Research Topics
| Angelo A IzzoSummaryAffiliation: Colorado State University Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
A matrix metalloproteinase inhibitor promotes granuloma formation during the early phase of Mycobacterium tuberculosis pulmonary infectionA A Izzo
Department of Microbiology, Midwestern University, Downers Grove, IL 60515, USA
Tuberculosis (Edinb) 84:387-96. 2004..Granuloma formation requires immune cell infiltration and concurrent extensive remodeling of pulmonary tissue which we hypothesize to be the result of increased matrix metalloproteinases (MMP) activity...- NIH pre-clinical screening program: overview and current statusAngelo Izzo
Department of Microbiology, Colorado State University, Immunology and Pathology, Mycobacterial Research Laboratories, 1682 Campus Delivery, Fort Collins 80523 1682, USA
Tuberculosis (Edinb) 85:25-8. 2005..The current screening program at Colorado State University has tested a wide range of novel vaccine candidates... 
The protective effect of the Mycobacterium bovis BCG vaccine is increased by coadministration with the Mycobacterium tuberculosis 72-kilodalton fusion polyprotein Mtb72F in M. tuberculosis-infected guinea pigsLise Brandt
Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins 80523, USA
Infect Immun 72:6622-32. 2004..Collectively, these data suggest that enhancing BCG is a valid vaccination strategy for tuberculosis that is worthy of clinical evaluation...- Decreased survival of guinea pigs infected with Mycobacterium tuberculosis after multiple BCG vaccinationsRandall J Basaraba
Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523, USA
Vaccine 24:280-6. 2006..These data indicate that multiple BCG vaccination, which is akin to super-infection with the living vaccine, leads to major organ failure pathology... - Tracking antigen-specific CD8 T lymphocytes in the lungs of mice vaccinated with the Mtb72F polyproteinScott M Irwin
Mycobacterial Research Laboratories, Department of Microbiology, Immunology, and Pathology, Colorado State University, 1682 Campus Delivery, Fort Collins, CO 80523 1682, USA
Infect Immun 73:5809-16. 2005..These data support the hypothesis that M. tuberculosis-specific CD8 T cells can be targeted by vaccination with the Mtb72F polyprotein... - BCG sub-strains induce variable protection against virulent pulmonary Mycobacterium tuberculosis infection, with the capacity to drive Th2 immunityAndrew Keyser
Department of Microbiology, Immunology and Pathology, Colorado State University, 1682 Campus Delivery, Fort Collins, CO 80523, USA
Vaccine 29:9308-15. 2011..tuberculosis... - Role for matrix metalloproteinase 9 in granuloma formation during pulmonary Mycobacterium tuberculosis infectionJennifer L Taylor
Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, 200 West Lake Street, 1682 Campus Delivery, Fort Collins, CO 80523 1682, USA
Infect Immun 74:6135-44. 2006.... 
Mycobacterial infection induces the secretion of high-mobility group box 1 proteinAjay Grover
Department of Microbiology, Colorado State University, Fort Collins, CO 80523, USA
Cell Microbiol 10:1390-404. 2008..We conclude that HMGB1 is secreted by macrophages during tuberculosis and it may act as a signal of tissue or cellular injury and enhances immune response...- Lack of alpha-1 integrin alters lesion morphology during pulmonary Mycobacterium tuberculosis infectionJennifer L Taylor
Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523, USA
Tuberculosis (Edinb) 88:444-52. 2008..tuberculosis infected lungs, it does play a role in granuloma structure and integrity during the chronic phase of infection... - Memory T lymphocytes generated by Mycobacterium bovis BCG vaccination reside within a CD4 CD44lo CD62 Ligandhi populationAndre Kipnis
Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523, USA
Infect Immun 73:7759-64. 2005..Upon cell transfer, however, cells expressing a resting/naïve phenotype (CD44lo CD62Lhi) were capable of protecting the recipients from a virulent challenge infection, suggesting the emergence of T-cell memory from within this subset... - BAT3 regulates Mycobacterium tuberculosis protein ESAT-6-mediated apoptosis of macrophagesAjay Grover
Departments of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado, United States of America
PLoS ONE 7:e40836. 2012..Taken together, the data suggest that BAT3 plays a role in the early immune response to M. tuberculosis infection and may be a key protein associated with the fate of antigen presenting cells during infection... - Disruption of granulocyte macrophage-colony stimulating factor production in the lungs severely affects the ability of mice to control Mycobacterium tuberculosis infectionMercedes Gonzalez-Juarrero
Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, 80523, USA
J Leukoc Biol 77:914-22. 2005..tuberculosis bacterial growth... - HspX-mediated protection against tuberculosis depends on its chaperoning of a mycobacterial moleculeJennifer L Taylor
Department of Microbiology, Mycobacteria Research Laboratories, Immunology and Pathology, Colorado State University, Fort Collins, CO, USA
Immunol Cell Biol 90:945-54. 2012..These data suggest the possibility that the native form may chaperone an immunogenic and protective antigen that is mycobacteria-specific... - Magnetic resonance imaging of pulmonary lesions in guinea pigs infected with Mycobacterium tuberculosisSusan L Kraft
Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, Colorado 80523, USA
Infect Immun 72:5963-71. 2004..Further development of this technical approach could be very useful in tracking lesion size, number, and progression in the search for new tuberculosis vaccines... - Kinetics of the immune response profile in guinea pigs after vaccination with Mycobacterium bovis BCG and infection with Mycobacterium tuberculosisAjay Grover
Colorado State University, Department of Microbiology, Immunology, and Pathology, 1682 Campus Delivery, Fort Collins, CO 80523, USA
Infect Immun 77:4837-46. 2009..Our data suggest that day 40 postinfection may be a pivotal time point in determining vaccine efficacy and prolonged survival and that BCG promotes the capacity of T cells in the lungs to respond to infection... - Efficient immunization and cross-priming by vaccine adjuvants containing TLR3 or TLR9 agonists complexed to cationic liposomesKaren Zaks
Department of Microbiology, Immunology, and Pathology, University of Cincinnati College of Medicine and Cincinnati Children s Hospital, OH 45229, USA
J Immunol 176:7335-45. 2006..tuberculosis. These results suggest that certain TLR agonists can be combined with cationic liposomes to produce uniquely effective vaccine adjuvants capable of eliciting strong T cell responses against protein and peptide Ags... - Mycobacterium bovis BCG vaccine strains lack narK2 and narX induction and exhibit altered phenotypes during dormancyRyan W Honaker
University of Colorado Denver, School of Medicine, Department of Microbiology, P18 9115, 12800 East 19th Avenue, P O Box 6511, Aurora, CO 80045, USA
Infect Immun 76:2587-93. 2008..These findings demonstrate defects in DosR regulon expression during dormancy and phenotypic variation between commonly used BCG vaccine strains... - Oral immunogenicity of a plant-made, subunit, tuberculosis vaccineM Manuela Rigano
The Biodesign Institute at Arizona State University, School of Life Sciences, Arizona State University, Tempe, AZ 85287-4501, USA
Vaccine 24:691-5. 2006..In addition, a Th2 response was induced in the Peyer's patch. This is the first report of an orally delivered, subunit, tuberculosis vaccine priming an antigen-specific, Th1 response... - The gastrointestinal pharmacology of cannabinoids: an updateAngela A Coutts
School of Medical Sciences, College of Life Sciences and Medicine, University of Aberdeen, Institute of Medical Sciences, Foresterhill, Aberdeen AB25 2ZD, Scotland
Curr Opin Pharmacol 4:572-9. 2004..Endocannabinoids also activate cannabinoid CB(2) and vanilloid VR1 receptors in certain inflammatory states. Thus endocannabinoid metabolism could provide a useful therapeutic target for many gastrointestinal disorders... - Identification of novel resident pulmonary stem cells: form and function of the lung side populationSusan M Majka
Department of Medicine, Cardiovascular Pulmonary Research Section, University of Colorado Health Sciences Center, 4200 East 9th Avenue, SOM 3811, mail stop B 133, Denver, Colorado 80262, USA
Stem Cells 23:1073-81. 2005..The identification of this target population will potentially allow earlier treatment and, long term, a functional restoration of injured pulmonary tissue and lung health... - Fatty acid amide hydrolase controls mouse intestinal motility in vivoRaffaele Capasso
Department of Experimental Pharmacology, University of Naples Federico II, Naples, Italy
Gastroenterology 129:941-51. 2005..The physiologic role of FAAH in the gut is largely unexplored. In the present study, we evaluated the possible role of FAAH in regulating intestinal motility in mice in vivo... - Dysregulation of peripheral endocannabinoid levels in hyperglycemia and obesity: Effect of high fat dietsIsabel Matias
Endocannabinoid Research Group, Institute of Biomolecular Chemistry, Consiglio Nazionale delle Ricerche, Pozzuoli NA, Italy
Mol Cell Endocrinol 286:S66-78. 2008..The potential implications of these and previous findings in the general framework of the proposed roles of the EC system in the control of metabolic, endocrine and cardiovascular and renal functions are discussed... - Synthesis by microwave irradiation and antidiarrhoeal activity of benzotriazinone and saccharine derivativesFerdinando Fiorino
Dipartimento di Chimica Farmaceutica e Tossicologica, , Federico II, Napoli, Italy
Arch Pharm (Weinheim) 338:548-55. 2005..Good yields and short reaction times are the main advantages of our synthetic route. Among the tested compounds, compound 12 inhibited motility both in in-vitro and in-vivo tests... - Inhibitory effect of the anorexic compound oleoylethanolamide on gastric emptying in control and overweight miceGabriella Aviello
Endocannabinoid Research Group, Department of Experimental Pharmacology, University of Naples Federico II, Naples, Italy
J Mol Med (Berl) 86:413-22. 2008..The inhibitory effect of OEA on gastric emptying here observed might underlie part of the anorexic effects of this compound previously reported... - Endocannabinoid dysregulation in the pancreas and adipose tissue of mice fed with a high-fat dietKatarzyna M Starowicz
Endocannabinoid Research Group, Consiglio Nazionale delle Ricerche, Pozzuoli, Italy
Obesity (Silver Spring) 16:553-65. 2008..Their pancreatic and adipose tissue levels are elevated during hyperglycemia and obesity, but the mechanisms underlying these alterations are not understood... - Isolation of new rotenoids from Boerhaavia diffusa and evaluation of their effect on intestinal motilityFrancesca Borrelli
Dipartimento di Farmacologia Sperimentale, Universita di Napoli Federico II, via D Montesano 49, 80131 Naples, Italy
Planta Med 71:928-32. 2005..Three of them (boeravinone G, boeravinone E and compound 5) exhibited spasmolytic activity. Preliminary structure-activity relationships have been established highlighting the effect of substitutions on rings B and D... - Effect of Boswellia serrata on intestinal motility in rodents: inhibition of diarrhoea without constipationFrancesca Borrelli
Department of Experimental Pharmacology, University of Naples Federico II, Italy
Br J Pharmacol 148:553-60. 2006..These results could explain, at least in part, the clinical efficacy of this Ayurvedic remedy in reducing diarrhoea in patients with inflammatory bowel disease... - The sapogenin atroviolacegenin and its diglycoside atroviolaceoside from Allium atroviolaceumBehzad Zolfaghari
Department of Pharmacognosy, Isfahan University of Medical Sciences, Hezar Jerib Avenue, 73461 Isfahan, Iran
J Nat Prod 69:191-5. 2006..The absence of activity for both atroviolacegenin and atroviolaceoside highlighted the key role of the furostanol-type aglycone moiety for antispasmodic activity... - Structure-activity relationships for saponins from Allium hirtifolium and Allium elburzense and their antispasmodic activityElisa Barile
DISTAAM, , Campobasso, Italy
Planta Med 71:1010-8. 2005..The observed effect therefore contributes to the explanation of the traditional use of onion and garlic in the treatment of disturbances of the gastrointestinal tract...
Research Grants
- Metalloproteinase Functon in Tuberculosis GranulomasAngelo Izzo; Fiscal Year: 2004....