Research Topics
| Robert J KemppainenSummaryAffiliation: College of Veterinary Medicine Country: USA Publications
| Collaborators
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Detail Information
Publications
Dexamethasone rapidly induces a novel ras superfamily member-related gene in AtT-20 cellsR J Kemppainen
Department of Physiology and Pharmacology, Auburn University College of Veterinary Medicine, Auburn, Alabama 36849, USA
J Biol Chem 273:3129-31. 1998..The function of this gene is unknown; however, its wide distribution and rapid induction by Dex suggests the possibility of a role in glucocorticoid action in a variety of tissues...- Diagnosis of canine hypothyroidism. Perspectives from a testing laboratoryR J Kemppainen
Department of Anatomy, Physiology and Pharmacology, Auburn University College of Veterinary Medicine, Endocrine Diagnostic Service, Auburn, Alabama, USA
Vet Clin North Am Small Anim Pract 31:951-62, vii. 2001..Other tests that are less commonly used are also discussed. Examples of interpretation of test results in individual hypothyroid-suspect dogs are presented for illustration... - Identification of a glucocorticoid response element in the 3'-flanking region of the human Dexras1 geneRobert J Kemppainen
Department of Anatomy, Physiology and Pharmacology, Auburn University, College of Veterinary Medicine, 213 Greene Hall, Auburn, AL 36849, USA
Biochim Biophys Acta 1627:85-9. 2003..This element conferred rapid glucocorticoid responsiveness when inserted into a homologous promoter-driven luciferase reporter. A point mutation within the 15-bp GRE abolished this glucocorticoid responsiveness... - Intramuscular administration of a low dose of ACTH for ACTH stimulation testing in dogsEllen N Behrend
Department of Clinical Sciences, College of Veterinary Medicine, Auburn University, AL 36849, USA
J Am Vet Med Assoc 229:528-30. 2006..CONCLUSIONS AND CLINICAL RELEVANCE: Results suggest that in healthy dogs and dogs with hyperadrenocorticism, administration of cosyntropin at a dose of 5 microg/kg, IV or IM, resulted in equivalent adrenal gland stimulation... 
Seasonal variation in results of diagnostic tests for pituitary pars intermedia dysfunction in older, clinically normal geldingsChristopher M Schreiber
Department of Clinical Sciences, College of Veterinary Medicine, Auburn University, Auburn, AL 36849, USA
J Am Vet Med Assoc 241:241-8. 2012....- Effect of glucocorticoid administration on serum aldosterone concentration in clinically normal dogsAnne M Corrigan
Department of Clinical Sciences, College of Veterinary Medicine, Auburn University, Auburn, AL 36849, USA
Am J Vet Res 71:649-54. 2010..To evaluate the effects of oral administration of anti-inflammatory dosages of prednisone for 28 days on serum aldosterone, cortisol, and electrolyte concentrations in clinically normal dogs... - Serum 17-alpha-hydroxyprogesterone and corticosterone concentrations in dogs with nonadrenal neoplasia and dogs with suspected hyperadrenocorticismEllen N Behrend
Department of Clinical Sciences, College of Veterinary Medicine, Auburn University, AL 36849, USA
J Am Vet Med Assoc 227:1762-7. 2005..Changes in serum 17OHP or corticosterone concentrations after administration of ACTH are proportionate with changes in cortisol concentration... - Pituitary-adrenal function in dogs with acute critical illnessLinda G Martin
Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Washington State University, Pullman, WA 99164 6610, USA
J Am Vet Med Assoc 233:87-95. 2008..To evaluate pituitary-adrenal function in critically ill dogs with sepsis, severe trauma, and gastric dilatation-volvulus (GDV)... - Canine hypophysectomy using a ventral paramedian approachTodd W Axlund
Department of Clinical Sciences and Anatomy, College of Veterinary Medicine, Auburn University, Auburn, AL 36849, USA
Vet Surg 34:179-89. 2005..To evaluate the degree of pituitary exposure, completeness of hypophysectomy, and perioperative morbidity associated with an alternative paramedian surgical approach and excisional technique for the canine pituitary gland... - Comparative analysis of Xenopus tropicalis hepcidin I and hepcidin II genesXueyou Hu
Department of Anatomy, Physiology and Pharmacology, Auburn University, Auburn, AL, USA
Gene 426:91-7. 2008..Hence, X. tropicalis is a useful model for the study of molecular evolution, transcriptional regulation, and structure-activity relationships of vertebrate hepcidins... - Measurement of total thyroxine concentration in serum from dogs and cats by use of various methodsRobert J Kemppainen
Department of Anatomy, Physiology and Pharmacology, College of Veterinary Medicine, Auburn University, Auburn, AL 36849, USA
Am J Vet Res 67:259-65. 2006..CONCLUSIONS AND CLINICAL RELEVANCE: Total T4 concentrations determined in dogs and cats by use of 4 commonly used methods provided similar and consistent results... - Validation of a low-dose ACTH stimulation test in healthy adult horsesAllison J Stewart
Department of Clinical Sciences, College of Veterinary Medicine, Auburn University, Auburn, AL 36849, USA
J Am Vet Med Assoc 239:834-41. 2011..To determine the lowest ACTH dose that would induce a maximum increase in serum cortisol concentration in healthy adult horses and identify the time to peak cortisol concentration... - Effects of oral administration of controlled-ileal-release budesonide and assessment of pituitary-adrenocortical axis suppression in clinically normal dogsShannon T Stroup
Department of Clinical Sciences, College of Veterinary Medicine, Auburn University, AL 36849, USA
Am J Vet Res 67:1173-8. 2006..Budesonide may be a good alternative to traditional cortico-steroids if used short-term for acute exacerbations of inflammatory bowel disease... - Use of compounded adrenocorticotropic hormone (ACTH) for adrenal function testing in dogsRobert J Kemppainen
Department of Anatomy, Physiology, and Pharmacology, College of Veterinary Medicine, Auburn University, Auburn, Alabama 36849, USA
J Am Anim Hosp Assoc 41:368-72. 2005.... - Corticosterone- and aldosterone-secreting adrenocortical tumor in a dogEllen N Behrend
Department of Clinical Sciences College of Veterinary Medicine, Auburn University, Auburn, AL 36849, USA
J Am Vet Med Assoc 226:1662-6, 1659. 2005..Hyperaldosteronemia was detected as well. Treatment with mitotane was instituted and successful for a period of 4-months until the dog was euthanatized for neurologic problems that were most likely unrelated to endocrine disease... - Diagnosis of hyperadrenocorticism in dogs: a survey of internists and dermatologistsEllen N Behrend
Department of Anatomy, Physiology and Pharmacology, College of Veterinary Medicine, Auburn University, AL 36849, USA
J Am Vet Med Assoc 220:1643-9. 2002..A variety of tests were used to differentiate pituitary-dependent HAC from HAC secondary to an AT... - Molecular and functional characterization of bovine beta-defensin-1Shelly Aono
Department of Anatomy, Physiology and Pharmacology, Auburn University, Auburn, AL 34849, USA
Vet Immunol Immunopathol 113:181-90. 2006..A synthetic bBD-1 peptide demonstrates potent antibacterial activity against Escherichia coli. The widespread expression of bBD-1 mRNA indicates that bBD-1 may play an important role in the bovine host defense against infections... - Evaluation of an in-house enzyme-linked immunosorbent assay for quantitative measurement of serum total thyroxine concentration in dogs and catsJill C Lurye
Department of Clinical Sciences, College of Veterinary Medicine, Auburn University, AL 36849, USA
J Am Vet Med Assoc 221:243-9. 2002..Thus, we concluded that the in-house ELISA kit was not accurate for determining serum total T4 concentrations in dogs and cats... - Acute inhibition of carboxypeptidase E expression in AtT-20 cells does not affect regulated secretion of ACTHRobert J Kemppainen
Departments of Anatomy, Physiology, and Pharmacology, College of Veterinary Medicine, Auburn University, Auburn, AL 36849, USA
Regul Pept 165:174-9. 2010..These results, whereby RNAi was used to acutely suppress CPE, do not support a role for this protein as necessary for or central to sorting of POMC/ACTH to the regulated secretory pathway in AtT-20 cells... - Regulation of adiponectin secretion by endothelin-1Kristen J Clarke
Department of Anatomy, Physiology and Pharmacology, College of Veterinary Medicine, Auburn University, Auburn, AL 36849 5518, USA
Biochem Biophys Res Commun 312:945-9. 2003..Our findings suggest vascular factors such as ET-1 may play a role in the regulation of adiponectin secretion and whole body energy metabolism... - Pituitary ACTH and adrenocortical secretion in critically ill dogsJennifer E Prittie
Department of Medicine, Bobst Hospital, The Animal Medical Center, New York, NY 10021, USA
J Am Vet Med Assoc 220:615-9. 2002..CONCLUSIONS AND CLINICAL RELEVANCE: Results indicate that none of the critically ill dogs in our study population developed adrenal insufficiency during hospitalization in the ICU...