Brian J Geiss

Summary

Affiliation: Colorado State University
Country: USA

Publications

  1. pmc Subgenomic reporter RNA system for detection of alphavirus infection in mosquitoes
    J Jordan Steel
    Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, Colorado, United States of America
    PLoS ONE 8:e84930. 2013
  2. pmc Analysis of RNA binding by the dengue virus NS5 RNA capping enzyme
    Brittney R Henderson
    Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, Colorado, United States of America
    PLoS ONE 6:e25795. 2011
  3. pmc Ring around the Ro-sie: RNA-mediated alterations of PNPase activity
    Brian J Geiss
    Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523, USA
    Cell 153:12-4. 2013
  4. pmc Recombination-ready Sindbis replicon expression vectors for transgene expression
    Brian J Geiss
    Arthropod Borne and Infectious Diseases Laboratory, Department of Molecular Biology, Immunology, and Pathology, Colorado State University, Fort Collins, CO 80523, USA
    Virol J 4:112. 2007
  5. pmc Analysis of flavivirus NS5 methyltransferase cap binding
    Brian J Geiss
    Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO 80523, USA
    J Mol Biol 385:1643-54. 2009
  6. pmc Actively replicating West Nile virus is resistant to cytoplasmic delivery of siRNA
    Brian J Geiss
    Department of Medicine, Washington University School of Medicine, 660 South Euclid Avenue, Box 8051, St Louis, MO 63110, USA
    Virol J 2:53. 2005
  7. pmc A high-throughput screening assay for the identification of flavivirus NS5 capping enzyme GTP-binding inhibitors: implications for antiviral drug development
    Brian J Geiss
    Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO, USA
    J Biomol Screen 16:852-61. 2011
  8. pmc Identification of a novel antiviral inhibitor of the flavivirus guanylyltransferase enzyme
    Hillary J Stahla-Beek
    School of Biological Sciences, University of Northern Colorado, Greeley, Colorado, USA
    J Virol 86:8730-9. 2012
  9. pmc Infectious alphavirus production from a simple plasmid transfection+
    J Jordan Steel
    Department of Microbiology, Immunology, and Pathology, 1682 Campus Delivery, Colorado State University, Fort Collins, CO 80523, USA
    Virol J 8:356. 2011
  10. pmc Suppression of RNA interference increases alphavirus replication and virus-associated mortality in Aedes aegypti mosquitoes
    Chris M Cirimotich
    Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523, USA
    BMC Microbiol 9:49. 2009

Collaborators

Detail Information

Publications13

  1. pmc Subgenomic reporter RNA system for detection of alphavirus infection in mosquitoes
    J Jordan Steel
    Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, Colorado, United States of America
    PLoS ONE 8:e84930. 2013
    ..This virus inducible reporter system demonstrates a novel approach for detecting non-recombinant virus infection in mosquito cell culture and in live transgenic mosquitoes. ..
  2. pmc Analysis of RNA binding by the dengue virus NS5 RNA capping enzyme
    Brittney R Henderson
    Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, Colorado, United States of America
    PLoS ONE 6:e25795. 2011
    ..The mode of RNA binding appears similar to that found with other methyltransferase enzymes, and a discussion of diphosphorylated RNA binding is presented...
  3. pmc Ring around the Ro-sie: RNA-mediated alterations of PNPase activity
    Brian J Geiss
    Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523, USA
    Cell 153:12-4. 2013
    ..They show that a noncoding RNA interacts with an exoribonuclease, altering its substrate specificity and enzymatic activity by serving as a ribonucleoprotein scaffold and, perhaps, a gate for entry of the RNA substrate...
  4. pmc Recombination-ready Sindbis replicon expression vectors for transgene expression
    Brian J Geiss
    Arthropod Borne and Infectious Diseases Laboratory, Department of Molecular Biology, Immunology, and Pathology, Colorado State University, Fort Collins, CO 80523, USA
    Virol J 4:112. 2007
    ....
  5. pmc Analysis of flavivirus NS5 methyltransferase cap binding
    Brian J Geiss
    Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO 80523, USA
    J Mol Biol 385:1643-54. 2009
    ..A detailed model of how the flavivirus MTase protein binds RNA cap structures is presented...
  6. pmc Actively replicating West Nile virus is resistant to cytoplasmic delivery of siRNA
    Brian J Geiss
    Department of Medicine, Washington University School of Medicine, 660 South Euclid Avenue, Box 8051, St Louis, MO 63110, USA
    Virol J 2:53. 2005
    ..Here, we examine the ability of exogenous small interfering RNAs (siRNAs) to block the replication of West Nile virus in human cells...
  7. pmc A high-throughput screening assay for the identification of flavivirus NS5 capping enzyme GTP-binding inhibitors: implications for antiviral drug development
    Brian J Geiss
    Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO, USA
    J Biomol Screen 16:852-61. 2011
    ..The results presented indicate that the flavivirus CE cap-binding site is a valuable new target site for antiviral drug discovery and should be further exploited for broad-spectrum anti-flaviviral drug development...
  8. pmc Identification of a novel antiviral inhibitor of the flavivirus guanylyltransferase enzyme
    Hillary J Stahla-Beek
    School of Biological Sciences, University of Northern Colorado, Greeley, Colorado, USA
    J Virol 86:8730-9. 2012
    ..The results of this study describe the first inhibitor that targets the GTP-binding/guanylyltransferase activity of the flavivirus RNA capping enzyme...
  9. pmc Infectious alphavirus production from a simple plasmid transfection+
    J Jordan Steel
    Department of Microbiology, Immunology, and Pathology, 1682 Campus Delivery, Colorado State University, Fort Collins, CO 80523, USA
    Virol J 8:356. 2011
    ..This system represents a more efficient method for producing recombinant Sindbis viruses...
  10. pmc Suppression of RNA interference increases alphavirus replication and virus-associated mortality in Aedes aegypti mosquitoes
    Chris M Cirimotich
    Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523, USA
    BMC Microbiol 9:49. 2009
    ....
  11. pmc Focus on flaviviruses: current and future drug targets
    Brian J Geiss
    Department of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, CO 80523, USA
    Future Med Chem 1:327-44. 2009
    ..There is currently no effective clinical treatment for any flaviviral infection. Therefore, there is a great need for the identification of novel inhibitors to target the virus life cycle...
  12. ncbi request reprint A rapid and quantitative assay for measuring antibody-mediated neutralization of West Nile virus infection
    Theodore C Pierson
    Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Virology 346:53-65. 2006
    ..WNV RVPs are capable of only a single round of infection, can be used under BSL-2 conditions, and offer a rapid and quantitative approach for detecting virus entry and its inhibition by neutralizing antibody...
  13. ncbi request reprint Herpes simplex virus 2 VP22 phosphorylation induced by cellular and viral kinases does not influence intracellular localization
    Brian J Geiss
    Department of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, St Louis, MO 63104 1083, USA
    Virology 330:74-81. 2004
    ....