Z Josh Huang
Affiliation: Cold Spring Harbor Laboratory
Krishnan K, Wang B, Lu J, Wang L, Maffei A, Cang J, et al
. MeCP2 regulates the timing of critical period plasticity that shapes functional connectivity in primary visual cortex. Proc Natl Acad Sci U S A. 2015;112:E4782-91 pubmed publisher
..Our results identify molecular changes in a defined cortical cell type and link aberrant developmental trajectory to functional deficits in a model of neuropsychiatric disorder. ..
Wang X, Tucciarone J, Jiang S, Yin F, Wang B, Wang D, et al
. Genetic Single Neuron Anatomy Reveals Fine Granularity of Cortical Axo-Axonic Cells. Cell Rep. 2019;26:3145-3159.e5 pubmed publisher
..This platform will facilitate genetically targeted, high-resolution, and scalable single neuron anatomy in the mouse brain. ..
Huang Z. Toward a genetic dissection of cortical circuits in the mouse. Neuron. 2014;83:1284-302 pubmed publisher
Kelly S, Raudales R, He M, Lee J, Kim Y, Gibb L, et al
. Radial Glial Lineage Progression and Differential Intermediate Progenitor Amplification Underlie Striatal Compartments and Circuit Organization. Neuron. 2018;99:345-361.e4 pubmed publisher
..Notably, direct and indirect pathway SPNs arise within both aIPS and bIPM pools, suggesting that striosome-matrix architecture is the fundamental organizational plan of basal ganglia circuitry. ..
Lu J, Tucciarone J, Lin Y, Huang Z. Input-specific maturation of synaptic dynamics of parvalbumin interneurons in primary visual cortex. Proc Natl Acad Sci U S A. 2014;111:16895-900 pubmed publisher
..Although short-term depression of long-range inputs is well-suited for afferent signal detection, the robust dynamics of local inputs may facilitate rapid and proportional PVN recruitment in regulating local circuit operations. ..
Huang Z, Zeng H. Genetic approaches to neural circuits in the mouse. Annu Rev Neurosci. 2013;36:183-215 pubmed publisher
..Here we review recent progress in genetic tool development and advances in genetic analysis of neural circuits in the mouse. We also discuss future directions and implications for understanding brain disorders. ..
He M, Tucciarone J, Lee S, Nigro M, Kim Y, Levine J, et al
. Strategies and Tools for Combinatorial Targeting of GABAergic Neurons in Mouse Cerebral Cortex. Neuron. 2016;91:1228-1243 pubmed publisher
..These strategies and tools will facilitate studying GABAergic neurons throughout the mouse brain. ..
He M, Huang Z. Genetic approaches to access cell types in mammalian nervous systems. Curr Opin Neurobiol. 2018;50:109-118 pubmed publisher
..Novel approaches that bypass the germline, such as somatic cell engineering and cell surface-based gene delivery, may reduce the barrier of genetic access to mammalian cell types. ..
Paul A, Crow M, Raudales R, He M, Gillis J, Huang Z. Transcriptional Architecture of Synaptic Communication Delineates GABAergic Neuron Identity. Cell. 2017;171:522-539.e20 pubmed publisher
..This molecular genetic framework of neuronal identity integrates cell phenotypes along multiple axes and provides a foundation for discovering and classifying neuron types. ..