M W Wooten

Summary

Affiliation: College of Veterinary Medicine
Country: USA

Publications

  1. pmc Nerve growth factor stimulates multisite tyrosine phosphorylation and activation of the atypical protein kinase C's via a src kinase pathway
    M W Wooten
    Department of Biological Sciences, Auburn University, 331 Funchess Hall, Auburn, AL 36849, USA
    Mol Cell Biol 21:8414-27. 2001
  2. ncbi request reprint Transport of protein kinase C isoforms to the nucleus of PC12 cells by nerve growth factor: association of atypical zeta-PKC with the nuclear matrix
    M W Wooten
    Department of Zoology, Auburn University, Alabama 36849, USA
    J Neurosci Res 49:393-403. 1997
  3. ncbi request reprint Delta-protein kinase C phosphorylation parallels inhibition of nerve growth factor-induced differentiation independent of changes in Trk A and MAP kinase signalling in PC12 cells
    M W Wooten
    Department of Zoology, Auburn University, AL 36849
    Cell Signal 10:265-76. 1998
  4. pmc Mapping of atypical protein kinase C within the nerve growth factor signaling cascade: relationship to differentiation and survival of PC12 cells
    M W Wooten
    Department of Biological Sciences, Program in Cell and Molecular Biosciences, Auburn University, AL 36849, USA
    Mol Cell Biol 20:4494-504. 2000
  5. ncbi request reprint Nerve growth factor stimulates the interaction of ZIP/p62 with atypical protein kinase C and targets endosomal localization: evidence for regulation of nerve growth factor-induced differentiation
    I S Samuels
    Department of Biological Sciences, Program in Cellular and Molecular Biosciences, Auburn University, Auburn, Alabama 36849, USA
    J Cell Biochem 82:452-66. 2001
  6. ncbi request reprint Overexpression of atypical PKC in PC12 cells enhances NGF-responsiveness and survival through an NF-kappaB dependent pathway
    M W Wooten
    Department of Biological Sciences, Auburn University, Alabama, USA
    Cell Death Differ 6:753-64. 1999
  7. ncbi request reprint Identification of Src as a novel atypical protein kinase C-interacting protein
    M L Seibenhener
    Department of Biological Sciences, Auburn University, Alabama 36849, USA
    Mol Cell Biol Res Commun 2:28-31. 1999
  8. ncbi request reprint A role for zeta protein kinase C in nerve growth factor-induced differentiation of PC12 cells
    M W Wooten
    Department of Zoology, Auburn University, Alabama 36849
    Cell Growth Differ 5:395-403. 1994
  9. ncbi request reprint Atypical PKC zeta is activated by ceramide, resulting in coactivation of NF-kappaB/JNK kinase and cell survival
    Y M Wang
    Department of Zoology, Auburn University, Alabama, USA
    J Neurosci Res 55:293-302. 1999
  10. ncbi request reprint Modulation of zeta-protein kinase C by cyclic AMP in PC12 cells occurs through phosphorylation by protein kinase A
    M W Wooten
    Department of Zoology, Auburn University, AL 36849-5414, USA
    J Neurochem 67:1023-31. 1996

Collaborators

Detail Information

Publications16

  1. pmc Nerve growth factor stimulates multisite tyrosine phosphorylation and activation of the atypical protein kinase C's via a src kinase pathway
    M W Wooten
    Department of Biological Sciences, Auburn University, 331 Funchess Hall, Auburn, AL 36849, USA
    Mol Cell Biol 21:8414-27. 2001
    ..In summary, we have identified a novel mechanism for NGF-induced activation of atypical PKC involving tyrosine phosphorylation by c-Src...
  2. ncbi request reprint Transport of protein kinase C isoforms to the nucleus of PC12 cells by nerve growth factor: association of atypical zeta-PKC with the nuclear matrix
    M W Wooten
    Department of Zoology, Auburn University, Alabama 36849, USA
    J Neurosci Res 49:393-403. 1997
    ..Taken together, these findings suggest that zeta-PKC may be involved in the regulation of nuclear processes...
  3. ncbi request reprint Delta-protein kinase C phosphorylation parallels inhibition of nerve growth factor-induced differentiation independent of changes in Trk A and MAP kinase signalling in PC12 cells
    M W Wooten
    Department of Zoology, Auburn University, AL 36849
    Cell Signal 10:265-76. 1998
    ..Moreover, these data reveal the existence of a signalling pathway independent of MAP kinase that affects NGF differentiation in a negative fashion...
  4. pmc Mapping of atypical protein kinase C within the nerve growth factor signaling cascade: relationship to differentiation and survival of PC12 cells
    M W Wooten
    Department of Biological Sciences, Program in Cell and Molecular Biosciences, Auburn University, AL 36849, USA
    Mol Cell Biol 20:4494-504. 2000
    ..On the basis of these findings, Src emerges as a critical upstream regulator of both PKC-iota and the NF-kappaB pathway...
  5. ncbi request reprint Nerve growth factor stimulates the interaction of ZIP/p62 with atypical protein kinase C and targets endosomal localization: evidence for regulation of nerve growth factor-induced differentiation
    I S Samuels
    Department of Biological Sciences, Program in Cellular and Molecular Biosciences, Auburn University, Auburn, Alabama 36849, USA
    J Cell Biochem 82:452-66. 2001
    ..Collectively, these findings demonstrate that ZIP/p62 acts as a shuttling protein involved in routing activated aPKC to an endosomal compartment and is required for mediating NGF's biological properties...
  6. ncbi request reprint Overexpression of atypical PKC in PC12 cells enhances NGF-responsiveness and survival through an NF-kappaB dependent pathway
    M W Wooten
    Department of Biological Sciences, Auburn University, Alabama, USA
    Cell Death Differ 6:753-64. 1999
    ..Collectively, these findings demonstrate that atypical PKC-iota lies in a pathway that regulates NF-kappaB and contributes to both neurotrophin-mediated differentiation and survival signaling...
  7. ncbi request reprint Identification of Src as a novel atypical protein kinase C-interacting protein
    M L Seibenhener
    Department of Biological Sciences, Auburn University, Alabama 36849, USA
    Mol Cell Biol Res Commun 2:28-31. 1999
    ..Taken together, these findings support a novel role for the interaction of src and atypical PKC in vivo, which is dependent upon the activity of src and the tyrosine phosphorylation state of PKC-zeta...
  8. ncbi request reprint A role for zeta protein kinase C in nerve growth factor-induced differentiation of PC12 cells
    M W Wooten
    Department of Zoology, Auburn University, Alabama 36849
    Cell Growth Differ 5:395-403. 1994
    ..In addition, the zeta-pseudosubstrate peptide inhibited NGF-induced activation of PKC-zeta.(ABSTRACT TRUNCATED AT 250 WORDS)..
  9. ncbi request reprint Atypical PKC zeta is activated by ceramide, resulting in coactivation of NF-kappaB/JNK kinase and cell survival
    Y M Wang
    Department of Zoology, Auburn University, Alabama, USA
    J Neurosci Res 55:293-302. 1999
    ..These findings support a role for ceramide-induced PKC zeta activity in the control of cell survival signaling via a pathway that also activates JNK kinase...
  10. ncbi request reprint Modulation of zeta-protein kinase C by cyclic AMP in PC12 cells occurs through phosphorylation by protein kinase A
    M W Wooten
    Department of Zoology, Auburn University, AL 36849-5414, USA
    J Neurochem 67:1023-31. 1996
    ..Taken together, these findings are consistent with the hypothesis that protein phosphorylation of PKC acts as a positive effector of its enzyme activity and may serve as a negative modulator for interaction with other proteins...
  11. ncbi request reprint The atypical protein kinase C-interacting protein p62 is a scaffold for NF-kappaB activation by nerve growth factor
    M W Wooten
    Department of Biological Sciences, Program in Cell and Molecular Biosciences, Auburn University, Auburn, Alabama 36849, USA
    J Biol Chem 276:7709-12. 2001
    ..Moreover, we demonstrated that p62 serves as a scaffold for activation of the NF-kappaB pathway, which mediates NGF survival and differentiation responses...
  12. ncbi request reprint Nucleolin is a protein kinase C-zeta substrate. Connection between cell surface signaling and nucleus in PC12 cells
    G Zhou
    Department of Zoology, Auburn University, Auburn, Alabama 36849 5414, USA
    J Biol Chem 272:31130-7. 1997
    ..Taken together, the findings presented herein document that nucleolin is a target of PKC-zeta that serves to relay NGF signals from cell surface to nucleus in PC12 cells...
  13. ncbi request reprint Purification and characterization of a novel protamine kinase in HL60 cells
    Y Soh
    Department of Biological Sciences, Auburn University, Auburn, AL 36849, USA
    J Biochem 127:95-103. 2000
    ..These results suggest that protamine kinase in HL60 cells is involved in the late stage of the macrophage-monocytic differentiation pathway and may play a role in maintenance of the differentiation after HL60 cells are committed...
  14. ncbi request reprint The role of ubiquitin in neurotrophin receptor signalling and sorting
    M W Wooten
    Program in Cellular and Molecular Biosciences, Department of Biological Sciences, 331 Funchess Hall, Auburn University, Auburn, AL 36849, USA
    Biochem Soc Trans 34:757-60. 2006
    ..Altogether, these findings reveal Lys63-linked polyubiquitin chains and the shuttling protein p62 co-ordinately regulate TrkA internalization, trafficking and sorting...
  15. ncbi request reprint Function for NF-kB in neuronal survival: regulation by atypical protein kinase C
    M W Wooten
    Department of Biological Sciences, Auburn University, Auburn, Alabama, USA
    J Neurosci Res 58:607-11. 1999
    ..Moreover, atypical protein kinase (aPKC) has been shown to play a novel role in modulating the NF-kB pathway. In this review, I focus on neurons and the factors that contribute to regulation of NF-kB via aPKC...
  16. ncbi request reprint Identification of a major endogenous substrate for phospholipid/Ca2+-dependent kinase in pancreatic acini as Gc (vitamin D-binding protein)
    M W Wooten
    FEBS Lett 191:97-101. 1985
    ..These findings indicate the potential usefulness of Gc as a defined substrate for further studies of the biological role of C-kinase activity in pancreatic acini and possibly in other cells...