Christopher A Del Negro

Summary

Affiliation: College of William and Mary
Country: USA

Publications

  1. pmc Physiological and morphological properties of Dbx1-derived respiratory neurons in the pre-Botzinger complex of neonatal mice
    Maria Cristina D Picardo
    Department of Applied Science, McGlothlin Street Hall, Room 318, The College of William and Mary, Williamsburg, VA 23187 8795, USA
    J Physiol 591:2687-703. 2013
  2. pmc Dendritic calcium activity precedes inspiratory bursts in preBotzinger complex neurons
    Christopher A Del Negro
    Department of Applied Science, McGlothlin Street Hall, The College of William and Mary, Williamsburg, Virginia 23187, USA
    J Neurosci 31:1017-22. 2011
  3. pmc Asymmetric control of inspiratory and expiratory phases by excitability in the respiratory network of neonatal mice in vitro
    Christopher A Del Negro
    Systems Neurobiology Laboratory, Department of Neurobiology, David Geffen School of Medicine at the University of California Los Angeles, Box 951763, Los Angeles, CA 90095 1763, USA
    J Physiol 587:1217-31. 2009
  4. pmc A 'group pacemaker' mechanism for respiratory rhythm generation
    Christopher A Del Negro
    Department of Applied Science, The College of William and Mary, Williamsburg, VA 23187 8795, USA
    J Physiol 586:2245-6. 2008
  5. ncbi request reprint What role do pacemakers play in the generation of respiratory rhythm?
    Christopher A Del Negro
    The College of William and Mary, Department of Applied Science, Williamsburg, Virginia, USA
    Adv Exp Med Biol 605:88-93. 2008
  6. ncbi request reprint Sodium and calcium current-mediated pacemaker neurons and respiratory rhythm generation
    Christopher A Del Negro
    Systems Neurobiology Laboratory, Department of Neurobiology, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, California 90095 1763, USA
    J Neurosci 25:446-53. 2005
  7. pmc Inspiratory bursts in the preBötzinger complex depend on a calcium-activated non-specific cation current linked to glutamate receptors in neonatal mice
    Ryland W Pace
    Department of Applied Science, McGlothlin Street Hall, Room 303, The College of William and Mary, Williamsburg, VA 23187 8795, USA
    J Physiol 582:113-25. 2007
  8. pmc Synaptically activated burst-generating conductances may underlie a group-pacemaker mechanism for respiratory rhythm generation in mammals
    Christopher A Del Negro
    Department of Applied Science, McGlothlin Street Hall, The College of William and Mary, Williamsburg, Virginia, USA
    Prog Brain Res 187:111-36. 2010
  9. doi request reprint AMPA and metabotropic glutamate receptors cooperatively generate inspiratory-like depolarization in mouse respiratory neurons in vitro
    Ryland W Pace
    Department of Applied Science, McGlothlin Street Hall, Room 318, The College of William and Mary, Williamsburg, VA 23187 8795, USA
    Eur J Neurosci 28:2434-42. 2008
  10. pmc 4-Aminopyridine-sensitive outward currents in preBötzinger complex neurons influence respiratory rhythm generation in neonatal mice
    John A Hayes
    Department of Applied Science, McGlothlin Street Hall, Room 318, The College of William and Mary, Williamsburg, VA 23187 8795, USA
    J Physiol 586:1921-36. 2008

Research Grants

Collaborators

Detail Information

Publications18

  1. pmc Physiological and morphological properties of Dbx1-derived respiratory neurons in the pre-Botzinger complex of neonatal mice
    Maria Cristina D Picardo
    Department of Applied Science, McGlothlin Street Hall, Room 318, The College of William and Mary, Williamsburg, VA 23187 8795, USA
    J Physiol 591:2687-703. 2013
    ....
  2. pmc Dendritic calcium activity precedes inspiratory bursts in preBotzinger complex neurons
    Christopher A Del Negro
    Department of Applied Science, McGlothlin Street Hall, The College of William and Mary, Williamsburg, Virginia 23187, USA
    J Neurosci 31:1017-22. 2011
    ..These data provide new evidence that respiratory rhythmogenesis may depend on dendritic burst-generating conductances activated in the context of network activity...
  3. pmc Asymmetric control of inspiratory and expiratory phases by excitability in the respiratory network of neonatal mice in vitro
    Christopher A Del Negro
    Systems Neurobiology Laboratory, Department of Neurobiology, David Geffen School of Medicine at the University of California Los Angeles, Box 951763, Los Angeles, CA 90095 1763, USA
    J Physiol 587:1217-31. 2009
    ..We propose that the respiratory network functions over a broad range of frequencies by engaging distinct mechanisms from those controlling inspiratory duration and pattern that specifically govern the interburst interval...
  4. pmc A 'group pacemaker' mechanism for respiratory rhythm generation
    Christopher A Del Negro
    Department of Applied Science, The College of William and Mary, Williamsburg, VA 23187 8795, USA
    J Physiol 586:2245-6. 2008
  5. ncbi request reprint What role do pacemakers play in the generation of respiratory rhythm?
    Christopher A Del Negro
    The College of William and Mary, Department of Applied Science, Williamsburg, Virginia, USA
    Adv Exp Med Biol 605:88-93. 2008
    ..In this group-pacemaker framework, individual pacemaker neurons can be embedded but play the same role as every other network constituent...
  6. ncbi request reprint Sodium and calcium current-mediated pacemaker neurons and respiratory rhythm generation
    Christopher A Del Negro
    Systems Neurobiology Laboratory, Department of Neurobiology, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, California 90095 1763, USA
    J Neurosci 25:446-53. 2005
    ..When I(NaP) and I(CAN) are removed pharmacologically, the rhythm can be maintained by boosting neural excitability, which is inconsistent with a pacemaker-essential mechanism of respiratory rhythmogenesis by the preBotzinger complex...
  7. pmc Inspiratory bursts in the preBötzinger complex depend on a calcium-activated non-specific cation current linked to glutamate receptors in neonatal mice
    Ryland W Pace
    Department of Applied Science, McGlothlin Street Hall, Room 303, The College of William and Mary, Williamsburg, VA 23187 8795, USA
    J Physiol 582:113-25. 2007
    ..We conclude that I(CAN) underlies robust inspiratory drive potentials in preBötC neurons, and is only fully evoked by ionotropic and metabotropic glutamatergic synaptic inputs, i.e. by network activity...
  8. pmc Synaptically activated burst-generating conductances may underlie a group-pacemaker mechanism for respiratory rhythm generation in mammals
    Christopher A Del Negro
    Department of Applied Science, McGlothlin Street Hall, The College of William and Mary, Williamsburg, Virginia, USA
    Prog Brain Res 187:111-36. 2010
    ..Because the cellular burst-generating mechanism is linked to network synaptic drive we dub this type of system a group pacemaker...
  9. doi request reprint AMPA and metabotropic glutamate receptors cooperatively generate inspiratory-like depolarization in mouse respiratory neurons in vitro
    Ryland W Pace
    Department of Applied Science, McGlothlin Street Hall, Room 318, The College of William and Mary, Williamsburg, VA 23187 8795, USA
    Eur J Neurosci 28:2434-42. 2008
    ....
  10. pmc 4-Aminopyridine-sensitive outward currents in preBötzinger complex neurons influence respiratory rhythm generation in neonatal mice
    John A Hayes
    Department of Applied Science, McGlothlin Street Hall, Room 318, The College of William and Mary, Williamsburg, VA 23187 8795, USA
    J Physiol 586:1921-36. 2008
    ....
  11. ncbi request reprint Respiratory rhythm: an emergent network property?
    Christopher A Del Negro
    Systems Neurobiology Laboratory, Department of Neurobiology, University of California Los Angeles, Box 95 1763, 90095, USA
    Neuron 34:821-30. 2002
    ..05) does not affect respiratory rhythm. These results suggest that voltage-dependent bursting in pacemaker neurons is not essential for respiratory rhythmogenesis, which may instead be an emergent network property...
  12. pmc Understanding the rhythm of breathing: so near, yet so far
    Jack L Feldman
    Department of Neurobiology, David Geffen School of Medicine, University of California, Los Angeles, California 90095 1763, USA
    Annu Rev Physiol 75:423-52. 2013
    ....
  13. pmc Phosphatidylinositol 4,5-bisphosphate regulates inspiratory burst activity in the neonatal mouse preBötzinger complex
    Erin A Crowder
    Department of Applied Science, McGlothlin Street Hall, The College of William and Mary, Williamsburg, VA 23187 8795, USA
    J Physiol 582:1047-58. 2007
    ..We propose that PIP(2) protects I(CAN) from rundown by interacting directly with underlying ion channels and preventing desensitization, which may enhance the robustness of respiratory rhythm...
  14. pmc Role of persistent sodium current in mouse preBötzinger Complex neurons and respiratory rhythm generation
    Ryland W Pace
    Department of Applied Science, The College of William and Mary, Williamsburg, VA 23187 8795, USA
    J Physiol 580:485-96. 2007
    ....
  15. pmc Cumulative lesioning of respiratory interneurons disrupts and precludes motor rhythms in vitro
    John A Hayes
    Department of Applied Science, College of William and Mary, Williamsburg, VA 23187 8795, USA
    Proc Natl Acad Sci U S A 109:8286-91. 2012
    ..These results suggest that the preBötC can sustain insults that destroy no more than ≈18% of its constituent interneurons, which may have implications for the onset of respiratory pathologies in disease states...
  16. ncbi request reprint Neurokinin receptor-expressing pre-botzinger complex neurons in neonatal mice studied in vitro
    John A Hayes
    Dept of Applied Science, McGlothlin Street Hall, Rm 303, The College of William and Mary, Williamsburg, VA 23187 8795, USA
    J Neurophysiol 97:4215-24. 2007
    ....
  17. pmc Looking for inspiration: new perspectives on respiratory rhythm
    Jack L Feldman
    Department of Neurobiology, David Geffen School of Medicine at the University of California, Los Angeles, Box 951763, Los Angeles, California 90095 1763, USA
    Nat Rev Neurosci 7:232-42. 2006
    ..Lesion studies suggest that respiratory cell death might explain morbidity and mortality associated with neurodegenerative disorders and ageing...
  18. pmc Automated cell-specific laser detection and ablation of neural circuits in neonatal brain tissue
    Xueying Wang
    Department of Applied Science, McGlothlin Street Hall, Room 318, The College of William and Mary, Williamsburg, VA 23187 8795, USA
    J Physiol 591:2393-401. 2013
    ....

Research Grants1

  1. Neurophysiology of breathing behavior in mammals studied in neonatal mice in vitr
    Christopher A Del Negro; Fiscal Year: 2010
    ..The new knowledge obtained will serve as a foundation for the treatment and prevention of respiratory disorders with a central neural etiology, and elucidate circuit-level properties that underlie rhythmic motor behaviors in general. ..