denver, Colorado 80262, USA
    Stem Cells 23:1073-81. 2005
    ..The identification of this target population will potentially allow earlier treatment and, long term, a functional restoration of injured pulmonary tissue and lung health...
  21. ncbi request reprint Fatty acid amide hydrolase controls mouse intestinal motility in vivo
    Raffaele Capasso
    Department of Experimental Pharmacology, University of Naples Federico II, Naples, Italy
    Gastroenterology 129:941-51. 2005
    ..The physiologic role of FAAH in the gut is largely unexplored. In the present study, we evaluated the possible role of FAAH in regulating intestinal motility in mice in vivo...
  22. doi request reprint Dysregulation of peripheral endocannabinoid levels in hyperglycemia and obesity: Effect of high fat diets
    Isabel Matias
    Endocannabinoid Research Group, Institute of Biomolecular Chemistry, Consiglio Nazionale delle Ricerche, Pozzuoli NA, Italy
    Mol Cell Endocrinol 286:S66-78. 2008
    ..The potential implications of these and previous findings in the general framework of the proposed roles of the EC system in the control of metabolic, endocrine and cardiovascular and renal functions are discussed...
  23. ncbi request reprint Synthesis by microwave irradiation and antidiarrhoeal activity of benzotriazinone and saccharine derivatives
    Ferdinando Fiorino
    Dipartimento di Chimica Farmaceutica e Tossicologica, Universita Degli Studi Di Napoli, Federico II, Napoli, Italy
    Arch Pharm (Weinheim) 338:548-55. 2005
    ..Good yields and short reaction times are the main advantages of our synthetic route. Among the tested compounds, compound 12 inhibited motility both in in-vitro and in-vivo tests...
  24. doi request reprint Inhibitory effect of the anorexic compound oleoylethanolamide on gastric emptying in control and overweight mice
    Gabriella Aviello
    Endocannabinoid Research Group, Department of Experimental Pharmacology, University of Naples Federico II, Naples, Italy
    J Mol Med (Berl) 86:413-22. 2008
    ..The inhibitory effect of OEA on gastric emptying here observed might underlie part of the anorexic effects of this compound previously reported...
  25. doi request reprint Endocannabinoid dysregulation in the pancreas and adipose tissue of mice fed with a high-fat diet
    Katarzyna M Starowicz
    Endocannabinoid Research Group, Consiglio Nazionale delle Ricerche, Pozzuoli, Italy
    Obesity (Silver Spring) 16:553-65. 2008
    ..Their pancreatic and adipose tissue levels are elevated during hyperglycemia and obesity, but the mechanisms underlying these alterations are not understood...
  26. ncbi request reprint Isolation of new rotenoids from Boerhaavia diffusa and evaluation of their effect on intestinal motility
    Francesca Borrelli
    Dipartimento di Farmacologia Sperimentale, Universita di Napoli Federico II, via D Montesano 49, 80131 Naples, Italy
    Planta Med 71:928-32. 2005
    ..Three of them (boeravinone G, boeravinone E and compound 5) exhibited spasmolytic activity. Preliminary structure-activity relationships have been established highlighting the effect of substitutions on rings B and D...
  27. pmc Effect of Boswellia serrata on intestinal motility in rodents: inhibition of diarrhoea without constipation
    Francesca Borrelli
    Department of Experimental Pharmacology, University of Naples Federico II, Italy
    Br J Pharmacol 148:553-60. 2006
    ..These results could explain, at least in part, the clinical efficacy of this Ayurvedic remedy in reducing diarrhoea in patients with inflammatory bowel disease...
  28. ncbi request reprint The sapogenin atroviolacegenin and its diglycoside atroviolaceoside from Allium atroviolaceum
    Behzad Zolfaghari
    Department of Pharmacognosy, Isfahan University of Medical Sciences, Hezar Jerib Avenue, 73461 Isfahan, Iran
    J Nat Prod 69:191-5. 2006
    ..The absence of activity for both atroviolacegenin and atroviolaceoside highlighted the key role of the furostanol-type aglycone moiety for antispasmodic activity...
  29. ncbi request reprint Structure-activity relationships for saponins from Allium hirtifolium and Allium elburzense and their antispasmodic activity
    Elisa Barile
    DISTAAM, Università degli Studi del Molise, Campobasso, Italy
    Planta Med 71:1010-8. 2005
    ..The observed effect therefore contributes to the explanation of the traditional use of onion and garlic in the treatment of disturbances of the gastrointestinal tract...

Research Grants1