L Bruce Gladden

Summary

Affiliation: College of Veterinary Medicine
Country: USA

Publications

  1. doi request reprint A lactatic perspective on metabolism
    L Bruce Gladden
    Department of Kinesiology, Auburn University, Auburn, AL 36849 5323, USA
    Med Sci Sports Exerc 40:477-85. 2008
  2. ncbi request reprint Muscle as a consumer of lactate
    L B Gladden
    Department of Health and Human Performance, Auburn University, AL 36849 5323, USA
    Med Sci Sports Exerc 32:764-71. 2000
  3. doi request reprint 200th anniversary of lactate research in muscle
    L Bruce Gladden
    Department of Kinesiology, Auburn University, Auburn, AL 36849 5323, United States
    Exerc Sport Sci Rev 36:109-15. 2008
  4. doi request reprint Current trends in lactate metabolism: introduction
    L Bruce Gladden
    Department of Kinesiology, Auburn University, Auburn, AL 36849 5323, USA
    Med Sci Sports Exerc 40:475-6. 2008
  5. pmc Is there an intracellular lactate shuttle in skeletal muscle?
    L Bruce Gladden
    Department of Kinesiology, 2050 Memorial Coliseum, Auburn University, Auburn, AL 36849 5323, USA
    J Physiol 582:899. 2007
  6. pmc Lactate metabolism: a new paradigm for the third millennium
    L B Gladden
    Department of Health and Human Performance, 2050 Memorial Coliseum, Auburn University, Auburn, AL 36849 5323, USA
    J Physiol 558:5-30. 2004
  7. doi request reprint A prior bout of contractions speeds VO2 and blood flow on-kinetics and reduces the VO2 slow-component amplitude in canine skeletal muscle contracting in situ
    Andres Hernandez
    Department of Kinesiology, Auburn University, Auburn, AL, USA
    J Appl Physiol (1985) 108:1169-76. 2010
  8. doi request reprint VO(2) on-kinetics in isolated canine muscle in situ during slowed convective O(2) delivery
    Matthew L Goodwin
    Department of Kinesiology, Auburn University, Auburn, Alabama, USA
    J Appl Physiol (1985) 112:9-19. 2012
  9. pmc Kinetic control of oxygen consumption during contractions in self-perfused skeletal muscle
    Rob C I Wüst
    Department of Kinesiology, Auburn University, Auburn, AL, USA
    J Physiol 589:3995-4009. 2011
  10. doi request reprint Contraction-by-contraction VO2 and computer-controlled pump perfusion as novel techniques to study skeletal muscle metabolism in situ
    Andres Hernandez
    Department of Kinesiology, Auburn University, Auburn, AL 36849 5323, USA
    J Appl Physiol (1985) 108:705-12. 2010

Collaborators

Detail Information

Publications25

  1. doi request reprint A lactatic perspective on metabolism
    L Bruce Gladden
    Department of Kinesiology, Auburn University, Auburn, AL 36849 5323, USA
    Med Sci Sports Exerc 40:477-85. 2008
    ..Surprisingly, there is little direct mechanistic evidence regarding cause and effect in acid-base balance. However, there is insufficient evidence to discard the term "lactic acidosis."..
  2. ncbi request reprint Muscle as a consumer of lactate
    L B Gladden
    Department of Health and Human Performance, Auburn University, AL 36849 5323, USA
    Med Sci Sports Exerc 32:764-71. 2000
    ..The future challenge is to understand the regulatory roles of both lactate metabolism and membrane transport of lactate...
  3. doi request reprint 200th anniversary of lactate research in muscle
    L Bruce Gladden
    Department of Kinesiology, Auburn University, Auburn, AL 36849 5323, United States
    Exerc Sport Sci Rev 36:109-15. 2008
    ..Today, the exact mechanism of intramuscular lactate oxidation and the relationship of lactate dehydrogenase to mitochondria remain unresolved as animated debate surrounds the intracellular lactate shuttle...
  4. doi request reprint Current trends in lactate metabolism: introduction
    L Bruce Gladden
    Department of Kinesiology, Auburn University, Auburn, AL 36849 5323, USA
    Med Sci Sports Exerc 40:475-6. 2008
    ..They also postulate that lactate is a cell-signaling molecule, "lactormone," that can upregulate gene and protein expression. Both papers have been updated since their original presentations and represent the current state of knowledge...
  5. pmc Is there an intracellular lactate shuttle in skeletal muscle?
    L Bruce Gladden
    Department of Kinesiology, 2050 Memorial Coliseum, Auburn University, Auburn, AL 36849 5323, USA
    J Physiol 582:899. 2007
  6. pmc Lactate metabolism: a new paradigm for the third millennium
    L B Gladden
    Department of Health and Human Performance, 2050 Memorial Coliseum, Auburn University, Auburn, AL 36849 5323, USA
    J Physiol 558:5-30. 2004
    ....
  7. doi request reprint A prior bout of contractions speeds VO2 and blood flow on-kinetics and reduces the VO2 slow-component amplitude in canine skeletal muscle contracting in situ
    Andres Hernandez
    Department of Kinesiology, Auburn University, Auburn, AL, USA
    J Appl Physiol (1985) 108:1169-76. 2010
    ..Additionally, altered motor unit recruitment at the onset of a second bout is not a prerequisite for reductions in the VO2 slow-component amplitude after a priming contractile bout in canine muscle in situ...
  8. doi request reprint VO(2) on-kinetics in isolated canine muscle in situ during slowed convective O(2) delivery
    Matthew L Goodwin
    Department of Kinesiology, Auburn University, Auburn, Alabama, USA
    J Appl Physiol (1985) 112:9-19. 2012
    ....
  9. pmc Kinetic control of oxygen consumption during contractions in self-perfused skeletal muscle
    Rob C I Wüst
    Department of Kinesiology, Auburn University, Auburn, AL, USA
    J Physiol 589:3995-4009. 2011
    ..Rather an allosteric or 'parallel activation' mechanism of energy consuming and producing processes is required to explain the kinetic control of VO2 in mammalian skeletal muscle...
  10. doi request reprint Contraction-by-contraction VO2 and computer-controlled pump perfusion as novel techniques to study skeletal muscle metabolism in situ
    Andres Hernandez
    Department of Kinesiology, Auburn University, Auburn, AL 36849 5323, USA
    J Appl Physiol (1985) 108:705-12. 2010
    ..These new techniques significantly improve on existing methods for mechanistically altering blood flow kinetics as well as accurately measuring muscle oxygen consumption kinetics during transitions between metabolic rates...
  11. ncbi request reprint Cause and effect
    L Bruce Gladden
    Auburn University, USA
    J Appl Physiol 105:364. 2008
  12. ncbi request reprint Effect of rhythmic tetanic skeletal muscle contractions on peak muscle perfusion
    John L Dobson
    Department of Health and Human Performance, Auburn University, Alabama 36849 5323, USA
    J Appl Physiol (1985) 94:11-9. 2003
    ..This argues against a primary role for the muscle pump in achieving peak skeletal muscle blood flow...
  13. ncbi request reprint Red blood cell lactate transport in sickle disease and sickle cell trait
    Robin E Pattillo
    School of Nursing, Auburn Univ, Auburn, AL, USA
    J Appl Physiol 99:822-7. 2005
    ....
  14. ncbi request reprint Lactate metabolism in resting and contracting canine skeletal muscle with elevated lactate concentration
    Kevin M Kelley
    Department of Health and Human Performance, College of Veterinary Medicine, Auburn University, Auburn, Alabama 36849, USA
    J Appl Physiol (1985) 93:865-72. 2002
    ..These results suggest that oxidation is a limited means for lactate disposal in resting canine GP exposed to elevated lactate concentrations due to the muscle's low resting metabolic rate...
  15. ncbi request reprint Effect of epinephrine on net lactate uptake by contracting skeletal muscle
    J J Hamann
    Department of Health and Human Performance, Auburn University, Auburn, AL 36849, USA
    J Appl Physiol (1985) 91:2635-41. 2001
    ..This study suggests that epinephrine can have a profound effect on net La(-) uptake by contracting muscle and that these effects are elicited through beta-adrenergic-receptor stimulation...
  16. ncbi request reprint Effect of a myocardial volume overload on lactate transport in skeletal muscle sarcolemmal vesicles
    W G Aschenbach
    Department of Health and Human Performance, Auburn University, Auburn University College of Veterinary Medicine, Auburn, Alabama 36849, USA
    Am J Physiol Regul Integr Comp Physiol 281:R176-86. 2001
    ..In conclusion, a 10-wk MVO did not alter MCT-mediated La(-) transport or protein expression but was associated with modest changes in myofibrillar proteins and impaired SL diffusive properties...
  17. ncbi request reprint Lactic acid accumulation is an advantage/disadvantage during muscle activity
    L Bruce Gladden
    J Appl Physiol 100:2100-1. 2006
  18. pmc Oxygen uptake on-kinetics in dog gastrocnemius in situ following activation of pyruvate dehydrogenase by dichloroacetate
    Bruno Grassi
    Dipartimento di Scienze e Tecnologie Biomediche, Universita degli Studi di Milano, I 20090 Segrate MI, Italy
    J Physiol 538:195-207. 2002
    ..5 +/- 1.4 s in DCA (n.s.). In this experimental model, activation of PDC by DCA resulted in a stockpiling of acetyl groups at rest and less muscle fatigue, but it did not affect 'anaerobic' energy provision and V(O2) on-kinetics...
  19. doi request reprint Progressive recruitment of muscle fibers is not necessary for the slow component of VO2 kinetics
    Jerzy A Zoladz
    Department of Physiology and Biochemistry, University School of Physical Education, Krakow, Poland
    J Appl Physiol (1985) 105:575-80. 2008
    ....
  20. ncbi request reprint Effect of myocardial volume overload and heart failure on lactate transport into isolated cardiac myocytes
    Ronald K Evans
    School of Human Performance and Recreation, The University of Southern Mississippi, Hattiesburg, Mississippi 39406, USA
    J Appl Physiol (1985) 94:1169-76. 2003
    ..These alterations would likely benefit the cell by attenuating intracellular acidification during a period of increased myocardial load...
  21. ncbi request reprint Mammalian skeletal muscle can convert lactate to glycogen
    L Bruce Gladden
    J Appl Physiol 100:2109; author reply 2109-10. 2006
  22. ncbi request reprint Caffeine administration results in greater tension development in previously fatigued canine muscle in situ
    Richard A Howlett
    Department of Medicine, University of California, San Diego, La Jolla, CA 92093 0623, USA
    Exp Physiol 90:873-9. 2005
    ..This suggests that, in this in situ isolated whole muscle model, alteration of Ca2+ metabolism is probably only one cause of fatigue...
  23. ncbi request reprint Model of oxygen transport and metabolism predicts effect of hyperoxia on canine muscle oxygen uptake dynamics
    Nicola Lai
    Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH 44106, USA
    J Appl Physiol 103:1366-78. 2007
    ..These in silico derived results cannot be obtained from experimental observations alone...
  24. pmc Effects of nitric oxide synthase inhibition by L-NAME on oxygen uptake kinetics in isolated canine muscle in situ
    Bruno Grassi
    Dipartimento di Scienze e Tecnologie Biomediche, Universita degli Studi di Milano, LITA via Fratelli Cervi 93, I 20090 Segrate MI, Italy
    J Physiol 568:1021-33. 2005
    ..4 +/- 1.0). Contrary to our hypothesis, NOS inhibition did not accelerate muscle VO2 kinetics. The down-regulation of mitochondrial respiration by NO does not limit the kinetics of adjustment of oxidative metabolism at exercise onset...
  25. ncbi request reprint Comments on point:counterpoint: "the lactate paradox does/does not occur during exercise at high altitude"
    L Bruce Gladden
    J Appl Physiol 102:2405; author reply 2409-10. 2007