A J Silva

Summary

Affiliation: Cold Spring Harbor Laboratory
Country: USA

Publications

  1. ncbi CREB and memory
    A J Silva
    Cold Spring Harbor Laboratory, Harbor, New York 11724, USA
    Annu Rev Neurosci 21:127-48. 1998
  2. ncbi A mouse model for the learning and memory deficits associated with neurofibromatosis type I
    A J Silva
    Cold Spring Harbor Laboratory, New York 11724, USA
    Nat Genet 15:281-4. 1997
  3. ncbi Impaired learning in mice with abnormal short-lived plasticity
    A J Silva
    Cold Spring Harbor Laboratory, New York 11724, USA
    Curr Biol 6:1509-18. 1996
  4. ncbi Hippocampus-dependent learning and memory is impaired in mice lacking the Ras-guanine-nucleotide releasing factor 1 (Ras-GRF1)
    K P Giese
    Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
    Neuropharmacology 41:791-800. 2001
  5. ncbi Spaced training induces normal long-term memory in CREB mutant mice
    J H Kogan
    Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA
    Curr Biol 7:1-11. 1997
  6. ncbi Reduced K+ channel inactivation, spike broadening, and after-hyperpolarization in Kvbeta1.1-deficient mice with impaired learning
    K P Giese
    Cold Spring Harbor Laboratory, New York 11724, USA
    Learn Mem 5:257-73. 1998
  7. ncbi Autophosphorylation at Thr286 of the alpha calcium-calmodulin kinase II in LTP and learning
    K P Giese
    Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
    Science 279:870-3. 1998
  8. ncbi Deficient long-term memory in mice with a targeted mutation of the cAMP-responsive element-binding protein
    R Bourtchuladze
    Cold Spring Harbor Laboratory, New York 11724
    Cell 79:59-68. 1994
  9. ncbi Learning deficits, but normal development and tumor predisposition, in mice lacking exon 23a of Nf1
    R M Costa
    Departments of Neurobiology, Psychiatry and Psychology, BRI, UCLA, Los Angeles, California, USA
    Nat Genet 27:399-405. 2001
  10. ncbi Alpha-CaMKII-dependent plasticity in the cortex is required for permanent memory
    P W Frankland
    Departments of Neurobiology, Psychiatry and Psychology, Brain Research Institute, University of California, Los Angeles, California 90095 1761, USA
    Nature 411:309-13. 2001

Collaborators

Detail Information

Publications27

  1. ncbi CREB and memory
    A J Silva
    Cold Spring Harbor Laboratory, Harbor, New York 11724, USA
    Annu Rev Neurosci 21:127-48. 1998
    ....
  2. ncbi A mouse model for the learning and memory deficits associated with neurofibromatosis type I
    A J Silva
    Cold Spring Harbor Laboratory, New York 11724, USA
    Nat Genet 15:281-4. 1997
    ....
  3. ncbi Impaired learning in mice with abnormal short-lived plasticity
    A J Silva
    Cold Spring Harbor Laboratory, New York 11724, USA
    Curr Biol 6:1509-18. 1996
    ....
  4. ncbi Hippocampus-dependent learning and memory is impaired in mice lacking the Ras-guanine-nucleotide releasing factor 1 (Ras-GRF1)
    K P Giese
    Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
    Neuropharmacology 41:791-800. 2001
    ..These studies indicate that Ras-GRF1 plays a role in hippocampal-dependent learning and memory...
  5. ncbi Spaced training induces normal long-term memory in CREB mutant mice
    J H Kogan
    Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA
    Curr Biol 7:1-11. 1997
    ..Interestingly, studies with cultured Aplysia neurons indicated that removing a CREB repressor promoted the formation of long-term facilitation, a cellular model of non-associative memory...
  6. ncbi Reduced K+ channel inactivation, spike broadening, and after-hyperpolarization in Kvbeta1.1-deficient mice with impaired learning
    K P Giese
    Cold Spring Harbor Laboratory, New York 11724, USA
    Learn Mem 5:257-73. 1998
    ..1 subunit contributes to certain types of learning and memory...
  7. ncbi Autophosphorylation at Thr286 of the alpha calcium-calmodulin kinase II in LTP and learning
    K P Giese
    Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
    Science 279:870-3. 1998
    ..Thus, the autophosphorylation of alphaCaMKII at Thr286 appears to be required for LTP and learning...
  8. ncbi Deficient long-term memory in mice with a targeted mutation of the cAMP-responsive element-binding protein
    R Bourtchuladze
    Cold Spring Harbor Laboratory, New York 11724
    Cell 79:59-68. 1994
    ..However, paired-pulse facilitation and posttetanic potentiation are normal. These results implicate CREB-dependent transcription in mammalian long-term memory...
  9. ncbi Learning deficits, but normal development and tumor predisposition, in mice lacking exon 23a of Nf1
    R M Costa
    Departments of Neurobiology, Psychiatry and Psychology, BRI, UCLA, Los Angeles, California, USA
    Nat Genet 27:399-405. 2001
    ..Our findings have implications for the development of a treatment for the learning disabilities associated with NF1 and indicate that the GAP domain of NF1 modulates learning and memory...
  10. ncbi Alpha-CaMKII-dependent plasticity in the cortex is required for permanent memory
    P W Frankland
    Departments of Neurobiology, Psychiatry and Psychology, Brain Research Institute, University of California, Los Angeles, California 90095 1761, USA
    Nature 411:309-13. 2001
    ....
  11. ncbi The CRE/CREB pathway is transiently expressed in thalamic circuit development and contributes to refinement of retinogeniculate axons
    T A Pham
    Department of Psychiatry and Behavioral Sciences, Graduate Program in Neurobiology and Behavior, University of Washington School of Medicine, Seattle, WA 98195, USA
    Neuron 31:409-20. 2001
    ..These results suggest an important role of the CRE/CREB transcriptional pathway in the coordination of experience-independent circuit remodeling during forebrain development...
  12. ncbi Abnormal hippocampal spatial representations in alphaCaMKIIT286A and CREBalphaDelta- mice
    Y H Cho
    Department of Psychology, Boston University, Boston, MA 02215, USA
    Science 279:867-9. 1998
    ..Thus, LTP appears to be important for the fine tuning and stabilization of place cells, and these place cell properties may be necessary for spatial learning...
  13. ncbi Sensorimotor gating abnormalities in young males with fragile X syndrome and Fmr1-knockout mice
    P W Frankland
    Department of Neurobiology, UCLA, Los Angeles, CA 90095, USA
    Mol Psychiatry 9:417-25. 2004
    ..However, since these phenotypic changes are opposite in direction, they also suggest that murine compensatory mechanisms following loss of FMR1 function differ from those in humans...
  14. ncbi The contribution of autophosphorylated alpha-calcium-calmodulin kinase II to injury-induced persistent pain
    K P Zeitz
    Departments of Anatomy and Physiology and the W M Keck Foundation Center for Integrative Neuroscience, University of California at San Francisco, San Francisco, CA 94080, USA
    Neuroscience 128:889-98. 2004
    ....
  15. ncbi Deficits in memory and motor performance in synaptotagmin IV mutant mice
    G D Ferguson
    Department of Biological Chemistry, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 97:5598-603. 2000
    ..These studies demonstrate that Syt IV is critical for brain function and suggest that the Syt IV mutation affects hippocampal-dependent learning and memory, as well as motor coordination...
  16. ncbi Study of the safety, immunogenicity and efficacy of attenuated and killed Leishmania (Leishmania) major vaccines in a rhesus monkey (Macaca mulatta) model of the human disease
    V F Amaral
    Departamento de Imunologia, Instituto Oswaldo Cruz-Fiocruz, Rio de Janeiro, Brasil
    Mem Inst Oswaldo Cruz 97:1041-8. 2002
    ..We concluded that both vaccine protocols used in this study are safe in primates, but require further improvement for vaccine application...
  17. ncbi Inducible repression of CREB function disrupts amygdala-dependent memory
    S A Josselyn
    Department of Neurobiology, Brain Research Institute, 695 Young Drive South, Gonda Building, UCLA, Los Angeles, CA 90095 1761, USA
    Neurobiol Learn Mem 82:159-63. 2004
    ..Together, these findings indicate that CREB-mediated transcription and protein synthesis are required for conditioned taste aversion memory...
  18. ncbi Inducible, pharmacogenetic approaches to the study of learning and memory
    M Ohno
    Departments of Neurobiology, Psychiatry and Psychology, Brain Research Institute, University of California, Los Angeles, California 90095 1761, USA
    Nat Neurosci 4:1238-43. 2001
    ..This pharmacogenetic approach combines the high temporal specificity that pharmacological manipulations offer, with the molecular specificity of genetic disruptions...
  19. ncbi Effect of creatine on swimming velocity, body composition and hydrodynamic variables
    A J Silva
    Department of Sport CIFOP, University of Trás os Montes e Alto Douro UTAD, Vila Real, Portugal
    J Sports Med Phys Fitness 47:58-64. 2007
    ..To investigate the effect of oral CS on swimming velocity, body composition and hydrodynamic variables during the period of final preparation of competitive junior female swimmers...
  20. ncbi Leishmania (Leishmania) major-infected rhesus macaques (Macaca mulatta) develop varying levels of resistance against homologous re-infections
    V F Amaral
    Departamento de Imunologia, Instituto Oswaldo Cruz-Fiocruz, 21045-900 Rio de Janeiro, RJ, Brasil
    Mem Inst Oswaldo Cruz 96:795-804. 2001
    ..This primate model should be useful for measuring vaccine effectiveness against the human disease...
  21. ncbi Analgesic and antiinflammatory activities of vernonioside B2 from Vernonia condensata
    A L Valverde
    NPPN, Universidade Federal do Rio de Janeiro, CCS, Bloco H, , Rio de Janeiro, Brazil, CEP 21941-590
    Phytother Res 15:263-4. 2001
    ..The compound reduced writhings (93.28%) and Evans blue dye diffusion (91.80%) induced by acetic acid (0.1 N) in a dose-dependent manner...
  22. ncbi Impaired spatial learning in alpha-calcium-calmodulin kinase II mutant mice
    A J Silva
    Howard Hughes Medical Institute, Center for Cancer Research, Cambridge, MA
    Science 257:206-11. 1992
    ..The data considerably strengthen the contention that the synaptic changes exhibited in LTP are the basis for spatial memory...
  23. ncbi Deficient plasticity in the primary visual cortex of alpha-calcium/calmodulin-dependent protein kinase II mutant mice
    J A Gordon
    Department of Physiology, University of California, San Francisco 94143 0444, USA
    Neuron 17:491-9. 1996
    ..These data indicate that loss of alpha CaMKII results in a severe but variable defect in neuronal plasticity...
  24. ncbi Ischemia-induced neuronal damage: a role for calcium/calmodulin-dependent protein kinase II
    M N Waxham
    Department of Neurobiology and Anatomy, University of Texas Medical School at Houston 77225, USA
    J Cereb Blood Flow Metab 16:1-6. 1996
    ....
  25. ncbi Deficient hippocampal long-term potentiation in alpha-calcium-calmodulin kinase II mutant mice
    A J Silva
    Howard Hughes Medical Institute, Center for Cancer Research, Cambridge, MA
    Science 257:201-6. 1992
    ..Despite normal postsynaptic mechanisms, these mice are deficient in their ability to produce LTP and are therefore a suitable model for studying the relation between LTP and learning processes...
  26. ncbi Alpha calcium/calmodulin kinase II mutant mice: deficient long-term potentiation and impaired spatial learning
    A J Silva
    Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge 02139
    Cold Spring Harb Symp Quant Biol 57:527-39. 1992
  27. ncbi Evidence that many of the DISC1 isoforms in C57BL/6J mice are also expressed in 129S6/SvEv mice
    K Ishizuka
    Mol Psychiatry 12:897-9. 2007