Research Topics
Species | Lihong H BuSummaryAffiliation: Colorado State University Country: USA Publications
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Publications
Visual spatial memory is enhanced in female rats (but inhibited in males) by dietary soy phytoestrogensT D Lund
The Neuroscience Center Brigham Young University, Provo, Utah 84602, USA
BMC Neurosci 2:20. 2001..Additionally, brain phytoestrogen, calbindin (CALB), and cyclooxygenase-2 (COX-2) levels were determined...- Androgen receptor expression in the rat prostate is down-regulated by dietary phytoestrogensTrent D Lund
Department of Biomedical Sciences, Colorado State University, Fort Collins, Colorado, USA
Reprod Biol Endocrinol 2:5. 2004..Proliferation of prostate cells is, at least in part, under control of estrogen receptor beta (ER-beta). Phytoestrogens bind ER-beta with high affinity and therefore may have antiproliferative effects in the prostate... 
Androgen inhibits, while oestrogen enhances, restraint-induced activation of neuropeptide neurones in the paraventricular nucleus of the hypothalamusT D Lund
Department of Biomedical Sciences, Colorado State University, Fort Collins, CO 80523 1670, USA
J Neuroendocrinol 16:272-8. 2004..Vasopressin hnRNA expression was also increased in response to stress, and this increase was attenuated by DHTP. These findings indicate that gonadal hormones influence the reactivity of the hypothalamic-pituitary adrenal axis to stress...- Dihydrotestosterone may inhibit hypothalamo-pituitary-adrenal activity by acting through estrogen receptor in the male mouseTrent D Lund
Department of Biomedical Sciences, Colorado State University, Anatomy W103, 1617 Campus Delivery, Fort Collins, CO 80523 1670, USA
Neurosci Lett 365:43-7. 2004..These studies also suggest that the DHT metabolites may be functionally relevant when considering hormonal responses to stress... - Novel actions of estrogen receptor-beta on anxiety-related behaviorsTrent D Lund
Department of Biomedical Science, Colorado State University, Anatomy W103, 1617 Campus Delivery, Fort Collins, Colorado 80523 1670, USA
Endocrinology 146:797-807. 2005..Tamoxifen blocked the previously identified anxiolytic actions of DPN. Taken together, these findings suggest that the anxiolytic properties of estrogens are ERbeta mediated... - Manipulation of prenatal hormones and dietary phytoestrogens during adulthood alter the sexually dimorphic expression of visual spatial memoryT D Lund
The Neuroscience Center Brigham Young University, Provo, Utah 84602, USA
BMC Neurosci 2:21. 2001..Additionally, the influence of dietary soy phytoestrogens (i.e., the presence of high or low estrogen-like compounds present in the animal's diet) on VSM was examined in combination with the prenatal hormonal manipulations... - The androgen 5alpha-dihydrotestosterone and its metabolite 5alpha-androstan-3beta, 17beta-diol inhibit the hypothalamo-pituitary-adrenal response to stress by acting through estrogen receptor beta-expressing neurons in the hypothalamusTrent D Lund
Department of Biomedical Sciences, Colorado State University, Fort Collins, Colorado 80523, USA
J Neurosci 26:1448-56. 2006..Together, these studies indicate that the inhibitory effects of DHT on HPA axis activity may be in part mediated via its conversion to 3beta-diol and subsequent binding to ERbeta... - Dietary soy phytoestrogens produce anxiolytic effects in the elevated plus-mazeT D Lund
Neuroscience Center, Brigham Young University, Provo, UT 84602, USA
Brain Res 913:180-4. 2001..Phytoestrogens produced anxiolytic effects in both male and female Long-Evans rats. Additionally, phytoestrogens decreased body weight but increased consumption of food and/or water... - Equol is a novel anti-androgen that inhibits prostate growth and hormone feedbackTrent D Lund
Department of Biomedical Sciences, Colorado State University, Fort Collins, Colorado 80524, USA
Biol Reprod 70:1188-95. 2004.... - Altered sexually dimorphic nucleus of the preoptic area (SDN-POA) volume in adult Long-Evans rats by dietary soy phytoestrogensT D Lund
The Neuroscience Center, Brigham Young University, Provo, UT 84602, USA
Brain Res 914:92-9. 2001..These data suggest that consumption of phytoestrogens via a soy diet, significantly: (1) decreases body and prostate weight, (2) delays puberty onset, and (3) alters SDN-POA volumes during adulthood... - Dietary soy phytoestrogen effects on brain structure and aromatase in Long-Evans ratsE D Lephart
Neuroscience Center, Brigham Young University, Provo, UT 84602, USA
Neuroreport 12:3451-5. 2001..e. anteroventral periventricular nucleus; AVPV) in male, but not in female rats. Since most commercial animal diets contain significant concentrations of phytoestrogens their influence on brain structure should be considered... - Pre- or postnatal testosterone and flutamide effects on sexually dimorphic nuclei of the rat hypothalamusT D Lund
Department of Psychology, Brigham Young University, Provo, UT 84602, USA
Brain Res Dev Brain Res 120:261-6. 2000..The present findings establish that pre- or postnatal hormonal environments are crucial in influencing sexual morphology on the developing brain... - Brain androgen and progesterone metabolizing enzymes: biosynthesis, distribution and functionE D Lephart
Neuroscience Center, Brigham Young University, 633 WIDB, Provo, UT 84602, USA
Brain Res Brain Res Rev 37:25-37. 2001..a low phytoestrogen diet on visual spatial memory in male and female rats is presented... - Estrogens and phytoestrogens: brain plasticity of sexually dimorphic brain volumesE D Lephart
The Neuroscience Center, 633 WIDB, Brigham Young University, Provo, UT 84602, USA
J Steroid Biochem Mol Biol 85:299-309. 2003..In summary, consumption of dietary phytoestrogens (estrogen mimics) can alter hormone-sensitive hypothalamic brain volumes in rodents during adulthood... - Corticotropin-releasing hormone heterogeneous nuclear RNA (hnRNA) and immunoreactivity are induced in extrahypothalamic brain sites by kainic-acid-induced seizures and are modulated by estrogenChad D Foradori
Department of Biomedical Sciences, Anatomy and Neurobiology Section, Colorado State University, Fort Collins, CO 80523, USA
Brain Res 1164:44-54. 2007..These results suggest a time-dependent activation of the CRH system following activation of kainate receptors, which may result in long-term changes in the expression of extrahypothalamic CRH... - Phytoestrogens: implications in neurovascular researchEdwin D Lephart
Department of Physiology and Developmental Biology, Neuroscience Center, 633 WIDB, Brigham Young University, Provo, Utah 84602, USA
Curr Neurovasc Res 1:455-64. 2004..Because of their diverse health effects and widespread availability in soy foods, dietary phytoestrogens merit continued research into their effects on human health and cognitive function... - Phytoestrogens: hormonal action and brain plasticityEdwin D Lephart
The Neuroscience Center, Brigham Young University, 633 WIDB, Provo, UT 84602, USA
Brain Res Bull 65:193-8. 2005.... - Neurobehavioral effects of dietary soy phytoestrogensEdwin D Lephart
Neuroscience Center, 633 WIDB, Brigham Young University, Provo, UT 86402, USA
Neurotoxicol Teratol 24:5-16. 2002.... - The androgen metabolite, 5alpha-androstane-3beta, 17beta-diol, is a potent modulator of estrogen receptor-beta1-mediated gene transcription in neuronal cellsToni R Pak
Department of Biomedical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, Colorado 80523, USA
Endocrinology 146:147-55. 2005..These data provide evidence for activation of ER signaling pathways by an androgen metabolite in neuronal cells... - Behavioral effects of endocrine-disrupting substances: phytoestrogensEdwin D Lephart
Department of Physiology and Developmental Biology, Neuroscience Center, Brigham Young University, Provo, UT, USA
ILAR J 45:443-54. 2004..Regulatory behaviors such as food and water intake, adipose deposition and leptin, and insulin levels affected by dietary isoflavones are also discussed... - Transcranial magnetic stimulation (TMS) effects on testosterone, prolactin, and corticosterone in adult male ratsDawson W Hedges
Department of Psychology and the Neuroscience Center, Brigham Young University, Provo, Utah 84602, USA
Biol Psychiatry 51:417-21. 2002.... - Evidence that atrazine and diaminochlorotriazine inhibit the estrogen/progesterone induced surge of luteinizing hormone in female Sprague-Dawley rats without changing estrogen receptor actionTami S McMullin
Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, Colorado 80523, USA
Toxicol Sci 79:278-86. 2004..Collectively, these results indicate that although ATRA is capable of binding ER in vitro, the suppression of LH after treatment with high doses of ATRA is not due to alterations of hypothalamic ER function... - Dietary soy phytoestrogens effects on retinal thickness in ratsTrent D Lund
633 WIDB, The Neuroscience Center, Brigham Young University, Provo, UT 84602, USA
Nutr Neurosci 6:47-51. 2003..These data suggest that phytoestrogens influence rat retinal characteristics in a sexually dimorphic manner (more robust effect in males vs. females) and that this influence can occur even in adulthood... 
An alternate pathway for androgen regulation of brain function: activation of estrogen receptor beta by the metabolite of dihydrotestosterone, 5alpha-androstane-3beta,17beta-diolRobert J Handa
Department of Biomedical Sciences Neurosciences Division, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80523, USA
Horm Behav 53:741-52. 2008..These novel findings compel us to re-evaluate the interpretation of past studies and the design of future experiments aimed at elucidating the specific effects of androgen receptor signaling pathways...- Transcranial magnetic stimulation effects on one-trial learning and response to anxiogenic stimuli in adult male ratsDawson W Hedges
Department of Psychology and the Neuroscience Center, Brigham Young University, Provo, Utah, USA
J ECT 21:25-30. 2005..In summary, these findings support previous reports that TMS does not interfere with memory function. There was no evidence of an anxiolytic response from TMS in rats as assessed by the elevated plus maze test... - S-equol, a potent ligand for estrogen receptor beta, is the exclusive enantiomeric form of the soy isoflavone metabolite produced by human intestinal bacterial floraKenneth D R Setchell
Division of Pathology, Clinical Mass Spectrometry, Cincinnati Children s Hospital Medical Center, and the Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati 45229, OH, USA
Am J Clin Nutr 81:1072-9. 2005..Equol, unlike the soy isoflavones daidzein or genistein, has a chiral center and therefore can occur as 2 distinct diastereoisomers... - Duration of transcranial magnetic stimulation effects on the neuroendocrine stress response and coping behavior of adult male ratsDawson W Hedges
Department of Psychology, Brigham Young University, Provo, UT 84602, USA
Prog Neuropsychopharmacol Biol Psychiatry 27:633-8. 2003..This research was undertaken to investigate the duration of these behavioral and neuroendocrine effects of TMS in rats...