Joel S Bedford

Summary

Affiliation: Colorado State University
Country: USA

Publications

  1. ncbi request reprint Radiation Research Society. 1952-2002. Historical and current highlights in radiation biology: has anything important been learned by irradiating cells?
    Joel S Bedford
    Department of Radiological Health Sciences, Colorado State University, Fort Collins, Colorado 80523 1673, USA
    Radiat Res 158:251-91. 2002
  2. doi request reprint Some unsolved problems and unresolved issues in radiation cytogenetics: a review and new data on roles of homologous recombination and non-homologous end joining
    Hatsumi Nagasawa
    Department of Environmental and Radiological Health Sciences, 1618 Campus Delivery, Colorado State University, Fort Collins, CO 80523, USA
    Mutat Res 701:12-22. 2010
  3. doi request reprint Radiation leukemogenesis in mice: loss of PU.1 on chromosome 2 in CBA and C57BL/6 mice after irradiation with 1 GeV/nucleon 56Fe ions, X rays or gamma rays. Part I. Experimental observations
    Yuanlin Peng
    Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, Colorado 80523, USA
    Radiat Res 171:474-83. 2009
  4. doi request reprint Radiation leukemogenesis in mice: loss of PU.1 on chromosome 2 in CBA and C57BL/6 mice after irradiation with 1 GeV/nucleon 56Fe ions, X rays or gamma Rays. Part II. Theoretical considerations based on microdosimetry and the initial induction of chromosom
    Yuanlin Peng
    Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, Colorado 80523, USA
    Radiat Res 171:484-93. 2009
  5. doi request reprint Incidence of acute myeloid leukemia and hepatocellular carcinoma in mice irradiated with 1 GeV/nucleon (56)Fe ions
    Michael M Weil
    Department of Environmental and Radiological Health Sciences and, Colorado State University, Fort Collins, Colorado 80523, USA
    Radiat Res 172:213-9. 2009
  6. doi request reprint Variations in radiosensitivity among individuals: a potential impact on risk assessment?
    Takamitsu A Kato
    Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO 80523, USA
    Health Phys 97:470-80. 2009
  7. ncbi request reprint Studies on chromosome aberration induction: what can they tell us about DNA repair?
    Susan M Bailey
    Colorado State University, Fort Collins, CO 80523, USA
    DNA Repair (Amst) 5:1171-81. 2006
  8. doi request reprint Comparison of several radiation effects in human MCF10A mammary epithelial cells cultured as 2D monolayers or 3D acinar stuctures in matrigel
    Yu Fen Lin
    Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, Colorado 80523, USA
    Radiat Res 171:708-15. 2009
  9. doi request reprint Low doses of alpha particles do not induce sister chromatid exchanges in bystander Chinese hamster cells defective in homologous recombination
    Hatsumi Nagasawa
    Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO 80523, USA
    DNA Repair (Amst) 7:515-22. 2008
  10. ncbi request reprint A defect in DNA double strand break processing in cells from unaffected parents of retinoblastoma patients and other apparently normal humans
    Takamitsu A Kato
    Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO 80523, United States
    DNA Repair (Amst) 6:818-29. 2007

Collaborators

Detail Information

Publications21

  1. ncbi request reprint Radiation Research Society. 1952-2002. Historical and current highlights in radiation biology: has anything important been learned by irradiating cells?
    Joel S Bedford
    Department of Radiological Health Sciences, Colorado State University, Fort Collins, Colorado 80523 1673, USA
    Radiat Res 158:251-91. 2002
    ..This review summarizes some of the highlights in these areas, and points to numerous examples where indeed, many things of considerable fundamental importance have been learned by irradiating cells...
  2. doi request reprint Some unsolved problems and unresolved issues in radiation cytogenetics: a review and new data on roles of homologous recombination and non-homologous end joining
    Hatsumi Nagasawa
    Department of Environmental and Radiological Health Sciences, 1618 Campus Delivery, Colorado State University, Fort Collins, CO 80523, USA
    Mutat Res 701:12-22. 2010
    ....
  3. doi request reprint Radiation leukemogenesis in mice: loss of PU.1 on chromosome 2 in CBA and C57BL/6 mice after irradiation with 1 GeV/nucleon 56Fe ions, X rays or gamma rays. Part I. Experimental observations
    Yuanlin Peng
    Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, Colorado 80523, USA
    Radiat Res 171:474-83. 2009
    ..If so, PU.1 loss could be used to systematically assess the potential leukemogenic effects of other ions and energies in the space radiation environment...
  4. doi request reprint Radiation leukemogenesis in mice: loss of PU.1 on chromosome 2 in CBA and C57BL/6 mice after irradiation with 1 GeV/nucleon 56Fe ions, X rays or gamma Rays. Part II. Theoretical considerations based on microdosimetry and the initial induction of chromosom
    Yuanlin Peng
    Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, Colorado 80523, USA
    Radiat Res 171:484-93. 2009
    ..1 deletions, an independent prediction of PU.1 loss agreed well with measurements described in the accompanying paper...
  5. doi request reprint Incidence of acute myeloid leukemia and hepatocellular carcinoma in mice irradiated with 1 GeV/nucleon (56)Fe ions
    Michael M Weil
    Department of Environmental and Radiological Health Sciences and, Colorado State University, Fort Collins, Colorado 80523, USA
    Radiat Res 172:213-9. 2009
    ..These data suggest a difference in the effects of HZE iron ions on the induction of leukemia compared to solid tumors, suggesting potentially different mechanisms of tumorigenesis...
  6. doi request reprint Variations in radiosensitivity among individuals: a potential impact on risk assessment?
    Takamitsu A Kato
    Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO 80523, USA
    Health Phys 97:470-80. 2009
    ..A low dose-rate assay was used to amplify such differences. Another promising assay combines G(2) chromosomal radiosensitivity with the above gamma-H2AX foci on mitotic chromosomes. There are other potentially useful assays as well...
  7. ncbi request reprint Studies on chromosome aberration induction: what can they tell us about DNA repair?
    Susan M Bailey
    Colorado State University, Fort Collins, CO 80523, USA
    DNA Repair (Amst) 5:1171-81. 2006
    ..We will first briefly summarize some early studies that serve as a reminder of the background on which current studies are based, and then carry forward to the present day certain interesting facets of these studies...
  8. doi request reprint Comparison of several radiation effects in human MCF10A mammary epithelial cells cultured as 2D monolayers or 3D acinar stuctures in matrigel
    Yu Fen Lin
    Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, Colorado 80523, USA
    Radiat Res 171:708-15. 2009
    ..While this does not mean that such differences cannot occur in other situations, it does mean that they do not generally or necessarily occur...
  9. doi request reprint Low doses of alpha particles do not induce sister chromatid exchanges in bystander Chinese hamster cells defective in homologous recombination
    Hatsumi Nagasawa
    Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO 80523, USA
    DNA Repair (Amst) 7:515-22. 2008
    ..These data suggest that Brca2 and the Rad51 paralogs contribute to DNA damage repair processes induced in bystander cells (presumably oxidative damage repair in S-phase cells) following irradiation with very low doses of alpha particles...
  10. ncbi request reprint A defect in DNA double strand break processing in cells from unaffected parents of retinoblastoma patients and other apparently normal humans
    Takamitsu A Kato
    Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO 80523, United States
    DNA Repair (Amst) 6:818-29. 2007
    ..In the G(2)/M gamma-H2AX assay, the relative sensitivities were similar to those seen in the low dose-rate G(0) assay and tracked with chromosomal radiosensitivity, but some differences were observed...
  11. ncbi request reprint Deficiency in the catalytic subunit of DNA-dependent protein kinase causes down-regulation of ATM
    Yuanlin Peng
    Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, Colorado 80523, USA
    Cancer Res 65:1670-7. 2005
    ....
  12. ncbi request reprint Caffeine eliminates gamma-ray-induced G2-phase delay in human tumor cells but not in normal cells
    Mitra N Jha
    Department of Radiological Health Sciences, Colorado State University, Fort Collins, Colorado 80523 1673, USA
    Radiat Res 157:26-31. 2002
    ..Thus it is likely that caffeine is eliminating the radiation-induced G2-phase delay through a Ca(++)-independent mechanism, such as the inhibition of a cell cycle-regulating kinase...
  13. pmc G2-phase chromosomal radiosensitivity of primary fibroblasts from hereditary retinoblastoma family members and some apparently normal controls
    Paul F Wilson
    Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, Colorado 80523, USA
    Radiat Res 173:62-70. 2010
    ....
  14. ncbi request reprint Applications of RNA interference for studies in DNA damage processing, genome stability, mutagenesis, and cancer
    Joel S Bedford
    Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO 80523, USA
    Semin Cancer Biol 13:301-8. 2003
    ..In this paper, we review some applications of this technology for studies in DNA damage processing, genome stability, mutagenesis, and cancer...
  15. doi request reprint Comparison of the induction and disappearance of DNA double strand breaks and gamma-H2AX foci after irradiation of chromosomes in G1-phase or in condensed metaphase cells
    Takamitsu A Kato
    Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO 80523, United States
    Mutat Res 639:108-12. 2008
    ..On the other hand, no difference was seen for the gel electrophoresis assay. Our data may suggest the limited accessibility of dephosphorylation enzyme in irradiated metaphase cells or trapped gamma-H2AX in condensed chromatin...
  16. ncbi request reprint Cytotoxicity of cigarette smoke condensate is not due to DNA double strand breaks: Comparative studies using radiosensitive mutant and wild-type CHO cells
    Takamitsu Kato
    Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, USA
    Int J Radiat Biol 83:583-91. 2007
    ....
  17. ncbi request reprint Education and training for radiation scientists: radiation research program and American Society of Therapeutic Radiology and Oncology Workshop, Bethesda, Maryland, May 12-14, 2003
    C Norman Coleman
    Radiation Research Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Bethesda, Maryland, USA
    Radiat Res 160:729-37. 2003
    ..5) Educate other scientists and the general public on the quantitative, basic, molecular, translational and applied aspects of radiation sciences...
  18. ncbi request reprint Induction of DNA double strand breaks by arsenite: comparative studies with DNA breaks induced by X-rays
    Ryuichi Okayasu
    International Space Radiation Laboratory and Environmental Toxicological Research Group, National Institute of Radiological Sciences, 4 9 1 Anagawa, Inage Ku, Chiba 263 8555, Japan
    DNA Repair (Amst) 2:309-14. 2003
    ..Based on these data, further mechanistic investigations including the involvement of DNA-DSB repair proteins are warranted in the recovery process from arsenic (As) exposure...
  19. ncbi request reprint Inhibition of DNA-double strand break repair by antimony compounds
    Sentaro Takahashi
    Environmental and Toxicological Research Group, National Institute of Radiological Sciences, 4 9 1 Anagawa, Inage Ku, 263 8555, Chiba, Japan
    Toxicology 180:249-56. 2002
    ..This is the first report to indicate that antimony compounds may inhibit the repair of radiation-induced DNA DSB...
  20. pmc Physical mapping of genes in somatic cell radiation hybrids by comparative genomic hybridization to cDNA microarrays
    Johann Y Lin
    Department of Vascular Biology, The Scripps Research Institute, 10550 N, Torrey Pines Road, La Jolla, CA 92037, USA
    Genome Biol 3:RESEARCH0026. 2002
    ..Here we report experiments that establish the validity and efficacy of the methodology...
  21. pmc A unique role of the DNA fragmentation factor in maintaining genomic stability
    Bin Yan
    Departments of Radiation Oncology and Pathology, Duke University Medical Center, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 103:1504-9. 2006
    ....