H T Cline

Summary

Affiliation: Cold Spring Harbor Laboratory
Country: USA

Publications

  1. pmc Low lead levels stunt neuronal growth in a reversible manner
    H T Cline
    Cold Spring Harbor Laboratory, NY 11724, USA
    Proc Natl Acad Sci U S A 93:9915-20. 1996
  2. ncbi request reprint Synaptogenesis: a balancing act between excitation and inhibition
    Hollis Cline
    Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, NY 11724, USA
    Curr Biol 15:R203-5. 2005
  3. ncbi request reprint Dendritic arbor development and synaptogenesis
    H T Cline
    Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA
    Curr Opin Neurobiol 11:118-26. 2001
  4. ncbi request reprint Maturation of a central glutamatergic synapse
    G Wu
    Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
    Science 274:972-6. 1996
  5. pmc Promotion of dendritic growth by CPG15, an activity-induced signaling molecule
    E Nedivi
    Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA
    Science 281:1863-6. 1998
  6. pmc Developmental regulation of CPG15 expression in Xenopus
    E Nedivi
    Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA
    J Comp Neurol 435:464-73. 2001
  7. ncbi request reprint Single-cell electroporation for gene transfer in vivo
    K Haas
    Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
    Neuron 29:583-91. 2001
  8. ncbi request reprint Synapse formation: if it looks like a duck and quacks like a duck
    I Cantallops
    Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA
    Curr Biol 10:R620-3. 2000
  9. ncbi request reprint Sperry and Hebb: oil and vinegar?
    Hollis Cline
    Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA
    Trends Neurosci 26:655-61. 2003
  10. pmc The regulation of dendritic arbor development and plasticity by glutamatergic synaptic input: a review of the synaptotrophic hypothesis
    Hollis Cline
    Cold Spring Harbour Laboratory, 1 Bungtown Road, Cold Spring Harbour, NY 11724, USA
    J Physiol 586:1509-17. 2008

Collaborators

Detail Information

Publications33

  1. pmc Low lead levels stunt neuronal growth in a reversible manner
    H T Cline
    Cold Spring Harbor Laboratory, NY 11724, USA
    Proc Natl Acad Sci U S A 93:9915-20. 1996
    ..These studies indicate that impaired neuronal growth may be responsible in part for lead-induced cognitive deficits and that chelator treatment counteracts this effect...
  2. ncbi request reprint Synaptogenesis: a balancing act between excitation and inhibition
    Hollis Cline
    Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, NY 11724, USA
    Curr Biol 15:R203-5. 2005
    ..These findings, together with data indicating that the genes encoding neuroligin and PSD95 are altered in autism patients, suggest that a molecular understanding of complex neurological diseases is within reach...
  3. ncbi request reprint Dendritic arbor development and synaptogenesis
    H T Cline
    Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA
    Curr Opin Neurobiol 11:118-26. 2001
    ..The different roles of synaptic activity with respect to structural plasticity probably reflect the regulated spatiotemporal expression of key components within signaling pathways...
  4. ncbi request reprint Maturation of a central glutamatergic synapse
    G Wu
    Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
    Science 274:972-6. 1996
    ..Newly formed synapses may be silent unless sufficient depolarization is provided by coincident activity that could activate postsynaptic CaMKII, resulting in the appearance of AMPA responses...
  5. pmc Promotion of dendritic growth by CPG15, an activity-induced signaling molecule
    E Nedivi
    Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA
    Science 281:1863-6. 1998
    ..CPG15 may represent a new class of activity-regulated, membrane-bound, growth-promoting proteins that permit exquisite spatial and temporal control of neuronal structure...
  6. pmc Developmental regulation of CPG15 expression in Xenopus
    E Nedivi
    Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA
    J Comp Neurol 435:464-73. 2001
    ..These data support a model in which CPG15 expressed in retinal ganglion cells is trafficked to retinal axons, where it modulates postsynaptic dendritic arbor elaboration, and synaptic maturation...
  7. ncbi request reprint Single-cell electroporation for gene transfer in vivo
    K Haas
    Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
    Neuron 29:583-91. 2001
    ..This technique will allow unprecedented spatial and temporal control over gene delivery and protein expression...
  8. ncbi request reprint Synapse formation: if it looks like a duck and quacks like a duck
    I Cantallops
    Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA
    Curr Biol 10:R620-3. 2000
    ..This single molecular interaction appears to initiate clustering of synaptic vesicles, assembly of vesicle-release machinery and morphological changes at the presynaptic membrane...
  9. ncbi request reprint Sperry and Hebb: oil and vinegar?
    Hollis Cline
    Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA
    Trends Neurosci 26:655-61. 2003
    ..This debate is presented simplistically here in terms of Sperry's chemoaffinity hypothesis versus Hebb's rules of correlation-based synaptic change, which are often presented as being mutually exclusive - much like oil and vinegar...
  10. pmc The regulation of dendritic arbor development and plasticity by glutamatergic synaptic input: a review of the synaptotrophic hypothesis
    Hollis Cline
    Cold Spring Harbour Laboratory, 1 Bungtown Road, Cold Spring Harbour, NY 11724, USA
    J Physiol 586:1509-17. 2008
    ....
  11. ncbi request reprint Synaptic plasticity: importance of proteasome-mediated protein turnover
    Hollis Cline
    Cold Spring Harbor Laboratory, Beckman Building, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA
    Curr Biol 13:R514-6. 2003
    ..The ubiquitin-proteasome system regulates protein degradation in every eukaryotic cell. Recent work has shown that protein turnover mediated by the ubiquitin-proteasome system plays a key role in synaptic plasticity...
  12. ncbi request reprint Homer expression in the Xenopus tadpole nervous system
    Lisa Foa
    Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA
    J Comp Neurol 487:42-53. 2005
    ..The high level of conservation of the xhomer1 gene and the protein expression in the developing nervous system suggest that Homer1 expression may be important for normal neuronal circuit development...
  13. ncbi request reprint Visual experience regulates metabotropic glutamate receptor-mediated plasticity of AMPA receptor synaptic transmission by homer1a induction
    Kendall Van Keuren-Jensen
    Department of Neurobiology and Behavior, State University of New York at Stony Brook, Stony Brook, New York 11794 5230, USA
    J Neurosci 26:7575-80. 2006
    ..This is the first evidence that mGluR-mediated changes in AMPA transmission can be regulated by Homer proteins in response to physiologically relevant stimuli...
  14. pmc AMPA receptors regulate experience-dependent dendritic arbor growth in vivo
    Kurt Haas
    Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA
    Proc Natl Acad Sci U S A 103:12127-31. 2006
    ..These results indicate that AMPAR-mediated transmission underlies experience-dependent dendritic arbor growth by stabilizing branches, and support a competition-based model for dendrite growth...
  15. ncbi request reprint Increased expression of the immediate-early gene arc/arg3.1 reduces AMPA receptor-mediated synaptic transmission
    Emiliano M Rial Verde
    Watson School of Biological Sciences, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA
    Neuron 52:461-74. 2006
    ..Our results demonstrate that Arc/Arg3.1 reduces the number of GluR2/3 receptors leading to a decrease in AMPAR-mediated synaptic currents, consistent with a role in the homeostatic regulation of synaptic strength...
  16. ncbi request reprint Enhanced visual activity in vivo forms nascent synapses in the developing retinotectal projection
    Carlos D Aizenman
    Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
    J Neurophysiol 97:2949-57. 2007
    ..This suggests that in vivo visual stimulation increases synapses that have a low Pr and that have properties consistent with immature synapses...
  17. doi request reprint Rapid activity-dependent delivery of the neurotrophic protein CPG15 to the axon surface of neurons in intact Xenopus tadpoles
    Isabel Cantallops
    Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA
    Dev Neurobiol 68:744-59. 2008
    ..The results indicate that the delivery of the neurotrophic protein CPG15 to the axon surface can be regulated on a rapid time scale by activity-dependent mechanisms in vivo...
  18. ncbi request reprint In vivo single-cell electroporation for transfer of DNA and macromolecules
    Jennifer E Bestman
    Cold Spring Harbor Laboratory, Watson School of Biological Sciences, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA
    Nat Protoc 1:1267-72. 2006
    ..Single-cell electroporation is an affordable method to fluorescently label and genetically manipulate individual cells. This powerful technique enables observation of single cells in an otherwise normal environment...
  19. ncbi request reprint Coordinated motor neuron axon growth and neuromuscular synaptogenesis are promoted by CPG15 in vivo
    Ashkan Javaherian
    Graduate Program in Genetics, Stony Brook University, Stony Brook, New York 11790, USA
    Neuron 45:505-12. 2005
    ..CPG15 expression enhances the development of motor neuron axon arbors by promoting neuromuscular synaptogenesis and by increasing the addition of new axon branches...
  20. pmc Insulin receptor signaling regulates synapse number, dendritic plasticity, and circuit function in vivo
    Shu Ling Chiu
    Watson School of Biological Sciences and Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
    Neuron 58:708-19. 2008
    ..These data indicate that insulin receptor signaling regulates circuit function and plasticity by controlling synapse density...
  21. ncbi request reprint Regulation of rho GTPases by crosstalk and neuronal activity in vivo
    Zheng Li
    Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
    Neuron 33:741-50. 2002
    ..These data suggest a link between glutamate receptor function, Rho GTPase activity, and dendritic arbor growth in the intact animal...
  22. ncbi request reprint Targeted electroporation in Xenopus tadpoles in vivo--from single cells to the entire brain
    Kurt Haas
    Differentiation 70:148-54. 2002
    ....
  23. ncbi request reprint Rho GTPases and activity-dependent dendrite development
    Linda Van Aelst
    Cold Spring Harbor Lab, Cold Spring Harbor, New York, New York 11724, USA
    Curr Opin Neurobiol 14:297-304. 2004
    ..The Rho GTPases have emerged as key integrators of these environmental cues to regulate the underlying dendritic cytoskeleton...
  24. doi request reprint Roles of NR2A and NR2B in the development of dendritic arbor morphology in vivo
    Rebecca C Ewald
    Watson School of Biological Sciences and Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA
    J Neurosci 28:850-61. 2008
    ..These experiments indicate that NR2A and NR2B have subunit-specific properties in dendritic arbor development, but also overlapping functions, indicating a requirement for both subunits in neuronal development...
  25. ncbi request reprint Visually driven modulation of glutamatergic synaptic transmission is mediated by the regulation of intracellular polyamines
    Carlos D Aizenman
    Cold Spring Harbor Laboratory, Beckman Building, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA
    Neuron 34:623-34. 2002
    ..Regulation of polyamine synthesis by physiological stimuli is a novel form of modulation of synaptic transmission important for understanding the short-term effects of enhanced sensory experience during development...
  26. ncbi request reprint Refining the roles of GABAergic signaling during neural circuit formation
    Colin J Akerman
    Department of Pharmacology, University of Oxford, Mansfield Road, Oxford, UK, OX1 3QT
    Trends Neurosci 30:382-9. 2007
    ....
  27. ncbi request reprint Dendrite growth increased by visual activity requires NMDA receptor and Rho GTPases
    Wun Chey Sin
    Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA
    Nature 419:475-80. 2002
    ..The results delineate a role for Rho GTPases in the structural plasticity driven by visual stimulation in vivo...
  28. ncbi request reprint Time-lapse in vivo imaging of the morphological development of Xenopus optic tectal interneurons
    Gang Yi Wu
    Cold Spring Harbor Laboratory, New York 11724, USA
    J Comp Neurol 459:392-406. 2003
    ..Because the majority of synaptic contacts are formed on dendrites, the structural changes we observed in interneuronal dendritic arbors suggest that optic tectal circuits are extremely plastic during early stages of development...
  29. ncbi request reprint Control of axon branch dynamics by correlated activity in vivo
    Edward S Ruthazer
    Cold Spring Harbor Laboratory, One Bungtown Road, Cold Spring Harbor, NY 11724, USA
    Science 301:66-70. 2003
    ..These results describe a correlation-based mechanism by which visual experience directly governs axon branch dynamics that contribute to the development of topographic maps...
  30. ncbi request reprint Visually driven regulation of intrinsic neuronal excitability improves stimulus detection in vivo
    Carlos D Aizenman
    Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
    Neuron 39:831-42. 2003
    ..The synaptic and intrinsic adaptations function together to keep tectal neurons within a constant operating range, while making the intact visual system less responsive to background activity yet more sensitive to burst stimuli...
  31. ncbi request reprint Depolarizing GABAergic conductances regulate the balance of excitation to inhibition in the developing retinotectal circuit in vivo
    Colin J Akerman
    Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA
    J Neurosci 26:5117-30. 2006
    ..Therefore, depolarizing GABAergic transmission plays a pivotal role in the maturation of excitatory transmission and controls the balance of excitation and inhibition in the developing retinotectal circuit...
  32. ncbi request reprint Stabilization of axon branch dynamics by synaptic maturation
    Edward S Ruthazer
    Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724 0100, USA
    J Neurosci 26:3594-603. 2006
    ..Visual stimulation for 4 h enhanced the stability of the arbor at intense presynaptic puncta while concurrently inducing the retraction of exploratory branches with only faintly labeled or no synaptic sites...
  33. ncbi request reprint Insights into activity-dependent map formation from the retinotectal system: a middle-of-the-brain perspective
    Edward S Ruthazer
    Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA
    J Neurobiol 59:134-46. 2004
    ..Finally, we review recent experiments in other CNS projections that support the proposition that cooperation between molecular guidance cues and activity-dependent processes constitutes a general paradigm for CNS map formation...