Research Topics
| M K BoudreauxSummaryAffiliation: College of Veterinary Medicine Country: USA Publications
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Detail Information
Publications
Clinical, biochemical, and molecular aspects of Glanzmann's thrombasthenia in humans and dogsM K Boudreaux
Department of Pathobiology, College of Veterinary Medicine, Auburn University, AL 36849 5519, USA
Vet Pathol 38:249-60. 2001..The following review focuses on the structure and function of this platelet receptor and reviews the molecular, biochemical, and clinical aspects of Glanzmann's thrombasthenia in humans and dogs...- Evaluation of antithrombin-III activity as a coindicator of disseminated intravascular coagulation in cats with induced feline infectious peritonitis virus infectionM K Boudreaux
Department of Pathobiology, College of Veterinary Medicine, Auburn University AL 36849 1159
Am J Vet Res 50:1910-3. 1989..On PID 4 and 16 or 21, results of coagulation screening tests indicated that all cats had disseminated intravascular coagulation. Histologically, cats also had severe fibrinonecrotizing thrombovasculitis... - Molecular and genetic basis for thrombasthenic thrombopathia in otterhoundsM K Boudreaux
Department of Pathobiology, College of Veterinary Medicine, Auburn University, AL 36849-5519, USA
Am J Vet Res 62:1797-804. 2001..CONCLUSIONS AND CLINICAL RELEVANCE: These studies suggest that thrombasthenic thrombopathia of Otterhounds is homologous phenotypically and has a similar molecular basis to type-I Glanzmann's thrombasthenia in humans... - Two genetic defects in alphaIIb are associated with type I Glanzmann's thrombasthenia in a Great Pyrenees dog: a 14-base insertion in exon 13 and a splicing defect of intron 13D L Lipscomb
Department of Pathobiology, College of Veterinary Medicine, Auburn University, AL 36849, USA
Vet Pathol 37:581-8. 2000..A defined molecular basis for canine GT will enhance ongoing gene therapy research and increase the understanding of structure-function relationships of this integrin... - Nucleotide sequence of the canine alphaIIb gene from platelet-derived cDNAD L Lipscomb
Department of Pathobiology, College of Veterinary Medicine, Auburn University, AL 36849, USA
Am J Vet Res 62:1486-92. 2001..To determine the nucleotide sequence of the alphaIIb gene from canine platelet-derived cDNA... - Characterization of the cDNA Encoding alphaIIb and beta3 in normal horses and two horses with Glanzmann thrombastheniaP W Christopherson
Department of Pathobiology, 166 Greene Hall, College of Veterinary Medicine, Auburn University, AL 36849 5519, USA
Vet Pathol 43:78-82. 2006..The subunits are encoded by separate genes and both subunits must be expressed for a stable complex to form on the platelet surface; therefore, a defect in either gene can result in GT... - Platelet function, antithrombin-III activity, and fibrinogen concentration in heartworm-infected and heartworm-negative dogs treated with thiacetarsamideM K Boudreaux
Department of Pathobiology, College of Veterinary Medicine, Auburn University, AL 36849 5519
Am J Vet Res 52:1986-91. 1991..In this study, thiacetarsamide was procagulatory in heartworm-negative dogs and may be an important contributing factor to the thromboembolism observed with adulticidal therapy... - Enhanced platelet reactivity in cats experimentally infected with feline infectious peritonitis virusM K Boudreaux
Auburn University, College of Veterinary Medicine, Department of Pathobiology, AL
Vet Pathol 27:269-73. 1990..Although the mechanism for the enhanced platelet responses observed on day 4 was unknown, a direct effect on the virus on platelets, mononuclear inflammatory cells, and endothelial cells must be considered... - DNA sequence of the canine platelet beta3 gene from cDNA: comparison of canine and mouse beta3 to segments that encode alloantigenic sites and functional domains of beta3 in human beingsD L Lipscomb
Department of Pathobiology, College of Veterinary Medicine, Auburn University, Alabama 36849, USA
J Lab Clin Med 134:313-21. 1999..Knowledge of the beta3 gene nucleotide sequence of normal dogs will facilitate the understanding of platelet alphaIIb beta3 structure-function relationships... - Use of a polymerase chain reaction assay to detect infection with Eperythrozoon wenyoni in cattleJ M Vandervoort
Department of Small Animal Medicine and Surgery, College of Veterinary Medicine, University of Illinois, Urbana 61801, USA
J Am Vet Med Assoc 219:1432-4. 2001..CONCLUSIONS AND CLINICAL RELEVANCE: Results suggest that a PCR assay may be an effective method for detecting E wenyoni infection in cattle and that the PCR assay may be a more sensitive test than evaluation of blood smears... 
Mutation in beta1-tubulin correlates with macrothrombocytopenia in Cavalier King Charles SpanielsB Davis
Department of Pathobiology, Auburn University, AL 36849 5519, USA
J Vet Intern Med 22:540-5. 2008..Cavalier King Charles Spaniels (CKCS) have a high prevalence of inherited macrothrombocytopenia. The purpose of this study was to determine if a mutation in beta1-tubulin correlated with presumptive inherited macrothrombocytopenia...- Calcium diacylglycerol guanine nucleotide exchange factor I (CalDAG-GEFI) gene mutations in a thrombopathic Simmental calfM K Boudreaux
Department of Pathobiology, Auburn University, AL 36849 5519, USA
Vet Pathol 44:932-5. 2007..This change is likely responsible for the thrombopathic phenotype observed in Simmental cattle and underscores the critical nature of this signal transduction protein in platelets...