Robert J Kemppainen

Summary

Affiliation: College of Veterinary Medicine
Country: USA

Publications

  1. ncbi Dexamethasone rapidly induces a novel ras superfamily member-related gene in AtT-20 cells
    R J Kemppainen
    Department of Physiology and Pharmacology, Auburn University College of Veterinary Medicine, Auburn, Alabama 36849, USA
    J Biol Chem 273:3129-31. 1998
  2. ncbi Identification of a glucocorticoid response element in the 3'-flanking region of the human Dexras1 gene
    Robert J Kemppainen
    Department of Anatomy, Physiology and Pharmacology, Auburn University, College of Veterinary Medicine, 213 Greene Hall, Auburn, AL 36849, USA
    Biochim Biophys Acta 1627:85-9. 2003
  3. ncbi Diagnosis of canine hypothyroidism. Perspectives from a testing laboratory
    R J Kemppainen
    Department of Anatomy, Physiology and Pharmacology, Auburn University College of Veterinary Medicine, Endocrine Diagnostic Service, Auburn, Alabama, USA
    Vet Clin North Am Small Anim Pract 31:951-62, vii. 2001
  4. ncbi Intramuscular administration of a low dose of ACTH for ACTH stimulation testing in dogs
    Ellen N Behrend
    Department of Clinical Sciences, College of Veterinary Medicine, Auburn University, AL 36849, USA
    J Am Vet Med Assoc 229:528-30. 2006
  5. ncbi Validation of a low-dose adrenocorticotropic hormone stimulation test in healthy neonatal foals
    Allison J Stewart
    Department of Clinical Sciences, College of Veterinary Medicine, Auburn University, Auburn, AL 36849, USA
    J Am Vet Med Assoc 243:399-405. 2013
  6. doi Seasonal variation in results of diagnostic tests for pituitary pars intermedia dysfunction in older, clinically normal geldings
    Christopher M Schreiber
    Department of Clinical Sciences, College of Veterinary Medicine, Auburn University, Auburn, AL 36849, USA
    J Am Vet Med Assoc 241:241-8. 2012
  7. ncbi Effect of glucocorticoid administration on serum aldosterone concentration in clinically normal dogs
    Anne M Corrigan
    Department of Clinical Sciences, College of Veterinary Medicine, Auburn University, Auburn, AL 36849, USA
    Am J Vet Res 71:649-54. 2010
  8. doi Pituitary-adrenal function in dogs with acute critical illness
    Linda G Martin
    Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Washington State University, Pullman, WA 99164 6610, USA
    J Am Vet Med Assoc 233:87-95. 2008
  9. ncbi Serum 17-alpha-hydroxyprogesterone and corticosterone concentrations in dogs with nonadrenal neoplasia and dogs with suspected hyperadrenocorticism
    Ellen N Behrend
    Department of Clinical Sciences, College of Veterinary Medicine, Auburn University, AL 36849, USA
    J Am Vet Med Assoc 227:1762-7. 2005
  10. doi Comparative analysis of Xenopus tropicalis hepcidin I and hepcidin II genes
    Xueyou Hu
    Department of Anatomy, Physiology and Pharmacology, Auburn University, Auburn, AL, USA
    Gene 426:91-7. 2008

Collaborators

Detail Information

Publications23

  1. ncbi Dexamethasone rapidly induces a novel ras superfamily member-related gene in AtT-20 cells
    R J Kemppainen
    Department of Physiology and Pharmacology, Auburn University College of Veterinary Medicine, Auburn, Alabama 36849, USA
    J Biol Chem 273:3129-31. 1998
    ..The function of this gene is unknown; however, its wide distribution and rapid induction by Dex suggests the possibility of a role in glucocorticoid action in a variety of tissues...
  2. ncbi Identification of a glucocorticoid response element in the 3'-flanking region of the human Dexras1 gene
    Robert J Kemppainen
    Department of Anatomy, Physiology and Pharmacology, Auburn University, College of Veterinary Medicine, 213 Greene Hall, Auburn, AL 36849, USA
    Biochim Biophys Acta 1627:85-9. 2003
    ..This element conferred rapid glucocorticoid responsiveness when inserted into a homologous promoter-driven luciferase reporter. A point mutation within the 15-bp GRE abolished this glucocorticoid responsiveness...
  3. ncbi Diagnosis of canine hypothyroidism. Perspectives from a testing laboratory
    R J Kemppainen
    Department of Anatomy, Physiology and Pharmacology, Auburn University College of Veterinary Medicine, Endocrine Diagnostic Service, Auburn, Alabama, USA
    Vet Clin North Am Small Anim Pract 31:951-62, vii. 2001
    ..Other tests that are less commonly used are also discussed. Examples of interpretation of test results in individual hypothyroid-suspect dogs are presented for illustration...
  4. ncbi Intramuscular administration of a low dose of ACTH for ACTH stimulation testing in dogs
    Ellen N Behrend
    Department of Clinical Sciences, College of Veterinary Medicine, Auburn University, AL 36849, USA
    J Am Vet Med Assoc 229:528-30. 2006
    ..To compare adrenal gland stimulation achieved following administration of cosyntropin (5 microg/kg [2.3 microg/lb]) IM versus IV in healthy dogs and dogs with hyperadrenocorticism...
  5. ncbi Validation of a low-dose adrenocorticotropic hormone stimulation test in healthy neonatal foals
    Allison J Stewart
    Department of Clinical Sciences, College of Veterinary Medicine, Auburn University, Auburn, AL 36849, USA
    J Am Vet Med Assoc 243:399-405. 2013
    ..To determine the lowest ACTH dose that would induce a significant increase in serum cortisol concentration and identify the time to peak cortisol concentration in healthy neonatal foals...
  6. doi Seasonal variation in results of diagnostic tests for pituitary pars intermedia dysfunction in older, clinically normal geldings
    Christopher M Schreiber
    Department of Clinical Sciences, College of Veterinary Medicine, Auburn University, Auburn, AL 36849, USA
    J Am Vet Med Assoc 241:241-8. 2012
    ....
  7. ncbi Effect of glucocorticoid administration on serum aldosterone concentration in clinically normal dogs
    Anne M Corrigan
    Department of Clinical Sciences, College of Veterinary Medicine, Auburn University, Auburn, AL 36849, USA
    Am J Vet Res 71:649-54. 2010
    ..To evaluate the effects of oral administration of anti-inflammatory dosages of prednisone for 28 days on serum aldosterone, cortisol, and electrolyte concentrations in clinically normal dogs...
  8. doi Pituitary-adrenal function in dogs with acute critical illness
    Linda G Martin
    Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Washington State University, Pullman, WA 99164 6610, USA
    J Am Vet Med Assoc 233:87-95. 2008
    ..To evaluate pituitary-adrenal function in critically ill dogs with sepsis, severe trauma, and gastric dilatation-volvulus (GDV)...
  9. ncbi Serum 17-alpha-hydroxyprogesterone and corticosterone concentrations in dogs with nonadrenal neoplasia and dogs with suspected hyperadrenocorticism
    Ellen N Behrend
    Department of Clinical Sciences, College of Veterinary Medicine, Auburn University, AL 36849, USA
    J Am Vet Med Assoc 227:1762-7. 2005
    ..To assess serum 17-alpha-hydroxyprogesterone (17OHP) and corticosterone concentrations in dogs with nonadrenal neoplasia and dogs being screened for hyperadrenocorticism...
  10. doi Comparative analysis of Xenopus tropicalis hepcidin I and hepcidin II genes
    Xueyou Hu
    Department of Anatomy, Physiology and Pharmacology, Auburn University, Auburn, AL, USA
    Gene 426:91-7. 2008
    ..Hence, X. tropicalis is a useful model for the study of molecular evolution, transcriptional regulation, and structure-activity relationships of vertebrate hepcidins...
  11. ncbi Measurement of total thyroxine concentration in serum from dogs and cats by use of various methods
    Robert J Kemppainen
    Department of Anatomy, Physiology and Pharmacology, College of Veterinary Medicine, Auburn University, Auburn, AL 36849, USA
    Am J Vet Res 67:259-65. 2006
    ..To compare results obtained from assay of total thyroxine (T4) concentration in serum of dogs and cats by use of 4 methods...
  12. ncbi Canine hypophysectomy using a ventral paramedian approach
    Todd W Axlund
    Department of Clinical Sciences and Anatomy, College of Veterinary Medicine, Auburn University, Auburn, AL 36849, USA
    Vet Surg 34:179-89. 2005
    ..To evaluate the degree of pituitary exposure, completeness of hypophysectomy, and perioperative morbidity associated with an alternative paramedian surgical approach and excisional technique for the canine pituitary gland...
  13. ncbi Inoculation of dogs with a recombinant ACTH vaccine
    Robert J Kemppainen
    Department of Anatomy, Physiology, and Pharmacology, College of Veterinary Medicine, Auburn University, Auburn, AL 36849
    Am J Vet Res 74:1499-505. 2013
    ..To determine whether inoculation of healthy dogs with a recombinant peptide containing 3 copies of ACTH would result in the production of antibodies against ACTH and whether this would affect pituitary-adrenocortical function...
  14. doi Validation of a low-dose ACTH stimulation test in healthy adult horses
    Allison J Stewart
    Department of Clinical Sciences, College of Veterinary Medicine, Auburn University, Auburn, AL 36849, USA
    J Am Vet Med Assoc 239:834-41. 2011
    ..To determine the lowest ACTH dose that would induce a maximum increase in serum cortisol concentration in healthy adult horses and identify the time to peak cortisol concentration...
  15. ncbi Use of compounded adrenocorticotropic hormone (ACTH) for adrenal function testing in dogs
    Robert J Kemppainen
    Department of Anatomy, Physiology, and Pharmacology, College of Veterinary Medicine, Auburn University, Auburn, Alabama 36849, USA
    J Am Anim Hosp Assoc 41:368-72. 2005
    ....
  16. ncbi Corticosterone- and aldosterone-secreting adrenocortical tumor in a dog
    Ellen N Behrend
    Department of Clinical Sciences College of Veterinary Medicine, Auburn University, Auburn, AL 36849, USA
    J Am Vet Med Assoc 226:1662-6, 1659. 2005
    ..Hyperaldosteronemia was detected as well. Treatment with mitotane was instituted and successful for a period of 4-months until the dog was euthanatized for neurologic problems that were most likely unrelated to endocrine disease...
  17. ncbi Effects of oral administration of controlled-ileal-release budesonide and assessment of pituitary-adrenocortical axis suppression in clinically normal dogs
    Shannon T Stroup
    Department of Clinical Sciences, College of Veterinary Medicine, Auburn University, AL 36849, USA
    Am J Vet Res 67:1173-8. 2006
    ..To evaluate the effects of oral administration of controlled-ileal-release (CIR) budesonide on the pituitary-adrenal axis in dogs with a normal gastrointestinal mucosal barrier...
  18. ncbi Diagnosis of hyperadrenocorticism in dogs: a survey of internists and dermatologists
    Ellen N Behrend
    Department of Anatomy, Physiology and Pharmacology, College of Veterinary Medicine, Auburn University, AL 36849, USA
    J Am Vet Med Assoc 220:1643-9. 2002
    ..To determine testing protocols used by board-certified internists and dermatologists for diagnosis of hyperadrenocorticism (HAC) in dogs...
  19. ncbi Molecular and functional characterization of bovine beta-defensin-1
    Shelly Aono
    Department of Anatomy, Physiology and Pharmacology, Auburn University, Auburn, AL 34849, USA
    Vet Immunol Immunopathol 113:181-90. 2006
    ..A synthetic bBD-1 peptide demonstrates potent antibacterial activity against Escherichia coli. The widespread expression of bBD-1 mRNA indicates that bBD-1 may play an important role in the bovine host defense against infections...
  20. ncbi Evaluation of an in-house enzyme-linked immunosorbent assay for quantitative measurement of serum total thyroxine concentration in dogs and cats
    Jill C Lurye
    Department of Clinical Sciences, College of Veterinary Medicine, Auburn University, AL 36849, USA
    J Am Vet Med Assoc 221:243-9. 2002
    ..To compare serum total thyroxine (T4) concentrations obtained with an in-house ELISA and a validated radioimmunoassay (RIA)...
  21. ncbi Regulation of adiponectin secretion by endothelin-1
    Kristen J Clarke
    Department of Anatomy, Physiology and Pharmacology, College of Veterinary Medicine, Auburn University, Auburn, AL 36849 5518, USA
    Biochem Biophys Res Commun 312:945-9. 2003
    ..Our findings suggest vascular factors such as ET-1 may play a role in the regulation of adiponectin secretion and whole body energy metabolism...
  22. doi Acute inhibition of carboxypeptidase E expression in AtT-20 cells does not affect regulated secretion of ACTH
    Robert J Kemppainen
    Departments of Anatomy, Physiology, and Pharmacology, College of Veterinary Medicine, Auburn University, Auburn, AL 36849, USA
    Regul Pept 165:174-9. 2010
    ..These results, whereby RNAi was used to acutely suppress CPE, do not support a role for this protein as necessary for or central to sorting of POMC/ACTH to the regulated secretory pathway in AtT-20 cells...
  23. ncbi Pituitary ACTH and adrenocortical secretion in critically ill dogs
    Jennifer E Prittie
    Department of Medicine, Bobst Hospital, The Animal Medical Center, New York, NY 10021, USA
    J Am Vet Med Assoc 220:615-9. 2002
    ..To evaluate pituitary-adrenal function in a population of critically ill dogs by measuring serial plasma concentrations of basal cortisol, ACTH-stimulated cortisol, and endogenous ACTH...