Brian J Geiss
Affiliation: Colorado State University
- Ring around the Ro-sie: RNA-Mediated Alterations of PNPase ActivityBrian J Geiss
Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523, USA Electronic address
Cell 153:12-4. 2013..They show that a noncoding RNA interacts with an exoribonuclease, altering its substrate specificity and enzymatic activity by serving as a ribonucleoprotein scaffold and, perhaps, a gate for entry of the RNA substrate...
- Actively replicating West Nile virus is resistant to cytoplasmic delivery of siRNABrian J Geiss
Department of Medicine, Washington University School of Medicine, 660 South Euclid Avenue, Box 8051, St Louis, MO 63110, USA
Virol J 2:53. 2005..Here, we examine the ability of exogenous small interfering RNAs (siRNAs) to block the replication of West Nile virus in human cells...
- Recombination-ready Sindbis replicon expression vectors for transgene expressionBrian J Geiss
Arthropod Borne and Infectious Diseases Laboratory, Department of Molecular Biology, Immunology, and Pathology, Colorado State University, Fort Collins, CO 80523, USA
Virol J 4:112. 2007....
- Analysis of flavivirus NS5 methyltransferase cap bindingBrian J Geiss
Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO 80523, USA
J Mol Biol 385:1643-54. 2009..A detailed model of how the flavivirus MTase protein binds RNA cap structures is presented...
- A high-throughput screening assay for the identification of flavivirus NS5 capping enzyme GTP-binding inhibitors: implications for antiviral drug developmentBrian J Geiss
Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO, USA
J Biomol Screen 16:852-61. 2011..The results presented indicate that the flavivirus CE cap-binding site is a valuable new target site for antiviral drug discovery and should be further exploited for broad-spectrum anti-flaviviral drug development...
- Analysis of RNA binding by the dengue virus NS5 RNA capping enzymeBrittney R Henderson
Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, Colorado, United States of America
PLoS ONE 6:e25795. 2011..The mode of RNA binding appears similar to that found with other methyltransferase enzymes, and a discussion of diphosphorylated RNA binding is presented...
- Suppression of RNA interference increases alphavirus replication and virus-associated mortality in Aedes aegypti mosquitoesChris M Cirimotich
Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523, USA
BMC Microbiol 9:49. 2009....
- Infectious alphavirus production from a simple plasmid transfection+J Jordan Steel
Department of Microbiology, Immunology, and Pathology, 1682 Campus Delivery, Colorado State University, Fort Collins, CO 80523, USA
Virol J 8:356. 2011..This system represents a more efficient method for producing recombinant Sindbis viruses...
- A rapid and quantitative assay for measuring antibody-mediated neutralization of West Nile virus infectionTheodore C Pierson
Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Virology 346:53-65. 2006..WNV RVPs are capable of only a single round of infection, can be used under BSL-2 conditions, and offer a rapid and quantitative approach for detecting virus entry and its inhibition by neutralizing antibody...
- Focus on flaviviruses: current and future drug targetsBrian J Geiss
Department of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, CO 80523, USA
Future Med Chem 1:327-44. 2009..There is currently no effective clinical treatment for any flaviviral infection. Therefore, there is a great need for the identification of novel inhibitors to target the virus life cycle...
- Herpes simplex virus 2 VP22 phosphorylation induced by cellular and viral kinases does not influence intracellular localizationBrian J Geiss
Department of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, St. Louis, MO 63104-1083, USA
Virology 330:74-81. 2004....