R Malinow

Summary

Affiliation: Cold Spring Harbor Laboratory
Country: USA

Publications

  1. pmc AMPA receptor trafficking and long-term potentiation
    Roberto Malinow
    Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
    Philos Trans R Soc Lond B Biol Sci 358:707-14. 2003
  2. ncbi request reprint Neuroscience. Matters of size
    Charles Kopec
    Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
    Science 314:1554-5. 2006
  3. ncbi request reprint LTP mechanisms: from silence to four-lane traffic
    R Malinow
    Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
    Curr Opin Neurobiol 10:352-7. 2000
  4. ncbi request reprint AMPA receptor trafficking and synaptic plasticity
    Roberto Malinow
    Cold Spring Harbor Laboratory, New York 11724, USA
    Annu Rev Neurosci 25:103-26. 2002
  5. ncbi request reprint Rapid spine delivery and redistribution of AMPA receptors after synaptic NMDA receptor activation
    S H Shi
    Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
    Science 284:1811-6. 1999
  6. ncbi request reprint Subunit-specific rules governing AMPA receptor trafficking to synapses in hippocampal pyramidal neurons
    S Shi
    Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
    Cell 105:331-43. 2001
  7. ncbi request reprint Postsynaptic conversion of silent synapses during LTP affects synaptic gain and transmission dynamics
    J C Poncer
    Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA
    Nat Neurosci 4:989-96. 2001
  8. ncbi request reprint Maturation of a central glutamatergic synapse
    G Wu
    Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
    Science 274:972-6. 1996
  9. pmc CA1 long-term potentiation is diminished but present in hippocampal slices from alpha-CaMKII mutant mice
    H L Hinds
    Cold Spring Harbor Laboratory, New York 11724, USA
    Learn Mem 5:344-54. 1998
  10. ncbi request reprint AMPA receptor phosphorylation during synaptic plasticity
    J Boehm
    Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
    Biochem Soc Trans 33:1354-6. 2005

Research Grants

  1. Mechanisms of synaptic LTP
    Roberto Malinow; Fiscal Year: 2007

Collaborators

  • Y Hayashi
  • K Svoboda
  • H T Cline
  • Y Wang
  • J J Zhu
  • Y Zhong
  • J C Poncer
  • R S Petralia
  • D P Smith
  • Z Jia
  • J Roder
  • Z Xie
  • G Wu
  • Ingrid Ehrlich
  • J E Ledoux
  • P Osten
  • Andres Barria
  • Paul Lombroso
  • Robert Malenka
  • G Kohr
  • Lin Mei
  • Jose Esteban
  • Charles D Kopec
  • Jannic Boehm
  • Helen Hsieh
  • Bo Li
  • David Fernandez de Sevilla
  • Deepa V Venkitaramani
  • Hailan Hu
  • Eleonore Real
  • Myoung Goo Kang
  • Richard L Huganir
  • Charles Kopec
  • Emiliano M Rial Verde
  • J Boehm
  • Simon Rumpel
  • Takeshi Iwatsubo
  • Taisuke Tomita
  • Sangram Sisodia
  • Alexander Kolleker
  • Kenneth J Seidenman
  • Flavio Kamenetz
  • Takuya Takahashi
  • Antonella Piccini
  • S Shi
  • A Piccini
  • Angel Nunez
  • Washington Buño
  • Michel Borde
  • S H Shi
  • Helmut W Kessels
  • Sylvain Lesne
  • Ran Sook Woo
  • Christopher K Cain
  • Helmut W H G Kessels
  • Kogo Takamiya
  • Gunnar K Gouras
  • David E A Bush
  • William J Netzer
  • Jeannie Chin
  • Z F Mainen
  • Chihiro Sato
  • Paul F Worley
  • Jane Lee-Osbourne
  • H L Hinds
  • Wei Wei
  • Richard C Johnson
  • Anthony Zador
  • Thilo Borchardt
  • Richard Huganir
  • Guy Seabrook
  • Jordan P Steinberg
  • Volker Mack
  • Yi Qin
  • Peter H Seeburg
  • David Borchelt
  • Bettina J Schupp
  • S H Zaman
  • R J Wenthold
  • S Tonegawa

Detail Information

Publications39

  1. pmc AMPA receptor trafficking and long-term potentiation
    Roberto Malinow
    Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
    Philos Trans R Soc Lond B Biol Sci 358:707-14. 2003
    ..I review studies from our laboratory that support a critical role for AMPA receptor trafficking in LTP and experience-dependent plasticity...
  2. ncbi request reprint Neuroscience. Matters of size
    Charles Kopec
    Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
    Science 314:1554-5. 2006
  3. ncbi request reprint LTP mechanisms: from silence to four-lane traffic
    R Malinow
    Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
    Curr Opin Neurobiol 10:352-7. 2000
    ..Recent findings, regarding basic properties of synaptic transmission, appear to reconcile these diverging views...
  4. ncbi request reprint AMPA receptor trafficking and synaptic plasticity
    Roberto Malinow
    Cold Spring Harbor Laboratory, New York 11724, USA
    Annu Rev Neurosci 25:103-26. 2002
    ..While much work remains to understand the molecular basis for synaptic plasticity, recent results on AMPA receptor trafficking provide a clear conceptual framework for future studies...
  5. ncbi request reprint Rapid spine delivery and redistribution of AMPA receptors after synaptic NMDA receptor activation
    S H Shi
    Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
    Science 284:1811-6. 1999
    ....
  6. ncbi request reprint Subunit-specific rules governing AMPA receptor trafficking to synapses in hippocampal pyramidal neurons
    S Shi
    Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
    Cell 105:331-43. 2001
    ..The combination of regulated addition and continuous replacement of synaptic receptors can stabilize long-term changes in synaptic efficacy and may serve as a general model for how surface receptor number is established and maintained...
  7. ncbi request reprint Postsynaptic conversion of silent synapses during LTP affects synaptic gain and transmission dynamics
    J C Poncer
    Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA
    Nat Neurosci 4:989-96. 2001
    ..Functional conversion of silent synapses permits postsynaptic sampling from additional release sites and thereby affects the dynamics and gain of signals conveyed between neurons...
  8. ncbi request reprint Maturation of a central glutamatergic synapse
    G Wu
    Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
    Science 274:972-6. 1996
    ..Newly formed synapses may be silent unless sufficient depolarization is provided by coincident activity that could activate postsynaptic CaMKII, resulting in the appearance of AMPA responses...
  9. pmc CA1 long-term potentiation is diminished but present in hippocampal slices from alpha-CaMKII mutant mice
    H L Hinds
    Cold Spring Harbor Laboratory, New York 11724, USA
    Learn Mem 5:344-54. 1998
    ..However, tetani of increasing frequency (50, 100, and 200 Hz) did not reveal a higher threshold for potentiation in (-/-) alpha-CaMKII mice compared with (+/+) alpha-CaMKII controls...
  10. ncbi request reprint AMPA receptor phosphorylation during synaptic plasticity
    J Boehm
    Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
    Biochem Soc Trans 33:1354-6. 2005
    ..The regulated insertion of these receptors is a key event in the induction of LTP. Here, we discuss the phosphorylation of GluR1 and GluR4 and its role in receptor delivery and neuronal plasticity...
  11. ncbi request reprint Postnatal synaptic potentiation: delivery of GluR4-containing AMPA receptors by spontaneous activity
    J J Zhu
    Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA
    Nat Neurosci 3:1098-106. 2000
    ..Thus, this sequence of subunit-specific trafficking events triggered by spontaneous activity in early postnatal development may be crucial for initial establishment of long-lasting functional circuitry...
  12. ncbi request reprint Use-dependent AMPA receptor block in mice lacking GluR2 suggests postsynaptic site for LTP expression
    Z F Mainen
    Cold Spring Harbor Laboratory, New York 11724, USA
    Nat Neurosci 1:579-86. 1998
    ..Our results indicate that the recruitment of new AMPA receptors and/or an increase in the conductance of these receptors is responsible for the expression of CA1 LTP...
  13. ncbi request reprint Genetic manipulation of the odor-evoked distributed neural activity in the Drosophila mushroom body
    Y Wang
    Cold Spring Harbor Lab, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA
    Neuron 29:267-76. 2001
    ..These results suggest that the spatial pattern of the distributed neural activity may contribute to coding of odor information at the second relay of the olfactory system...
  14. ncbi request reprint Transient oxygen-glucose deprivation induces rapid morphological changes in rat hippocampal dendrites
    A Piccini
    Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
    Neuropharmacology 41:724-9. 2001
    ..We propose that dendritic reorganization, resembling that occurring after tetanic stimulation, may be an early stage response to compensate the loss of synapses caused by ischemia-induced neuronal injury...
  15. ncbi request reprint Glutamate receptor exocytosis and spine enlargement during chemically induced long-term potentiation
    Charles D Kopec
    Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA
    J Neurosci 26:2000-9. 2006
    ..Interestingly, during chemLTP induction, spines increase in volume before accumulation of AMPA receptors on their surface, indicating that distinct mechanisms underlie changes in morphology and receptor content...
  16. ncbi request reprint Synaptic incorporation of AMPA receptors during LTP is controlled by a PKC phosphorylation site on GluR1
    Jannic Boehm
    Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA
    Neuron 51:213-25. 2006
    ..We conclude that the phosphorylation of GluR1 S818 by PKC is a critical event in the plasticity-driven synaptic incorporation of AMPA receptors...
  17. ncbi request reprint Two mutations preventing PDZ-protein interactions of GluR1 have opposite effects on synaptic plasticity
    Jannic Boehm
    Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA
    Learn Mem 13:562-5. 2006
    ..Here, we resolve this conflict by showing that apparently similar C-terminal mutations of the GluR1 PDZ-ligand domain result in opposite physiological phenotypes during activity- and CamKII-induced synaptic plasticity...
  18. ncbi request reprint Increased expression of the immediate-early gene arc/arg3.1 reduces AMPA receptor-mediated synaptic transmission
    Emiliano M Rial Verde
    Watson School of Biological Sciences, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA
    Neuron 52:461-74. 2006
    ..Our results demonstrate that Arc/Arg3.1 reduces the number of GluR2/3 receptors leading to a decrease in AMPAR-mediated synaptic currents, consistent with a role in the homeostatic regulation of synaptic strength...
  19. pmc AMPAR removal underlies Abeta-induced synaptic depression and dendritic spine loss
    Helen Hsieh
    Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA
    Neuron 52:831-43. 2006
    ..Our studies indicate the central role played by AMPA receptor trafficking in Abeta-induced modification of synaptic structure and function...
  20. ncbi request reprint GluR1 links structural and functional plasticity at excitatory synapses
    Charles D Kopec
    Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA
    J Neurosci 27:13706-18. 2007
    ....
  21. pmc PSD-95 is required for activity-driven synapse stabilization
    Ingrid Ehrlich
    Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
    Proc Natl Acad Sci U S A 104:4176-81. 2007
    ..Taken together, our data support a model in which appropriate levels of PSD-95 are required for activity-dependent synapse stabilization after initial phases of synaptic potentiation...
  22. pmc The neuregulin-1 receptor erbB4 controls glutamatergic synapse maturation and plasticity
    Bo Li
    Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
    Neuron 54:583-97. 2007
    ..These findings link proposed effectors in schizophrenia: NRG1/erbB4 signaling perturbation, neurodevelopmental deficit, and glutamatergic hypofunction...
  23. ncbi request reprint Emotion enhances learning via norepinephrine regulation of AMPA-receptor trafficking
    Hailan Hu
    Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
    Cell 131:160-73. 2007
    ....
  24. pmc Beta-amyloid modulation of synaptic transmission and plasticity
    Deepa V Venkitaramani
    Child Study Center, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Neurosci 27:11832-7. 2007
  25. ncbi request reprint NMDA receptor subunit composition controls synaptic plasticity by regulating binding to CaMKII
    Andres Barria
    Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA
    Neuron 48:289-301. 2005
    ..The switch from NR2B to NR2A content in synaptic NMDA-Rs normally observed in many brain regions may contribute to reduced plasticity by controlling the binding of active CaMKII...
  26. ncbi request reprint Postsynaptic receptor trafficking underlying a form of associative learning
    Simon Rumpel
    Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
    Science 308:83-8. 2005
    ..Thus, the encoding of memories in the lateral amygdala is mediated by AMPA receptor trafficking, is widely distributed, and displays little redundancy...
  27. ncbi request reprint Acute versus chronic NMDA receptor blockade and synaptic AMPA receptor delivery
    J Julius Zhu
    Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA
    Nat Neurosci 5:513-4. 2002
  28. ncbi request reprint Multiple mechanisms for the potentiation of AMPA receptor-mediated transmission by alpha-Ca2+/calmodulin-dependent protein kinase II
    Jean Christophe Poncer
    Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA
    J Neurosci 22:4406-11. 2002
    ..These results reveal that several key features of long-term potentiation of hippocampal glutamatergic synapses are reproduced by the sole activity of alphaCaMKII...
  29. ncbi request reprint Critical postsynaptic density 95/disc large/zonula occludens-1 interactions by glutamate receptor 1 (GluR1) and GluR2 required at different subcellular sites
    Antonella Piccini
    Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA
    J Neurosci 22:5387-92. 2002
    ..GluR1 mutants accumulate in the dendrite, whereas GluR2 mutants accumulate in dendritic spines. This suggests that the critical PDZ domain interactions are required for entry into spines for GluR1 and for entry into synapses for GluR2...
  30. ncbi request reprint Subunit-specific NMDA receptor trafficking to synapses
    Andres Barria
    Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA
    Neuron 35:345-53. 2002
    ..Thus, as with AMPA-Rs, synaptic trafficking of NMDA-Rs is tightly regulated and has subunit-specific rules with functionally important consequences...
  31. ncbi request reprint Ras and Rap control AMPA receptor trafficking during synaptic plasticity
    J Julius Zhu
    Cold Spring Harbor Laboratory, 1 Bungtown Road, NY 11724, USA
    Cell 110:443-55. 2002
    ..Thus, Ras and Rap, whose activity can be controlled by postsynaptic enzymes, serve as independent regulators for potentiating and depressing central synapses...
  32. ncbi request reprint PKA phosphorylation of AMPA receptor subunits controls synaptic trafficking underlying plasticity
    Jose A Esteban
    Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA
    Nat Neurosci 6:136-43. 2003
    ..Thus, PKA phosphorylation of AMPA receptor subunits contributes to diverse mechanisms underlying synaptic plasticity...
  33. ncbi request reprint Experience strengthening transmission by driving AMPA receptors into synapses
    Takuya Takahashi
    Jones Laboratory, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
    Science 299:1585-8. 2003
    ..In general, synaptic incorporation of AMPA-Rs in vivo conforms to rules identified in vitro and contributes to plasticity driven by natural stimuli in the mammalian brain...
  34. ncbi request reprint APP processing and synaptic function
    Flavio Kamenetz
    Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
    Neuron 37:925-37. 2003
    ..Disruption of this feedback system could contribute to disease progression in AD...
  35. ncbi request reprint Glutamate receptor subunit 2 Serine 880 phosphorylation modulates synaptic transmission and mediates plasticity in CA1 pyramidal cells
    Kenneth J Seidenman
    Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA
    J Neurosci 23:9220-8. 2003
    ..Disruption of the interaction between GluR2 and GRIP/ABP by S880 phosphorylation may thus facilitate removal of synaptic AMPA receptors and mediate some forms of activity-dependent synaptic depression...
  36. ncbi request reprint Glutamatergic plasticity by synaptic delivery of GluR-B(long)-containing AMPA receptors
    Alexander Kolleker
    Max Planck Institute for Medical Research, Department of Molecular Neurobiology, Jahnstrasse 29, 69120, Heidelberg, Germany
    Neuron 40:1199-212. 2003
    ..Trafficking of GluR-B(long)-containing receptors thus mediates a GluR-A-independent form of glutamatergic synaptic plasticity in the juvenile hippocampus...
  37. ncbi request reprint Postsynaptic density 95 controls AMPA receptor incorporation during long-term potentiation and experience-driven synaptic plasticity
    Ingrid Ehrlich
    Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA
    J Neurosci 24:916-27. 2004
    ..We conclude that PSD-95 controls activity-dependent AMPAR incorporation at synapses via PDZ interactions not only during LTP in vitro but also during experience-driven synaptic strengthening by natural stimuli in vivo...
  38. ncbi request reprint A robust automated method to analyze rodent motion during fear conditioning
    Charles D Kopec
    Cold Spring Harbor Laboratory, Jones Building, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA
    Neuropharmacology 52:228-33. 2007
    ..This automated analysis of fear conditioning will permit a more rapid and accurate assessment of the role of LTP in memory...
  39. doi request reprint Cholinergic-mediated IP3-receptor activation induces long-lasting synaptic enhancement in CA1 pyramidal neurons
    David Fernandez de Sevilla
    Instituto Cajal, Consejo Superior de Investigaciones Cientificas, 28002 Madrid, Spain
    J Neurosci 28:1469-78. 2008
    ..We conclude that Ca2+ released from postsynaptic endoplasmic reticulum stores is the critical event in the induction of this unique form of long-lasting synaptic enhancement...

Research Grants1

  1. Mechanisms of synaptic LTP
    Roberto Malinow; Fiscal Year: 2007
    ..generate transgenic mice with dominant negative AMPA-receptor mutations that perturb regulated or constitutive delivery. ..