Dmitri Chklovskii

Summary

Affiliation: Cold Spring Harbor Laboratory
Country: USA

Publications

  1. pmc Wiring optimization can relate neuronal structure and function
    Beth L Chen
    Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
    Proc Natl Acad Sci U S A 103:4723-8. 2006
  2. pmc Highly nonrandom features of synaptic connectivity in local cortical circuits
    Sen Song
    Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, USA
    PLoS Biol 3:e68. 2005
  3. pmc Search for computational modules in the C. elegans brain
    Markus Reigl
    Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
    BMC Biol 2:25. 2004
  4. pmc Power-law for axon diameters at branch point
    Dmitri B Chklovskii
    Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
    BMC Neurosci 4:18. 2003
  5. ncbi request reprint Maps in the brain: what can we learn from them?
    Dmitri B Chklovskii
    Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA
    Annu Rev Neurosci 27:369-92. 2004
  6. ncbi request reprint Exact solution for the optimal neuronal layout problem
    Dmitri B Chklovskii
    Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
    Neural Comput 16:2067-78. 2004
  7. ncbi request reprint Synaptic connectivity and neuronal morphology: two sides of the same coin
    Dmitri B Chklovskii
    Cold Spring Harbor Laboratory, NY 11724, USA
    Neuron 43:609-17. 2004
  8. ncbi request reprint Geometric and functional organization of cortical circuits
    Gordon M G Shepherd
    Howard Hughes Medical Institute, Cold Spring Harbor, New York 11724, USA
    Nat Neurosci 8:782-90. 2005
  9. doi request reprint A cost-benefit analysis of neuronal morphology
    Quan Wen
    Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA
    J Neurophysiol 99:2320-8. 2008
  10. ncbi request reprint Class-specific features of neuronal wiring
    Armen Stepanyants
    Cold Spring Harbor Laboratory, New York 11724, USA
    Neuron 43:251-9. 2004

Research Grants

  1. Statistics, geometry & plasticity of cortical circuits
    Dmitri Chklovskii; Fiscal Year: 2006
  2. Statistics, geometry & plasticity of cortical circuits
    Dmitri Chklovskii; Fiscal Year: 2007

Detail Information

Publications16

  1. pmc Wiring optimization can relate neuronal structure and function
    Beth L Chen
    Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
    Proc Natl Acad Sci U S A 103:4723-8. 2006
    ..We propose that biological factors relating to axonal guidance and command neuron functions contribute to these deviations. We capture these factors by proposing a modified wiring cost function...
  2. pmc Highly nonrandom features of synaptic connectivity in local cortical circuits
    Sen Song
    Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, USA
    PLoS Biol 3:e68. 2005
    ..Therefore, the local cortical network structure can be viewed as a skeleton of stronger connections in a sea of weaker ones. Such a skeleton is likely to play an important role in network dynamics and should be investigated further...
  3. pmc Search for computational modules in the C. elegans brain
    Markus Reigl
    Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
    BMC Biol 2:25. 2004
    ..elegans nervous system's wiring diagram...
  4. pmc Power-law for axon diameters at branch point
    Dmitri B Chklovskii
    Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
    BMC Neurosci 4:18. 2003
    ..Axon calibers vary widely among different animals, neuron classes, and even within the same neuron. What determines the diameter of axon branches?..
  5. ncbi request reprint Maps in the brain: what can we learn from them?
    Dmitri B Chklovskii
    Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA
    Annu Rev Neurosci 27:369-92. 2004
    ..These solutions can help us in inferring intracortical connectivity and, ultimately, in understanding the function of the visual system...
  6. ncbi request reprint Exact solution for the optimal neuronal layout problem
    Dmitri B Chklovskii
    Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
    Neural Comput 16:2067-78. 2004
    ..These solutions make the inverse problem of inferring neuronal connectivity from neuronal layout more tractable...
  7. ncbi request reprint Synaptic connectivity and neuronal morphology: two sides of the same coin
    Dmitri B Chklovskii
    Cold Spring Harbor Laboratory, NY 11724, USA
    Neuron 43:609-17. 2004
    ..Moreover, the actual lengths of axons and dendrites are close to the smallest possible length for a given interconnectivity, arguing that high interconnectivity is essential for cortical function...
  8. ncbi request reprint Geometric and functional organization of cortical circuits
    Gordon M G Shepherd
    Howard Hughes Medical Institute, Cold Spring Harbor, New York 11724, USA
    Nat Neurosci 8:782-90. 2005
    ..A large plasticity potential appears to be incorporated into these circuits, allowing for functional 'tuning' with fixed axonal and dendritic arbor geometry...
  9. doi request reprint A cost-benefit analysis of neuronal morphology
    Quan Wen
    Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA
    J Neurophysiol 99:2320-8. 2008
    ..The theory predicts that adjacent Purkinje dendritic arbors should spatially segregate. In addition, we propose two explicit cost function expressions, falsifiable by measuring dendritic caliber near bifurcations...
  10. ncbi request reprint Class-specific features of neuronal wiring
    Armen Stepanyants
    Cold Spring Harbor Laboratory, New York 11724, USA
    Neuron 43:251-9. 2004
    ..Our results define distinct class-specific rules in establishing synaptic connectivity, which could be crucial in formulating a canonical cortical circuit...
  11. ncbi request reprint Wiring optimization in cortical circuits
    Dmitri B Chklovskii
    Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
    Neuron 34:341-7. 2002
    ..We have measured the fraction of the volume occupied by each cellular component and find that the volume of wire is close to the predicted optimal value...
  12. ncbi request reprint Geometry and structural plasticity of synaptic connectivity
    Armen Stepanyants
    Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA
    Neuron 34:275-88. 2002
    ..6-1.8 from area V1 to areas V2, V4, and 7a. Since the filling fraction is much smaller than 1, spine remodeling can make a large contribution to structural plasticity...
  13. ncbi request reprint Neurogeometry and potential synaptic connectivity
    Armen Stepanyants
    Department of Physics and Center for Interdisciplinary Research on Complex Systems, Northeastern University, 110 Forsyth Street, Boston, MA 02115, USA
    Trends Neurosci 28:387-94. 2005
    ..In addition to describing potential synaptic connectivity in neuronal circuits, neurogeometry provides insight into basic features of functional connectivity, such as specificity and plasticity...
  14. ncbi request reprint Local potential connectivity in cat primary visual cortex
    Armen Stepanyants
    Physics Department and Center for Interdisciplinary Research on Complex Systems, Northeastern University, Boston, MA 02115, USA
    Cereb Cortex 18:13-28. 2008
    ..Here, only nearby neurons are capable of establishing more than one potential synapse, implying that within the ocular dominance column these connections have more limited potential for circuit remodeling...
  15. pmc Segregation of the brain into gray and white matter: a design minimizing conduction delays
    Quan Wen
    Department of Physics and Astronomy, State University of New York at Stony Brook, Stony Brook, New York, United States of America
    PLoS Comput Biol 1:e78. 2005
    ..These results provide a possible explanation for the structure of various regions of the vertebrate brain, such as the mammalian neocortex and neostriatum, the avian telencephalon, and the spinal cord...
  16. ncbi request reprint Optimal information storage in noisy synapses under resource constraints
    Lav R Varshney
    Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Neuron 52:409-23. 2006
    ..Solutions of our constrained optimization problems are not only consistent with existing experimental measurements but also make nontrivial predictions...

Research Grants4

  1. Statistics, geometry & plasticity of cortical circuits
    Dmitri Chklovskii; Fiscal Year: 2006
    ..All theoretical work will be carried out in close collaborations with several experimental groups. ..
  2. Statistics, geometry & plasticity of cortical circuits
    Dmitri Chklovskii; Fiscal Year: 2007
    ..All theoretical work will be carried out in close collaborations with several experimental groups. ..