Affiliation: Colorado State University
- Unique mechanism of action of the thiourea drug isoxyl on Mycobacterium tuberculosisBenjawan Phetsuksiri
Department of Microbiology, Pathology, and Immunology, Colorado State University, Fort Collins, Colorado 80523 1682, USA
J Biol Chem 278:53123-30. 2003..These results validate membrane-bound Delta9-desaturase, DesA3, as a new therapeutic target, and the thioureas as anti-tuberculosis drugs worthy of further development...
- Morphological features and signature gene response elicited by inactivation of FtsI in Mycobacterium tuberculosisRichard A Slayden
Department of Microbiology, Mycobacteria Research Laboratories, Colorado State University, Fort Collins, CO 80523, USA
J Antimicrob Chemother 63:451-7. 2009....
- Immune response to Mycobacterium tuberculosis and identification of molecular markers of diseaseMercedes Gonzalez-Juarrero
Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO, USA
Am J Respir Cell Mol Biol 40:398-409. 2009..tuberculosis infection, and unique molecular markers associated with disease progression and state, were identified...
- Characterizing septum inhibition in Mycobacterium tuberculosis for novel drug discoveryLaurel Respicio
Rocky Mountain Regional Center of Excellence, Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523, United States
Tuberculosis (Edinb) 88:420-9. 2008....
- Targeting fatty acid biosynthesis for the development of novel chemotherapeutics against Mycobacterium tuberculosis: evaluation of A-ring-modified diphenyl ethers as high-affinity InhA inhibitorsMelissa E Boyne
Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523 1682, USA
Antimicrob Agents Chemother 51:3562-7. 2007..The next step in optimization of the pharmacophore for preclinical evaluation is modification of the B ring to increase the bioavailability to that required for oral delivery...
- Updating and curating metabolic pathways of TBRichard A Slayden
Colorado State University, Fort Collins, CO, USA
Tuberculosis (Edinb) 93:47-59. 2013..The greatest benefit of functional annotation information of genome sequence is that it fuels TB research for drug discovery, diagnostics, vaccine development and epidemiology...
- Mycobacterium tuberculosis septum site determining protein, Ssd encoded by rv3660c, promotes filamentation and elicits an alternative metabolic and dormancy stress responseKathleen England
Mycobacteria Research Laboratories, Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO 80523, USA
BMC Microbiol 11:79. 2011..tuberculosis...
- Implications of high level pseudogene transcription in Mycobacterium lepraeDiana L Williams
HRSA, BPHC, Division of National Hansen s Disease Programs, Laboratory Research Branch, Molecular Biology Research Department, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA, USA
BMC Genomics 10:397. 2009..Preliminary evidence suggests that some pseudogenes are expressed. Therefore, defining pseudogene transcriptional and translational potentials of this genome should increase our understanding of their impact on M. leprae physiology...
- Isothermal amplification and molecular typing of the obligate intracellular pathogen Mycobacterium leprae isolated from tissues of unknown originsNathan A Groathouse
Department of Microbiology, Immunology and Pathology, Colorado State University, B208 Microbiology Building, Fort Collins, CO 80523 1682, USA
J Clin Microbiol 44:1502-8. 2006..This is the first study to demonstrate that serial whole-genome amplification can be coupled with error-sensitive molecular typing methods with low-copy-number sequences from tissues containing an obligate intracellular pathogen...
- Identification of cell cycle regulators in Mycobacterium tuberculosis by inhibition of septum formation and global transcriptional analysisRichard A Slayden
Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523, USA
Microbiology 152:1789-97. 2006....
- Use of protein microarrays to define the humoral immune response in leprosy patients and identification of disease-state-specific antigenic profilesNathan A Groathouse
Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO 80523 1682, USA
Infect Immun 74:6458-66. 2006..leprae protein antigens produced in recombinant form...
- Menaquinone synthesis is critical for maintaining mycobacterial viability during exponential growth and recovery from non-replicating persistenceRakesh K Dhiman
Colorado State University, Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, 1682 Campus Delivery, Fort Collins, CO 80523, USA
Mol Microbiol 72:85-97. 2009..Thus, the results provide insight into the physiology of mycobacterial persistence and a basis for the development of novel drugs that enhance eradication of persistent bacilli and latent tuberculosis...
- Disease state differentiation and identification of tuberculosis biomarkers via native antigen array profilingMark J Sartain
Mycobacteria Research Laboratories, Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, Colorado 80521, USA
Mol Cell Proteomics 5:2102-13. 2006..Moreover four novel B cell antigens (BfrB, LppZ, SodC, and TrxC) of human tuberculosis were identified...
- Targeting FtsZ for antituberculosis drug discovery: noncytotoxic taxanes as novel antituberculosis agentsQing Huang
Department of Chemistry, State University of New York at Stony Brook, New York 11794 3400, USA
J Med Chem 49:463-6. 2006..Treatment of MTB cells with TRA 3aa and 10a at the MIC caused filamentation and prolongation of the cells, a phenotypic response to FtsZ inactivation...
- Synthesis and in vitro antimycobacterial activity of B-ring modified diaryl ether InhA inhibitorsChristopher W am Ende
Institute of Chemical Biology and Drug Discovery, Department of Chemistry, Stony Brook University, Stony Brook, NY 11794 3400, USA
Bioorg Med Chem Lett 18:3029-33. 2008..Compounds 3c, 3e, and 14a show comparable MIC(90) values to that of 19, but have improved ClogP values...
- FtsZ: a novel target for tuberculosis drug discoveryQing Huang
Department of Chemistry, State University of New York at Stony Brook, Stony Brook, New York, 11794 3400, USA
Curr Top Med Chem 7:527-43. 2007..This review describes the function and dynamic behaviors of FtsZ, its homology to tubulin, and recent development of FtsZ inhibitors as potential anti-TB agents...
- Development of modern InhA inhibitors to combat drug resistant strains of Mycobacterium tuberculosisPeter J Tonge
Department of Chemistry, Stony Brook University, Stony Brook, NY 11794 3400, USA
Curr Top Med Chem 7:489-98. 2007..tuberculosis...
- High affinity InhA inhibitors with activity against drug-resistant strains of Mycobacterium tuberculosisTodd J Sullivan
Department of Chemistry, SUNY Stony Brook, Stony Brook, New York 11794 3400, USA
ACS Chem Biol 1:43-53. 2006....
- Combinatorial lead optimization of [1,2]-diamines based on ethambutol as potential antituberculosis preclinical candidatesRichard E Lee
Tuberculosis Research Section, NIAID, National Institutes of Health, Rockville, Maryland 20850, USA
J Comb Chem 5:172-87. 2003..N-Geranyl-N'-(2-adamantyl)ethane-1,2-diamine (109), the most active of these diamines, displayed a 14-35-fold improvement in activity in vitro against Mycobacterium tuberculosis, as compared to EMB...
- Hypoxic response of Mycobacterium tuberculosis studied by metabolic labeling and proteome analysis of cellular and extracellular proteinsIda Rosenkrands
Department of TB Immunology, Statens Serum Institut, Copenhagen, Denmark
J Bacteriol 184:3485-91. 2002..These results extend our understanding of the hypoxic response in M. tuberculosis and potentially provide important insights into the physiology of the latent bacilli...
- Regulation of Cellular division in M. tuberculosisRICHARD SLAYDEN; Fiscal Year: 2006..Thus, the studies proposed in this application are designed to examine the replication dynamics of MTB, specifically focusing on cell cycle-regulated genes that are involved in cell division. ..