Anthony M Zador

Summary

Affiliation: Cold Spring Harbor Laboratory
Country: USA

Publications

  1. pmc Corticostriatal neurons in auditory cortex drive decisions during auditory discrimination
    Petr Znamenskiy
    Watson School of Biological Sciences, Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA
    Nature 497:482-5. 2013
  2. pmc PINP: a new method of tagging neuronal populations for identification during in vivo electrophysiological recording
    Susana Q Lima
    Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, USA
    PLoS ONE 4:e6099. 2009
  3. pmc Sequencing the connectome
    Anthony M Zador
    Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, United States of America
    PLoS Biol 10:e1001411. 2012
  4. pmc Long-lasting context dependence constrains neural encoding models in rodent auditory cortex
    Hiroki Asari
    Cold Spring Harbor Laboratory, Watson School of Biological Sciences, Cold Spring Harbor, New York 11724, USA
    J Neurophysiol 102:2638-56. 2009
  5. pmc Sparse representation of sounds in the unanesthetized auditory cortex
    Tomás Hromádka
    Cold Spring Harbor Laboratory, Watson School of Biological Sciences, Cold Spring Harbor, New York, United States of America
    PLoS Biol 6:e16. 2008
  6. pmc Engaging in an auditory task suppresses responses in auditory cortex
    Gonzalo H Otazu
    Cold Spring Harbor, New York, USA
    Nat Neurosci 12:646-54. 2009
  7. ncbi request reprint Non-Gaussian membrane potential dynamics imply sparse, synchronous activity in auditory cortex
    Michael R Deweese
    Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA
    J Neurosci 26:12206-18. 2006
  8. pmc Differences in sensitivity to neural timing among cortical areas
    Yang Yang
    Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA
    J Neurosci 32:15142-7. 2012
  9. pmc The functional asymmetry of auditory cortex is reflected in the organization of local cortical circuits
    HYSELL V OVIEDO
    Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, USA
    Nat Neurosci 13:1413-20. 2010
  10. pmc Representations in auditory cortex
    Tomás Hromádka
    Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA
    Curr Opin Neurobiol 19:430-3. 2009

Collaborators

Detail Information

Publications25

  1. pmc Corticostriatal neurons in auditory cortex drive decisions during auditory discrimination
    Petr Znamenskiy
    Watson School of Biological Sciences, Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA
    Nature 497:482-5. 2013
    ..Striatal projections are widespread in cortex and may provide a general mechanism for the control of motor decisions by sensory cortex...
  2. pmc PINP: a new method of tagging neuronal populations for identification during in vivo electrophysiological recording
    Susana Q Lima
    Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, USA
    PLoS ONE 4:e6099. 2009
    ..PINP can be readily extended to other populations of genetically identifiable neurons, and will provide a useful method for probing the functional role of different neuronal populations in vivo...
  3. pmc Sequencing the connectome
    Anthony M Zador
    Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, United States of America
    PLoS Biol 10:e1001411. 2012
    ..An inexpensive high-throughput technique for establishing circuit connectivity at single neuron resolution could transform neuroscience research...
  4. pmc Long-lasting context dependence constrains neural encoding models in rodent auditory cortex
    Hiroki Asari
    Cold Spring Harbor Laboratory, Watson School of Biological Sciences, Cold Spring Harbor, New York 11724, USA
    J Neurophysiol 102:2638-56. 2009
    ....
  5. pmc Sparse representation of sounds in the unanesthetized auditory cortex
    Tomás Hromádka
    Cold Spring Harbor Laboratory, Watson School of Biological Sciences, Cold Spring Harbor, New York, United States of America
    PLoS Biol 6:e16. 2008
    ..Our results are compatible with a model in which most neurons are silent much of the time, and in which representations are composed of small dynamic subsets of highly active neurons...
  6. pmc Engaging in an auditory task suppresses responses in auditory cortex
    Gonzalo H Otazu
    Cold Spring Harbor, New York, USA
    Nat Neurosci 12:646-54. 2009
    ..Instead, the engaged condition possesses a characteristic and distinct neural signature in which sound-evoked responses are paradoxically suppressed...
  7. ncbi request reprint Non-Gaussian membrane potential dynamics imply sparse, synchronous activity in auditory cortex
    Michael R Deweese
    Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA
    J Neurosci 26:12206-18. 2006
    ..These dynamics suggest a computational scheme in which spike timing is controlled by concerted firing among input neurons rather than by small fluctuations in a sea of background activity...
  8. pmc Differences in sensitivity to neural timing among cortical areas
    Yang Yang
    Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA
    J Neurosci 32:15142-7. 2012
    ..Our results suggest that different cortical areas are adapted to the specific structure of the input signals they process, and that precise spike timing may play a more important role for some cortical areas than for others...
  9. pmc The functional asymmetry of auditory cortex is reflected in the organization of local cortical circuits
    HYSELL V OVIEDO
    Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, USA
    Nat Neurosci 13:1413-20. 2010
    ..Our results are consistent with the hypothesis that auditory cortical microcircuitry is specialized to the one-dimensional representation of frequency in the auditory cortex...
  10. pmc Representations in auditory cortex
    Tomás Hromádka
    Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA
    Curr Opin Neurobiol 19:430-3. 2009
    ..Whether the ability of auditory cortex to exploit fine temporal differences in cortical activity is unique to auditory modality, or represents a general strategy used by cortical circuits remains an open question...
  11. pmc Millisecond-scale differences in neural activity in auditory cortex can drive decisions
    Yang Yang
    Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA
    Nat Neurosci 11:1262-3. 2008
    ..We used chronically implanted microelectrode pairs to stimulate neurons in the rat auditory cortex directly and found that rats can exploit differences in the timing of cortical activity that are as short as 3 ms to guide decisions...
  12. pmc Up states are rare in awake auditory cortex
    Tomás Hromádka
    Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, USA
    J Neurophysiol 109:1989-95. 2013
    ..We suggest that the near absence of long up states in awake auditory cortex may reflect an adaptation to the rapid processing of auditory stimuli...
  13. pmc The auditory cortex mediates the perceptual effects of acoustic temporal expectation
    Santiago Jaramillo
    Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, USA
    Nat Neurosci 14:246-51. 2011
    ..Our results indicate that changes in neuronal representation as early as primary sensory cortex mediate the perceptual advantage conferred by temporal expectation...
  14. pmc Auditory thalamus and auditory cortex are equally modulated by context during flexible categorization of sounds
    Santiago Jaramillo
    Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724
    J Neurosci 34:5291-301. 2014
    ..Our results suggest that the AC and thalamus play only a limited role in mediating changes in associations between acoustic stimuli and behavioral responses. ..
  15. pmc Toward the mechanisms of auditory attention
    Tomás Hromádka
    Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
    Hear Res 229:180-5. 2007
    ..Here we present our program for studying auditory attention, specifically for development of rodent models of attention and finding the neural correlates of attention...
  16. ncbi request reprint Reliability and representational bandwidth in the auditory cortex
    Michael R Deweese
    Cold Spring Harbor Laboratory, Watson School of Biological Sciences, Cold Spring Harbor, New York 11724, USA
    Neuron 48:479-88. 2005
    ....
  17. ncbi request reprint Synaptic mechanisms of forward suppression in rat auditory cortex
    Michael Wehr
    Cold Spring Harbor Laboratory, New York 11724, USA
    Neuron 47:437-45. 2005
    ....
  18. pmc Correlated connectivity and the distribution of firing rates in the neocortex
    Alexei A Koulakov
    Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA
    J Neurosci 29:3685-94. 2009
    ..Our results represent a first step toward reconciling sparse activity and sparse connectivity in cortical networks...
  19. ncbi request reprint Shared and private variability in the auditory cortex
    Michael R Deweese
    Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA
    J Neurophysiol 92:1840-55. 2004
    ....
  20. ncbi request reprint Linearity of cortical receptive fields measured with natural sounds
    Christian K Machens
    Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA
    J Neurosci 24:1089-100. 2004
    ..Rather, the highly nonlinear response properties of auditory cortical neurons must be attributable to nonlinear interactions between sound frequencies and time-varying properties of the neural encoder...
  21. ncbi request reprint Sparse representations for the cocktail party problem
    Hiroki Asari
    Watson School of Biological Sciences, Cold Spring Harbor, New York 11724, USA
    J Neurosci 26:7477-90. 2006
    ....
  22. ncbi request reprint Balanced inhibition underlies tuning and sharpens spike timing in auditory cortex
    Michael Wehr
    Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA
    Nature 426:442-6. 2003
    ..Balanced inhibition might thus serve to increase the temporal precision and thereby reduce the randomness of cortical operation, rather than to increase noise as has been proposed previously...
  23. pmc PTEN regulation of local and long-range connections in mouse auditory cortex
    Qiaojie Xiong
    Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA
    J Neurosci 32:1643-52. 2012
    ..Together, our results suggest that local and long-range hyperconnectivity may constitute a physiological basis for the effects of mutations in PTEN and possibly other ASD candidate genes...
  24. ncbi request reprint Neural gallops across auditory streams
    Michael R Deweese
    Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA
    Neuron 48:5-7. 2005
    ..In this issue of Neuron, Micheyl et al. provide the most direct evidence to date linking single-unit spiking responses from auditory cortex to the perception of distinct auditory streams...
  25. ncbi request reprint Binary spiking in auditory cortex
    Michael R Deweese
    Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA
    J Neurosci 23:7940-9. 2003
    ....

Research Grants11

  1. Functional microcircuitry underlying sound processing in the primary auditory cor
    Anthony Zador; Fiscal Year: 2009
    ..If successful, our studies will lead to improved strategies for diagnosing and treating these and related disorders. ..
  2. Stimulus-evoked responses in the auditory cortex
    Anthony Zador; Fiscal Year: 2003
    ..In particular, we will make extensive use of in vivo whole cell patch clamp recording, a powerful technique we have successfully adapted to the rat primary auditory cortex. ..
  3. Functional microcircuitry underlying sound processing in the primary auditory cor
    Anthony M Zador; Fiscal Year: 2010
    ..If successful, our studies will lead to improved strategies for diagnosing and treating these and related disorders. ..
  4. Functional microcircuitry underlying sound processing in the primary auditory cor
    Anthony Zador; Fiscal Year: 2009
    ..If successful, our studies will lead to improved strategies for diagnosing and treating these and related disorders. ..
  5. Stimulus-evoked responses in the auditory cortex
    Anthony Zador; Fiscal Year: 2007
    ..In particular, we will make extensive use of in vivo whole cell patch clamp recording, a powerful technique we have successfully adapted to the rat primary auditory cortex. ..
  6. Stimulus-evoked responses in the auditory cortex
    Anthony Zador; Fiscal Year: 2006
    ..In particular, we will make extensive use of in vivo whole cell patch clamp recording, a powerful technique we have successfully adapted to the rat primary auditory cortex. ..
  7. High-throughput DNA sequencing method for probing the connectivity of neural circ
    Anthony M Zador; Fiscal Year: 2010
    ..We propose to develop a method for identifying these connections in animal models of disease. Our method will have a profound impact on understanding the causes of these diseases. ..