M Hengartner

Summary

Affiliation: Cold Spring Harbor Laboratory
Country: USA

Publications

  1. ncbi request reprint Programmed cell death in invertebrates
    M O Hengartner
    Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA
    Curr Opin Genet Dev 6:34-8. 1996
  2. ncbi request reprint The biochemistry of apoptosis
    M O Hengartner
    Cold Spring Harbor Laboratory, New York 11724, USA
    Nature 407:770-6. 2000
  3. pmc Calcium dynamics during fertilization in C. elegans
    A D Samuel
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts, USA
    BMC Dev Biol 1:8. 2001
  4. ncbi request reprint Genetic control of programmed cell death and aging in the nematode Caenorhabditis elegans
    M O Hengartner
    Cold Spring Harbor Laboratory, New York 11724, USA
    Exp Gerontol 32:363-74. 1997
  5. ncbi request reprint Syndecan regulates cell migration and axon guidance in C. elegans
    Christa Rhiner
    Institute of Molecular Biology, University of Zurich, 8057, Switzerland
    Development 132:4621-33. 2005
  6. ncbi request reprint URI-1 is required for DNA stability in C. elegans
    Christine T Parusel
    Eidgenoessische Technische Hochschule Zuerich, Institute of Cell Biology, CH 8093 Zuerich, Switzerland
    Development 133:621-9. 2006
  7. ncbi request reprint Developmental apoptosis in C. elegans: a complex CEDnario
    Guillaume Lettre
    Division of Genetics, Children s Hospital, 300 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nat Rev Mol Cell Biol 7:97-108. 2006
  8. ncbi request reprint Finding function in novel targets: C. elegans as a model organism
    Titus Kaletta
    Devgen, Technologie park 30, B 9052 Gent, Belgium
    Nat Rev Drug Discov 5:387-98. 2006
  9. pmc C. elegans GLA-3 is a novel component of the MAP kinase MPK-1 signaling pathway required for germ cell survival
    Ekaterini A Kritikou
    Institute of Molecular Biology, University of Zurich, 8057 Zurich, Switzerland
    Genes Dev 20:2279-92. 2006
  10. ncbi request reprint Deleted in cancer 1 (DICE1) is an essential protein controlling the topology of the inner mitochondrial membrane in C. elegans
    Sung Min Han
    Department of Biochemistry, College of Science, Yonsei University, Seoul 120 749, Korea
    Development 133:3597-606. 2006

Collaborators

  • BRUCE A BOWERMAN
  • S J Martin
  • Michael A Herman
  • Oliver Hobert
  • Jason M Kinchen
  • Mingjian Lu
  • Kodi S Ravichandran
  • Ekaterini A Kritikou
  • Doris Klingele
  • E Randal Hofmann
  • Guillaume Lettre
  • John Sondek
  • Cynthia Grimsley
  • Lisa B Haney
  • Soyoung Lee
  • Stephanie Züllig
  • Kimon Doukoumetzidis
  • Rebecca C Taylor
  • Titus Kaletta
  • Sung Min Han
  • Christine T Parusel
  • Lilli Stergiou
  • Christa Rhiner
  • Kent L Rossman
  • Marc Vidal
  • Stuart Milstein
  • Xinzhu Deng
  • Annie Carole Tosello-Trampont
  • Cynthia M Grimsley
  • Enrico Brugnera
  • Colin D deBakker
  • Daniel J Hoeppner
  • Robert J Harrington
  • Natasha P Degtyareva
  • Steve N Gagnon
  • A D Samuel
  • Annie Tosello-Trampont
  • Costi D Sifri
  • Johann Almendinger
  • Virginie Horn
  • Robert A Schlegel
  • Winship Herr
  • Yi Liu
  • Steve J Charette
  • Shu Ito
  • Marko Jovanovic
  • Gabriela Brumatti
  • Lukas J Neukomm
  • Chris P M Reutelingsperger
  • Joanna Wysocka
  • Nicholas N Lyssenko
  • Eric Julien
  • Margaret S Halleck
  • W Brent Derry
  • Se Jin Lee
  • Erica Bogan
  • Tae Hoon Lee
  • Ji Young Mun
  • Hyeon Sook Koo
  • Moon Jeong Kim
  • Pierre Olivier Vidalain
  • Sung Sik Han
  • Monica Gotta
  • Wilhelm Krek
  • Phillip Gray
  • Thomas G Chappell
  • Juan Cabello
  • Ralf Schnabel
  • Richard Feichtinger
  • Erika Fröhli
  • Kelvin Wong
  • Stephan Gysi
  • Alex Hajnal
  • Heinke Schnabel
  • Vijay Yajnik
  • Matthew Hall
  • Darren R Veach
  • Mona S Spector
  • Barbara Conradt
  • Susan Granat
  • Qi Chen
  • Carlos Cordon-Cardo
  • Pei Ken Hsu
  • Li Chun Cheng
  • Bayard Clarkson
  • Athanasios Glekas
  • Richard Kolesnick
  • Alberto Villanueva
  • Paola Capodieci
  • William G Bornmann

Detail Information

Publications26

  1. ncbi request reprint Programmed cell death in invertebrates
    M O Hengartner
    Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA
    Curr Opin Genet Dev 6:34-8. 1996
    ..Characterization of these genes has revealed that the process of programmed cell death is evolutionarily conserved and has shed light on the molecular nature of the apoptotic machinery...
  2. ncbi request reprint The biochemistry of apoptosis
    M O Hengartner
    Cold Spring Harbor Laboratory, New York 11724, USA
    Nature 407:770-6. 2000
    ..Here I review the basic components of the death machinery, describe how they interact to regulate apoptosis in a coordinated manner, and discuss the main pathways that are used to activate cell death...
  3. pmc Calcium dynamics during fertilization in C. elegans
    A D Samuel
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts, USA
    BMC Dev Biol 1:8. 2001
    ..Motivated by the experimental possibilities inherent in using such a well-established model organism, we have characterized fertilization-induced calcium dynamics in C. elegans...
  4. ncbi request reprint Genetic control of programmed cell death and aging in the nematode Caenorhabditis elegans
    M O Hengartner
    Cold Spring Harbor Laboratory, New York 11724, USA
    Exp Gerontol 32:363-74. 1997
    ..Although a large number of mutations have been isolated that affect either apoptosis or aging in C. elegans, there is so far no evidence that the genetic pathways that control these processes might overlap...
  5. ncbi request reprint Syndecan regulates cell migration and axon guidance in C. elegans
    Christa Rhiner
    Institute of Molecular Biology, University of Zurich, 8057, Switzerland
    Development 132:4621-33. 2005
    ..Taken together, our experiments show that distinct HS modification patterns on SDN-1 are involved in regulating axon guidance and cell migration in C. elegans...
  6. ncbi request reprint URI-1 is required for DNA stability in C. elegans
    Christine T Parusel
    Eidgenoessische Technische Hochschule Zuerich, Institute of Cell Biology, CH 8093 Zuerich, Switzerland
    Development 133:621-9. 2006
    ..Furthermore, they imply that URI-1 participates in a pathway(s) that is associated with the suppression of endogenous genotoxic DNA damage and highlight a role for URI-1 in the control of genome integrity...
  7. ncbi request reprint Developmental apoptosis in C. elegans: a complex CEDnario
    Guillaume Lettre
    Division of Genetics, Children s Hospital, 300 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nat Rev Mol Cell Biol 7:97-108. 2006
    ..Exciting insights into the regulation and execution of apoptosis in C. elegans have recently been made. These new findings will undoubtedly influence our perception of developmental apoptosis in more complex species, including humans...
  8. ncbi request reprint Finding function in novel targets: C. elegans as a model organism
    Titus Kaletta
    Devgen, Technologie park 30, B 9052 Gent, Belgium
    Nat Rev Drug Discov 5:387-98. 2006
    ..This review describes how C. elegans models can be used to advance our understanding of the molecular mechanisms of drug action and disease pathogenesis...
  9. pmc C. elegans GLA-3 is a novel component of the MAP kinase MPK-1 signaling pathway required for germ cell survival
    Ekaterini A Kritikou
    Institute of Molecular Biology, University of Zurich, 8057 Zurich, Switzerland
    Genes Dev 20:2279-92. 2006
    ..elegans germline and functions as a negative regulator of the MAPK signaling pathway during vulval development and in muscle cells...
  10. ncbi request reprint Deleted in cancer 1 (DICE1) is an essential protein controlling the topology of the inner mitochondrial membrane in C. elegans
    Sung Min Han
    Department of Biochemistry, College of Science, Yonsei University, Seoul 120 749, Korea
    Development 133:3597-606. 2006
    ..In summary, C. elegans DIC-1 plays a crucial role in the formation of normal morphology of the mitochondrial cristae/inner membrane. Our results suggest that human DICE1 may have several functions in multiple intracellular locations...
  11. ncbi request reprint Establishing a blueprint for CED-3-dependent killing through identification of multiple substrates for this protease
    Rebecca C Taylor
    Molecular Cell Biology Laboratory, The Smurfit Institute of Genetics, Trinity College, Dublin 2, Ireland
    J Biol Chem 282:15011-21. 2007
    ..Further analysis of these substrates is likely to yield important insights into the mechanism of killing by CED-3 and its human caspase counterparts...
  12. ncbi request reprint Aminophospholipid translocase TAT-1 promotes phosphatidylserine exposure during C. elegans apoptosis
    Stephanie Züllig
    Institute of Molecular Biology, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Curr Biol 17:994-9. 2007
    ..tat-1(RNAi) also reduced the efficiency of cell-corpse clearance, suggesting that PS exposure acts as an "eat-me" signal in worms. We propose that tat-1 homologs might also play an important role in PS exposure in mammals...
  13. pmc Epigenetic regulation of histone H3 serine 10 phosphorylation status by HCF-1 proteins in C. elegans and mammalian cells
    Soyoung Lee
    Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, United States of America
    PLoS ONE 2:e1213. 2007
    ....
  14. ncbi request reprint Two pathways converge at CED-10 to mediate actin rearrangement and corpse removal in C. elegans
    Jason M Kinchen
    Department of Molecular Genetics and Microbiology, State University of New York, Stony Brook, New York 11743, USA
    Nature 434:93-9. 2005
    ....
  15. ncbi request reprint A Steric-inhibition model for regulation of nucleotide exchange via the Dock180 family of GEFs
    Mingjian Lu
    Beirne Carter Center for Immunology Research, Department of Microbiology, University of Virginia, Charlottesville, VA 22908 USA
    Curr Biol 15:371-7. 2005
    ..This steric-inhibition model may be a general mechanism for regulating multiple SH3-domain-containing Dock180 family members and may have implications for a variety of biological processes...
  16. ncbi request reprint Tales of cannibalism, suicide, and murder: Programmed cell death in C. elegans
    Jason M Kinchen
    Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, New York 11743, USA
    Curr Top Dev Biol 65:1-45. 2005
    ..It is our purpose in this Chapter to familiarize the reader with the topic of programmed cell death in C. elegans and its relevance to current research in the fields of apoptosis and cell corpse clearance...
  17. pmc Caenorhabditis elegans DNA mismatch repair gene msh-2 is required for microsatellite stability and maintenance of genome integrity
    Natasha P Degtyareva
    Department of Biology and Curriculum in Genetics and Molecular Biology, University of North Carolina, Chapel Hill, NC 27599 3280, USA
    Proc Natl Acad Sci U S A 99:2158-63. 2002
    ..These results demonstrate that msh-2 function in C. elegans is important in regulating both short- and long-term genomic stability...
  18. ncbi request reprint The C. elegans LAR-like receptor tyrosine phosphatase PTP-3 and the VAB-1 Eph receptor tyrosine kinase have partly redundant functions in morphogenesis
    Robert J Harrington
    Department of Molecular, Cell, and Developmental Biology, Sinsheimer Laboratories, University of California, Santa Cruz, CA 95064, USA
    Development 129:2141-53. 2002
    ..The genetic interaction of vab-1 and ptp-3 suggests that LAR-like RPTPs and Eph receptors have related and partly redundant functions in C. elegans morphogenesis...
  19. pmc The genes pme-1 and pme-2 encode two poly(ADP-ribose) polymerases in Caenorhabditis elegans
    Steve N Gagnon
    Department of Pediatrics, Laval University Medical Research Centre and Faculty of Medicine, Laval University, Quebec, Canada
    Biochem J 368:263-71. 2002
    ..Together, these results show that PARP-1 and -2 are conserved in evolution and must have important functions in multicellular organisms. We propose using C. elegans as a model to understand better the functions of these enzymes...
  20. ncbi request reprint Caenorhabditis elegans HUS-1 is a DNA damage checkpoint protein required for genome stability and EGL-1-mediated apoptosis
    E Randal Hofmann
    Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA
    Curr Biol 12:1908-18. 2002
    ..However, in metazoans, DNA damage can induce apoptosis as well. How DNA damage activates the apoptotic machinery is not fully understood...
  21. ncbi request reprint Dock180 and ELMO1 proteins cooperate to promote evolutionarily conserved Rac-dependent cell migration
    Cynthia M Grimsley
    Beirne Carter Center for Immunology Research and the Department of Microbiology, University of Virginia, Charlottesville, Virginia 22908, USA
    J Biol Chem 279:6087-97. 2004
    ..This finding suggests that Rac activation by the ELMO.Dock180 complex at discrete intracellular locations mediated by the N-terminal 330 amino acids of ELMO1 rather than generalized Rac activation plays a role in cell migration...
  22. ncbi request reprint PH domain of ELMO functions in trans to regulate Rac activation via Dock180
    Mingjian Lu
    Beirne Carter Center for Immunology Research, Department of Microbiology, University of Virginia, Charlottesville, Virginia 22908, USA
    Nat Struct Mol Biol 11:756-62. 2004
    ..These data reveal a new mode of action of PH domains and a novel, evolutionarily conserved mechanism by which a bipartite GEF can activate Rac...
  23. ncbi request reprint Caenorhabditis elegans ABL-1 antagonizes p53-mediated germline apoptosis after ionizing irradiation
    Xinzhu Deng
    Laboratory of Signal Transduction, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Nat Genet 36:906-12. 2004
    ..These studies indicate that ABL-1 distinguishes proapoptotic signals triggered by two different DNA-damaging agents and suggest that C. elegans might provide tissue models for development of anticancer drugs...
  24. ncbi request reprint eor-1 and eor-2 are required for cell-specific apoptotic death in C. elegans
    Daniel J Hoeppner
    Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
    Dev Biol 274:125-38. 2004
    ..We propose that eor-1 and eor-2 function together throughout the nervous system to promote terminal differentiation of neurons and function specifically in male HSNs to promote apoptotic death of the HSNs...
  25. ncbi request reprint Phagocytosis of apoptotic cells is regulated by a UNC-73/TRIO-MIG-2/RhoG signaling module and armadillo repeats of CED-12/ELMO
    Colin D deBakker
    Department of Microbiology, Beirne Carter Center for Immunology Research, University of Virginia, Charlottesville, VA 22908, USA
    Curr Biol 14:2208-16. 2004
    ..However, the components upstream of ELMO and Dock180 during engulfment remain elusive...
  26. pmc A pathway for phagosome maturation during engulfment of apoptotic cells
    Jason M Kinchen
    Beirne Carter Center for Immunology Research, University of Virginia, Charlottesville, VA 22908, USA
    Nat Cell Biol 10:556-66. 2008
    ..Finally, we have also identified a previously undescribed biochemical complex containing Vps34, dynamin and Rab5(GDP), thus providing a mechanism for Rab5 recruitment to the nascent phagosome...