Amol Amin

Summary

Affiliation: Colorado State University
Country: USA

Publications

  1. ncbi request reprint Unique mechanism of action of the thiourea drug isoxyl on Mycobacterium tuberculosis
    Benjawan Phetsuksiri
    Department of Microbiology, Pathology, and Immunology, Colorado State University, Fort Collins, Colorado 80523 1682, USA
    J Biol Chem 278:53123-30. 2003
  2. pmc Morphological features and signature gene response elicited by inactivation of FtsI in Mycobacterium tuberculosis
    Richard A Slayden
    Department of Microbiology, Mycobacteria Research Laboratories, Colorado State University, Fort Collins, CO 80523, USA
    J Antimicrob Chemother 63:451-7. 2009
  3. pmc Immune response to Mycobacterium tuberculosis and identification of molecular markers of disease
    Mercedes Gonzalez-Juarrero
    Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO, USA
    Am J Respir Cell Mol Biol 40:398-409. 2009
  4. ncbi request reprint Characterizing septum inhibition in Mycobacterium tuberculosis for novel drug discovery
    Laurel Respicio
    Rocky Mountain Regional Center of Excellence, Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523, United States
    Tuberculosis (Edinb) 88:420-9. 2008
  5. pmc Targeting fatty acid biosynthesis for the development of novel chemotherapeutics against Mycobacterium tuberculosis: evaluation of A-ring-modified diphenyl ethers as high-affinity InhA inhibitors
    Melissa E Boyne
    Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523 1682, USA
    Antimicrob Agents Chemother 51:3562-7. 2007
  6. pmc A trisubstituted benzimidazole cell division inhibitor with efficacy against Mycobacterium tuberculosis
    Susan E Knudson
    Mycobacteria Research Laboratories, Department Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado, United States of America
    PLoS ONE 9:e93953. 2014
  7. pmc MazF6 toxin of Mycobacterium tuberculosis demonstrates antitoxin specificity and is coupled to regulation of cell growth by a Soj-like protein
    Melissa V Ramirez
    Mycobacteria Research Laboratories, Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO 80523, USA
    BMC Microbiol 13:240. 2013
  8. ncbi request reprint Updating and curating metabolic pathways of TB
    Richard A Slayden
    Colorado State University, Fort Collins, CO, USA
    Tuberculosis (Edinb) 93:47-59. 2013
  9. pmc Mycobacterium tuberculosis septum site determining protein, Ssd encoded by rv3660c, promotes filamentation and elicits an alternative metabolic and dormancy stress response
    Kathleen England
    Mycobacteria Research Laboratories, Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO 80523, USA
    BMC Microbiol 11:79. 2011
  10. pmc Implications of high level pseudogene transcription in Mycobacterium leprae
    Diana L Williams
    HRSA, BPHC, Division of National Hansen s Disease Programs, Laboratory Research Branch, Molecular Biology Research Department, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA, USA
    BMC Genomics 10:397. 2009

Research Grants

  1. Regulation of Cellular division in M. tuberculosis
    RICHARD SLAYDEN; Fiscal Year: 2006
  2. Regulation of Cellular division in M. tuberculosis
    RICHARD SLAYDEN; Fiscal Year: 2003
  3. Regulation of Cellular division in M. tuberculosis
    RICHARD SLAYDEN; Fiscal Year: 2004
  4. Regulation of Cellular division in M. tuberculosis
    RICHARD SLAYDEN; Fiscal Year: 2005

Collaborators

Detail Information

Publications22

  1. ncbi request reprint Unique mechanism of action of the thiourea drug isoxyl on Mycobacterium tuberculosis
    Benjawan Phetsuksiri
    Department of Microbiology, Pathology, and Immunology, Colorado State University, Fort Collins, Colorado 80523 1682, USA
    J Biol Chem 278:53123-30. 2003
    ..These results validate membrane-bound Delta9-desaturase, DesA3, as a new therapeutic target, and the thioureas as anti-tuberculosis drugs worthy of further development...
  2. pmc Morphological features and signature gene response elicited by inactivation of FtsI in Mycobacterium tuberculosis
    Richard A Slayden
    Department of Microbiology, Mycobacteria Research Laboratories, Colorado State University, Fort Collins, CO 80523, USA
    J Antimicrob Chemother 63:451-7. 2009
    ....
  3. pmc Immune response to Mycobacterium tuberculosis and identification of molecular markers of disease
    Mercedes Gonzalez-Juarrero
    Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO, USA
    Am J Respir Cell Mol Biol 40:398-409. 2009
    ..tuberculosis infection, and unique molecular markers associated with disease progression and state, were identified...
  4. ncbi request reprint Characterizing septum inhibition in Mycobacterium tuberculosis for novel drug discovery
    Laurel Respicio
    Rocky Mountain Regional Center of Excellence, Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523, United States
    Tuberculosis (Edinb) 88:420-9. 2008
    ....
  5. pmc Targeting fatty acid biosynthesis for the development of novel chemotherapeutics against Mycobacterium tuberculosis: evaluation of A-ring-modified diphenyl ethers as high-affinity InhA inhibitors
    Melissa E Boyne
    Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523 1682, USA
    Antimicrob Agents Chemother 51:3562-7. 2007
    ..The next step in optimization of the pharmacophore for preclinical evaluation is modification of the B ring to increase the bioavailability to that required for oral delivery...
  6. pmc A trisubstituted benzimidazole cell division inhibitor with efficacy against Mycobacterium tuberculosis
    Susan E Knudson
    Mycobacteria Research Laboratories, Department Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado, United States of America
    PLoS ONE 9:e93953. 2014
    ..tuberculosis clinical strains with varying susceptibility and efficacy in animal models of infection, and that trisubstituted benzimidazoles continue to be a platform for the development of novel inhibitors with efficacy...
  7. pmc MazF6 toxin of Mycobacterium tuberculosis demonstrates antitoxin specificity and is coupled to regulation of cell growth by a Soj-like protein
    Melissa V Ramirez
    Mycobacteria Research Laboratories, Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO 80523, USA
    BMC Microbiol 13:240. 2013
    ..Based on previous reports and our recent studies, we reason that, in order to establish NRP, cells are halted in the cell cycle at the point of septum formation by coupled regulatory mechanisms...
  8. ncbi request reprint Updating and curating metabolic pathways of TB
    Richard A Slayden
    Colorado State University, Fort Collins, CO, USA
    Tuberculosis (Edinb) 93:47-59. 2013
    ..The greatest benefit of functional annotation information of genome sequence is that it fuels TB research for drug discovery, diagnostics, vaccine development and epidemiology...
  9. pmc Mycobacterium tuberculosis septum site determining protein, Ssd encoded by rv3660c, promotes filamentation and elicits an alternative metabolic and dormancy stress response
    Kathleen England
    Mycobacteria Research Laboratories, Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO 80523, USA
    BMC Microbiol 11:79. 2011
    ..tuberculosis...
  10. pmc Implications of high level pseudogene transcription in Mycobacterium leprae
    Diana L Williams
    HRSA, BPHC, Division of National Hansen s Disease Programs, Laboratory Research Branch, Molecular Biology Research Department, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA, USA
    BMC Genomics 10:397. 2009
    ..Preliminary evidence suggests that some pseudogenes are expressed. Therefore, defining pseudogene transcriptional and translational potentials of this genome should increase our understanding of their impact on M. leprae physiology...
  11. ncbi request reprint Identification of cell cycle regulators in Mycobacterium tuberculosis by inhibition of septum formation and global transcriptional analysis
    Richard A Slayden
    Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523, USA
    Microbiology 152:1789-97. 2006
    ....
  12. pmc Isothermal amplification and molecular typing of the obligate intracellular pathogen Mycobacterium leprae isolated from tissues of unknown origins
    Nathan A Groathouse
    Department of Microbiology, Immunology and Pathology, Colorado State University, B208 Microbiology Building, Fort Collins, CO 80523 1682, USA
    J Clin Microbiol 44:1502-8. 2006
    ..This is the first study to demonstrate that serial whole-genome amplification can be coupled with error-sensitive molecular typing methods with low-copy-number sequences from tissues containing an obligate intracellular pathogen...
  13. pmc Use of protein microarrays to define the humoral immune response in leprosy patients and identification of disease-state-specific antigenic profiles
    Nathan A Groathouse
    Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO 80523 1682, USA
    Infect Immun 74:6458-66. 2006
    ..leprae protein antigens produced in recombinant form...
  14. doi request reprint Menaquinone synthesis is critical for maintaining mycobacterial viability during exponential growth and recovery from non-replicating persistence
    Rakesh K Dhiman
    Colorado State University, Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, 1682 Campus Delivery, Fort Collins, CO 80523, USA
    Mol Microbiol 72:85-97. 2009
    ..Thus, the results provide insight into the physiology of mycobacterial persistence and a basis for the development of novel drugs that enhance eradication of persistent bacilli and latent tuberculosis...
  15. ncbi request reprint Disease state differentiation and identification of tuberculosis biomarkers via native antigen array profiling
    Mark J Sartain
    Mycobacteria Research Laboratories, Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, Colorado 80521, USA
    Mol Cell Proteomics 5:2102-13. 2006
    ..Moreover four novel B cell antigens (BfrB, LppZ, SodC, and TrxC) of human tuberculosis were identified...
  16. pmc Targeting FtsZ for antituberculosis drug discovery: noncytotoxic taxanes as novel antituberculosis agents
    Qing Huang
    Department of Chemistry, State University of New York at Stony Brook, New York 11794 3400, USA
    J Med Chem 49:463-6. 2006
    ..Treatment of MTB cells with TRA 3aa and 10a at the MIC caused filamentation and prolongation of the cells, a phenotypic response to FtsZ inactivation...
  17. ncbi request reprint Combinatorial lead optimization of [1,2]-diamines based on ethambutol as potential antituberculosis preclinical candidates
    Richard E Lee
    Tuberculosis Research Section, NIAID, National Institutes of Health, Rockville, Maryland 20850, USA
    J Comb Chem 5:172-87. 2003
    ..N-Geranyl-N'-(2-adamantyl)ethane-1,2-diamine (109), the most active of these diamines, displayed a 14-35-fold improvement in activity in vitro against Mycobacterium tuberculosis, as compared to EMB...
  18. pmc Synthesis and in vitro antimycobacterial activity of B-ring modified diaryl ether InhA inhibitors
    Christopher W am Ende
    Institute of Chemical Biology and Drug Discovery, Department of Chemistry, Stony Brook University, Stony Brook, NY 11794 3400, USA
    Bioorg Med Chem Lett 18:3029-33. 2008
    ..Compounds 3c, 3e, and 14a show comparable MIC(90) values to that of 19, but have improved ClogP values...
  19. ncbi request reprint High affinity InhA inhibitors with activity against drug-resistant strains of Mycobacterium tuberculosis
    Todd J Sullivan
    Department of Chemistry, SUNY Stony Brook, Stony Brook, New York 11794 3400, USA
    ACS Chem Biol 1:43-53. 2006
    ....
  20. ncbi request reprint Development of modern InhA inhibitors to combat drug resistant strains of Mycobacterium tuberculosis
    Peter J Tonge
    Department of Chemistry, Stony Brook University, Stony Brook, NY 11794 3400, USA
    Curr Top Med Chem 7:489-98. 2007
    ..tuberculosis...
  21. ncbi request reprint FtsZ: a novel target for tuberculosis drug discovery
    Qing Huang
    Department of Chemistry, State University of New York at Stony Brook, Stony Brook, New York, 11794 3400, USA
    Curr Top Med Chem 7:527-43. 2007
    ..This review describes the function and dynamic behaviors of FtsZ, its homology to tubulin, and recent development of FtsZ inhibitors as potential anti-TB agents...
  22. pmc Hypoxic response of Mycobacterium tuberculosis studied by metabolic labeling and proteome analysis of cellular and extracellular proteins
    Ida Rosenkrands
    Department of TB Immunology, Statens Serum Institut, Copenhagen, Denmark
    J Bacteriol 184:3485-91. 2002
    ..These results extend our understanding of the hypoxic response in M. tuberculosis and potentially provide important insights into the physiology of the latent bacilli...

Research Grants5

  1. Regulation of Cellular division in M. tuberculosis
    RICHARD SLAYDEN; Fiscal Year: 2006
    ..Thus, the studies proposed in this application are designed to examine the replication dynamics of MTB, specifically focusing on cell cycle-regulated genes that are involved in cell division. ..
  2. Regulation of Cellular division in M. tuberculosis
    RICHARD SLAYDEN; Fiscal Year: 2003
    ..Thus, the studies proposed in this application are designed to examine the replication dynamics of MTB, specifically focusing on cell cycle-regulated genes that are involved in cell division. ..
  3. Regulation of Cellular division in M. tuberculosis
    RICHARD SLAYDEN; Fiscal Year: 2004
    ..Thus, the studies proposed in this application are designed to examine the replication dynamics of MTB, specifically focusing on cell cycle-regulated genes that are involved in cell division. ..
  4. Regulation of Cellular division in M. tuberculosis
    RICHARD SLAYDEN; Fiscal Year: 2005
    ..Thus, the studies proposed in this application are designed to examine the replication dynamics of MTB, specifically focusing on cell cycle-regulated genes that are involved in cell division. ..