Research Topics
| Michael ZhangSummaryAffiliation: Cold Spring Harbor Laboratory Country: USA Publications
Research Grants
| Collaborators
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Detail Information
Publications
Development of the human cancer microRNA networkSanghamitra Bandyopadhyay
Machine Intelligence Unit, Indian Statistical Institute, Kolkata, India
Silence 1:6. 2010..However limited attempt has been made to collate this multitude of information and obtain a global perspective of miRNA dysregulation in multiple cancer types...- Identifying combinatorial regulation of transcription factors and binding motifsMamoru Kato
Human Genome Center, Institute of Medical Science, University of Tokyo, 4-6-1 Shirokane-dai, Minato-ku, Tokyo 108-8639, Japan
Genome Biol 5:R56. 2004.... - Genome-wide promoter extraction and analysis in human, mouse, and ratZhenyu Xuan
Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA
Genome Biol 6:R72. 2005.... - Boosting with stumps for predicting transcription start sitesXiaoyue Zhao
Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA
Genome Biol 8:R17. 2007..CoreBoost improves greatly on locating transcription start sites. We also demonstrate that by further utilizing some tissue-specific information, better accuracy can be achieved... - Determination of enriched histone modifications in non-genic portions of the human genomeJeffrey A Rosenfeld
Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
BMC Genomics 10:143. 2009..Chromatin immunoprecipitation followed by high-throughput sequencing (ChIP-seq) has recently been used to identify the modification patterns for the methylation and acetylation of many different histone tails in genes and enhancers... - A highly conserved regulatory element controls hematopoietic expression of GATA-2 in zebrafishZhongan Yang
Department of Molecular, Cell and Developmental Biology, University of California Los Angeles, Los Angeles, California 90095 1606, USA
BMC Dev Biol 7:97. 2007..Identification and characterization of these elements should help elucidating transcription regulatory mechanisms of GATA-2 expression in hematopoietic lineage... - SFSSClass: an integrated approach for miRNA based tumor classificationRamkrishna Mitra
Machine Intelligence Unit, Indian Statistical Institute, Kolkata, India
BMC Bioinformatics 11:S22. 2010..A judicious integration of such knowledge with effective miRNA and sample selection through a biclustering approach could be an important step in improving the accuracy of tumor classification... - Using quality scores and longer reads improves accuracy of Solexa read mappingAndrew D Smith
Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11274, USA
BMC Bioinformatics 9:128. 2008..Two sources of information that are often ignored when mapping reads from the Solexa technology are the 3' ends of longer reads, which contain a much higher frequency of sequencing errors, and the base-call quality scores... - Statistical significance of cis-regulatory modulesDustin E Schones
Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
BMC Bioinformatics 8:19. 2007..While various algorithms for this purpose have been introduced, most are not well suited for rapid, genome scale scanning... - Profiling alternatively spliced mRNA isoforms for prostate cancer classificationChaolin Zhang
Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
BMC Bioinformatics 7:202. 2006..Here, we investigate the advantage of using splice isoforms, which couple transcriptional and splicing regulation, for cancer classification... - Extracting functional information from microarrays: a challenge for functional genomicsMichael Q Zhang
Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA
Proc Natl Acad Sci U S A 99:12509-11. 2002 
Computational prediction of eukaryotic protein-coding genesMichael Q Zhang
Watson School of Biological Sciences, Cold Spring Harbor Laboratory, 1 Bungtown Road, PO Box 100, Cold Spring Harbor, New York 11724, USA
Nat Rev Genet 3:698-709. 2002..Here, I discuss these approaches and explain why they have become essential for the analyses of newly sequenced genomes...- Predicting methylation status of CpG islands in the human brainFang Fang
Bioinformatics Division, TNLIST, Department of Automation, Tsinghua University 100084 China
Bioinformatics 22:2204-9. 2006..AVAILABILITY: An online predictor based on MethCGI is available at http://166.111.201.7/MethCGI.html CONTACT: SUPPLEMENTARY INFORMATION: Supplementary data available at Bioinformatics online and http://166.111.201.7/help.html... - Tissue-specific regulatory elements in mammalian promotersAndrew D Smith
Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
Mol Syst Biol 3:73. 2007..In a broader context, methods used to construct the catalog provide a model for the analysis of genomic regions that regulate differentially expressed genes... - Adaptively inferring human transcriptional subnetworksDebopriya Das
Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, NY 11274, USA
Mol Syst Biol 2:2006.0029. 2006.... - DWE: discriminating word enumeratorPavel Sumazin
Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA
Bioinformatics 21:31-8. 2005..Tissue-specific transcription factor binding sites give insight into tissue-specific transcription regulation... - Interacting models of cooperative gene regulationDebopriya Das
Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
Proc Natl Acad Sci U S A 101:16234-9. 2004..We believe our multivariate adaptive regression splines-based approach will become more significant when applied to higher eukaryotes, especially mammals, where cooperative control of gene regulation is absolutely essential... - TRED: a Transcriptional Regulatory Element Database and a platform for in silico gene regulation studiesFang Zhao
Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA
Nucleic Acids Res 33:D103-7. 2005..TRED can provide good training datasets for further genome-wide cis-regulatory element prediction and annotation, assist detailed functional studies and facilitate the decipher of gene regulatory networks (http://rulai.cshl.edu/TRED)... - Transcription factor binding element detection using functional clustering of mutant expression dataGengxin Chen
Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA
Nucleic Acids Res 32:2362-71. 2004..Functional clustering included in our approach may also provide new insights into the function of the relevant transcription factor... - GFScan: a gene family search tool at genomic DNA levelZhenyu Xuan
Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA
Genome Res 12:1142-9. 2002..We also showed that motifs constructed based on human genes could be used to search the mouse genome to identify orthologous family members in mouse. This program is available at http://www.cshl.org/mzhanglab/... - Distribution of SR protein exonic splicing enhancer motifs in human protein-coding genesJinhua Wang
Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA
Nucleic Acids Res 33:5053-62. 2005..Our results underline the importance of ESE-mediated SR protein function in the process of exon definition, in the context of both constitutive splicing and regulated alternative splicing... - Computational comparison of two mouse draft genomes and the human golden pathZhenyu Xuan
Cold Spring Harbor Laboratory, New York, NY 11724, USA
Genome Biol 4:R1. 2003..From the CSEs, we estimate the total number of human protein-coding genes to be about 40,000. This searchable publicly available online CSEdb will expedite new discoveries through comparative genomics... - Using CorePromoter to find human core promotersMichael Q Zhang
Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, USA
Curr Protoc Bioinformatics . 2005..The protocols in this unit introduce its basic methodology and discuss how to apply it to a sample problem in conjunction with other gene-finding programs... - Computational analyses of eukaryotic promotersMichael Q Zhang
Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA
BMC Bioinformatics 8:S3. 2007..More details may be found in the extended references. This review is based on a summer lecture given at Max Planck Institute at Berlin in 2005... - The mouse genome: experimental examination of gene predictions and transcriptional start sitesSujit Dike
Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA
Genome Res 14:2424-9. 2004..This approach can be a useful tool in the ongoing efforts to increase the quality of gene annotations, especially transcriptional start sites, in complex genomes... - High definition profiling of mammalian DNA methylation by array capture and single molecule bisulfite sequencingEmily Hodges
Watson School of Biological Sciences, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA
Genome Res 19:1593-605. 2009..Methylation, along with specific histone marks, was enriched in exonic regions, suggesting that chromatin states can foreshadow the content of mature mRNAs... - An increased specificity score matrix for the prediction of SF2/ASF-specific exonic splicing enhancersPhilip J Smith
Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA
Hum Mol Genet 15:2490-508. 2006..Finally, we have derived an increased specificity score matrix that incorporates information from both of our SF2/ASF-specific matrices and that accurately predicts the exon-skipping phenotypes of deleterious point mutations... - Mining ChIP-chip data for transcription factor and cofactor binding sitesAndrew D Smith
Cold Spring Harbor Laboratory 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA
Bioinformatics 21:i403-12. 2005..Identification of single motifs and motif pairs that can be used to predict transcription factor localization in ChIP-chip data, and gene expression in tissue-specific microarray data... - Similarity of position frequency matrices for transcription factor binding sitesDustin E Schones
Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA
Bioinformatics 21:307-13. 2005..The ability to compare PFMs representing binding sites is especially important for de novo sequence motif discovery, where it is desirable to compare putative matrices to one another and to known matrices... - Identifying cooperativity among transcription factors controlling the cell cycle in yeastNilanjana Banerjee
Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA
Nucleic Acids Res 31:7024-31. 2003..This study is an example of how systematic combination of diverse data types along with new functional genomic approaches can provide a rigorous platform to map TF interactions more efficiently... - Direct coupling of the cell cycle and cell death machinery by E2FZaher Nahle
Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
Nat Cell Biol 4:859-64. 2002..The data also underscore how cell cycle progression can be coupled to the apoptotic machinery... - Putative zinc finger protein binding sites are over-represented in the boundaries of methylation-resistant CpG islands in the human genomeShicai Fan
MOE Key Laboratory of Bioinformatics and Bioinformatics Division, TNLIST, Department of Automation, Tsinghua University, Beijing 100084, China
PLoS ONE 2:e1184. 2007..Understanding about mechanisms that may lead to the methylation resistance of CpG islands is still very poor... - ESEfinder: A web resource to identify exonic splicing enhancersLuca Cartegni
Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
Nucleic Acids Res 31:3568-71. 2003.... - Evolutionary impact of limited splicing fidelity in mammalian genesChaolin Zhang
Cold Spring Harbor Laboratory, NY 11724, USA
Trends Genet 23:484-8. 2007..These results suggest AS events introducing mild changes are generally favored during evolution and explain the excess of shorter, frame-preserving cassette exons in present mammalian genomes... - A clustering property of highly-degenerate transcription factor binding sites in the mammalian genomeChaolin Zhang
Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA
Nucleic Acids Res 34:2238-46. 2006..We propose that this arrangement provides a favorable genomic landscape for functional target site selection... - From worm to human: bioinformatics approaches to identify FOXO target genesZhenyu Xuan
Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA
Mech Ageing Dev 126:209-15. 2005..Here we demonstrate how to identify FOXO target genes and their potential cis-regulatory binding sites in the promoters via bioinformatics approaches. These results provide new testable hypotheses for further experimental verifications... - Identifying tissue-selective transcription factor binding sites in vertebrate promotersAndrew D Smith
Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11274, USA
Proc Natl Acad Sci U S A 102:1560-5. 2005.... - Computational prediction of methylation status in human genomic sequencesRajdeep Das
Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
Proc Natl Acad Sci U S A 103:10713-6. 2006..Using hdfinder, we have depicted the entire genomic methylation patterns for all 22 human autosomes... - Regulating gene expression through RNA nuclear retentionKannanganattu V Prasanth
Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA
Cell 123:249-63. 2005..This mechanism of action highlights an important paradigm for the role of a nuclear-retained stable RNA transcript in regulating gene expression... - Neural potential of a stem cell population in the hair follicleJohn L Mignone
Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA
Cell Cycle 6:2161-70. 2007..Our results show that nestin-expressing cells in the bulge region of the hair follicle have stem cell-like properties, are multipotent, and can effectively generate cells of neural lineage in vitro and in vivo... - Identification of synaptic targets of Drosophila pumilioGengxin Chen
Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, USA
PLoS Comput Biol 4:e1000026. 2008..Finally, we show that the endogenous dlg1 mRNA can be regulated by Pumilio in a neuronal context, the adult mushroom bodies (MB), which is an anatomical site of memory storage... - DNA motifs in human and mouse proximal promoters predict tissue-specific expressionAndrew D Smith
Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA
Proc Natl Acad Sci U S A 103:6275-80. 2006..The identification in proximal promoters of cis-regulatory modules with tissue-specific activity lays the groundwork for complete characterization and deciphering of cis-regulatory DNA code in mammalian genomes... - Functional genomics as applied to mapping transcription regulatory networksNila Banerjee
Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA
Curr Opin Microbiol 5:313-7. 2002..We focus in particular on the budding yeast Saccharomyces cerevisiae... - Defining the regulatory network of the tissue-specific splicing factors Fox-1 and Fox-2Chaolin Zhang
Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA
Genes Dev 22:2550-63. 2008..We also identified instances of binding site creation or loss in different vertebrate lineages and human populations, which likely reflect fine-tuning of gene expression regulation during evolution... - Dual-specificity splice sites function alternatively as 5' and 3' splice sitesChaolin Zhang
Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA
Proc Natl Acad Sci U S A 104:15028-33. 2007..We discuss the implications of this unusual splicing pattern for the diverse mechanisms of exon recognition and for gene evolution... - Critical roles for Dicer in the female germlineElizabeth P Murchison
Cold Spring Harbor Laboratory, Watson School of Biological Sciences and Howard Hughes Medical Institute, Cold Spring Harbor, New York 11724, USA
Genes Dev 21:682-93. 2007..Our studies identify Dicer as central to a regulatory network that controls oocyte gene expression programs and that promotes genomic integrity in a cell type notoriously susceptible to aneuploidy... - RNA landscape of evolution for optimal exon and intron discriminationChaolin Zhang
Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA
Proc Natl Acad Sci U S A 105:5797-802. 2008..Our results suggest that human genes have been optimized for exon and intron discrimination through an RNA landscape shaped during evolution... - Genome-wide mapping and analysis of active promoters in mouse embryonic stem cells and adult organsLeah O Barrera
Ludwig Institute for Cancer Research, UCSD School of Medicine, La Jolla, California 92093 0653, USA
Genome Res 18:46-59. 2008..Our results provide a resource for exploring promoter Polr2a binding and epigenetic states across pluripotent and differentiated cell types in mammals... - Combinatorial patterns of histone acetylations and methylations in the human genomeZhibin Wang
Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, US National Institutes of Health, Bethesda, Maryland 20892, USA
Nat Genet 40:897-903. 2008..Our data suggest that these histone modifications may act cooperatively to prepare chromatin for transcriptional activation... - ZOOM! Zillions of oligos mappedHao Lin
Institute for Computing Technology, Chinese Academy of Sciences, Beijing, China
Bioinformatics 24:2431-7. 2008..Resequencing and personalized medicine need much faster software to map these deep sequencing reads to a reference genome, to identify SNPs or rare transcripts... - Network-based global inference of human disease genesXuebing Wu
MOE Key Laboratory of Bioinformatics and Bioinformatics Division, TNLIST Department of Automation, Tsinghua University, Beijing, China
Mol Syst Biol 4:189. 2008.... - Poly A- transcripts expressed in HeLa cellsQingfa Wu
Center for Functional Genomics, Division of Medical Genetics, Department of Medicine, ENH Research Institute, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America
PLoS ONE 3:e2803. 2008..Most transcripts identified so far are poly A+ transcripts, whereas the poly A- transcripts remain largely unknown... - Histone methylation marks play important roles in predicting the methylation status of CpG islandsShicai Fan
MOE Key Laboratory of Bioinformatics and Bioinformatics Division, TNLIST Department of Automation, Tsinghua University, FIT Building 1 107, Beijing 100084, China
Biochem Biophys Res Commun 374:559-64. 2008..And the established open environment may be a prerequisite for or a consequence of the function implementation of zinc finger proteins that could protect CpG islands from DNA methylation... - Scanning the human genome at kilobase resolutionJun Chen
Center for Functional Genomics, Division of Medical Genetics, Department of Medicine, ENH Research Institute, Northwestern University, Evanston, Illinois 60201, USA
Genome Res 18:751-62. 2008.... - Interferon regulatory factors are transcriptional regulators of adipogenesisJun Eguchi
Division of Endocrinology and Metabolism, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
Cell Metab 7:86-94. 2008..This analysis suggests an important role for IRF proteins in adipocyte biology and demonstrates the utility of this approach in identifying cis- and trans-acting factors not previously suspected to participate in adipogenesis... - A global transcriptional regulatory role for c-Myc in Burkitt's lymphoma cellsZirong Li
Ludwig Institute for Cancer Research, University of California at San Diego School of Medicine, 9500 Gilman Drive, La Jolla, CA 92093 0653, USA
Proc Natl Acad Sci U S A 100:8164-9. 2003..Taken together, these results suggest a general role for overexpressed c-Myc in global transcriptional regulation in some cancer cells and point toward molecular mechanisms for c-Myc function in malignant transformation... - Evidence and characteristics of putative human alpha recombination hotspotsJing Zhang
MOE Key Laboratory of Bioinformatics, Department of Automation, Tsinghua University, Bejing, China
Hum Mol Genet 13:2823-8. 2004..These long-sought putative human alpha recombination hotspots should deserve further experimental investigations... - Genome-wide prediction and analysis of function-specific transcription factor binding sitesFan Long
Aventis Pharmaceuticals Inc, Route 202 206, Bridgewater, NJ 08807, USA
In Silico Biol 4:395-410. 2004..Our tools and analysis provide a new resource for deciphering transcription regulation in different biological paradigms... - Large-scale structure of genomic methylation patternsRobert A Rollins
Department of Genetics and Development, College of Physicians and Surgeons of Columbia University, Columbia University, New York, NY 10032, USA
Genome Res 16:157-63. 2006..This suggestion is compatible with the finding that cytosine methylation is universal among large-genome eukaryotes, while many eukaryotes with genome sizes <5 x 10(8) bp do not methylate their DNA... - A new method for detecting human recombination hotspots and its applications to the HapMap ENCODE dataJun Li
Bioinformatics Division, Tsinghua National Laboratory for Information Science and Technology, Tsinghua University, Beijing 100084, China
Am J Hum Genet 79:628-39. 2006..In particular, we observed that DNaseI-hypersensitive sites are enriched in hotspots, suggesting the existence of human beta hotspots similar to those found in yeast... - Computational prediction of novel components of lung transcriptional networksM Juanita Martinez
Lovelace Respiratory Research Institute, 2425 Ridgecrest Dr SE, Albuquerque, NM 87108, USA
Bioinformatics 23:21-9. 2007..Little is known regarding the transcriptional mechanisms involved in forming and maintaining epithelial cell lineages of the mammalian respiratory tract... - Pan-genome isolation of low abundance transcripts using SAGE tagYeong Cheol Kim
Center for Functional Genomics, Division of Medical Genetics, Department of Medicine, ENH Research Institute, Northwestern University, Evanston, IL 60201, USA
FEBS Lett 580:6721-9. 2006..Our study shows the prevalence of novel low abundance transcripts that can be isolated efficiently through SAGE tags mis-priming... - Computing exact P-values for DNA motifsJing Zhang
State Key Laboratory of Intelligent Technology and System, Department of Computer Science and Technology, Tsinghua University, Beijing 100084, China
Bioinformatics 23:531-7. 2007..They often significantly deviate from the true P-value by orders of magnitude. Exact P-value computation is needed for ranking the motifs. Furthermore, surprisingly, the complexity of the problem is unknown... - Analysis of the vertebrate insulator protein CTCF-binding sites in the human genomeTae Hoon Kim
Ludwig Institute for Cancer Research, Department of Cellular and Molecular Medicine, University of California, San Diego School of Medicine, La Jolla, CA 92093 0653, USA
Cell 128:1231-45. 2007..In addition, CTCF localization is largely invariant across different cell types. Our results provide a resource for investigating insulator function and possible other general and evolutionarily conserved activities of CTCF sites... - Predictive models of gene regulation: application of regression methods to microarray dataDebopriya Das
Lawrence Berkeley National Laboratory, Berkeley, CA, USA
Methods Mol Biol 377:95-110. 2007..Periodic regulation of the cell cycle, connection with underlying energetics, and the inference of combinatorial logic are also discussed. An implementation based on regression splines is discussed in detail... - OSCAR: one-class SVM for accurate recognition of cis-elementsBo Jiang
MOE Key Laboratory of Bioinformatics, Bioinformatics Division, TNLIST Department of Automation, Tsinghua University, Beijing 100084, China
Bioinformatics 23:2823-8. 2007..Recent biological and computational researches, however, suggest that there exist not only locational preferences of binding, but also correlations between transcription factors... - Prediction of transcription start sites based on feature selection using AMOSAXi Wang
Bioinformatics Division, TNLIST and Department of Automation, Tsinghua Univ, Beijing 100084, China
Comput Syst Bioinformatics Conf 6:183-93. 2007..This system is found to be comparable to, often better than, several existing methods in terms of different quantitative performance measures... - Identification of phylogenetically conserved microRNA cis-regulatory elements across 12 Drosophila speciesXiaowo Wang
MOE Key Laboratory of Bioinformatics and Bioinformatics Division, TNLIST Department of Automation, Tsinghua University, Beijing 100084, China
Bioinformatics 24:165-71. 2008..MicroRNAs are a class of endogenous small RNAs that play regulatory roles. Intergenic miRNAs are believed to be transcribed independently, but the transcriptional control of these crucial regulators is still poorly understood... - Gene expression profiling in developing human hippocampusYan Zhang
Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China
J Neurosci Res 70:200-8. 2002....
Research Grants
- Computational and experimental modeling of RNA SplicingMichael Zhang; Fiscal Year: 2009....
- Computational Modeling of Mammalian PromotersMichael Zhang; Fiscal Year: 2009..Such models are likely to offer new insights into mechanisms of gene regulation or mis-regulation, and will generate many hypotheses for further functional studies on global regulation of gene expression. ..
- IDENTIFICATION OF PROTEIN CODING GENES IN HUMAN GENOMESMichael Zhang; Fiscal Year: 2005..The methods and tools resulting from this project will help molecular biologists to find human genes and to interpret the structures/functions more efficiently and more accurately. ..
- IDENTIFICATION OF PROTEIN CODING GENES IN HUMAN GENOMESMichael Zhang; Fiscal Year: 2002..The investigators predict that methods and tools resulting from this project will help molecular biologists to find human genes and to interpret the structures/functions more efficiently and more accurately. ..
- COMPUTATIONAL ANALYSIS OF GENOME EXPRESSION DATAMichael Zhang; Fiscal Year: 2002..abstract_text> ..
- PROTEIN CODING GENES IN THE HUMAN GENOMEMichael Zhang; Fiscal Year: 1999..The methods and tools resulting from this project will help molecular biologists to find human genes and to interpret the structure/functions more quickly and accurately. ..
- Computational and experimental modeling of RNA SplicingMichael Zhang; Fiscal Year: 2009....