David D Frisbie

Summary

Affiliation: Colorado State University
Country: USA

Publications

  1. doi request reprint Evaluation of adipose-derived stromal vascular fraction or bone marrow-derived mesenchymal stem cells for treatment of osteoarthritis
    David D Frisbie
    Equine Orthopaedic Research Center, Department of Clinical Sciences, Colorado State University, 300 West Drake Road, Fort Collins, Colorado 80523, USA
    J Orthop Res 27:1675-80. 2009
  2. doi request reprint Serum biomarker levels for musculoskeletal disease in two- and three-year-old racing Thoroughbred horses: A prospective study of 130 horses
    D D Frisbie
    Gail Holmes Equine Orthopaedic Research Center, Colorado State University, USA
    Equine Vet J 42:643-51. 2010
  3. ncbi request reprint Future directions in treatment of joint disease in horses
    David D Frisbie
    Department of Clinical Sciences, Colorado State University, 2503 Bay Farm Road, Delivery Code 0912, Fort Collins, CO 80523, USA
    Vet Clin North Am Equine Pract 21:713-24, viii. 2005
  4. doi request reprint Evaluation of intra-articular mesenchymal stem cells to augment healing of microfractured chondral defects
    C Wayne McIlwraith
    Orthopaedic Research Center, Colorado State University, Fort Collins, Colorado 80523, USA
    Arthroscopy 27:1552-61. 2011
  5. doi request reprint Development of an in vitro model of injury-induced osteoarthritis in cartilage explants from adult horses through application of single-impact compressive overload
    Christina M Lee
    Orthopaedic Research Center, Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80523
    Am J Vet Res 74:40-7. 2013
  6. pmc Dynamic compression stimulates proteoglycan synthesis by mesenchymal stem cells in the absence of chondrogenic cytokines
    John D Kisiday
    Orthopaedic Research Center, Department of Clinical Science, Colorado State University, Fort Collins, Colorado 80523, USA
    Tissue Eng Part A 15:2817-24. 2009
  7. doi request reprint Evaluation of the effect of extracorporeal shock wave treatment on experimentally induced osteoarthritis in middle carpal joints of horses
    David D Frisbie
    Equine Orthopaedic Research Center, Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80523, USA
    Am J Vet Res 70:449-54. 2009
  8. ncbi request reprint IL-1ra/IGF-1 gene therapy modulates repair of microfractured chondral defects
    Sophie Morisset
    Orthopaedic Research Center, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80524, USA
    Clin Orthop Relat Res 462:221-8. 2007
  9. doi request reprint Evaluation of topically administered diclofenac liposomal cream for treatment of horses with experimentally induced osteoarthritis
    David D Frisbie
    Gail Holmes Equine Orthopaedic Research Center, Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80523, USA
    Am J Vet Res 70:210-5. 2009
  10. doi request reprint Evaluation of polysulfated glycosaminoglycan or sodium hyaluronan administered intra-articularly for treatment of horses with experimentally induced osteoarthritis
    David D Frisbie
    Gail Holmes Equine Orthopaedic Research Center, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80523 1678, USA
    Am J Vet Res 70:203-9. 2009

Detail Information

Publications35

  1. doi request reprint Evaluation of adipose-derived stromal vascular fraction or bone marrow-derived mesenchymal stem cells for treatment of osteoarthritis
    David D Frisbie
    Equine Orthopaedic Research Center, Department of Clinical Sciences, Colorado State University, 300 West Drake Road, Fort Collins, Colorado 80523, USA
    J Orthop Res 27:1675-80. 2009
    ..Overall, the findings of this study were not significant enough to recommend the use of stem cells for the treatment of osteoarthritis represented in this model...
  2. doi request reprint Serum biomarker levels for musculoskeletal disease in two- and three-year-old racing Thoroughbred horses: A prospective study of 130 horses
    D D Frisbie
    Gail Holmes Equine Orthopaedic Research Center, Colorado State University, USA
    Equine Vet J 42:643-51. 2010
    ..Biomarkers have shown some in vivo promise for the detection of musculoskeletal injuries, but further study to assess biomarker levels in clinical orthopaedic disease is required...
  3. ncbi request reprint Future directions in treatment of joint disease in horses
    David D Frisbie
    Department of Clinical Sciences, Colorado State University, 2503 Bay Farm Road, Delivery Code 0912, Fort Collins, CO 80523, USA
    Vet Clin North Am Equine Pract 21:713-24, viii. 2005
    ....
  4. doi request reprint Evaluation of intra-articular mesenchymal stem cells to augment healing of microfractured chondral defects
    C Wayne McIlwraith
    Orthopaedic Research Center, Colorado State University, Fort Collins, Colorado 80523, USA
    Arthroscopy 27:1552-61. 2011
    ..This study evaluated intra-articular injection of bone marrow-derived mesenchymal stem cells (BMSCs) to augment healing with microfracture compared with microfracture alone...
  5. doi request reprint Development of an in vitro model of injury-induced osteoarthritis in cartilage explants from adult horses through application of single-impact compressive overload
    Christina M Lee
    Orthopaedic Research Center, Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80523
    Am J Vet Res 74:40-7. 2013
    ..To develop an in vitro model of cartilage injury in full-thickness equine cartilage specimens that can be used to simulate in vivo disease and evaluate treatment efficacy...
  6. pmc Dynamic compression stimulates proteoglycan synthesis by mesenchymal stem cells in the absence of chondrogenic cytokines
    John D Kisiday
    Orthopaedic Research Center, Department of Clinical Science, Colorado State University, Fort Collins, Colorado 80523, USA
    Tissue Eng Part A 15:2817-24. 2009
    ..Taken together, these data suggest that the duration of loading necessary to stimulate mechanoinduction of MSCs may not be optimal for neo-tissue accumulation in the presence of chondrogenic cytokines...
  7. doi request reprint Evaluation of the effect of extracorporeal shock wave treatment on experimentally induced osteoarthritis in middle carpal joints of horses
    David D Frisbie
    Equine Orthopaedic Research Center, Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80523, USA
    Am J Vet Res 70:449-54. 2009
    ....
  8. ncbi request reprint IL-1ra/IGF-1 gene therapy modulates repair of microfractured chondral defects
    Sophie Morisset
    Orthopaedic Research Center, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80524, USA
    Clin Orthop Relat Res 462:221-8. 2007
    ..These data suggest in vivo gene therapy can improve biologic processes associated with chondral defect repair...
  9. doi request reprint Evaluation of topically administered diclofenac liposomal cream for treatment of horses with experimentally induced osteoarthritis
    David D Frisbie
    Gail Holmes Equine Orthopaedic Research Center, Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80523, USA
    Am J Vet Res 70:210-5. 2009
    ..To assess the clinical, biochemical, and histologic effects of topically administered diclofenac liposomal cream (DLC) in the treatment of horses with experimentally induced osteoarthritis...
  10. doi request reprint Evaluation of polysulfated glycosaminoglycan or sodium hyaluronan administered intra-articularly for treatment of horses with experimentally induced osteoarthritis
    David D Frisbie
    Gail Holmes Equine Orthopaedic Research Center, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80523 1678, USA
    Am J Vet Res 70:203-9. 2009
    ..To assess clinical, biochemical, and histologic effects of polysulfated glycosaminoglycan (PSGAG) or sodium hyaluronan administered intra-articularly in treatment of horses with experimentally induced osteoarthritis...
  11. doi request reprint Effects of extracorporeal shock wave therapy and polysulfated glycosaminoglycan treatment on subchondral bone, serum biomarkers, and synovial fluid biomarkers in horses with induced osteoarthritis
    Chris E Kawcak
    Gail Holmes Equine Orthopaedic Research Center, Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80523, USA
    Am J Vet Res 72:772-9. 2011
    ..To evaluate effects of extracorporeal shock wave therapy (ESWT) and polysulfated glycosaminoglycan treatment (PSGAGT) on subchondral bone (SCB), serum biomarkers, and synovial fluid biomarkers in horses with induced osteoarthritis...
  12. pmc Osteoblastic differentiation of human and equine adult bone marrow-derived mesenchymal stem cells when BMP-2 or BMP-7 homodimer genetic modification is compared to BMP-2/7 heterodimer genetic modification in the presence and absence of dexamethasone
    Ryan S Carpenter
    Orthopaedic Research Center, Colorado State University, Fort Collins, Colorado 80523, USA
    J Orthop Res 28:1330-7. 2010
    ....
  13. pmc Synoviocytes protect cartilage from the effects of injury in vitro
    Christina M Lee
    Orthopaedic Research Center, Department of Clinical Sciences, College of Veterinary Medicine, Colorado State University, 300 West Drake Rd, Fort Collins, Colorado CO 80523, USA
    BMC Musculoskelet Disord 14:54. 2013
    ..Although much research of injury induced OA has focused on cartilage, OA is a disease that affects the whole joint organ...
  14. doi request reprint Gene biomarkers in peripheral white blood cells of horses with experimentally induced osteoarthritis
    J Lacy Kamm
    Gail Holmes Orthopaedic Research Center, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80523
    Am J Vet Res 74:115-21. 2013
    ..To use microarray analysis to identify genes that are differentially expressed in horses with experimentally induced osteoarthritis...
  15. doi request reprint Evaluation of intramuscularly administered sodium pentosan polysulfate for treatment of experimentally induced osteoarthritis in horses
    C Wayne McIlwraith
    Gail Holmes Equine Orthopaedic Research Center, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80523, USA
    Am J Vet Res 73:628-33. 2012
    ..To assess clinical, radiographic, histologic, and biochemical effects of sodium pentosan polysulfate (NaPPS) administered IM for treatment of experimentally induced osteoarthritis in horses...
  16. ncbi request reprint Clinical, biochemical, and histologic effects of intra-articular administration of autologous conditioned serum in horses with experimentally induced osteoarthritis
    David D Frisbie
    Equine Orthopaedic Research Center, Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80523, USA
    Am J Vet Res 68:290-6. 2007
    ..To assess the clinical, biochemical, and histologic effects of intra-articular administration of autologous conditioned serum (ACS) in the treatment of experimentally induced osteoarthritis in horses...
  17. doi request reprint Induction of bone marrow mesenchymal stem cell chondrogenesis following short-term suspension culture
    John D Kisiday
    Orthopaedic Research Center, Department of Clinical Science, Colorado State University, Fort Collins, Colorado, USA
    J Orthop Res 29:26-32. 2011
    ....
  18. ncbi request reprint Use of scintigraphy for assessment of fracture healing and early diagnosis of osteomyelitis following fracture repair in rabbits
    Louise L Southwood
    Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins 80523, USA
    Am J Vet Res 64:736-45. 2003
    ..To evaluate use of technetium Tc 99m disodium hydroxymethylene diphosphonate (99m-Tc-HDP) for assessing fracture healing and 99m-Tc-HDP and technetium Tc 99m ciprofloxacin (99m-Tc-CIPRO) for early diagnosis of osteomyelitis in rabbits...
  19. ncbi request reprint Evaluation of Ad-BMP-2 for enhancing fracture healing in an infected defect fracture rabbit model
    Louise L Southwood
    Orthopaedic Research Laboratory, Department of Clinical Sciences, Colorado State University, Fort Collins, CO, USA
    J Orthop Res 22:66-72. 2004
    ..This could have been a result of the sclerosing agent, which may have damaged the cells in the defect...
  20. ncbi request reprint Evaluation of adult equine bone marrow- and adipose-derived progenitor cell chondrogenesis in hydrogel cultures
    John D Kisiday
    Orthopaedic Research Center, Department of Clinical Science, Colorado State University, 300 W Drake Road, Fort Collins, Colorado 80523, USA
    J Orthop Res 26:322-31. 2008
    ..Therefore, this study showed both protein and gene expression evidence of superior chondrogenesis of BM-MSCs relative to ADPCs...
  21. doi request reprint In vivo evaluation of autologous cartilage fragment-loaded scaffolds implanted into equine articular defects and compared with autologous chondrocyte implantation
    David D Frisbie
    Orthopaedic Research Center, Colorado State University, 300 West Drake, Fort Collins, CO 80523, USA
    Am J Sports Med 37:71S-80S. 2009
    ..Current autologous chondrocyte implantation (ACI) techniques require 2 surgical procedures: 1 for cell harvest and 1 for reimplantation of cultured cells. A 1-step procedure is more desirable...
  22. ncbi request reprint Evaluation of avocado and soybean unsaponifiable extracts for treatment of horses with experimentally induced osteoarthritis
    Christopher E Kawcak
    Gail Holmes Equine Orthopaedic Research Center, Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80523, USA
    Am J Vet Res 68:598-604. 2007
    ..To evaluate the use of a combination of avocado and soybean unsaponifiable (ASU) extracts for the treatment of experimentally induced osteoarthritis in horses...
  23. ncbi request reprint Determination and use of mechanical nociceptive thresholds of the thoracic limb to assess pain associated with induced osteoarthritis of the middle carpal joint in horses
    Kevin K Haussler
    Gail Holmes Equine Orthopaedic Research Center, Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80523, USA
    Am J Vet Res 68:1167-76. 2007
    ..To establish reference mechanical nociceptive threshold (MNT) values of the equine thoracic limb and to assess the use of MNT values to detect pain associated with induced osteoarthritis in the middle carpal joint...
  24. doi request reprint Effects of equine bone marrow aspirate volume on isolation, proliferation, and differentiation potential of mesenchymal stem cells
    John D Kisiday
    Orthopaedic Research Center, Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Studies, Colorado State University, Fort Collins, CO 80523, USA
    Am J Vet Res 74:801-7. 2013
    ..To compare the mesenchymal stem cell (MSC) yield and chondrogenic and osteogenic differentiation from 5- and 50-mL bone marrow aspirates from horses...
  25. doi request reprint Effect of scaffold dilution on migration of mesenchymal stem cells from fibrin hydrogels
    Benjamin W Hale
    Orthopaedic Research Center, Department of Clinical Science, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, 80523, USA
    Am J Vet Res 73:313-8. 2012
    ..To evaluate the effect of fibrin concentrations on mesenchymal stem cell (MSC) migration out of autologous and commercial fibrin hydrogels...
  26. ncbi request reprint Delivery of growth factors using gene therapy to enhance bone healing
    Louise L Southwood
    Orthopaedic Research Center, Colorado State University, Fort Collins, CO, USA
    Vet Surg 33:565-78. 2004
    ..To review the delivery of growth factors using gene therapy for enhancing long-bone fracture healing...
  27. doi request reprint Expansion of mesenchymal stem cells on fibrinogen-rich protein surfaces derived from blood plasma
    John D Kisiday
    Department of Clinical Science, Colorado State University, Fort Collins, CO, USA
    J Tissue Eng Regen Med 5:600-11. 2011
    ..Taken together, these factors indicate that substrates obtained from simple and inexpensive processing of blood enhance MSC proliferation and promote efficient coverage of expansion surfaces...
  28. doi request reprint Cell-based therapies for equine joint disease
    David D Frisbie
    Equine Orthopaedic Research Center, Department of Clinical Sciences, College of Veterinary Medicine and Biological Sciences, Colorado State University, 300 West Drake Road, Fort Collins, CO 80523, USA
    Vet Clin North Am Equine Pract 27:335-49. 2011
    ..This article focuses on cell-based therapies for treatment of equine joint disease. Results from experimental model and human clinical studies are presented along with available data from equine studies...
  29. doi request reprint Mechanical injury of explants from the articulating surface of the inner meniscus
    John D Kisiday
    Orthopaedic Research Center, Department of Clinical Science, Colorado State University, 300 W Drake Road, Fort Collins, CO 80523, USA
    Arch Biochem Biophys 494:138-44. 2010
    ..These data demonstrated a resiliency of the meniscus to injury, and that an acute increase in catabolic activities is not necessarily a consequence of mechanical overloading...
  30. doi request reprint Catabolic responses of chondrocyte-seeded peptide hydrogel to dynamic compression
    John D Kisiday
    Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA
    Ann Biomed Eng 37:1368-75. 2009
    ..These data suggest that partially mature cartilage tissue engineering constructs may be susceptible to catabolic degradation...
  31. ncbi request reprint Effects of calcified cartilage on healing of chondral defects treated with microfracture in horses
    David D Frisbie
    Equine Orthopaedic Research Center, Colorado State University, 300 West Drake Road, Fort Collins, 80523, USA
    Am J Sports Med 34:1824-31. 2006
    ..Microfracture of full-thickness articular defects has been shown to significantly enhance the amount of repair tissue. However, there is a suggestion that leaving calcified cartilage inhibits this repair response...
  32. doi request reprint Diagnostic stifle joint arthroscopy using a needle arthroscope in standing horses
    David D Frisbie
    Gail Holmes Equine Orthopaedic Research Center, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO
    Vet Surg 43:12-8. 2014
    ..To assess use of an 18 g arthroscope for diagnostic stifle joint examination in the standing horse...
  33. ncbi request reprint Evaluation of serum biochemical markers of bone metabolism for early diagnosis of nonunion and infected nonunion fractures in rabbits
    Louise L Southwood
    Orthopaedic Research Laboratory, Department of Clinical Sciences, Colorado State University, Fort Collins, CO 80523, USA
    Am J Vet Res 64:727-35. 2003
    ....
  34. doi request reprint The role of MRI in selected equine case management
    Myra F Barrett
    Department of Environmental and Radiological Health Sciences, Veterinary Teaching Hospital, Colorado State University, 300 West Drake, Fort Collins, CO 80523, USA
    Vet Clin North Am Equine Pract 28:647-58. 2012
    ..Using MRI as a diagnostic modality can help in developing an individualized treatment protocol. Case management can include both surgical and medical intervention. Various MRI findings and associated treatment protocols are described...
  35. ncbi request reprint Dual transduction of insulin-like growth factor-I and interleukin-1 receptor antagonist protein controls cartilage degradation in an osteoarthritic culture model
    Jennifer L Haupt
    Comparative Orthopaedics Laboratory, College of Veterinary Medicine, Cornell University, C3 176 Veterinary Medical Center, Ithaca, NY 14853, USA
    J Orthop Res 23:118-26. 2005
    ....