Thomas R Hansen

Summary

Affiliation: Colorado State University
Country: USA

Publications

  1. ncbi request reprint Expression of interferon (IFN)-stimulated genes in extrauterine tissues during early pregnancy in sheep is the consequence of endocrine IFN-tau release from the uterine vein
    Joao F Oliveira
    Animal Reproduction and Biotechnology Laboratory, Department of Biomedical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, Colorado 80523, USA
    Endocrinology 149:1252-9. 2008
  2. ncbi request reprint ISGylation: A Conserved Pathway in Mammalian Pregnancy
    Thomas R Hansen
    Animal Reproduction and Biotechnology Laboratory, Department of Biomedical Sciences, Colorado State University, 3197 Rampart Road, Fort Collins, CO, 80521, USA
    Adv Exp Med Biol 759:13-31. 2014
  3. pmc The chemokine receptor CXCR4 and its ligand CXCL12 are activated during implantation and placentation in sheep
    Ryan L Ashley
    Department of Animal and Range Sciences, New Mexico State University, Las Cruces, New Mexico, USA
    Reprod Biol Endocrinol 9:148. 2011
  4. pmc Ubp43 gene expression is required for normal Isg15 expression and fetal development
    Lea A Rempel
    Department of Animal Science, University of Wyoming, Laramie, Wyoming, 82071, USA
    Reprod Biol Endocrinol 5:13. 2007
  5. ncbi request reprint Endocrine actions of interferon-tau in ruminants
    T R Hansen
    Animal Reproduction and Biotechnology Laboratory, Department of Biomedical Sciences, Centro de Ciências Rurais, Universidade Federal de Santa Maria, 97105 900 Santa Maria, RS, Brazil
    Soc Reprod Fertil Suppl 67:325-40. 2010
  6. doi request reprint Maternal and fetal response to fetal persistent infection with bovine viral diarrhea virus
    Thomas R Hansen
    Animal Reproduction and Biotechnology Laboratory, Department of Biomedical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80523, USA
    Am J Reprod Immunol 64:295-306. 2010
  7. doi request reprint Endocrine delivery of interferon tau protects the corpus luteum from prostaglandin F2 alpha-induced luteolysis in ewes
    Alfredo Q Antoniazzi
    Animal Reproduction and Biotechnology Laboratory, Department of Biomedical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, Colorado 80521 1683, USA
    Biol Reprod 88:144. 2013
  8. pmc Persistent fetal infection with bovine viral diarrhea virus differentially affects maternal blood cell signal transduction pathways
    Natalia P Smirnova
    Department of Biomedical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, Colorado 80523 1683, USA
    Physiol Genomics 36:129-39. 2009
  9. pmc Pregnancy-associated genes contribute to antiluteolytic mechanisms in ovine corpus luteum
    Jared J Romero
    Animal Reproduction and Biotechnology Laboratory, Department of Biomedical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, Colorado
    Physiol Genomics 45:1095-108. 2013
  10. doi request reprint Differential expression of the type I interferon pathway during persistent and transient bovine viral diarrhea virus infection
    Megan L Shoemaker
    Department of Biomedical Sciences, Animal Reproduction and Biotechnology Laboratory, Colorado State University, Fort Collins, Colorado 80523, USA
    J Interferon Cytokine Res 29:23-35. 2009

Collaborators

Detail Information

Publications19

  1. ncbi request reprint Expression of interferon (IFN)-stimulated genes in extrauterine tissues during early pregnancy in sheep is the consequence of endocrine IFN-tau release from the uterine vein
    Joao F Oliveira
    Animal Reproduction and Biotechnology Laboratory, Department of Biomedical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, Colorado 80523, USA
    Endocrinology 149:1252-9. 2008
    ..It is concluded that uterine vein releases IFN-tau, which induces ISG in extrauterine tissues such as the CL during the time of maternal recognition of pregnancy...
  2. ncbi request reprint ISGylation: A Conserved Pathway in Mammalian Pregnancy
    Thomas R Hansen
    Animal Reproduction and Biotechnology Laboratory, Department of Biomedical Sciences, Colorado State University, 3197 Rampart Road, Fort Collins, CO, 80521, USA
    Adv Exp Med Biol 759:13-31. 2014
    ....
  3. pmc The chemokine receptor CXCR4 and its ligand CXCL12 are activated during implantation and placentation in sheep
    Ryan L Ashley
    Department of Animal and Range Sciences, New Mexico State University, Las Cruces, New Mexico, USA
    Reprod Biol Endocrinol 9:148. 2011
    ..The objectives of the current study were to determine if CXCL12 and CXCR4 were upregulated in: endometrium from pregnant compared to non-pregnant ewes and in, conceptuses, cotyledons, caruncles and intercaruncular tissue...
  4. pmc Ubp43 gene expression is required for normal Isg15 expression and fetal development
    Lea A Rempel
    Department of Animal Science, University of Wyoming, Laramie, Wyoming, 82071, USA
    Reprod Biol Endocrinol 5:13. 2007
    ..5 days post coitum (dpc). It was hypothesized that deletion of Ubp43 would cause disregulation of Isg15 in implantation sites, and that this would affect pregnancy rates...
  5. ncbi request reprint Endocrine actions of interferon-tau in ruminants
    T R Hansen
    Animal Reproduction and Biotechnology Laboratory, Department of Biomedical Sciences, Centro de Ciências Rurais, Universidade Federal de Santa Maria, 97105 900 Santa Maria, RS, Brazil
    Soc Reprod Fertil Suppl 67:325-40. 2010
    ..It also may have endocrine action through inducing luteal resistance to PGF and longer-term survival of the CL and maintenance of pregnancy...
  6. doi request reprint Maternal and fetal response to fetal persistent infection with bovine viral diarrhea virus
    Thomas R Hansen
    Animal Reproduction and Biotechnology Laboratory, Department of Biomedical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80523, USA
    Am J Reprod Immunol 64:295-306. 2010
    ..This results in induction of immune tolerance to the infecting BVDV strain and persistent infection (PI)...
  7. doi request reprint Endocrine delivery of interferon tau protects the corpus luteum from prostaglandin F2 alpha-induced luteolysis in ewes
    Alfredo Q Antoniazzi
    Animal Reproduction and Biotechnology Laboratory, Department of Biomedical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, Colorado 80521 1683, USA
    Biol Reprod 88:144. 2013
    ..It is concluded that endocrine delivery of roIFNT, regardless of route (uterine or jugular vein), effectively protects CL from the luteolytic actions of PGF by mechanisms that involve ISGs and stabilization of cell survival genes...
  8. pmc Persistent fetal infection with bovine viral diarrhea virus differentially affects maternal blood cell signal transduction pathways
    Natalia P Smirnova
    Department of Biomedical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, Colorado 80523 1683, USA
    Physiol Genomics 36:129-39. 2009
    ....
  9. pmc Pregnancy-associated genes contribute to antiluteolytic mechanisms in ovine corpus luteum
    Jared J Romero
    Animal Reproduction and Biotechnology Laboratory, Department of Biomedical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, Colorado
    Physiol Genomics 45:1095-108. 2013
    ..In conclusion, pregnancy circumvents luteolytic pathways and activates or stabilizes genes associated with interferon, chemokine, cell adhesion, cytoskeletal, and angiogenic pathways in the CL. ..
  10. doi request reprint Differential expression of the type I interferon pathway during persistent and transient bovine viral diarrhea virus infection
    Megan L Shoemaker
    Department of Biomedical Sciences, Animal Reproduction and Biotechnology Laboratory, Colorado State University, Fort Collins, Colorado 80523, USA
    J Interferon Cytokine Res 29:23-35. 2009
    ..This study lends new insights into the interactions between BVDV and its host, and can serve as a model for studies of the role of the IFN system in persistent infections...
  11. doi request reprint Deletion of the Isg15 gene results in up-regulation of decidual cell survival genes and down-regulation of adhesion genes: implication for regulation by IL-1beta
    Ryan L Ashley
    Department of Biomedical Sciences, Colorado State University, Fort Collins, Colorado 80523, USA
    Endocrinology 151:4527-36. 2010
    ..This fetal death also might relate to impaired IL-1beta signaling, because ISG15 and isgylation are induced by IL-1beta in human and murine endometrial stromal cells...
  12. ncbi request reprint Acute non-cytopathic bovine viral diarrhea virus infection induces pronounced type I interferon response in pregnant cows and fetuses
    Natalia P Smirnova
    Department of Biomedical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80523 1683, USA
    Virus Res 132:49-58. 2008
    ..PI fetuses presented with growth retardation. Infection of pregnant heifers with ncp BVDV2 early in gestation adversely affects fetal development and antiviral responses, despite protective immune responses in the dam...
  13. doi request reprint Uterine vein infusion of interferon tau (IFNT) extends luteal life span in ewes
    Rebecca C Bott
    Animal Reproduction and Biotechnology Laboratory, Department of Biomedical Sciences, Colorado State University, Fort Collins, CO 80523, USA
    Biol Reprod 82:725-35. 2010
    ..In conclusion, IFNT is released from the uterus into the uterine vein and acts through an endocrine mechanism to induce ISGs in the CL and delay luteolysis...
  14. doi request reprint Development of fetal and placental innate immune responses during establishment of persistent infection with bovine viral diarrhea virus
    Natalia P Smirnova
    Animal Reproduction and Biotechnology Laboratory, Department of Biomedical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, 1683 Campus Delivery, Fort Collins, CO 80523 1683, USA
    Virus Res 167:329-36. 2012
    ..The innate immune response might partially curtail viral replication in PI fetuses, but is not able to eliminate the virus in the absence of a virus-specific adaptive immune response...
  15. doi request reprint Gene profiling of inflammatory genes in day 18 endometria from pregnant and non-pregnant mares
    Amanda L Patterson
    Department of Animal Science, Colorado State University, Fort Collins, Colorado 80523 1680, USA
    Mol Reprod Dev 79:777-84. 2012
    ..The results from this study provide important new insights into endometrial gene expression in response to early equine pregnancy...
  16. ncbi request reprint Effects of in utero pestivirus infection on bovine fetal bone geometry, biomechanical properties and composition
    Brett T Webb
    Department of Biomedical Sciences, Colorado State University, Fort Collins, CO 80523, USA Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523, USA Electronic address
    Vet J 198:376-81. 2013
    ..Thus even when cortical thickness ratios are similar, differences in mid-diaphyseal diameter affect the error associated with the calculation of stress and strain by classical beam theory equations. ..
  17. doi request reprint Induction of interferon-gamma and downstream pathways during establishment of fetal persistent infection with bovine viral diarrhea virus
    Natalia P Smirnova
    Animal Reproduction and Biotechnology Laboratory, Department of Biomedical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, 1683 Campus Delivery, Fort Collins, CO 80523 1683, USA Electronic address
    Virus Res 183:95-106. 2014
    ..This is the first report indicating the possible presence of an adaptive immune response in persistent BVDV infections, which may be contributing to the observed reduction of viremia in PI fetuses. ..
  18. pmc Neuro-invasion by a 'Trojan Horse' strategy and vasculopathy during intrauterine flavivirus infection
    Helle Bielefeldt-Ohmann
    School of Veterinary Science, University of Queensland, Queensland, Australia
    Int J Exp Pathol 93:24-33. 2012
    ....
  19. pmc Maternal undernutrition induces differential cardiac gene expression in pulmonary hypertensive steers at high elevation
    Hyungchul Han
    Dept of Animal Sciences, Colorado State Univ, Fort Collins, CO 80523, USA
    Am J Physiol Heart Circ Physiol 295:H382-9. 2008
    ....