A W E Franz

Summary

Affiliation: Colorado State University
Country: USA

Publications

  1. pmc Comparison of transgene expression in Aedes aegypti generated by mariner Mos1 transposition and ΦC31 site-directed recombination
    Alexander W E Franz
    Arthropod Borne and Infectious Diseases Laboratory, Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO 80523, USA
    Insect Mol Biol 20:587-98. 2011
  2. pmc The RNA interference pathway affects midgut infection- and escape barriers for Sindbis virus in Aedes aegypti
    Cynthia C H Khoo
    Arthropod Borne and Infectious Diseases Laboratory, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523, USA
    BMC Microbiol 10:130. 2010
  3. doi Stability and loss of a virus resistance phenotype over time in transgenic mosquitoes harbouring an antiviral effector gene
    A W E Franz
    Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO, USA
    Insect Mol Biol 18:661-72. 2009
  4. pmc Transgene-mediated suppression of the RNA interference pathway in Aedes aegypti interferes with gene silencing and enhances Sindbis virus and dengue virus type 2 replication
    C C H Khoo
    Arthropod Borne and Infectious Diseases Laboratory, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523, USA
    Insect Mol Biol 22:104-14. 2013

Research Grants

Collaborators

Detail Information

Publications4

  1. pmc Comparison of transgene expression in Aedes aegypti generated by mariner Mos1 transposition and ΦC31 site-directed recombination
    Alexander W E Franz
    Arthropod Borne and Infectious Diseases Laboratory, Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO 80523, USA
    Insect Mol Biol 20:587-98. 2011
    ..aegypti and that the ΦC31 system can ensure predictable transgene expression in this mosquito species...
  2. pmc The RNA interference pathway affects midgut infection- and escape barriers for Sindbis virus in Aedes aegypti
    Cynthia C H Khoo
    Arthropod Borne and Infectious Diseases Laboratory, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523, USA
    BMC Microbiol 10:130. 2010
    ..We used these mosquitoes to reveal effects of RNAi impairment in the midgut on SINV replication, midgut infection and dissemination efficiencies, and mosquito longevity...
  3. doi Stability and loss of a virus resistance phenotype over time in transgenic mosquitoes harbouring an antiviral effector gene
    A W E Franz
    Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO, USA
    Insect Mol Biol 18:661-72. 2009
    ..Although the sequence of the transgene was not mutated, expression of the IR effector RNA was not detected and the Carb77 G(17) mosquitoes lost their ability to silence the DENV2 genome...
  4. pmc Transgene-mediated suppression of the RNA interference pathway in Aedes aegypti interferes with gene silencing and enhances Sindbis virus and dengue virus type 2 replication
    C C H Khoo
    Arthropod Borne and Infectious Diseases Laboratory, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523, USA
    Insect Mol Biol 22:104-14. 2013
    ..However, B2 expression in PUbB2 P61 did not increase the DENV2-QR94 dissemination rate, indicating that the infection phenotype was not primarily controlled by RNAi...

Research Grants3

  1. RNAi as a modulator of arbovirus vector competence in transgenic Aedes aegypti
    ALEXANDER WILLIAM EDUARD FRANZ; Fiscal Year: 2010
    ..aegypti when they are not controlled by the mosquito's RNAi response. The proposed research will help to reveal the impact of RNAi as an antiviral defense mechanism in the midgut of Ae. aegypti. ..