Marie W Wooten

Summary

Affiliation: College of Veterinary Medicine
Country: USA

Publications

  1. ncbi request reprint Structure and functional properties of the ubiquitin binding protein p62
    Thangiah Geetha
    Department of Biological Sciences, Program in Cellular and Molecular Biosciences, 331 Funchess Hall, Auburn University, Auburn, AL 36849, USA
    FEBS Lett 512:19-24. 2002
  2. ncbi request reprint In-gel kinase assay as a method to identify kinase substrates
    Marie W Wooten
    Department of Biological Sciences, Program in Cell Molecular Biosciences, Auburn University, Auburn, AL 36849, USA
    Sci STKE 2002:pl15. 2002
  3. ncbi request reprint The atypical protein kinase C-interacting protein p62 is a scaffold for NF-kappaB activation by nerve growth factor
    M W Wooten
    Department of Biological Sciences, Program in Cell and Molecular Biosciences, Auburn University, Auburn, Alabama 36849, USA
    J Biol Chem 276:7709-12. 2001
  4. ncbi request reprint The p62 scaffold regulates nerve growth factor-induced NF-kappaB activation by influencing TRAF6 polyubiquitination
    Marie W Wooten
    Department of Biological Sciences, Program in Cell and Molecular Biosciences, Auburn University, Alabama 36849, USA
    J Biol Chem 280:35625-9. 2005
  5. ncbi request reprint The role of ubiquitin in neurotrophin receptor signalling and sorting
    M W Wooten
    Program in Cellular and Molecular Biosciences, Department of Biological Sciences, 331 Funchess Hall, Auburn University, Auburn, AL 36849, USA
    Biochem Soc Trans 34:757-60. 2006
  6. doi request reprint Essential role of sequestosome 1/p62 in regulating accumulation of Lys63-ubiquitinated proteins
    Marie W Wooten
    Department of Biological Sciences, Program in Cell and Molecular Biosciences, Auburn University, Auburn, Alabama 36849, USA
    J Biol Chem 283:6783-9. 2008
  7. pmc TRAF6-mediated ubiquitination regulates nuclear translocation of NRIF, the p75 receptor interactor
    Thangiah Geetha
    Department of Biological Sciences and Program in Cell and Molecular Biosciences, Auburn University, Auburn, AL, USA
    EMBO J 24:3859-68. 2005
  8. pmc Sequestosome 1/p62 is a polyubiquitin chain binding protein involved in ubiquitin proteasome degradation
    M Lamar Seibenhener
    Program in Cell and Molecular Biosciences, Department of Biological Sciences, Auburn University, AL 36849, USA
    Mol Cell Biol 24:8055-68. 2004
  9. ncbi request reprint Lysine 63 polyubiquitination of the nerve growth factor receptor TrkA directs internalization and signaling
    Thangiah Geetha
    Department of Biological Sciences, Program in Cellular and Molecular Biosciences, Auburn University, Auburn, Alabama 36849, USA
    Mol Cell 20:301-12. 2005
  10. pmc AMPA receptor trafficking and synaptic plasticity require SQSTM1/p62
    Jianxiong Jiang
    Department of Biological Sciences and Program in Cellular and Molecular Biosciences, Auburn University, Auburn, Alabama 36849, USA
    Hippocampus 19:392-406. 2009

Collaborators

Detail Information

Publications47

  1. ncbi request reprint Structure and functional properties of the ubiquitin binding protein p62
    Thangiah Geetha
    Department of Biological Sciences, Program in Cellular and Molecular Biosciences, 331 Funchess Hall, Auburn University, Auburn, AL 36849, USA
    FEBS Lett 512:19-24. 2002
    ..Moreover, p62 is capable of binding ubiquitin (Ub) non-covalently through its Ub-associated domain. In this review, we will focus on the structure and function of ZIP/p62...
  2. ncbi request reprint In-gel kinase assay as a method to identify kinase substrates
    Marie W Wooten
    Department of Biological Sciences, Program in Cell Molecular Biosciences, Auburn University, Auburn, AL 36849, USA
    Sci STKE 2002:pl15. 2002
    ..The following Protocol provides a detailed method for performing the in-gel kinase assay and discusses the uses of the assay to evaluate kinase activity in the context of proliferation, differentiation, and survival pathways...
  3. ncbi request reprint The atypical protein kinase C-interacting protein p62 is a scaffold for NF-kappaB activation by nerve growth factor
    M W Wooten
    Department of Biological Sciences, Program in Cell and Molecular Biosciences, Auburn University, Auburn, Alabama 36849, USA
    J Biol Chem 276:7709-12. 2001
    ..Moreover, we demonstrated that p62 serves as a scaffold for activation of the NF-kappaB pathway, which mediates NGF survival and differentiation responses...
  4. ncbi request reprint The p62 scaffold regulates nerve growth factor-induced NF-kappaB activation by influencing TRAF6 polyubiquitination
    Marie W Wooten
    Department of Biological Sciences, Program in Cell and Molecular Biosciences, Auburn University, Alabama 36849, USA
    J Biol Chem 280:35625-9. 2005
    ..These results provide evidence for a mechanism whereby p62 serves to regulate the NF-kappaB pathway...
  5. ncbi request reprint The role of ubiquitin in neurotrophin receptor signalling and sorting
    M W Wooten
    Program in Cellular and Molecular Biosciences, Department of Biological Sciences, 331 Funchess Hall, Auburn University, Auburn, AL 36849, USA
    Biochem Soc Trans 34:757-60. 2006
    ..Altogether, these findings reveal Lys63-linked polyubiquitin chains and the shuttling protein p62 co-ordinately regulate TrkA internalization, trafficking and sorting...
  6. doi request reprint Essential role of sequestosome 1/p62 in regulating accumulation of Lys63-ubiquitinated proteins
    Marie W Wooten
    Department of Biological Sciences, Program in Cell and Molecular Biosciences, Auburn University, Auburn, Alabama 36849, USA
    J Biol Chem 283:6783-9. 2008
    ..Thus, p62 has a bifunctional role in regulation of an E3 ubiquitin-protein ligase, TRAF6, and a DUB, CYLD, to balance the turnover of Lys63-polyubiquitinated proteins such as TrkA...
  7. pmc TRAF6-mediated ubiquitination regulates nuclear translocation of NRIF, the p75 receptor interactor
    Thangiah Geetha
    Department of Biological Sciences and Program in Cell and Molecular Biosciences, Auburn University, Auburn, AL, USA
    EMBO J 24:3859-68. 2005
    ..Finally, unlike wild-type NRIF, the K19R NRIF failed to reconstitute p75-mediated apoptosis in nrif-/- neurons. These results reveal a unique mechanism of p75 signaling and a novel role for K63-linked ubiquitin chains...
  8. pmc Sequestosome 1/p62 is a polyubiquitin chain binding protein involved in ubiquitin proteasome degradation
    M Lamar Seibenhener
    Program in Cell and Molecular Biosciences, Department of Biological Sciences, Auburn University, AL 36849, USA
    Mol Cell Biol 24:8055-68. 2004
    ..Altogether, our results support the hypothesis that p62 may act as a critical ubiquitin chain-targeting factor that shuttles substrates for proteasomal degradation...
  9. ncbi request reprint Lysine 63 polyubiquitination of the nerve growth factor receptor TrkA directs internalization and signaling
    Thangiah Geetha
    Department of Biological Sciences, Program in Cellular and Molecular Biosciences, Auburn University, Auburn, Alabama 36849, USA
    Mol Cell 20:301-12. 2005
    ..These findings reveal that polyubiquitination serves as a common platform for the control of receptor internalization and signaling...
  10. pmc AMPA receptor trafficking and synaptic plasticity require SQSTM1/p62
    Jianxiong Jiang
    Department of Biological Sciences and Program in Cellular and Molecular Biosciences, Auburn University, Auburn, Alabama 36849, USA
    Hippocampus 19:392-406. 2009
    ..These findings support a model where p62 interaction and aPKC phosphorylation act together to mediate AMPA receptor trafficking and long-term synaptic plasticity in the hippocampus...
  11. ncbi request reprint Regulation of interleukin receptor-associated kinase (IRAK) phosphorylation and signaling by iota protein kinase C
    Vidya Mamidipudi
    Program in Cell and Molecular Biosciences, Department of Biological Sciences, Auburn University, Auburn, Alabama 36849, USA
    J Biol Chem 279:4161-5. 2004
    ..These findings provide insight into the underlying mechanism whereby IRAK regulates the kappaB pathway and reveal that IRAK is a substrate of iota PKC...
  12. doi request reprint Genetic inactivation of p62 leads to accumulation of hyperphosphorylated tau and neurodegeneration
    J Ramesh Babu
    Department of Biological Sciences, Program in Cellular and Molecular Biosciences, Auburn University, Auburn, Alabama 36849, USA
    J Neurochem 106:107-20. 2008
    ..Thus, these findings provide new insight into manifestation of sporadic Alzheimer disease and the impact of obesity...
  13. ncbi request reprint Sequestosome 1/p62 shuttles polyubiquitinated tau for proteasomal degradation
    Jeganathan Ramesh Babu
    Department of Biological Sciences, Program in Cell and Molecular Biosciences, Auburn University, AL 36849, USA
    J Neurochem 94:192-203. 2005
    ..We propose a model whereby either a decline in p62 expression or a decrease in proteasome activity may contribute to accumulation of insoluble/aggregated K63-polyubiquitinated tau...
  14. pmc Identification of a consensus site for TRAF6/p62 polyubiquitination
    Trafina Jadhav
    Program in Cellular and Molecular Biosciences, Department of Biological Sciences, Auburn University, 331 Funchess Hall, Auburn, AL 36849, USA
    Biochem Biophys Res Commun 371:521-4. 2008
    ..These findings reveal a possible selection process for targeting a specific lysine residue by a single E3 ligase and underscore the role of the scaffold, p62, in this process...
  15. pmc p62 serves as a shuttling factor for TrkA interaction with the proteasome
    Thangiah Geetha
    Department of Biological Sciences, Program in Cellular and Molecular Biosciences, Auburn University, Auburn, AL 36849, USA
    Biochem Biophys Res Commun 374:33-7. 2008
    ..These findings reveal that p62 serves as a shuttling factor for interaction of ubiquitinated substrates with the proteasome and could promote localized protein turnover in neurons...
  16. doi request reprint TrkA receptor endolysosomal degradation is both ubiquitin and proteasome dependent
    Thangiah Geetha
    Department of Biological Sciences, Program in Cellular and Molecular Biosciences, Auburn University, Auburn, AL 36849, USA
    Traffic 9:1146-56. 2008
    ..Taken together, our results reveal the existence of a novel proteasome-dependent step in receptor degradation...
  17. ncbi request reprint Nerve growth factor stimulates the interaction of ZIP/p62 with atypical protein kinase C and targets endosomal localization: evidence for regulation of nerve growth factor-induced differentiation
    I S Samuels
    Department of Biological Sciences, Program in Cellular and Molecular Biosciences, Auburn University, Auburn, Alabama 36849, USA
    J Cell Biochem 82:452-66. 2001
    ..Collectively, these findings demonstrate that ZIP/p62 acts as a shuttling protein involved in routing activated aPKC to an endosomal compartment and is required for mediating NGF's biological properties...
  18. ncbi request reprint Association of the atypical protein kinase C-interacting protein p62/ZIP with nerve growth factor receptor TrkA regulates receptor trafficking and Erk5 signaling
    Thangiah Geetha
    Department of Biological Sciences, Program in Cellular and Molecular Biosciences, Auburn University, Auburn, Alabama 36849, USA
    J Biol Chem 278:4730-9. 2003
    ..We propose that p62 plays a novel role in connecting receptor signals with the endosomal signaling network required for mediating TrkA-induced differentiation...
  19. ncbi request reprint Identification of interleukin 1 receptor-associated kinase as a conserved component in the p75-neurotrophin receptor activation of nuclear factor-kappa B
    Vidya Mamidipudi
    Department of Biological Sciences, Program in Cell and Molecular Biosciences, Auburn University, Auburn, Alabama 36849, USA
    J Biol Chem 277:28010-8. 2002
    ..Altogether, our data provide novel information regarding the proximal components involved in p75 receptor signaling and underscore the importance of the atypical PKC interacting protein p62 in this process...
  20. pmc Age-associated oxidative damage to the p62 promoter: implications for Alzheimer disease
    Yifeng Du
    Cellular and Molecular Biosciences Program, Department of Biological Sciences, Auburn University, AL 38849, USA
    Free Radic Biol Med 46:492-501. 2009
    ..Altogether, our results reveal that oxidative damage to the p62 promoter correlates with decreased expression of p62 and may contribute to age-associated neurodegenerative disease such as AD and others...
  21. ncbi request reprint Dual role for p75(NTR) signaling in survival and cell death: can intracellular mediators provide an explanation?
    Vidya Mamidipudi
    Department of Biological Sciences, Program in Cell and Molecular Biosciences, Auburn University, Auburn, Alabama 36849, USA
    J Neurosci Res 68:373-84. 2002
    ....
  22. ncbi request reprint Evidence for p62 aggregate formation: role in cell survival
    Michael G Paine
    Program in Cell and Molecular Biosciences, Auburn University, AL 36849, USA
    FEBS Lett 579:5029-34. 2005
    ..Altogether, these results suggest that p62 fibrils may influence cell viability and indicates an important role for p62 in aggresome formation...
  23. ncbi request reprint Atypical PKC zeta is activated by ceramide, resulting in coactivation of NF-kappaB/JNK kinase and cell survival
    Y M Wang
    Department of Zoology, Auburn University, Alabama, USA
    J Neurosci Res 55:293-302. 1999
    ..These findings support a role for ceramide-induced PKC zeta activity in the control of cell survival signaling via a pathway that also activates JNK kinase...
  24. ncbi request reprint Identification of Src as a novel atypical protein kinase C-interacting protein
    M L Seibenhener
    Department of Biological Sciences, Auburn University, Alabama 36849, USA
    Mol Cell Biol Res Commun 2:28-31. 1999
    ..Taken together, these findings support a novel role for the interaction of src and atypical PKC in vivo, which is dependent upon the activity of src and the tyrosine phosphorylation state of PKC-zeta...
  25. pmc SQSTM1/p62 interacts with HDAC6 and regulates deacetylase activity
    Jin Yan
    Department of Biological Sciences, Cellular and Molecular Biosciences Program, Auburn University, Auburn, Alabama, United States of America
    PLoS ONE 8:e76016. 2013
    ..Thus, our findings indicate that p62 plays a key role in regulating the recruitment of F-actin network assemblies to the MTOC, a critical cellular function that is required for successful autophagic clearance of protein aggregates. ..
  26. ncbi request reprint Phosphorylation of tyrosine 256 facilitates nuclear import of atypical protein kinase C
    Wendy O White
    Department of Biological Sciences, Auburn University, Auburn, Alabama 36849, USA
    J Cell Biochem 85:42-53. 2002
    ..Altogether, these findings document a novel role for the tyrosine phosphorylation in regulating import of atypical PKC into the nucleus...
  27. pmc Sequestosome 1/p62--more than just a scaffold
    M Lamar Seibenhener
    Department of Biological Sciences, Program in Cellular and Molecular Biosciences, 331 Funchess Hall, Auburn University, Auburn, AL 36849, United States
    FEBS Lett 581:175-9. 2007
    ..Sequestosome 1/p62 is a protein that is gaining attention as it is intimately involved in cell signaling, receptor internalization, and protein turnover. Herein we review recent advances in the field...
  28. ncbi request reprint A role for zeta protein kinase C in nerve growth factor-induced differentiation of PC12 cells
    M W Wooten
    Department of Zoology, Auburn University, Alabama 36849
    Cell Growth Differ 5:395-403. 1994
    ..In addition, the zeta-pseudosubstrate peptide inhibited NGF-induced activation of PKC-zeta.(ABSTRACT TRUNCATED AT 250 WORDS)..
  29. pmc Behavioral effects of SQSTM1/p62 overexpression in mice: support for a mitochondrial role in depression and anxiety
    M Lamar Seibenhener
    Dept Biological Sciences, Auburn University, 331 Funchess Hall, Auburn, AL 36832, USA
    Behav Brain Res 248:94-103. 2013
    ..These results suggest that SQSTM1/p62 provides an attractive target for therapeutic agents potentially suitable for the treatment of anxiety and affective spectrum disorders...
  30. pmc A Method to Identify p62's UBA Domain Interacting Proteins
    Julia W Pridgeon
    Department of Biological Sciences, Program in Cellular and Molecular Biosciences 331 Funchess Hall, Auburn University, Auburn, AL 36849 USA
    Biol Proced Online 5:228-237. 2003
    ..Our approach provides an easy route to the characterization of UBA domain interacting proteins and its application will unfold the important roles that the UBA domain plays...
  31. ncbi request reprint Modulation of zeta-protein kinase C by cyclic AMP in PC12 cells occurs through phosphorylation by protein kinase A
    M W Wooten
    Department of Zoology, Auburn University, AL 36849-5414, USA
    J Neurochem 67:1023-31. 1996
    ..Taken together, these findings are consistent with the hypothesis that protein phosphorylation of PKC acts as a positive effector of its enzyme activity and may serve as a negative modulator for interaction with other proteins...
  32. pmc A role for sequestosome 1/p62 in mitochondrial dynamics, import and genome integrity
    M Lamar Seibenhener
    Department of Biological Sciences, Cellular and Molecular Biosciences Program, Auburn University, AL 36849, USA
    Biochim Biophys Acta 1833:452-9. 2013
    ..We present evidence that these responses to the presence of p62 extend beyond the protein's immediate influence on membrane potential...
  33. ncbi request reprint Transport of protein kinase C isoforms to the nucleus of PC12 cells by nerve growth factor: association of atypical zeta-PKC with the nuclear matrix
    M W Wooten
    Department of Zoology, Auburn University, Alabama 36849, USA
    J Neurosci Res 49:393-403. 1997
    ..Taken together, these findings suggest that zeta-PKC may be involved in the regulation of nuclear processes...
  34. pmc Mapping of atypical protein kinase C within the nerve growth factor signaling cascade: relationship to differentiation and survival of PC12 cells
    M W Wooten
    Department of Biological Sciences, Program in Cell and Molecular Biosciences, Auburn University, AL 36849, USA
    Mol Cell Biol 20:4494-504. 2000
    ..On the basis of these findings, Src emerges as a critical upstream regulator of both PKC-iota and the NF-kappaB pathway...
  35. ncbi request reprint Delta-protein kinase C phosphorylation parallels inhibition of nerve growth factor-induced differentiation independent of changes in Trk A and MAP kinase signalling in PC12 cells
    M W Wooten
    Department of Zoology, Auburn University, AL 36849
    Cell Signal 10:265-76. 1998
    ..Moreover, these data reveal the existence of a signalling pathway independent of MAP kinase that affects NGF differentiation in a negative fashion...
  36. ncbi request reprint Overexpression of atypical PKC in PC12 cells enhances NGF-responsiveness and survival through an NF-kappaB dependent pathway
    M W Wooten
    Department of Biological Sciences, Auburn University, Alabama, USA
    Cell Death Differ 6:753-64. 1999
    ..Collectively, these findings demonstrate that atypical PKC-iota lies in a pathway that regulates NF-kappaB and contributes to both neurotrophin-mediated differentiation and survival signaling...
  37. ncbi request reprint Function for NF-kB in neuronal survival: regulation by atypical protein kinase C
    M W Wooten
    Department of Biological Sciences, Auburn University, Auburn, Alabama, USA
    J Neurosci Res 58:607-11. 1999
    ..Moreover, atypical protein kinase (aPKC) has been shown to play a novel role in modulating the NF-kB pathway. In this review, I focus on neurons and the factors that contribute to regulation of NF-kB via aPKC...
  38. pmc Nerve growth factor stimulates multisite tyrosine phosphorylation and activation of the atypical protein kinase C's via a src kinase pathway
    M W Wooten
    Department of Biological Sciences, Auburn University, 331 Funchess Hall, Auburn, AL 36849, USA
    Mol Cell Biol 21:8414-27. 2001
    ..In summary, we have identified a novel mechanism for NGF-induced activation of atypical PKC involving tyrosine phosphorylation by c-Src...
  39. pmc Oxidative damage to the promoter region of SQSTM1/p62 is common to neurodegenerative disease
    Yifeng Du
    Department of Biological Sciences, Cellular and Molecular Biosciences Program, 331 Funchess Hall, Auburn University, AL 38849, USA
    Neurobiol Dis 35:302-10. 2009
    ..Altogether these results suggest that pharmacological means to increase p62 expression may be beneficial in delaying the onset of neurodegeneration...
  40. ncbi request reprint Nucleolin is a protein kinase C-zeta substrate. Connection between cell surface signaling and nucleus in PC12 cells
    G Zhou
    Department of Zoology, Auburn University, Auburn, Alabama 36849 5414, USA
    J Biol Chem 272:31130-7. 1997
    ..Taken together, the findings presented herein document that nucleolin is a target of PKC-zeta that serves to relay NGF signals from cell surface to nucleus in PC12 cells...
  41. pmc Mining the TRAF6/p62 interactome for a selective ubiquitination motif
    Trafina S Jadhav
    Program in Cellular and Molecular Biosciences, Department of Biological Sciences, 331 Funchess Hall, Auburn University, Auburn, AL, 36849, USA
    BMC Proc 5:S4. 2011
    ..Collectively, our results reveal an unappreciated role for the scaffold protein in targeting ubiquitination. The findings described herein could be used to aid in identification of other E3/scaffold ubiquitination sites...
  42. ncbi request reprint Posttranslational modifications and receptor-associated proteins in AMPA receptor trafficking and synaptic plasticity
    Jianxiong Jiang
    Department of Biological Sciences and Program in Cellular and Molecular Biosciences, Auburn University, AL 36849, USA
    Neurosignals 15:266-82. 2006
    ..Here, we summarize recent studies on posttranslational modifications and associated proteins of AMPAR subunits, and their roles in receptor trafficking and synaptic plasticity...
  43. ncbi request reprint Purification and characterization of a novel protamine kinase in HL60 cells
    Y Soh
    Department of Biological Sciences, Auburn University, Auburn, AL 36849, USA
    J Biochem 127:95-103. 2000
    ..These results suggest that protamine kinase in HL60 cells is involved in the late stage of the macrophage-monocytic differentiation pathway and may play a role in maintenance of the differentiation after HL60 cells are committed...
  44. ncbi request reprint Nerve growth factor activates kinases that phosphorylate atypical protein kinase C
    Michel L Vandenplas
    Department of Large Animal Medicine, College of Veterinary Medicine, University of Georgia, Athens 30602, USA
    Cell Signal 14:359-63. 2002
    ..Upstream, pp175 and pp60 lie in a ras pathway, whereas pp87 lies in a pathway dependent upon src. Altogether, these findings reveal that the aPKCs are subject to regulation by a novel group of kinases...
  45. ncbi request reprint Signal integration and diversification through the p62 scaffold protein
    Jorge Moscat
    Department of Genome Science, Genome Research Institute, University of Cincinnati, 2180 E Galbraith Road, Cincinnati, OH 45237, USA
    Trends Biochem Sci 32:95-100. 2007
    ..The availability of mice in which p62 has been genetically inactivated is providing new insight into the mechanism and function of p62 at a whole-organism level...
  46. pmc Unc-51-like kinase 1/2-mediated endocytic processes regulate filopodia extension and branching of sensory axons
    Xiang Zhou
    Department of Cell Biology, Duke University Medical School, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 104:5842-7. 2007
    ..These results and additional studies suggest that Ulk1/2 proteins regulate filopodia extension and neurite branching during sensory axon outgrowth, probably through regulating TrkA receptor trafficking and signaling...
  47. ncbi request reprint Axonal guidance protein FEZ1 associates with tubulin and kinesin motor protein to transport mitochondria in neurites of NGF-stimulated PC12 cells
    Toshitsugu Fujita
    Department of Structural Molecular Biology, Institute of Scientific and Industrial Research, Osaka University, Ibaraki, Osaka 567 0047, Japan
    Biochem Biophys Res Commun 361:605-10. 2007
    ..Thus, our results suggest that the FEZ1/kinesin complex functions for the transport of mitochondria along microtubules toward the extending neurites in differentiating PC12 cells...