Joshua T Dubnau

Summary

Affiliation: Cold Spring Harbor Laboratory
Country: USA

Publications

  1. ncbi request reprint Neurogenetic dissection of conditioned behavior: evolution by analogy or homology?
    Josh Dubnau
    Cold Spring Harbor Laboratories, Cold Spring Harbor, NY 11724, USA
    J Neurogenet 17:295-326. 2003
  2. pmc Short- and long-term memory in Drosophila require cAMP signaling in distinct neuron types
    Allison L Blum
    Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA
    Curr Biol 19:1341-50. 2009
  3. pmc Activation of transposable elements during aging and neuronal decline in Drosophila
    Wanhe Li
    Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, USA
    Nat Neurosci 16:529-31. 2013
  4. pmc Transposable elements in TDP-43-mediated neurodegenerative disorders
    Wanhe Li
    Graduate Program in Molecular and Cellular Biology, Stony Brook University, Stony Brook, New York, United States of America
    PLoS ONE 7:e44099. 2012
  5. doi request reprint Systems memory consolidation in Drosophila
    Josh Dubnau
    Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
    Curr Opin Neurobiol 23:84-91. 2013
  6. ncbi request reprint Neural substrates of memory: from synapse to system
    Josh Dubnau
    Cold Spring Harbor Laboratories, 1 Bungtown Rd, Cold Spring Harbor, New York 11724, USA
    J Neurobiol 54:238-53. 2003
  7. ncbi request reprint The staufen/pumilio pathway is involved in Drosophila long-term memory
    Josh Dubnau
    Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA
    Curr Biol 13:286-96. 2003
  8. pmc Deconstructing memory in Drosophila
    Carla Margulies
    Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA
    Curr Biol 15:R700-13. 2005
  9. pmc Identification of synaptic targets of Drosophila pumilio
    Gengxin Chen
    Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, USA
    PLoS Comput Biol 4:e1000026. 2008
  10. pmc Parallel processing of olfactory memories in Drosophila
    Allison Blum
    Watson School of Biological Sciences, Cold Spring Harbor, NY, USA
    Fly (Austin) 4:163-6. 2010

Collaborators

  • Ann Shyn Chiang
  • Patrick Smith
  • Michael Zhang
  • Karen Zito
  • Wanhe Li
  • Lisa Prazak
  • Allison Blum
  • Allison L Blum
  • Gengxin Chen
  • Tim Tully
  • Carla Margulies
  • Gilbert L Henry
  • Delphine Theodorou
  • Lisa Krug
  • Servan GrĂ¼ninger
  • Nabanita Chatterjee
  • Molly Hammell
  • Ying Jin
  • Mike Cressy
  • Nishi Sinha
  • Jody Barditch
  • Qing Shuo Zhang
  • Adrian R Krainer
  • Michael Regulski

Detail Information

Publications11

  1. ncbi request reprint Neurogenetic dissection of conditioned behavior: evolution by analogy or homology?
    Josh Dubnau
    Cold Spring Harbor Laboratories, Cold Spring Harbor, NY 11724, USA
    J Neurogenet 17:295-326. 2003
  2. pmc Short- and long-term memory in Drosophila require cAMP signaling in distinct neuron types
    Allison L Blum
    Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA
    Curr Biol 19:1341-50. 2009
    ..At the neuroanatomical level, however, different temporal stages of memory can engage distinct neural circuits, a notion that has not been conceptually integrated with the cellular view...
  3. pmc Activation of transposable elements during aging and neuronal decline in Drosophila
    Wanhe Li
    Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, USA
    Nat Neurosci 16:529-31. 2013
    ..These findings suggest that transposon activation may contribute to age-dependent loss of neuronal function...
  4. pmc Transposable elements in TDP-43-mediated neurodegenerative disorders
    Wanhe Li
    Graduate Program in Molecular and Cellular Biology, Stony Brook University, Stony Brook, New York, United States of America
    PLoS ONE 7:e44099. 2012
    ..Third, we discovered that a large fraction of the TEs to which TDP-43 binds become de-repressed in mouse TDP-43 disease models. We propose the hypothesis that TE mis-regulation contributes to TDP-43 related neurodegenerative diseases...
  5. doi request reprint Systems memory consolidation in Drosophila
    Josh Dubnau
    Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
    Curr Opin Neurobiol 23:84-91. 2013
    ..The ease of cell type specific genetic manipulations in flies provides a unique opportunity to forge an integrated mechanistic understanding of biochemical and systems consolidation...
  6. ncbi request reprint Neural substrates of memory: from synapse to system
    Josh Dubnau
    Cold Spring Harbor Laboratories, 1 Bungtown Rd, Cold Spring Harbor, New York 11724, USA
    J Neurobiol 54:238-53. 2003
    ..Our objective here is to offer a conceptually unifying perspective and to discuss this perspective in relation to an experiment analysis of memory in Drosophila...
  7. ncbi request reprint The staufen/pumilio pathway is involved in Drosophila long-term memory
    Josh Dubnau
    Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA
    Curr Biol 13:286-96. 2003
    ..To date, little is known about the molecular-genetic mechanisms that contribute to this process during memory formation...
  8. pmc Deconstructing memory in Drosophila
    Carla Margulies
    Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA
    Curr Biol 15:R700-13. 2005
    ..We have attempted to use this integrative approach to evaluate distinct mechanistic hypotheses, and to propose critical experiments that will advance this field...
  9. pmc Identification of synaptic targets of Drosophila pumilio
    Gengxin Chen
    Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, USA
    PLoS Comput Biol 4:e1000026. 2008
    ..Finally, we show that the endogenous dlg1 mRNA can be regulated by Pumilio in a neuronal context, the adult mushroom bodies (MB), which is an anatomical site of memory storage...
  10. pmc Parallel processing of olfactory memories in Drosophila
    Allison Blum
    Watson School of Biological Sciences, Cold Spring Harbor, NY, USA
    Fly (Austin) 4:163-6. 2010
    ..Using an aversive olfactory conditioning task in Drosophila, we found that cAMP signaling in different neuron cell types is sufficient to support short or long-term memory independently...
  11. ncbi request reprint Chipping away at brain function: mining for insights with microarrays
    Gilbert L Henry
    Cold Spring Harbor Laboratory, 1 Bungtown Rd, Cold Spring Harbor, NY 11724, USA
    Curr Opin Neurobiol 13:570-6. 2003
    ..However, some recent papers have offered considerable biological insight by providing independent in vivo confirmation of the roles of candidate genes, offering a glimpse of the potential power of microarrays in neurobiological research...

Research Grants7

  1. Genome-wide regulatory network governing neuronal mRNA translation.
    Joshua T Dubnau; Fiscal Year: 2010
    ..This proposal describes a method that can provide individual reporters of the regulation of protein synthesis for each gene in the genome, and can identify the regulatory mechanisms controlling each one. ..
  2. Functional Anatomy of Learning and Memory in Drosophila
    JOSHUA DUBNAU; Fiscal Year: 2007
    ..As a result, an understanding of the "logic" of how information is processed in relatively simple nervous systems can greatly inform future investigations of human cognition. ..