M R Deschenes

Summary

Affiliation: College of William and Mary
Country: USA

Publications

  1. pmc When size really does matter
    Michael R Deschenes
    Department of Kinesiology and Program in Neuroscience, The College of William and Mary, Williamsburg, VA 23187 8795, USA
    J Physiol 579:567. 2007
  2. ncbi request reprint Neural factors account for strength decrements observed after short-term muscle unloading
    Michael R Deschenes
    Department of Kinesiology, The College of William and Mary, Williamsburg, Virginia 23187 8795, USA
    Am J Physiol Regul Integr Comp Physiol 282:R578-83. 2002
  3. ncbi request reprint The effects of sarcopenia on muscles with different recruitment patterns and myofiber profiles
    Michael R Deschenes
    Department of Kinesiology and Health Sciences, The College of William and Mary Williamsburg, VA 23187 8795, USA
    Curr Aging Sci 6:266-72. 2013
  4. pmc The effects of pre-habilitative conditioning on unloading-induced adaptations in young and aged neuromuscular systems
    Michael R Deschenes
    Department of Kinesiology and Health Sciences, The College of William and Mary, Williamsburg, VA 23187 8795, USA
    Exp Gerontol 47:687-94. 2012
  5. pmc Factors relating to gender specificity of unloading-induced declines in strength
    Michael R Deschenes
    Department of Kinesiology and Health Sciences, The College of William and Mary, Williamsburg, Virginia 23187 8795, USA
    Muscle Nerve 46:210-7. 2012
  6. ncbi request reprint Motor unit and neuromuscular junction remodeling with aging
    Michael R Deschenes
    Department of Kinesiology and Health Sciences, The College of William and Mary Williamsburg, VA 23187 8795, USA
    Curr Aging Sci 4:209-20. 2011
  7. ncbi request reprint Effects of aging on muscle fibre type and size
    Michael R Deschenes
    Department of Kinesiology, The College of William and Mary, Center for Excellence in Aging and Geriatric Health, Williamsburg, Virginia 23187 8795, USA
    Sports Med 34:809-24. 2004
  8. ncbi request reprint Neuromuscular adaptations to spaceflight are specific to postural muscles
    Michael R Deschenes
    Department of Kinesiology, College of William and Mary, Williamsburg, Virginia 23187 8795, USA
    Muscle Nerve 31:468-74. 2005
  9. doi request reprint Gender influences neuromuscular adaptations to muscle unloading
    Michael R Deschenes
    Department of Kinesiology, The College of William and Mary, Williamsburg, VA 23187 8795, USA
    Eur J Appl Physiol 105:889-97. 2009
  10. doi request reprint Adaptations to short-term muscle unloading in young and aged men
    Michael R Deschenes
    Department of Kinesiology, College of William and Mary, Williamsburg, VA 23187 8795, USA
    Med Sci Sports Exerc 40:856-63. 2008

Research Grants

Detail Information

Publications34

  1. pmc When size really does matter
    Michael R Deschenes
    Department of Kinesiology and Program in Neuroscience, The College of William and Mary, Williamsburg, VA 23187 8795, USA
    J Physiol 579:567. 2007
  2. ncbi request reprint Neural factors account for strength decrements observed after short-term muscle unloading
    Michael R Deschenes
    Department of Kinesiology, The College of William and Mary, Williamsburg, Virginia 23187 8795, USA
    Am J Physiol Regul Integr Comp Physiol 282:R578-83. 2002
    ..Our data confirm that the diminution in muscle function displayed after 2 wk of unloading is mainly due to neural, rather than contractile, disturbances...
  3. ncbi request reprint The effects of sarcopenia on muscles with different recruitment patterns and myofiber profiles
    Michael R Deschenes
    Department of Kinesiology and Health Sciences, The College of William and Mary Williamsburg, VA 23187 8795, USA
    Curr Aging Sci 6:266-72. 2013
    ..In sum, these data suggest that although sarcopenia may be ubiquitous among skeletal muscles, the degree of its impact displays specificity based not only on myofiber type composition, but also on muscle function. ..
  4. pmc The effects of pre-habilitative conditioning on unloading-induced adaptations in young and aged neuromuscular systems
    Michael R Deschenes
    Department of Kinesiology and Health Sciences, The College of William and Mary, Williamsburg, VA 23187 8795, USA
    Exp Gerontol 47:687-94. 2012
    ..Although more sensitive to the negative effects of muscle unloading, aged myofibers were also more responsive to the hypertrophic effects of pre-habilitative conditioning...
  5. pmc Factors relating to gender specificity of unloading-induced declines in strength
    Michael R Deschenes
    Department of Kinesiology and Health Sciences, The College of William and Mary, Williamsburg, Virginia 23187 8795, USA
    Muscle Nerve 46:210-7. 2012
    ....
  6. ncbi request reprint Motor unit and neuromuscular junction remodeling with aging
    Michael R Deschenes
    Department of Kinesiology and Health Sciences, The College of William and Mary Williamsburg, VA 23187 8795, USA
    Curr Aging Sci 4:209-20. 2011
    ....
  7. ncbi request reprint Effects of aging on muscle fibre type and size
    Michael R Deschenes
    Department of Kinesiology, The College of William and Mary, Center for Excellence in Aging and Geriatric Health, Williamsburg, Virginia 23187 8795, USA
    Sports Med 34:809-24. 2004
    ..Given the demographic trends evident in most western societies, i.e. increased number of those considered aged, management interventions for sarcopenia must become a major goal of the healthcare profession...
  8. ncbi request reprint Neuromuscular adaptations to spaceflight are specific to postural muscles
    Michael R Deschenes
    Department of Kinesiology, College of William and Mary, Williamsburg, Virginia 23187 8795, USA
    Muscle Nerve 31:468-74. 2005
    ..Our findings suggest that the deleterious effects of microgravity are most apparent among postural muscles, and are manifested both in myofibers and their synapses...
  9. doi request reprint Gender influences neuromuscular adaptations to muscle unloading
    Michael R Deschenes
    Department of Kinesiology, The College of William and Mary, Williamsburg, VA 23187 8795, USA
    Eur J Appl Physiol 105:889-97. 2009
    ....
  10. doi request reprint Adaptations to short-term muscle unloading in young and aged men
    Michael R Deschenes
    Department of Kinesiology, College of William and Mary, Williamsburg, VA 23187 8795, USA
    Med Sci Sports Exerc 40:856-63. 2008
    ..The purpose of this investigation was to determine whether young (21.7 yr) and aged (68.5 yr) men experienced similar responses to 7 d of muscle unloading (N = 10 per group)...
  11. ncbi request reprint Increased and decreased activity elicits specific morphological adaptations of the neuromuscular junction
    M R Deschenes
    Department of Kinesiology, and Program in Neuroscience, Adair Hall, The College of William and Mary, Williamsburg, VA 23187 8795, USA
    Neuroscience 137:1277-83. 2006
    ..post-synaptic) and nature (expansion vs. reduction) of that remodeling are specific to the form of the alteration in activity...
  12. ncbi request reprint Aged men experience disturbances in recovery following submaximal exercise
    Michael R Deschenes
    Department of Kinesiology, The College of William and Mary, Williamsburg, VA 23187 8795, USA
    J Gerontol A Biol Sci Med Sci 61:63-71. 2006
    ..Physiological responses to exercise of moderate intensity and duration among aged compared to young adults have yet to be clearly defined. Further, the effects of aging on the rate and effectiveness of postexercise recovery are unknown...
  13. pmc Moderate aging does not modulate morphological responsiveness of the neuromuscular system to chronic overload in Fischer 344 rats
    M R Deschenes
    Department of Kinesiology, College of William and Mary, Adair Hall, Campus Drive, Williamsburg, VA 23187 8795, USA
    Neuroscience 148:970-7. 2007
    ..These data indicate that moderate aging (the equivalent of 65 years in human lifetime) does not modify the sensitivity of the neuromuscular system to chronic overload...
  14. ncbi request reprint Effects of gender on physiological responses during submaximal exercise and recovery
    Michael R Deschenes
    Department of Kinesiology, The College of William and Mary, Williamsburg, VA 23187 8795, USA
    Med Sci Sports Exerc 38:1304-10. 2006
    ..This investigation was conducted to compare the physiological responses of men and women, both during and following an exercise bout at the same relative submaximal intensity...
  15. ncbi request reprint A comparison of physiological variables in aged and young women during and following submaximal exercise
    Michael R Deschenes
    Department of Kinesiology, The College of William and Mary, Williamsburg, Virginia 23187 8795, USA
    Am J Hum Biol 21:836-43. 2009
    ..Combined with our earlier study on men, these findings suggest that gender interacts with aging to determine whether age-related differences are manifested during exercise itself, or during postexercise recovery...
  16. ncbi request reprint Age-related differences in synaptic plasticity following muscle unloading
    Michael R Deschenes
    Department of Kinesiology, The College of William and Mary, Williamsburg, Virginia 23187 8795, USA
    J Neurobiol 57:246-56. 2003
    ..These data suggest that although young adult muscle maintains normal NMJ structure during prolonged exposure to unloading, aged NMJs experience significant adaptation to that stimulus...
  17. ncbi request reprint Effects of resistance training on neuromuscular junction morphology
    M R Deschenes
    Department of Kinesiology, College of William and Mary, Williamsburg, Virginia 23187 8795, USA
    Muscle Nerve 23:1576-81. 2000
    ..The data presented here indicate that the stimulus of resistance training was sufficiently potent to remodel NMJ structure, and that this effect cannot be attributed to muscle fiber hypertrophy or fiber type conversion...
  18. pmc Aging influences adaptations of the neuromuscular junction to endurance training
    M R Deschenes
    Department of Kinesiology and Health Sciences, College of William and Mary, Williamsburg, VA 23187 8795, USA
    Neuroscience 190:56-66. 2011
    ..Results also reveal complexity in the coordination of synaptic responses among different muscles, and different fiber types within muscles, in their adaptation to aging and exercise training...
  19. ncbi request reprint A comparison of the effects of unloading in young adult and aged skeletal muscle
    M R Deschenes
    Department of Kinesiology, The College of William and Mary, Williamsburg, VA 23187 8795, USA
    Med Sci Sports Exerc 33:1477-83. 2001
    ..The objective of this investigation was to determine whether morphological adaptations to unloading are different in young adult and aged skeletal muscle...
  20. ncbi request reprint Recovery of neuromuscular junction morphology following 16 days of spaceflight
    M R Deschenes
    Department of Kinesiology, The College of William and Mary, Williamsburg, Virginia 23187 8795, USA
    Synapse 42:177-84. 2001
    ..These results suggest that the neuromuscular system possesses a robust capacity to recover from spaceflight-induced perturbations upon return to normal gravitational influences...
  21. ncbi request reprint Aged men display blunted biorhythmic variation of muscle performance and physiological responses
    Michael R Deschenes
    Department of Kinesiology, The College of William and Mary, Williamsburg, Virginia 23187 8795, USA
    J Appl Physiol (1985) 92:2319-25. 2002
    ..These data confirm the blunting of biorhythmic variation in muscle performance and physiological variables, except for circulating hormones, in aged men...
  22. pmc Remodeling of the neuromuscular junction precedes sarcopenia related alterations in myofibers
    Michael R Deschenes
    Department of Kinesiology and Health Sciences, The College of William and Mary, Williamsburg, VA 23187 8795, USA
    Exp Gerontol 45:389-93. 2010
    ..These results indicate that age-related denervation occurs before myofiber atrophy, and that high amounts of neuromuscular activity may delay the onset of age-related denervation and sarcopenia...
  23. ncbi request reprint Unlike myofibers, neuromuscular junctions remain stable during prolonged muscle unloading
    Michael R Deschenes
    Department of Kinesiology, The College of William and Mary, Williamsburg, VA 23187 8795, USA
    J Neurol Sci 210:5-10. 2003
    ..This may be of benefit during post-unloading rehabilitative measures where effective neuromuscular communication is essential...
  24. ncbi request reprint Biorhythmic influences on functional capacity of human muscle and physiological responses
    M R Deschenes
    Department of Kinesiology, The College of William and Mary, Williamsburg, VA 23187 8795, USA
    Med Sci Sports Exerc 30:1399-407. 1998
    ....
  25. ncbi request reprint Muscle recruitment patterns regulate physiological responses during exercise of the same intensity
    M R Deschenes
    Department of Kinesiology, The College of William and Mary, Williamsburg, Virginia 23187 8795, USA
    Am J Physiol Regul Integr Comp Physiol 279:R2229-36. 2000
    ..These data indicated that the more pronounced muscle activation pattern associated with pedaling at 40 rpm resulted in greater physiological and psychophysiological stress than that observed at 80 rpm even though VO(2) was the same...
  26. ncbi request reprint Neuromuscular disturbance outlasts other symptoms of exercise-induced muscle damage
    M R Deschenes
    Department of Kinesiology, The College of William and Mary, Williamsburg, VA 23187 8795, USA
    J Neurol Sci 174:92-9. 2000
    ..While other symptoms of exercise-induced muscle damage dissipate within 7 days, neuromuscular perturbation persists for at least 10 days...
  27. ncbi request reprint Androgen receptor content following heavy resistance exercise in men
    Nicholas A Ratamess
    Human Performance Laboratory, Department of Kinesiology, Unit 1110, University of Connecticut, Storrs, CT 06269 1110, USA
    J Steroid Biochem Mol Biol 93:35-42. 2005
    ..This may have been due to greater protein catabolism associated with the higher level of stress following higher-volume resistance exercise...
  28. ncbi request reprint Pituitary-adrenal responses to arm versus leg exercise in untrained man
    Carl M Maresh
    Human Performance Laboratory, Department of Kinesiology, University of Connecticut, 2095 Hillside Road, Unit 1110, Storrs, 06269 1110, USA
    Eur J Appl Physiol 97:471-7. 2006
    ..It appears that the smaller muscle mass associated with AE was sufficient to stimulate these PA axis hormones in a manner similar to LE, despite the higher metabolic stress (i.e., plasma La-) associated with LE...
  29. ncbi request reprint Performance and physiologic adaptations to resistance training
    Michael R Deschenes
    Department of Kinesiology, The College of William and Mary, Williamsburg, VA 23187 8795, USA
    Am J Phys Med Rehabil 81:S3-16. 2002
    ....
  30. ncbi request reprint The neuromuscular junction: anatomical features and adaptations to various forms of increased, or decreased neuromuscular activity
    Meredith H Wilson
    Department of Kinesiology, The College of William and Mary, Williamsburg, Virginia 23187 8795, USA
    Int J Neurosci 115:803-28. 2005
    ..Increased activity, presented by exercise training, typically results in expansion of NMJ size. Disuse, brought about by neurotoxins, denervation, or spaceflight, also elicits substantial reconfiguring of the endplate...
  31. ncbi request reprint Exercise stimulates neovascularization in occluded muscle without affecting bFGF content
    M R Deschenes
    Department of Kinesiology, The College of William and Mary, Williamsburg, VA 23187 8795, USA
    Med Sci Sports Exerc 31:1599-604. 1999
    ....
  32. doi request reprint The efficacy of prehabilitative conditioning: ameliorating unloading-induced declines in the muscle function of humans
    Michael R Deschenes
    Department of Kinesiology, Adair Hall, The College of William and Mary, Williamsburg, VA 23187 8795, USA
    Am J Phys Med Rehabil 88:136-44. 2009
    ..To determine whether prehabilitation, or exercise performed before muscle unloading, can effectively mitigate decreases in neuromuscular function typically elicited by unloading...
  33. ncbi request reprint Responses of plasma proenkephalin peptide F in rats following 14 days of spaceflight
    William J Kraemer
    Human Performance Laboratory, Department of Kinesiology, University of Connecticut, Storrs, CT 06269 1110, USA
    Aviat Space Environ Med 75:114-7. 2004
    ..Proenkephalin peptide F [107-140] is related to the enhancement of immune function, while microgravity has been shown to cause immuno-suppression. We investigated the physiological response of proenkephalin peptide F to microgravity...
  34. ncbi request reprint Statistical analysis of fiber area in human skeletal muscle
    Michael R M McGuigan
    Department of Exercise and Sport Science, University of Wisconsin La Crosse, La Crosse, WI, USA
    Can J Appl Physiol 27:415-22. 2002
    ..These results indicate that for a needle biopsy different numbers of fibers are needed depending on the fiber type to accurately characterize the mean fiber population...

Research Grants1

  1. Pre-habilitation of Aged and Young Neuromuscular Systems
    MICHAEL DESCHENES; Fiscal Year: 2005
    ....