Brian J Geiss

Summary

Affiliation: Colorado State University
Country: USA

Publications

  1. ncbi Ring around the Ro-sie: RNA-Mediated Alterations of PNPase Activity
    Brian J Geiss
    Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523, USA Electronic address
    Cell 153:12-4. 2013
  2. ncbi Actively replicating West Nile virus is resistant to cytoplasmic delivery of siRNA
    Brian J Geiss
    Department of Medicine, Washington University School of Medicine, 660 South Euclid Avenue, Box 8051, St Louis, MO 63110, USA
    Virol J 2:53. 2005
  3. ncbi Recombination-ready Sindbis replicon expression vectors for transgene expression
    Brian J Geiss
    Arthropod Borne and Infectious Diseases Laboratory, Department of Molecular Biology, Immunology, and Pathology, Colorado State University, Fort Collins, CO 80523, USA
    Virol J 4:112. 2007
  4. ncbi Analysis of flavivirus NS5 methyltransferase cap binding
    Brian J Geiss
    Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO 80523, USA
    J Mol Biol 385:1643-54. 2009
  5. ncbi A high-throughput screening assay for the identification of flavivirus NS5 capping enzyme GTP-binding inhibitors: implications for antiviral drug development
    Brian J Geiss
    Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO, USA
    J Biomol Screen 16:852-61. 2011
  6. ncbi Analysis of RNA binding by the dengue virus NS5 RNA capping enzyme
    Brittney R Henderson
    Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, Colorado, United States of America
    PLoS ONE 6:e25795. 2011
  7. ncbi Suppression of RNA interference increases alphavirus replication and virus-associated mortality in Aedes aegypti mosquitoes
    Chris M Cirimotich
    Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523, USA
    BMC Microbiol 9:49. 2009
  8. ncbi Infectious alphavirus production from a simple plasmid transfection+
    J Jordan Steel
    Department of Microbiology, Immunology, and Pathology, 1682 Campus Delivery, Colorado State University, Fort Collins, CO 80523, USA
    Virol J 8:356. 2011
  9. ncbi A rapid and quantitative assay for measuring antibody-mediated neutralization of West Nile virus infection
    Theodore C Pierson
    Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Virology 346:53-65. 2006
  10. ncbi Focus on flaviviruses: current and future drug targets
    Brian J Geiss
    Department of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, CO 80523, USA
    Future Med Chem 1:327-44. 2009

Collaborators

Detail Information

Publications11

  1. ncbi Ring around the Ro-sie: RNA-Mediated Alterations of PNPase Activity
    Brian J Geiss
    Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523, USA Electronic address
    Cell 153:12-4. 2013
    ..They show that a noncoding RNA interacts with an exoribonuclease, altering its substrate specificity and enzymatic activity by serving as a ribonucleoprotein scaffold and, perhaps, a gate for entry of the RNA substrate...
  2. ncbi Actively replicating West Nile virus is resistant to cytoplasmic delivery of siRNA
    Brian J Geiss
    Department of Medicine, Washington University School of Medicine, 660 South Euclid Avenue, Box 8051, St Louis, MO 63110, USA
    Virol J 2:53. 2005
    ..Here, we examine the ability of exogenous small interfering RNAs (siRNAs) to block the replication of West Nile virus in human cells...
  3. ncbi Recombination-ready Sindbis replicon expression vectors for transgene expression
    Brian J Geiss
    Arthropod Borne and Infectious Diseases Laboratory, Department of Molecular Biology, Immunology, and Pathology, Colorado State University, Fort Collins, CO 80523, USA
    Virol J 4:112. 2007
    ....
  4. ncbi Analysis of flavivirus NS5 methyltransferase cap binding
    Brian J Geiss
    Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO 80523, USA
    J Mol Biol 385:1643-54. 2009
    ..A detailed model of how the flavivirus MTase protein binds RNA cap structures is presented...
  5. ncbi A high-throughput screening assay for the identification of flavivirus NS5 capping enzyme GTP-binding inhibitors: implications for antiviral drug development
    Brian J Geiss
    Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO, USA
    J Biomol Screen 16:852-61. 2011
    ..The results presented indicate that the flavivirus CE cap-binding site is a valuable new target site for antiviral drug discovery and should be further exploited for broad-spectrum anti-flaviviral drug development...
  6. ncbi Analysis of RNA binding by the dengue virus NS5 RNA capping enzyme
    Brittney R Henderson
    Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, Colorado, United States of America
    PLoS ONE 6:e25795. 2011
    ..The mode of RNA binding appears similar to that found with other methyltransferase enzymes, and a discussion of diphosphorylated RNA binding is presented...
  7. ncbi Suppression of RNA interference increases alphavirus replication and virus-associated mortality in Aedes aegypti mosquitoes
    Chris M Cirimotich
    Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523, USA
    BMC Microbiol 9:49. 2009
    ....
  8. ncbi Infectious alphavirus production from a simple plasmid transfection+
    J Jordan Steel
    Department of Microbiology, Immunology, and Pathology, 1682 Campus Delivery, Colorado State University, Fort Collins, CO 80523, USA
    Virol J 8:356. 2011
    ..This system represents a more efficient method for producing recombinant Sindbis viruses...
  9. ncbi A rapid and quantitative assay for measuring antibody-mediated neutralization of West Nile virus infection
    Theodore C Pierson
    Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Virology 346:53-65. 2006
    ..WNV RVPs are capable of only a single round of infection, can be used under BSL-2 conditions, and offer a rapid and quantitative approach for detecting virus entry and its inhibition by neutralizing antibody...
  10. ncbi Focus on flaviviruses: current and future drug targets
    Brian J Geiss
    Department of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, CO 80523, USA
    Future Med Chem 1:327-44. 2009
    ..There is currently no effective clinical treatment for any flaviviral infection. Therefore, there is a great need for the identification of novel inhibitors to target the virus life cycle...
  11. ncbi Herpes simplex virus 2 VP22 phosphorylation induced by cellular and viral kinases does not influence intracellular localization
    Brian J Geiss
    Department of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, St. Louis, MO 63104-1083, USA
    Virology 330:74-81. 2004
    ....