Marie W Wooten


Affiliation: College of Veterinary Medicine
Country: USA


  1. Wooten M, Seibenhener M, Mamidipudi V, Diaz Meco M, Barker P, Moscat J. The atypical protein kinase C-interacting protein p62 is a scaffold for NF-kappaB activation by nerve growth factor. J Biol Chem. 2001;276:7709-12 pubmed
    ..Moreover, we demonstrated that p62 serves as a scaffold for activation of the NF-kappaB pathway, which mediates NGF survival and differentiation responses. ..
  2. Wooten M, Geetha T, Seibenhener M, Babu J, Diaz Meco M, Moscat J. The p62 scaffold regulates nerve growth factor-induced NF-kappaB activation by influencing TRAF6 polyubiquitination. J Biol Chem. 2005;280:35625-9 pubmed
    ..These results provide evidence for a mechanism whereby p62 serves to regulate the NF-kappaB pathway. ..
  3. Wooten M, Geetha T, Babu J, Seibenhener M, Peng J, Cox N, et al. Essential role of sequestosome 1/p62 in regulating accumulation of Lys63-ubiquitinated proteins. J Biol Chem. 2008;283:6783-9 pubmed publisher
    ..Thus, p62 has a bifunctional role in regulation of an E3 ubiquitin-protein ligase, TRAF6, and a DUB, CYLD, to balance the turnover of Lys63-polyubiquitinated proteins such as TrkA. ..