Tatsuya Hirano

Summary

Affiliation: Cold Spring Harbor Laboratory
Country: USA

Publications

  1. pmc Identification and characterization of SA/Scc3p subunits in the Xenopus and human cohesin complexes
    A Losada
    Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA
    J Cell Biol 150:405-16. 2000
  2. ncbi request reprint SMC protein complexes and higher-order chromosome dynamics
    T Hirano
    Cold Spring Harbor Laboratory, New York, USA
    Curr Opin Cell Biol 10:317-22. 1998
  3. ncbi request reprint The ABCs of SMC proteins: two-armed ATPases for chromosome condensation, cohesion, and repair
    Tatsuya Hirano
    Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA
    Genes Dev 16:399-414. 2002
  4. ncbi request reprint Chromosome shaping by two condensins
    Tatsuya Hirano
    Cold Spring Harbor Laboratory, One Bungtown Road, Cold Spring Harbor, New York 11724, USA
    Cell Cycle 3:26-8. 2004
  5. pmc Bimodal activation of SMC ATPase by intra- and inter-molecular interactions
    M Hirano
    Cold Spring Harbor Laboratory, One Bungtown Road, PO Box 100, Cold Spring Harbor, NY 11724 0100, USA
    EMBO J 20:3238-50. 2001
  6. ncbi request reprint Chromosome cohesion, condensation, and separation
    T Hirano
    Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA
    Annu Rev Biochem 69:115-44. 2000
  7. pmc Hinge-mediated dimerization of SMC protein is essential for its dynamic interaction with DNA
    Michiko Hirano
    Cold Spring Harbor Laboratory, One Bungtown Road, PO Box 100, Cold Spring Harbor, NY 11724, USA
    EMBO J 21:5733-44. 2002
  8. pmc Reconstitution and subunit geometry of human condensin complexes
    Itay Onn
    Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
    EMBO J 26:1024-34. 2007
  9. pmc Human Wapl is a cohesin-binding protein that promotes sister-chromatid resolution in mitotic prophase
    Rita Gandhi
    Cold Spring Harbor Laboratory, One Bungtown Road, P O Box 100, Cold Spring Harbor, New York 11724, USA
    Curr Biol 16:2406-17. 2006
  10. ncbi request reprint Functional contribution of Pds5 to cohesin-mediated cohesion in human cells and Xenopus egg extracts
    Ana Losada
    Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA
    J Cell Sci 118:2133-41. 2005

Collaborators

Detail Information

Publications35

  1. pmc Identification and characterization of SA/Scc3p subunits in the Xenopus and human cohesin complexes
    A Losada
    Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA
    J Cell Biol 150:405-16. 2000
    ..These results shed light on the mechanism by which sister chromatid cohesion is partially dissolved in early mitosis, far before the onset of anaphase, in vertebrate cells...
  2. ncbi request reprint SMC protein complexes and higher-order chromosome dynamics
    T Hirano
    Cold Spring Harbor Laboratory, New York, USA
    Curr Opin Cell Biol 10:317-22. 1998
    ..Emerging evidence suggests that eukaryotic SMC proteins form large protein complexes with non-SMC subunits and act as key components for a wide variety of higher-order chromosome dynamics...
  3. ncbi request reprint The ABCs of SMC proteins: two-armed ATPases for chromosome condensation, cohesion, and repair
    Tatsuya Hirano
    Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA
    Genes Dev 16:399-414. 2002
  4. ncbi request reprint Chromosome shaping by two condensins
    Tatsuya Hirano
    Cold Spring Harbor Laboratory, One Bungtown Road, Cold Spring Harbor, New York 11724, USA
    Cell Cycle 3:26-8. 2004
    ..In vertebrate cells, two different condensin complexes make distinct mechanistic contributions to determining the shape and integrity of mitotic chromosomes...
  5. pmc Bimodal activation of SMC ATPase by intra- and inter-molecular interactions
    M Hirano
    Cold Spring Harbor Laboratory, One Bungtown Road, PO Box 100, Cold Spring Harbor, NY 11724 0100, USA
    EMBO J 20:3238-50. 2001
    ....
  6. ncbi request reprint Chromosome cohesion, condensation, and separation
    T Hirano
    Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA
    Annu Rev Biochem 69:115-44. 2000
    ..Recent genetic and biochemical studies have identified key components involved in these processes and started to uncover hitherto unexpected functional links between mitotic chromosome dynamics and other important chromosome functions...
  7. pmc Hinge-mediated dimerization of SMC protein is essential for its dynamic interaction with DNA
    Michiko Hirano
    Cold Spring Harbor Laboratory, One Bungtown Road, PO Box 100, Cold Spring Harbor, NY 11724, USA
    EMBO J 21:5733-44. 2002
    ..We propose that the hinge domain of SMC proteins is not a simple dimerization site, but rather it acts as an essential determinant of dynamic SMC-DNA interactions...
  8. pmc Reconstitution and subunit geometry of human condensin complexes
    Itay Onn
    Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
    EMBO J 26:1024-34. 2007
    ..Cleavage pattern of SMC2 by limited proteolysis is changed upon its binding to ATP or DNA. Our results shed new light on the architecture and dynamics of this highly elaborate machinery designed for chromosome assembly...
  9. pmc Human Wapl is a cohesin-binding protein that promotes sister-chromatid resolution in mitotic prophase
    Rita Gandhi
    Cold Spring Harbor Laboratory, One Bungtown Road, P O Box 100, Cold Spring Harbor, New York 11724, USA
    Curr Biol 16:2406-17. 2006
    ..This process is known as sister-chromatid resolution. Although two mitotic kinases have been implicated in this process, it remains unknown exactly how the cohesin-mediated linkage is destabilized at a mechanistic level...
  10. ncbi request reprint Functional contribution of Pds5 to cohesin-mediated cohesion in human cells and Xenopus egg extracts
    Ana Losada
    Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA
    J Cell Sci 118:2133-41. 2005
    ..This idea would explain why cells lacking Pds5 function display rather complex and diverse phenotypes in different organisms...
  11. pmc Cohesin release is required for sister chromatid resolution, but not for condensin-mediated compaction, at the onset of mitosis
    Ana Losada
    Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA
    Genes Dev 16:3004-16. 2002
    ..More importantly, our results strongly suggest that cohesin release at the onset of mitosis is essential for sister chromatid resolution but not for condensin-mediated compaction...
  12. ncbi request reprint Scc2 couples replication licensing to sister chromatid cohesion in Xenopus egg extracts
    Peter J Gillespie
    Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA
    Curr Biol 14:1598-603. 2004
    ..Our results suggest that vertebrate Scc2 couples replication licensing to sister chromatid cohesion by facilitating the loading of cohesin onto chromatin...
  13. ncbi request reprint Differential contributions of condensin I and condensin II to mitotic chromosome architecture in vertebrate cells
    Takao Ono
    Cold Spring Harbor Laboratory, One Bungtown Road, PO Box 100, Cold Spring Harbor, NY 11724, USA
    Cell 115:109-21. 2003
    ..We propose that the two condensin complexes make distinct mechanistic contributions to mitotic chromosome architecture in vertebrate cells...
  14. pmc Spatial and temporal regulation of Condensins I and II in mitotic chromosome assembly in human cells
    Takao Ono
    Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA
    Mol Biol Cell 15:3296-308. 2004
    ....
  15. pmc SMC proteins and chromosome mechanics: from bacteria to humans
    Tatsuya Hirano
    Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA
    Philos Trans R Soc Lond B Biol Sci 360:507-14. 2005
    ..It seems most likely that the action of SMC proteins is highly dynamic and plastic, possibly involving a diverse array of intramolecular and intermolecular protein-protein interactions...
  16. pmc ISWI remodeling complexes in Xenopus egg extracts: identification as major chromosomal components that are regulated by INCENP-aurora B
    David E MacCallum
    Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, NY 11724, USA
    Mol Biol Cell 13:25-39. 2002
    ..Apparently contradictory to the generally accepted model, we find that neither chromosome condensation nor chromosomal targeting of condensin is compromised when H3 phosphorylation is drastically reduced by depletion of INCENP-aurora B...
  17. ncbi request reprint Condensins: organizing and segregating the genome
    Tatsuya Hirano
    Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA
    Curr Biol 15:R265-75. 2005
    ..In bacterial cells, ancestral forms of condensins control chromosome dynamics. Dissecting the diverse functions of condensins is likely to be central to our understanding of genome organization, stability and evolution...
  18. ncbi request reprint How are cohesin rings opened and closed?
    Keishi Shintomi
    Cold Spring Harbor Laboratory, 1 Bungtown Road, PO Box 100, Cold Spring Harbor, NY 11724, USA
    Trends Biochem Sci 32:154-7. 2007
    ..An emerging idea is that the hinge and head domains cooperatively modulate cohesin-DNA interactions by opening and closing the ring in a highly regulated manner...
  19. ncbi request reprint At the heart of the chromosome: SMC proteins in action
    Tatsuya Hirano
    Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA
    Nat Rev Mol Cell Biol 7:311-22. 2006
    ..An emerging idea is that SMC proteins use a diverse array of intramolecular and intermolecular protein-protein interactions to actively fold, tether and manipulate DNA strands...
  20. ncbi request reprint Opening closed arms: long-distance activation of SMC ATPase by hinge-DNA interactions
    Michiko Hirano
    Cold Spring Harbor Laboratory, One Bungtown Road, Cold Spring Harbor, New York 11724, USA
    Mol Cell 21:175-86. 2006
    ..Our results suggest that SMC proteins possess an intrinsic property to change their own conformations upon binding to DNA...
  21. pmc A role of topoisomerase II in linking DNA replication to chromosome condensation
    Olivier Cuvier
    Cold Spring Harbor Laboratory, 1 Bungtown Rd, Cold Spring Harbor, NY 11724, USA
    J Cell Biol 160:645-55. 2003
    ..Our results suggest that topo II plays an important role in an early stage of chromosome condensation, and that this function of topo II is tightly coupled with prior DNA replication...
  22. pmc Positive and negative regulation of SMC-DNA interactions by ATP and accessory proteins
    Michiko Hirano
    Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
    EMBO J 23:2664-73. 2004
    ..We propose that the ATP-modulated engagement/disengagement cycle of SMC proteins plays both positive and negative roles in their dynamic interactions with dsDNA...
  23. ncbi request reprint Real-time detection of single-molecule DNA compaction by condensin I
    Terence R Strick
    Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA
    Curr Biol 14:874-80. 2004
    ..Condensin is thought to contribute to large-scale DNA compaction during mitotic chromosome assembly. It remains unknown, however, how the complex reconfigures DNA structure at a mechanistic level...
  24. ncbi request reprint SMC proteins
    Peter J Gillespie
    Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA
    Curr Biol 12:R513. 2002
  25. ncbi request reprint Misregulated chromosome condensation in MCPH1 primary microcephaly is mediated by condensin II
    Marc Trimborn
    Institut fur Humangenetik, Charite Universitatsmedizin Berlin, Berlin, Germany
    Cell Cycle 5:322-6. 2006
    ..Our results offer a molecular explanation for the aberrant chromosome condensation in MCPH1-deficiency and provide additional evidence that condensin I and II are regulated by distinct pathways...
  26. ncbi request reprint Cell biology: holding sisters for repair
    Tatsuya Hirano
    Nature 433:467-8. 2005
  27. pmc Visualization of early chromosome condensation: a hierarchical folding, axial glue model of chromosome structure
    Natashe Kireeva
    Department of Cell and Structural Biology, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    J Cell Biol 166:775-85. 2004
    ..We propose a unified model of chromosome structure in which hierarchical levels of chromatin folding are stabilized late in mitosis by an axial "glue."..
  28. pmc Condensin and cohesin display different arm conformations with characteristic hinge angles
    David E Anderson
    Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    J Cell Biol 156:419-24. 2002
    ..We propose that the "closed" conformation of condensin and the "open" conformation of cohesin are important structural properties that contribute to their specialized biochemical and physiological functions...
  29. ncbi request reprint The mitotic chromosome is an assembly of rigid elastic axes organized by structural maintenance of chromosomes (SMC) proteins and surrounded by a soft chromatin envelope
    Sébastien Almagro
    Laboratoire de Biologie Moléculaire et Cellulaire de la Différenciation, INSERM U309, Institut Albert Bonniot, Domaine de la Merci, 38706 La Tronche, France
    J Biol Chem 279:5118-26. 2004
    ..The extreme compaction of mitotic chromosomes is determined mainly by the high amount of bivalent ions bound to DNA at mitosis...
  30. ncbi request reprint The making of the mitotic chromosome: modern insights into classical questions
    Jason R Swedlow
    Division of Gene Regulation and Expression, University of Dundee, DD1 5EH, Dundee, United Kingdom
    Mol Cell 11:557-69. 2003
    ..In this review, we discuss recent work that sheds new light on the molecular and structural dynamics of mitotic chromosomes...
  31. pmc Distinct but overlapping domains of AKAP95 are implicated in chromosome condensation and condensin targeting
    Turid Eide
    Institute of Medical Biochemistry, University of Oslo, PO Box 1112, Blindern, N 0317 Oslo, Norway
    EMBO Rep 3:426-32. 2002
    ..Moreover, condensin recruitment to chromatin is not sufficient to promote condensation...
  32. ncbi request reprint Efficient supercoiling of DNA by a single condensin complex as revealed by electron spectroscopic imaging
    David P Bazett-Jones
    Programme in Cell Biology, Research Institute, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada
    Mol Cell 9:1183-90. 2002
    ..The current results suggest that the action of condensin is more dynamic and more efficient than that postulated before, providing fundamental insight into the energy-dependent mechanism of higher order chromatin folding...
  33. ncbi request reprint MEKK1 induces c-Jun complexes that act as negative regulators for cell survival and proliferation of HCC cells
    Fumitake Komoda
    Department of Medicine and Clinical Oncology K1, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuou ku, Chiba 260 8670, Japan
    Int J Oncol 21:553-9. 2002
    ..Especially in HuH7 cells, c-Jun transfected cells failed to make any colonies. Our data suggested that c-Jun activation can induce negative effect on survival and proliferation of HCC cells...
  34. ncbi request reprint Dynamic molecular linkers of the genome: the first decade of SMC proteins
    Ana Losada
    Spanish National Cancer Center CNIO, Madrid
    Genes Dev 19:1269-87. 2005
    ..Dissecting this class of chromosomal ATPases is likely to be central to our understanding of the structural basis of genome organization, stability, and evolution...
  35. doi request reprint Heterologous expression of lcc1 from Lentinula edodes in tobacco BY-2 cells results in the production an active, secreted form of fungal laccase
    Yuichi Sakamoto
    Iwate Biotechnology Research Center, 22 174 4 Narita, Kitakami, Iwate 024 0003, Japan
    Appl Microbiol Biotechnol 79:971-80. 2008
    ..These results suggest that heterologous expression of fungal Lcc1 in BY-2 cells will be a valuable tool for the production of sufficient quantities of active laccase for bioremediation...