Susan M Bailey

Summary

Affiliation: Colorado State University
Country: USA

Publications

  1. ncbi request reprint Telomeres and double-strand breaks - all's well that "ends" well.
    Susan M Bailey
    Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, Colorado 80523 1618, USA
    Radiat Res 169:1-7. 2008
  2. ncbi request reprint Chromosome Orientation fluorescence in situ hybridization or strand-specific FISH
    Susan M Bailey
    Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO, USA
    Methods Mol Biol 659:173-83. 2010
  3. ncbi request reprint Telomeres and DNA double-strand breaks: ever the twain shall meet?
    S M Bailey
    Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO 80523 1618, USA
    Cell Mol Life Sci 64:2956-64. 2007
  4. pmc Telomeres, chromosome instability and cancer
    Susan M Bailey
    Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO 80523, USA
    Nucleic Acids Res 34:2408-17. 2006
  5. ncbi request reprint Strand-specific fluorescence in situ hybridization: the CO-FISH family
    S M Bailey
    Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO 80523, USA
    Cytogenet Genome Res 107:14-7. 2004
  6. ncbi request reprint The kinase activity of DNA-PK is required to protect mammalian telomeres
    Susan M Bailey
    Department of Environmental and Radiological Health Sciences, Colorado State Univeristy, Fort Collins 80523, USA
    DNA Repair (Amst) 3:225-33. 2004
  7. pmc Regulatory roles of tankyrase 1 at telomeres and in DNA repair: suppression of T-SCE and stabilization of DNA-PKcs
    Ryan C Dregalla
    Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, 80523 1618, USA
    Aging (Albany NY) 2:691-708. 2010
  8. ncbi request reprint Partial deficiency of DNA-PKcs increases ionizing radiation-induced mutagenesis and telomere instability in human cells
    Ying Zhang
    Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO 80521, USA
    Cancer Lett 250:63-73. 2007
  9. ncbi request reprint Suppression of DNA-PK by RNAi has different quantitative effects on telomere dysfunction and mutagenesis in human lymphoblasts treated with gamma rays or HZE particles
    Qinming Zhang
    Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, Colorado 80523, USA
    Radiat Res 164:497-504. 2005
  10. pmc Telomere dysfunction and DNA-PKcs deficiency: characterization and consequence
    Eli S Williams
    Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, Colorado 80523 1618, USA
    Cancer Res 69:2100-7. 2009

Collaborators

Detail Information

Publications31

  1. ncbi request reprint Telomeres and double-strand breaks - all's well that "ends" well.
    Susan M Bailey
    Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, Colorado 80523 1618, USA
    Radiat Res 169:1-7. 2008
    ..The rest of the story waits to unfold...
  2. ncbi request reprint Chromosome Orientation fluorescence in situ hybridization or strand-specific FISH
    Susan M Bailey
    Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO, USA
    Methods Mol Biol 659:173-83. 2010
    ....
  3. ncbi request reprint Telomeres and DNA double-strand breaks: ever the twain shall meet?
    S M Bailey
    Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO 80523 1618, USA
    Cell Mol Life Sci 64:2956-64. 2007
    ....
  4. pmc Telomeres, chromosome instability and cancer
    Susan M Bailey
    Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO 80523, USA
    Nucleic Acids Res 34:2408-17. 2006
    ..Thus, the loss of a single telomere can result in on-going instability, affect multiple chromosomes, and generate many of the types of rearrangements commonly associated with human cancer...
  5. ncbi request reprint Strand-specific fluorescence in situ hybridization: the CO-FISH family
    S M Bailey
    Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO 80523, USA
    Cytogenet Genome Res 107:14-7. 2004
    ..Development and various applications of CO-FISH will be discussed: detection of cryptic inversions, discrimination between telomeres produced by leading- versus lagging-strand synthesis, and replication timing of mammalian telomeres...
  6. ncbi request reprint The kinase activity of DNA-PK is required to protect mammalian telomeres
    Susan M Bailey
    Department of Environmental and Radiological Health Sciences, Colorado State Univeristy, Fort Collins 80523, USA
    DNA Repair (Amst) 3:225-33. 2004
    ..These results indicate that the kinase activity of DNA-PK is crucial to reestablishing a protective terminal structure, specifically on telomeres replicated by leading-strand DNA synthesis...
  7. pmc Regulatory roles of tankyrase 1 at telomeres and in DNA repair: suppression of T-SCE and stabilization of DNA-PKcs
    Ryan C Dregalla
    Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, 80523 1618, USA
    Aging (Albany NY) 2:691-708. 2010
    ..We provide the first evidence for regulation of DNA-PKcs by tankyrase 1 PARP activity and taken together, identify roles of tankyrase 1 with implications not only for DNA repair and telomere biology, but also for cancer and aging...
  8. ncbi request reprint Partial deficiency of DNA-PKcs increases ionizing radiation-induced mutagenesis and telomere instability in human cells
    Ying Zhang
    Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO 80521, USA
    Cancer Lett 250:63-73. 2007
    ..Taken together, our results suggest that even partial deficiency of DNA repair proteins may represent a considerable risk to genomic stability...
  9. ncbi request reprint Suppression of DNA-PK by RNAi has different quantitative effects on telomere dysfunction and mutagenesis in human lymphoblasts treated with gamma rays or HZE particles
    Qinming Zhang
    Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, Colorado 80523, USA
    Radiat Res 164:497-504. 2005
    ....
  10. pmc Telomere dysfunction and DNA-PKcs deficiency: characterization and consequence
    Eli S Williams
    Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, Colorado 80523 1618, USA
    Cancer Res 69:2100-7. 2009
    ..These studies provide the first direct evidence of genetic susceptibility and environmental insult interactions leading to a unique and ongoing form of genomic instability capable of driving carcinogenesis...
  11. pmc Frequent recombination in telomeric DNA may extend the proliferative life of telomerase-negative cells
    Susan M Bailey
    Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO 80523, USA
    Nucleic Acids Res 32:3743-51. 2004
    ....
  12. ncbi request reprint NBS1 knockdown by small interfering RNA increases ionizing radiation mutagenesis and telomere association in human cells
    Ying Zhang
    Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, Colorado 80523, USA
    Cancer Res 65:5544-53. 2005
    ....
  13. pmc Hyper telomere recombination accelerates replicative senescence and may promote premature aging
    R Tanner Hagelstrom
    Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, 80523 1618, USA
    Proc Natl Acad Sci U S A 107:15768-73. 2010
    ..Furthermore, T-SCE-driven premature cellular senescence may be a factor contributing to accelerated aging in Werner and Bloom syndromes, but not XFE progeroid syndrome...
  14. pmc Murine Prkdc polymorphisms impact DNA-PKcs function
    Kristin M Fabre
    Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, Colorado 80523, USA
    Radiat Res 175:493-500. 2011
    ....
  15. ncbi request reprint Studies on chromosome aberration induction: what can they tell us about DNA repair?
    Susan M Bailey
    Colorado State University, Fort Collins, CO 80523, USA
    DNA Repair (Amst) 5:1171-81. 2006
    ..We will first briefly summarize some early studies that serve as a reminder of the background on which current studies are based, and then carry forward to the present day certain interesting facets of these studies...
  16. doi request reprint Feline chronic kidney disease is associated with shortened telomeres and increased cellular senescence
    Jessica M Quimby
    Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80523, USA
    Am J Physiol Renal Physiol 305:F295-303. 2013
    ..Our results suggest that shortened telomeres and increased senescence in the kidneys of CKD cats may represent novel targets for interventional therapy. ..
  17. doi request reprint CO-FISH, COD-FISH, ReD-FISH, SKY-FISH
    Eli S Williams
    Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO, USA
    Methods Mol Biol 735:113-24. 2011
    ..Cytogenet Genome Res 107, 14-17, 2004; Bailey and Cornforth, Cell Mol Life Sci 64:2956-2964, 2007; Bailey, Telomeres and Double-Strand Breaks - All's Well that "Ends" Well, Radiat Res 169:1-7, 2008)...
  18. ncbi request reprint Dysfunctional mammalian telomeres join with DNA double-strand breaks
    Susan M Bailey
    Department of Radiological Health Services, Colorado State University, Fort Collins, CO 80523 1618, USA
    DNA Repair (Amst) 3:349-57. 2004
    ..The high frequency of these events in scid cells indicates telomere dysfunction makes a strong, and previously unsuspected, contribution to the characteristic radiation sensitivity associated with DNA-PK deficiency...
  19. ncbi request reprint Directional genomic hybridization: inversions as a potential biodosimeter for retrospective radiation exposure
    F Andrew Ray
    Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO, 80523, USA
    Radiat Environ Biophys 53:255-63. 2014
    ..Our results show a dramatic dose-dependent difference in the yields of inversions induced by low-LET gamma rays, as compared to more damaging high-LET charged particles similar to those encountered in deep space...
  20. pmc Resveratrol reduces radiation-induced chromosome aberration frequencies in mouse bone marrow cells
    Ronald E Carsten
    Cell and Molecular Biology, Colorado State University, Fort Collins, CO 80523, USA
    Radiat Res 169:633-8. 2008
    ..This study is the first to demonstrate that resveratrol has radioprotective effects in vivo. These results support the use of resveratrol as a radioprotector with the potential for widespread application...
  21. pmc Directional genomic hybridization for chromosomal inversion discovery and detection
    F Andrew Ray
    Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO 80523 1618, USA
    Chromosome Res 21:165-74. 2013
    ....
  22. pmc DNA repair deficiency as a susceptibility marker for spontaneous lymphoma in golden retriever dogs: a case-control study
    Douglas H Thamm
    Flint Animal Cancer Center, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, Colorado, United States of America
    PLoS ONE 8:e69192. 2013
    ..These studies set the stage for larger confirmatory studies, as well as candidate-based approaches to probe specific genetic susceptibility factors. ..
  23. pmc TERRA, hnRNP A1, and DNA-PKcs Interactions at Human Telomeres
    Phuong N Le
    Department of Environmental and Radiological Health Sciences, Colorado State University Fort Collins, CO, USA
    Front Oncol 3:91. 2013
    ....
  24. pmc Deficiency in mammalian histone H2B ubiquitin ligase Bre1 (Rnf20/Rnf40) leads to replication stress and chromosomal instability
    Sophia B Chernikova
    Department of Radiation Oncology, Stanford University, Stanford, California 94305, USA
    Cancer Res 72:2111-9. 2012
    ....
  25. pmc Functional interaction between DNA-PKcs and telomerase in telomere length maintenance
    Silvia Espejel
    Department of Immunology and Oncology, National Centre of Biotechnology, E 28049 Madrid, Spain
    EMBO J 21:6275-87. 2002
    ..These results suggest a critical role of DNA-PKcs in both cancer and aging...
  26. ncbi request reprint Influence of dose rate on the induction of simple and complex chromosome exchanges by gamma rays
    Bradford D Loucas
    Department of Radiation Oncology, University of Texas Medical Branch, Galveston, Texas 77555 0656, USA
    Radiat Res 162:339-49. 2004
    ..For acute exposures, the ratio of simple reciprocal translocations to simple dicentrics was near unity...
  27. pmc Elevated telomere-telomere recombination in WRN-deficient, telomere dysfunctional cells promotes escape from senescence and engagement of the ALT pathway
    Purnima R Laud
    Department of Molecular Genetics, University of Texas, The M D Anderson Cancer Center, Houston, Texas 77030, USA
    Genes Dev 19:2560-70. 2005
    ....
  28. ncbi request reprint Pot1 deficiency initiates DNA damage checkpoint activation and aberrant homologous recombination at telomeres
    Ling Wu
    Department of Molecular Genetics, Box 1006, M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Cell 126:49-62. 2006
    ..Telomeric HR following Pot1a loss requires NBS1. Pot1a deletion also results in chromosomal instability. Our results suggest that POT1a is crucial for the maintenance of both telomere integrity and overall genomic stability...
  29. ncbi request reprint DNA double-strand breaks are not sufficient to initiate recruitment of TRF2
    Eli S Williams
    Nat Genet 39:696-8; author reply 698-9. 2007
  30. ncbi request reprint Telomere lengthening early in development
    Lin Liu
    Laboratory for Reproductive Medicine, Department of Obstetrics and Gynecology, University of South Florida College of Medicine, Tampa, Florida 33612, USA
    Nat Cell Biol 9:1436-41. 2007
    ....
  31. ncbi request reprint Dose responses for chromosome aberrations produced in noncycling primary human fibroblasts by alpha particles, and by gamma rays delivered at sublimiting low dose rates
    Michael N Cornforth
    Departments of Radiation Oncology and Human Biological Chemistry and Genetics, University of Texas Medical Branch, Galveston, Texas 77555 0656, USA
    Radiat Res 158:43-53. 2002
    ..Exposure to (238)Pu alpha particles also produced a linear dose response for total aberrations, whose slope-with respect to (137)Cs gamma rays as a reference radiation-implied a maximum RBE of 35 +/- 2...