Alea Mills

Summary

Affiliation: Cold Spring Harbor Laboratory
Country: USA

Publications

  1. ncbi A mouse chromosome 4 balancer ENU-mutagenesis screen isolates eleven lethal lines
    Melissa K Boles
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    BMC Genet 10:12. 2009
  2. ncbi p53: link to the past, bridge to the future
    Alea A Mills
    Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA
    Genes Dev 19:2091-9. 2005
  3. ncbi Throwing the cancer switch: reciprocal roles of polycomb and trithorax proteins
    Alea A Mills
    Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA
    Nat Rev Cancer 10:669-82. 2010
  4. ncbi Inducible systems see the light
    William M Keyes
    Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA
    Trends Biotechnol 21:53-5. 2003
  5. ncbi Differential expression of p63 isoforms in female reproductive organs
    Takeshi Kurita
    Department of Cancer Endocrinology, BC Cancer Agency, Vancouver, BC, Canada V5Z 1L3
    Mech Dev 122:1043-55. 2005
  6. ncbi p63 is an essential proapoptotic protein during neural development
    W Bradley Jacobs
    Cancer Research and Hospital for Sick Children, University of Toronto, Toronto ON, Canada M5G 1X8
    Neuron 48:743-56. 2005
  7. ncbi p63: oncogene or tumor suppressor?
    Alea A Mills
    Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
    Curr Opin Genet Dev 16:38-44. 2006
  8. ncbi p63 heterozygous mutant mice are not prone to spontaneous or chemically induced tumors
    William M Keyes
    Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
    Proc Natl Acad Sci U S A 103:8435-40. 2006
  9. ncbi p63 regulates an adhesion programme and cell survival in epithelial cells
    Danielle K Carroll
    Department of Cell Biology, Harvard Medical School, 240 Longwood Ave, Boston, MA 02115, USA
    Nat Cell Biol 8:551-61. 2006

Research Grants

  1. The Tumor Suppressive Role of CHD5
    Alea Mills; Fiscal Year: 2009
  2. The Tumor Suppressive Role of CHD5
    Alea A Mills; Fiscal Year: 2010
  3. The Tumor Suppressive Role of CHD5
    Alea A Mills; Fiscal Year: 2011

Collaborators

  • LEIF ELLISEN
  • William M Keyes
  • Melissa K Boles
  • Allan Bradley
  • Danielle K Carroll
  • Takeshi Kurita
  • W Bradley Jacobs
  • Andrew P Salinger
  • Andrea Maxwell
  • Karen K Hirschi
  • Lihua Lai
  • Bin Liu
  • Ivan Moskowitz
  • Monica J Justice
  • Ichiko Nishijima
  • Bonney M Wilkinson
  • Myles Brown
  • Fang Cheng
  • Jason S Carroll
  • Chee-Onn Leong
  • Xuecui Guo
  • Dennis R Roop
  • Joan S Brugge
  • Hannes Vogel
  • Yi Qi
  • Chee Onn Leong
  • Maranke I Koster
  • Kristin M Petherbridge
  • Roanna T Medina
  • David R Kaplan
  • Fanie Barnabe-Heider
  • Gerald R Cunha
  • Freda D Miller
  • Jasvinder K Atwal
  • Daniel Ho
  • Gregory Govoni
  • Stanley J Robboy

Detail Information

Publications9

  1. ncbi A mouse chromosome 4 balancer ENU-mutagenesis screen isolates eleven lethal lines
    Melissa K Boles
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    BMC Genet 10:12. 2009
    ..To functionally annotate the distal region of mouse chromosome 4, we performed an ENU-mutagenesis screen using a balancer chromosome targeted to this region of the genome...
  2. ncbi p53: link to the past, bridge to the future
    Alea A Mills
    Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA
    Genes Dev 19:2091-9. 2005
  3. ncbi Throwing the cancer switch: reciprocal roles of polycomb and trithorax proteins
    Alea A Mills
    Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA
    Nat Rev Cancer 10:669-82. 2010
    ..Recent work highlights the dynamic interplay between these opposing classes of proteins, providing new avenues for understanding how these epigenetic regulators function in tumorigenesis...
  4. ncbi Inducible systems see the light
    William M Keyes
    Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA
    Trends Biotechnol 21:53-5. 2003
    ..An extremely efficient system designed by nature -- that of the regulatable phytochrome system in plants -- has provided the basis for developing a novel inducible gene expression system...
  5. ncbi Differential expression of p63 isoforms in female reproductive organs
    Takeshi Kurita
    Department of Cancer Endocrinology, BC Cancer Agency, Vancouver, BC, Canada V5Z 1L3
    Mech Dev 122:1043-55. 2005
    ..Therefore, inhibition of p63 expression by DES should change the cell fate of human Müllerian duct epithelial cells and cause cervical/vaginal adenosis as previously demonstrated in mouse...
  6. ncbi p63 is an essential proapoptotic protein during neural development
    W Bradley Jacobs
    Cancer Research and Hospital for Sick Children, University of Toronto, Toronto ON, Canada M5G 1X8
    Neuron 48:743-56. 2005
    ..Thus, p63 is essential for developmental neuronal death, likely functioning both on its own, and as an obligate proapoptotic partner for p53...
  7. ncbi p63: oncogene or tumor suppressor?
    Alea A Mills
    Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
    Curr Opin Genet Dev 16:38-44. 2006
    ....
  8. ncbi p63 heterozygous mutant mice are not prone to spontaneous or chemically induced tumors
    William M Keyes
    Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
    Proc Natl Acad Sci U S A 103:8435-40. 2006
    ..These findings demonstrate that, in agreement with data from human tumors, p63 plays a markedly different biological role in cancer than p53...
  9. ncbi p63 regulates an adhesion programme and cell survival in epithelial cells
    Danielle K Carroll
    Department of Cell Biology, Harvard Medical School, 240 Longwood Ave, Boston, MA 02115, USA
    Nat Cell Biol 8:551-61. 2006
    ..Our results implicate p63 as a key regulator of cellular adhesion and survival in basal cells of the mammary gland and other stratified epithelial tissues...

Research Grants3

  1. The Tumor Suppressive Role of CHD5
    Alea Mills; Fiscal Year: 2009
    ..Therefore, a further study of the role of CHD5 in cancer is warranted to determine whether CHD5 offers novel strategies for designing more powerful anti-cancer therapies. ..
  2. The Tumor Suppressive Role of CHD5
    Alea A Mills; Fiscal Year: 2010
    ..Therefore, a further study of the role of CHD5 in cancer is warranted to determine whether CHD5 offers novel strategies for designing more powerful anti-cancer therapies. ..
  3. The Tumor Suppressive Role of CHD5
    Alea A Mills; Fiscal Year: 2011
    ..Therefore, a further study of the role of CHD5 in cancer is warranted to determine whether CHD5 offers novel strategies for designing more powerful anti-cancer therapies. ..