M HengartnerSummaryAffiliation: Cold Spring Harbor Laboratory Country: USA Publications
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Publications
Programmed cell death in invertebratesM O Hengartner
Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA
Curr Opin Genet Dev 6:34-8. 1996..Characterization of these genes has revealed that the process of programmed cell death is evolutionarily conserved and has shed light on the molecular nature of the apoptotic machinery...
Calcium dynamics during fertilization in C. elegansA D Samuel
Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts, USA
BMC Dev Biol 1:8. 2001..Motivated by the experimental possibilities inherent in using such a well-established model organism, we have characterized fertilization-induced calcium dynamics in C. elegans...- Genetic control of programmed cell death and aging in the nematode Caenorhabditis elegansM O Hengartner
Cold Spring Harbor Laboratory, New York 11724, USA
Exp Gerontol 32:363-74. 1997..Although a large number of mutations have been isolated that affect either apoptosis or aging in C. elegans, there is so far no evidence that the genetic pathways that control these processes might overlap... - The biochemistry of apoptosisM O Hengartner
Cold Spring Harbor Laboratory, New York 11724, USA
Nature 407:770-6. 2000..Here I review the basic components of the death machinery, describe how they interact to regulate apoptosis in a coordinated manner, and discuss the main pathways that are used to activate cell death... - Syndecan regulates cell migration and axon guidance in C. elegansChrista Rhiner
Institute of Molecular Biology, University of Zurich, 8057, Switzerland
Development 132:4621-33. 2005..Taken together, our experiments show that distinct HS modification patterns on SDN-1 are involved in regulating axon guidance and cell migration in C. elegans... - URI-1 is required for DNA stability in C. elegansChristine T Parusel
Eidgenoessische Technische Hochschule Zuerich, Institute of Cell Biology, CH 8093 Zuerich, Switzerland
Development 133:621-9. 2006..Furthermore, they imply that URI-1 participates in a pathway(s) that is associated with the suppression of endogenous genotoxic DNA damage and highlight a role for URI-1 in the control of genome integrity... - Developmental apoptosis in C. elegans: a complex CEDnarioGuillaume Lettre
Division of Genetics, Children's Hospital, 300 Longwood Avenue, Boston, Massachusetts 02115, USA
Nat Rev Mol Cell Biol 7:97-108. 2006..Exciting insights into the regulation and execution of apoptosis in C. elegans have recently been made. These new findings will undoubtedly influence our perception of developmental apoptosis in more complex species, including humans... - Finding function in novel targets: C. elegans as a model organismTitus Kaletta
Devgen, Technologie park 30, B 9052 Gent, Belgium
Nat Rev Drug Discov 5:387-98. 2006..This review describes how C. elegans models can be used to advance our understanding of the molecular mechanisms of drug action and disease pathogenesis... 
C. elegans GLA-3 is a novel component of the MAP kinase MPK-1 signaling pathway required for germ cell survivalEkaterini A Kritikou
Institute of Molecular Biology, University of Zurich, 8057 Zurich, Switzerland
Genes Dev 20:2279-92. 2006..elegans germline and functions as a negative regulator of the MAPK signaling pathway during vulval development and in muscle cells...- Deleted in cancer 1 (DICE1) is an essential protein controlling the topology of the inner mitochondrial membrane in C. elegansSung Min Han
Department of Biochemistry, College of Science, Yonsei University, Seoul 120 749, Korea
Development 133:3597-606. 2006..In summary, C. elegans DIC-1 plays a crucial role in the formation of normal morphology of the mitochondrial cristae/inner membrane. Our results suggest that human DICE1 may have several functions in multiple intracellular locations... - Establishing a blueprint for CED-3-dependent killing through identification of multiple substrates for this proteaseRebecca C Taylor
Molecular Cell Biology Laboratory, The Smurfit Institute of Genetics, Trinity College, Dublin 2, Ireland
J Biol Chem 282:15011-21. 2007..Further analysis of these substrates is likely to yield important insights into the mechanism of killing by CED-3 and its human caspase counterparts... - Aminophospholipid translocase TAT-1 promotes phosphatidylserine exposure during C. elegans apoptosisStephanie Züllig
Institute of Molecular Biology, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
Curr Biol 17:994-9. 2007..tat-1(RNAi) also reduced the efficiency of cell-corpse clearance, suggesting that PS exposure acts as an "eat-me" signal in worms. We propose that tat-1 homologs might also play an important role in PS exposure in mammals... - Epigenetic regulation of histone H3 serine 10 phosphorylation status by HCF-1 proteins in C. elegans and mammalian cellsSoyoung Lee
Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, United States of America
PLoS ONE 2:e1213. 2007.... - Two pathways converge at CED-10 to mediate actin rearrangement and corpse removal in C. elegansJason M Kinchen
Department of Molecular Genetics and Microbiology, State University of New York, Stony Brook, New York 11743, USA
Nature 434:93-9. 2005.... - A Steric-inhibition model for regulation of nucleotide exchange via the Dock180 family of GEFsMingjian Lu
Beirne Carter Center for Immunology Research, Department of Microbiology, University of Virginia, Charlottesville, VA 22908 USA
Curr Biol 15:371-7. 2005..This steric-inhibition model may be a general mechanism for regulating multiple SH3-domain-containing Dock180 family members and may have implications for a variety of biological processes... - Tales of cannibalism, suicide, and murder: Programmed cell death in C. elegansJason M Kinchen
Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, New York 11743, USA
Curr Top Dev Biol 65:1-45. 2005..It is our purpose in this Chapter to familiarize the reader with the topic of programmed cell death in C. elegans and its relevance to current research in the fields of apoptosis and cell corpse clearance... - Caenorhabditis elegans DNA mismatch repair gene msh-2 is required for microsatellite stability and maintenance of genome integrityNatasha P Degtyareva
Department of Biology and Curriculum in Genetics and Molecular Biology, University of North Carolina, Chapel Hill, NC 27599 3280, USA
Proc Natl Acad Sci U S A 99:2158-63. 2002..These results demonstrate that msh-2 function in C. elegans is important in regulating both short- and long-term genomic stability... - The C. elegans LAR-like receptor tyrosine phosphatase PTP-3 and the VAB-1 Eph receptor tyrosine kinase have partly redundant functions in morphogenesisRobert J Harrington
Department of Molecular, Cell, and Developmental Biology, Sinsheimer Laboratories, University of California, Santa Cruz, CA 95064, USA
Development 129:2141-53. 2002..The genetic interaction of vab-1 and ptp-3 suggests that LAR-like RPTPs and Eph receptors have related and partly redundant functions in C. elegans morphogenesis... - The genes pme-1 and pme-2 encode two poly(ADP-ribose) polymerases in Caenorhabditis elegansSteve N Gagnon
Department of Pediatrics, Laval University Medical Research Centre and Faculty of Medicine, Laval University, Quebec, Canada
Biochem J 368:263-71. 2002..Together, these results show that PARP-1 and -2 are conserved in evolution and must have important functions in multicellular organisms. We propose using C. elegans as a model to understand better the functions of these enzymes... - Caenorhabditis elegans HUS-1 is a DNA damage checkpoint protein required for genome stability and EGL-1-mediated apoptosisE Randal Hofmann
Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA
Curr Biol 12:1908-18. 2002..However, in metazoans, DNA damage can induce apoptosis as well. How DNA damage activates the apoptotic machinery is not fully understood... - Dock180 and ELMO1 proteins cooperate to promote evolutionarily conserved Rac-dependent cell migrationCynthia M Grimsley
Beirne Carter Center for Immunology Research and the Department of Microbiology, University of Virginia, Charlottesville, Virginia 22908, USA
J Biol Chem 279:6087-97. 2004..This finding suggests that Rac activation by the ELMO.Dock180 complex at discrete intracellular locations mediated by the N-terminal 330 amino acids of ELMO1 rather than generalized Rac activation plays a role in cell migration... - PH domain of ELMO functions in trans to regulate Rac activation via Dock180Mingjian Lu
Beirne Carter Center for Immunology Research, Department of Microbiology, University of Virginia, Charlottesville, Virginia 22908, USA
Nat Struct Mol Biol 11:756-62. 2004..These data reveal a new mode of action of PH domains and a novel, evolutionarily conserved mechanism by which a bipartite GEF can activate Rac... - Caenorhabditis elegans ABL-1 antagonizes p53-mediated germline apoptosis after ionizing irradiationXinzhu Deng
Laboratory of Signal Transduction, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
Nat Genet 36:906-12. 2004..These studies indicate that ABL-1 distinguishes proapoptotic signals triggered by two different DNA-damaging agents and suggest that C. elegans might provide tissue models for development of anticancer drugs... - eor-1 and eor-2 are required for cell-specific apoptotic death in C. elegansDaniel J Hoeppner
Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
Dev Biol 274:125-38. 2004..We propose that eor-1 and eor-2 function together throughout the nervous system to promote terminal differentiation of neurons and function specifically in male HSNs to promote apoptotic death of the HSNs... - Phagocytosis of apoptotic cells is regulated by a UNC-73/TRIO-MIG-2/RhoG signaling module and armadillo repeats of CED-12/ELMOColin D deBakker
Department of Microbiology, Beirne Carter Center for Immunology Research, University of Virginia, Charlottesville, VA 22908, USA
Curr Biol 14:2208-16. 2004..However, the components upstream of ELMO and Dock180 during engulfment remain elusive... - A pathway for phagosome maturation during engulfment of apoptotic cellsJason M Kinchen
Beirne Carter Center for Immunology Research, University of Virginia, Charlottesville, VA 22908, USA
Nat Cell Biol 10:556-66. 2008..Finally, we have also identified a previously undescribed biochemical complex containing Vps34, dynamin and Rab5(GDP), thus providing a mechanism for Rab5 recruitment to the nascent phagosome...